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Design and Method: 386 patients with TDM1 aged from 5 to 18 years old
from three different regions of Russian Federation were examined in the
course of screening programs. Average duration of TDM1 was 2,81 year. The
level of HbA1 and microalbuminuria (MAU) were measured on Bayer DCA
2000 analyzer. The ophthalmoscopy was performed by direct view method.
The technique of blood pressure (BP) measurement was standardized.
Statistical analysis was performed with -square criteria and Mann-Whitney
test.
Results: Children and adolescents with T1DM had BP level more higher
than the same rate in healthy children for equal aging group. 21 % of children
with T1DM had a systolic blood pressure (SBP) on 95 % for aging standard
(p 0,004). Diastolic blood pressure (DBP) levels were not significantly
different. During ophthalmoscopy the retinopathy was diagnosed in 12% of
patients, 1,1 % of adolescents had proliferative retinopathy at the duration of
T1DM more than 5 years. MAU was not indicated as neither children nor
adolescents. Median of HbA1 level in adolescents was on 1,6% in excess of
prepubertal children (9,8% vs 8,25%, p < 0,001), that indicate on pure
metabolic control in group of adolescents and high risk of microangiopathies
development.
Conclusions: SBP in diabetes children is an effective marker of early
development of retinopathy. Retinopathy and high SBP were combined
more frequently in adolescents with poor metabolic control.
PP.17.146