Leong PP, PhD

12/6/2014

Hypersensitivity
To describe pathophysiology and clinical outcome of the
following clinical examples

Type
Type
Type
Type

I atopic dermatitis
II erythroblastoma fetalis
III systemic lupus erythematous
IV contact dermatitis

Autoimmunity
To describe the pathophysiology and clinical outcome of
Grave disease and Hashimoto thyroiditis
Immunodeficiency
To understand the use of traditional chinese medicine
(TCM) approach for immunodeficiency

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Pruritus dermatitis (red, flare up & extremely itchy)

Common in individual with history of hay fever or
asthma
Associated with IgE antibody

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Immune mediated skin rash (swelling, erythema,

vesiculation) at the site of contact with a chemicals
Poison ivy
Nickel metal in costume jewelry
Dyes, perfume and etc

Mediated by sensitized Th1 cells

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Rh system antigen D
Two Rh blood type
Rh positive
Dominant
More common in population

Rh negative

Incompatible haemolysis

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First pregnancy

Second pregnancy and onwards (baby is Rh +ve)

baby safe
Rh ve mother acquires anti-Rh antibodies

Haemolytic disease of newborn brain damage,

mental retardted and even death

Production
of
antibodies
against
a
multitude of self-antigen including DNA
(single and double stranded), nucleolar
RNA, histones, RBCs, platelets. The disease
is caused by the direct activity of the autoantibodies and also by deposition of
soluble antibody-antigen complexes which
deposit along the walls of small blood
vessels inflammtion & cell damage

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Graves Disease

Hyperfunction of
thyroid gland
Bulging eye,
nervousness, enlarged
thyroid, fast heart beat

Hashimoto thryoiditis

Hypofunction of
thyroid gland
Fatigue, enlarged
thyroid, slow heart
beat

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Self-reactive
CTL

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Auto-antibody
against TSH
receptor

LPP

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http://www.tcmpage.com/hpimmunedef.html

Healthy == well functioning immune system

Immunodeficiency
Immune system is suppressed by certain factors
e.g. nutrition, lifestyle and etc
Vulnerable to disease, infection, allergy and even
cancer

Chinese Medicine Textbooks

(since thousand years ago)

Natural herbs
Dietary therapy
Acupuncture
Tai Chi
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http://www.tcmpage.com/hpimmunedef.html

Food with immune stimulation properties

Shiitake mushroom
Lentinan anti-viral, immune stimulant

Garlic, sesame seed, yogurt, fruits & vegetables

Micro-nutrient
Beta carotene, zinc and vitamin A, E and C

Low fat diet

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http://www.tcmpage.com/hpimmunedef.html

Astragalus (Huang Qi)

Strong immune enhancing effect increased
number & activity of WBC
Showed to restore function of immune cells in
cancer patient

Ginseng
Widely used
Protects the liver, stimulates immune system,
prevents radiation damage to nerve cells; has
antioxidant effects, prevents cancer

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http://www.tcmpage.com/hpimmunedef.html

Chi Spleen Tonic (Bu Zhong Yi Qi Tang)

Astragalus (Huang Qi)

Licorice (Gan Cao)

Agelica (Dang Gui)

Ginseng (Ren Shen)
Tangerine Peel (Chen Pi)
Cimicifuga (Sheng Ma)
Buplerum (Chai Hu)
Atractylodes (Bai Zhu)

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http://www.tcmpage.com/hpimmunedef.html

Immunenergy Formula - Shi Quan Da Bu Tang

Used to treat immune deficiency & fatigue
Often used for post-cancer management

Angelica (Dang Gui)

Cnidium (Chuan Qiong)

Peony (Bai Shao)
Rehmannia (Shu Di Huang)
Ginseng (Ren Shen)
Atractylodes (Bai Zhu)
Poria (Fu Ling)
Licorice (Gan Cao)
Astragalus (Huang Qi)
Cinnamon (Rou Gui)
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http://www.tcmpage.com/hpimmunedef.html

Regulation of immune system

Potential to treat wide range of health
problems including immunodeficiency
Effects
Increase the T cell count
Increase number of phagocytes
Increase WBC count and mobility

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Miranda Hitti, Tai Chi May Boost Immune System,

Journal of the American Geriatrics Society

Traditional Chinese martial art

may help to boost immune system in elderly people
Showed to mount a stronger immune response to
vaccine

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