Escolar Documentos
Profissional Documentos
Cultura Documentos
Introduction
Thyroiditis: Graves disease, Hashimotos
thyroiditis
Myasthenia gravis
Rheumatoid arthritis
Introduction
The immune system functions to protect the
host from invasion by foreign organism
However, this protective response can cause
damage to the host of it is directed against
the individuals own antigen.
These antigens are often referred as selfantigens, or autoantigens.
ii. Gender
Sex hormones might play a role, and
might explain why Graves disease affects
more women than men.
iii. Stress
Severe emotional stress or trauma might
trigger the onset of Graves disease in
people who are prone to getting it.
iv. Pregnancy
Pregnancy affects the thyroid. As many as 30
percent of young women who get Graves
disease have been pregnant in the 12
months prior to the onset of symptoms. This
suggests that pregnancy might trigger
Graves disease in some women..
iii. Infection
Infection might play a role in the onset of
Graves disease, but no studies have shown
infection to directly cause Graves disease.
e)
f)
g)
h)
i)
j)
Hand tremors
Rapid heartbeat
Frequent bowel movements
Weight loss without dieting
Fatigue or muscle weakness
Lighter menstrual flow and less
frequent periods
Treatment
- There are 3 main treatments for Graves'
disease :
a) Antithyroid medicine
Methimazole
Propylthiouracil
Sore muscles
Weight gain
Fatigue
Drowsiness
Forgetfulness
Puffy face
Constipation
a) ANTITHYROID ANTIBODIES
- Increased antithyroid antibodies provide
the most specific laboratory evidence of
Hashimotos thyroiditis. (but no all
cases).
b) TSH (THYROID-STIMULATING HORMONE
OR THYROTROPIN) TEST
- Increased TSH level in the blood is the
most accurate indicator of
hypothyroidism
c) OTHER TEST
- Free T4 (thyroxine)
A low level of free T4 is consistent with
thyroiD hormone deficiency.
- Fine-needle aspiration of the thyroid
A good way to diagnose difficult cases
and a necessary procedure if a thyroid
nodule is also present. (not necessary
for all patients)
Myasthenia grevis
What is Myasthenia grevis (MG)?
- MG is an autoimmune disease that
weakens the muscles.
- This muscle weakness usually occurs during
periods of activity and improves after
periods of rest.
a)
b)
c)
d)
How is MG diagnosed?
- MG is hard to diagnose because weakness is
a common symptom of many disorders.
- Performing some laboratory tests:
How is MG treated?
Treatment for MG may include:
a) Medications
Cholinesterase inhibitors: pyridostigmine
- These drugs help improve nerve signals to
muscles and increase muscle strength.
Immunosuppressive drugs
- Frequently used to suppress the production
of abnormal antibodies
b) Thymectomy
- This is the surgical removal of the thymus
gland, which is abnormal in most persons
with MG.
c) Plasmapheresis (Acute Weakness)
- This procedure removes abnormal
antibodies from the blood.
- This provides relief from MG symptoms in
many patients for a few weeks
Rheumatoid Athritis
What is Rheumatoid Athritis (RA)?
- RA is an inflammatory disease affecting
about 2.1 million people.
- It causes pain, swelling, stiffness, and loss
of function in the joints.
How is RA diagnosed?
- A diagnosis of rheumatoid arthritis can
generally be made following a thorough
medical history. (Children of parents who have
RA are more likely to have it)
- Physical examination, looking for:
i. Distribution of joints affected
ii. Joint swelling,warmth and range of motion
iii. Presence of nodules under the skin :
How is RA treated?
- Currently, there is no cure for RA.
- The goals of treatment of RA are to reduce
joint pain and swelling, relieve stiffness and
prevent joint damage.
- Treatment plans often include a
combination of rest, physical activity, joint
protection, use of heat or cold to reduce
pain, and physical or occupational therapy.