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PURPOSE: To describe a method for back-solving the power of an intraocular lens (IOL) in situ
based on laser biometry and ray-tracing analysis of the pseudophakic eye.
SETTING: University Eye Clinic, Aarhus Hospital, Aarhus, Denmark.
DESIGN: Evaluation of diagnostic test or technology.
METHODS: This study comprised pseudophakic eyes with an IOL power ranging from
2.00 to C36.00 diopters (D). Preoperatively, the corneal radius was measured with conventional
autokeratometry and the axial length (AL) with optical biometry. After surgery, the position of the
IOL was recorded using laser interferometry. Based on the postoperative refraction and the biometric measurements, a ray-tracing analysis was performed back-solving for the power of the IOL in
situ. The analysis was performed assuming pupil diameters from 0.0 to 8.0 mm with and
without correction for the Stiles-Crawford effect.
RESULTS: The study evaluated 767 pseudophakic eyes (583 patients). Assuming a 3.0 mm pupil,
the mean prediction error between the labeled and the calculated IOL power (G1 standard deviation
[SD]) was 0.26 D G 0.65 (SD) (range 2.4 to C1.8 D). The prediction error showed no bias with
IOL power or with AL. The calculated IOL power depended on the assumed pupil size and the StilesCrawford effect. However, the latter had a modulatory effect on the prediction error for large pupil
diameters (>5.0 mm) only.
CONCLUSION: The optics of the pseudophakic eye can be accurately described using exact ray
tracing and modern biometric techniques.
Financial Disclosure: Dr. Olsen is a shareholder of IOL Innovations Aps, manufacturer of the
PhacoOptics IOL calculation software. Dr. Funding has no financial or proprietary interest in any
material or method mentioned.
J Cataract Refract Surg 2012; 38:641647 Q 2012 ASCRS and ESCRS
Numerous methods and formulas have been described to determine the intraocular lens (IOL) power
to be implanted from preoperative data of the patient,
and these methods have improved significantly over
the years.14 However, not every patient ends up
exactly as expected and the question then arises as to
what caused this refractive surprise. Often, a measurement error is the cause. In this case, the error can
usually be identified by repeating all biometric measurements and comparing them with the preoperative
data. In some cases, the formula or the IOL constant is
to blame, especially when the formula or IOL constant
has not been updated recently. In other cases, the
patient had laser in situ keratomileusis (LASIK)
many years ago and does not tell the surgeon.
However, in some situations the reason for the
refractive surprise is not obvious and the following
question then arises: Do you actually know what
Q 2012 ASCRS and ESCRS
Published by Elsevier Inc.
641
642
Eye Model
Ray-tracing analysis of any optical system requires the
physical dimensions and refractive indices of all optical
media to be clearly defined. For the pseudophakic eye, the
cornea, the IOL, the distances between the interfaces, and
the AL have to be defined.
The refractive power of the cornea is often obtained by
keratometry, by which the anterior corneal radius of curvature is measured. However, the dioptric reading given by
the keratometer assumes a thin-lens calculation for corneal
power, as follows:
nc 1
r
where nc Z 1.3375 and r is the corneal radius in meters. This
keratometer value is not the true physiologic power, however.5 The correct optical model of the cornea requires it to
be assigned an anterior surface as well as a posterior surface,
each with a certain curvature. In most corneal models, the
posterior curvature is assumed to be a fixed ratio of the anterior curvature assuming a standard corneal shape. For many
years, the standard shape, and hence the radius of the posterior surface, was assumed to be as proposed by Gullstrand.6
It was not until recently that modern studies using Scheimpflug imaging and other techniques provided detailed information not only on the curvatures of both surfaces of the
cornea but also on their asphericity.79 Therefore, in the present study, the posterior surface of the cornea was assumed to
be a fixed ratio of the anterior surface according to the model
described by Dubbelman et al.8 so that
DZ
R2 Z 0:84 R1
where R2 is the radius of the posterior surface of the cornea
and R1 is the radius of the anterior surface of the cornea.
Also from the work of Dubbelman et al., the asphericity of
the corneal surfaces was assumed to depend on the age of
the patient according to the following equations:
Ka Z 0:76 0:003 age
Kp Z 0:76 0:325 Ka 0:0072 age
where Ka is the asphericity of the anterior surface of the
cornea, Kp is the asphericity of the posterior surface of the
cornea, and age is the age of the patient in years.
The refractive index of the cornea was assumed to be
a constant value of 1.376, and the thickness of the cornea
was assumed to be a constant value of 0.5 mm. (Initial experiments showed negligible effect when using the individually
measured corneal thickness.)
For more than a decade, the use of PCI10 has significantly
improved the precision by which the AL can be measured
compared with ultrasound. The first commercially available
PCI technique was the IOLMaster instrument. However,
precision is not the same as accuracy. For an accurate interpretation of the AL, it should be realized that the output
reading of the IOLMaster is not the true optical path length
of the eye. The readings given by the commercial version
of the IOLMaster device have been calibrated against immersion ultrasound according to the following formula11,12:
AxZeiss Z OPL=1:3549 1:3033=0:9571
where AxZeiss is the output reading of the PCI instrument
and OPL is the optical path length measured by PCI. Accordingly, the optical path length can be found as
643
by our group; for this reason, the index of 1.3616 was suggested.13 Using this latter value, an estimate of the geometric
distance was obtained according to the formula
T
D1 D2
n
where D12 is the total dioptric power of the thick lens, D1 is
the dioptric power of front surface, D2 is the dioptric power
of back surface, T is the thickness of the lens in meters, and n
is the refractive index of the material. The dioptric power of
each IOL surface was calculated according to the thin-lens
formula
Ray-Tracing Procedure
Ray tracing is a well-known procedure to analyze the
optical properties of any optical system using the Snell law
as follows:
sini n2
Z
sinu n1
where i is the incident angle of ray on the surface, u is the
refracted angle, n1 is the refractive index of first medium,
and n2 is the refractive index of the second medium. To
study the optical properties of the pseudophakic eye,
a computer program was written in Pascal (Borland Delphi, Inprise Corp.) to trace the ray intersections of an
incoming beam of rays through the optical media and
study the distribution of the intersections with the retina.
To validate the calculations, model eye data were exported
to the Zemax software (Radiant Zemax LLC) for optical
design.
When an optical engineer wants to build a complex optical
system, he or she may do so by solving for 1 or more variables, giving the best outcome while keeping the other conditions equal. The same principle can be applied to the
pseudophakic eye: To solve for the optical properties of the
IOL, we can use the actual refraction, the vertex distance,
the corneal curvature, the position of the IOL, and the optical
path length (rather, the geometric AL) to solve for the curvatures of the IOL optic that most effectively describes the total
optical system of the pseudophakic eye.
To solve for the curvatures of the IOL, something about
the shape of the optic must be known. Most IOL manufacturers will provide a cutting chart stating the diopter specific
values of refractive index, thickness, and curvatures of the
front surface and back surface of the IOL optic. Usually
such a chart will show that the IOL has a certain configuration; that is, a 1:1, 1:2, or 1:3 biconvex design. The manner
by which the IOL changes its physical curvatures over the
power range (ie, the shape factor) varies between manufacturers and between IOL models; however, in some cases,
the posterior curvature of the IOL optic is kept constant
over a certain power range while the anterior curvature
changes to produce the labeled power. In other models, the
IOL optic may keep its overall configuration constant over
the entire diopter range. The thickness of the IOL often follows a linear relationship with the power (minus-powered
IOLs excluded).
In the present study, the algorithm solving for the front
and back curvatures of the IOL was constructed from the
manufacturers stated information on the shape factor of
the IOL over the diopter range. The IOL curvatures (and
power-dependent thickness) were found by computer iterations while observing the width of the point-spread function
(PSF) at the retina until a minimum of the root-mean-square
deviations from the center was found.
D12 Z D1
n2 n1
r
where D is the dioptric power of the single surface, r is the
radius of curvature in meters, n1 is the refractive index of
the first medium, and n2 is the refractive index of the
second medium.
DZ
Outcome Measures
The error of the prediction was defined as the difference
between the calculated power and the implanted (labeled)
power of the IOL (labeled value minus predicted value). Statistical analysis was performed using distributional methods
and the statistical service of an Excel spreadsheet (Microsoft
Corp.). Distribution methods were used where appropriate.
Linear regression analysis was performed using the method
of least squares. A probability level of 0.05 (2 tailed) was
considered statistically significant.
RESULTS
The study included 767 eyes of 583 patients. The mean
age of the 234 men and 349 women was 69.7 years
(range 20 to 95 years). The mean IOL power was
C20.69 D.
The IOL power calculated by ray tracing was
linearly correlated with the implanted (labeled) power
(correlation coefficient r O 0.99, P!.00001) (Figure 2).
Assuming a 3.0 mm pupil, the mean difference between the calculated and the observed IOL power
644
Table 1. The mean error (calculated minus implanted value) predicting the implanted IOL power by ray tracing assuming different pupil
diameters in 767 cases.
Pupil (mm)
0.01
1.00
2.00
3.00
4.00
5.00
6.00
7.00
8.00
Mean error +0.21 G 0.65 +0.16 G 0.65 +0.00 G 0.65 0.26 G 0.65 0.64 G 0.66 1.16 G 0.67 1.79 G 0.69 2.54 G 0.71 3.45 G 0.75
(D) G SD
Range
2.01, +2.34 2.07, +2.28 2.21, +2.08 2.44, +1.78 2.86, +1.38 3.41, +0.91 4.04, +0.47 4.69, +0.11 5.40, 0,27
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Figure 4. Prediction error (difference between the labeled and calculated IOL power) versus the AL (767 cases).
Figure 5. Prediction error (difference between the labeled and calculated IOL power) versus the AL when the uncorrected IOLMaster
readings were used in the ray-tracing analysis (767 cases).
Figure 6. Prediction error (difference between the labeled and calculated IOL power) versus the assumed pupil diameter with and without correction for the Stiles-Crawford effect. The 2 curves differ
significantly from pupil diameters of 5.0 or more due to the modulatory effect of the Stiles-Crawford effect on spherical aberration. Bars
indicate standard deviations (767 cases).
646
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First author:
Thomas Olsen, MD, PhD
University Eye Clinic, Aarhus Hospital
NBG, Aarhus, Denmark