#1: Alcoholism Accumulation of

#2: Gallstones/Pancreatic Obstructions (tumors, etc) billirubin in the Jaundice

Abdominal Trauma bloodstream
causes Thus there is As manifested
Drug Use (Steroids, etc)
Leads to by
Metabolic alterations (hyperlipidemia, etc) Liver continues the
Infections (paramyxovirus, Coxsackie B Virus) conjugation of billirubin
Inherited/Genetic History of Acute Pancreatitis
Has increased Where Legend:
Autoimmune Diseases
risk to still
Age (50-60) Reflux of Bile from the
Common Bile duct
causes
Decreased Tone of Risk Factors
Obstruction of the
Sphincter of Oddi
Hepatopancreatic duct/ Ampulla Obstruction of the
causes Leads to Leads to
of Vater/ Sphincter of Oddi common bile duct
causing Leads to
Spasm & Edema Premature activation of Pathophysiology
causes Food Entry  Activation
Hyperglyce Pancreatic Enzymes (start:
Direct toxic of Cholecystokinin,
mia Trypsin)
As manifested by injury to causes Secretin, & Enterokinase
pancreatic cells
Edema/swelling & Increased pancreatic manifestations
As
causes irritation of pressure
Severe radiating causes Leads to manifest
peritoneum Spillage of Pancreatic ed by
Abdominal pain where Protein- rich fluid Ascit
causes Increased tension Enzymes into the accumulates in the es
Abdominal on pancreatic pancreatic parenchymal peritoneum
Distention tissue tissue
Leading to Such as
As manifested
an Phospholipase
Elevated Nauseaby & Lipase
Trypsin
Diaphragm Elastase A stimulates
Vomiting causes causes causes
As manifested Where
Elastic fibers Activation of Hydrolysis of Lipolysis
DOB by Activation
of blood other Phospholipid
Amylase of Kallikrein
vessels & enzymes s
Is then namely Where there Fatty Acids
Proteolysi Drained into ducts dissolve stimulat
Leads to Release ofis causes are released
s Bradykinin & es Compounds with Which binds
causes the Hemmorhage
Thrombo intrapancreat Kallidin strong cytotoxic to Ionized Calcium
As manifested release effects
sis of ic lymph causes Where there
by Leads to
pancreas system and Increased Vasodilation Damage of Cell causes is
Leads to Hypovolemi Body calcium
formation of the free a & Shock & Vascular membranes and ductal
Gangrene demands exceed
peritoneum
where Permeability system
calcium supply
Excess As manifested As manifested
causing Amylase Edema & by Fat Necrosis
by
picked up by Shock Hypocalcemi
Blood vessels a
Leads to the formation
of