Escolar Documentos
Profissional Documentos
Cultura Documentos
Opiates, NSAIDS,
Prostaglandins, and Steroids
Shan Nanji
+ Opiates
nMOA:
n Agonize Opiate receptors (MU-morphine; Deltaenkephalin; Kappa-dynorphin)
n Open K+ Channels
n Close Ca2+ Channels
n Decreases Synaptic Transmission
n Inhibit release of Ach, 5-HT, Glutamate, and
Substance P.
+ Opiates
nS/E:
n Addiction
n Respiratory Depression
n Constipation
n Will not develop tolerance to this side effect
n Miosis
n Will not develop tolerance to this side effect
n Toxicity (overdose) can be treated with
n _______________ or __________________
n Opioid Receptor Antagonists
Opiates
n
__________________
n
n Methadone
n Rx For Heroin WITHDRAWAL
n Because __________________
n Tincture
of Opium
n For Infants
n Meperidine
n __________________
n __________________
n Can Be Used For Gallstones
n Because It Doesnt Mess With CCK
n Loperamide
n Used to Control Diarrhea
n Decreases Mortality in Inflammatory Bowel Diseases (IBD)
Shan Nanji - NanjiMD@gmail.com
Opiates
n Diphenoxylate
n
n Dextroamethorphan
n Best Anti-Tussin DM
n Oxycodone
n Codone
n Fentanyl
n Used as an Anesthetic (also available in patch form)
n Pentazocine
n Morphine
n For severe pain
Shan Nanji - NanjiMD@gmail.com
Opiates
GABA Receptor Agonist
nBaclofen
n
Prostaglandins
__________________
PGF2
_________________
Can also induce
abortion
Latanaprost
Shan Nanji - NanjiMD@gmail.com
_______________ PGF2
n
n
n
Prostaglandins
nPGE1 Protects stomach via mucus and
dilates afferent arteriole
n
__________________
n
__________________
n
nPGE2
n
__________________
n
10
1 Misoprostil
nPGE2
Dinoprostone
nPGF2
Carbaprost
11
Aspirin (ASA)
n
Acidic
PC02
FIRST
SECOND
THIRD -gaba
HCO3
pH
12
NSAIDs
Indomethacin Most potent __________________
n Phenylbutazone
n Ibuprofen MC OTC
n Naproxen - __________________
n Ketorolac Morphine like potency, used in ________________
n Ketoprofen
n Sulindac
n Diclofenac
n
13
Steroids
nMechanism
of Action I-KISS
nI Inhibits __________________
nK
Kills T Cells
an__________________
nI Inhibits __________________
nS Stabilizes __________________
nS Stabilizes __________________
Shan Nanji - NanjiMD@gmail.com
14
Steroids
n Prednisone
n Methylprednisolone
n Triamcinolone
n Budesonide
n Hydrocortisone
n Beclomethasone
n Betamethasone
15
Steroids
n Dexamethasone
n Fludrocortisone
__________________
n Cypropterone
n Megesterol
n Fluticasone
Blocks ________________
__________________
16
Steroids
n Danazol
Rx for endometriosis
n Mometasone
n Bodosimide
n Cyclosenide