Effects of IMTH-232 when applied orally @25mg/days for a

period of 30 days to a volunteer female scientist of 26 years.

Documented after 60 days after the period of administration.

Mental function
Difficulty
The nerve cells in the brain release
remembering or
different amounts of some chemical
coming up with the messengers (which send impulses from
right word
cell to cell), and the number of
Difficulty
receptors on nerve cells may
concentrating
decrease. Thus, the brain does not
Difficulty
send or process impulse as well or as
learning new
quickly.
material
Physical activity
Unsteadiness or
loss of balance

Structures in the inner ear that help

with balance stiffen and deteriorate
slightly.
The part of the brain that controls
balance (cerebellum) may degenerate.

Dizziness or
light-headedness
when standing

The heart does not pump enough blood

to the head because the heart is less
able to respond to changes in
position.
The nervous system signals the heart
to increase blood flow less
effectively.
The blood vessels do not constrict
enough to maintain normal blood
pressure when a person stands.

Loss of muscle
strength

The number and size of muscle fibres

decrease.
The body produces less growth hormone
and (in men) less testosterone, which
help maintain muscles.

Difficulty moving
Less flexibility

Less joint fluid is produced.

The cartilage between bones in joints
becomes stiffer and may erode.
Tendons and ligaments become stiffer
and weaker.
Muscle tissue is lost, replaced by
fatty or fibrous tissue, decreasing
strength and making muscles stiffer.

Difficulty
exercising
strenuously

The heart cannot keep up with the

demand for more blood during
exercise. It cannot speed up as

quickly or pump as fast as it used

to, partly because the heart and
blood vessels become stiffer and less
elastic. Also, the heart does not
respond as quickly or as well to
chemical messengers that normally
stimulate it to speed up.
The lungs cannot keep up with the
demand for oxygen during exercise.
Less air is taken in with each
breath, and the lungs do not absorb
as much oxygen.
The senses
Need for reading
glasses

The lens of the eye stiffens, making

focusing on close objects more
difficult.

Difficulty seeing
in dim light

The retina of the eye becomes less

sensitive to light.
The lens of the eye becomes less
transparent.

Difficulty
adjusting to
changes in light
levels

The pupils react more slowly to

changes in light.
Darkened areas in the lens of the eye
increase glare.

Dry eyes

The number of cells that produce

fluids to lubricate the eyes
decreases.
The tear glands produce fewer tears.

Difficulty
understanding
words

Age-related hearing loss

(presbycusis) develops, which often
affects mainly high frequencies
(which include consonantsthe sounds
that help people identify words).

Loss of taste

Taste buds become less sensitive.

People detect odours less well
because the lining of the nose
becomes thinner and drier and the
nerve endings in the nose
deteriorate.

Dry mouth

Less saliva is produced.

Eating problems
Difficulty

The mouth is dry.

swallowing

The muscles involved in swallowing

weaken, and coordination is impaired.
People may not chew food enough
because teeth are missing or dentures
do not fit well. Then, chunks of food
are too large to swallow.
The bones at the top of the spine
change, tipping the head forward and
thus compressing the throat.

Disinterest in
eating

Taste decreases, making food less

appetizing.
Smell decreases, making food less
appetizing.
The mouth is dry, leading to loss of
taste.
Chewing may be difficult because
teeth are missing, jaw muscles are
weak, or dentures do not fit well.
Swallowing is difficult.

Skin and hair

Wrinkles
More tears in the
skin

The fat layer under the skin, which

acts as a cushion, thins.
The body produces less collagen and
elastin, which make the skin tough
and elastic.

Dry skin

Glands in the skin produce less oil.

Bruises and broken Blood vessels in the skin become more

blood vessels
fragile.
Slow healing of
wounds

The number of blood vessels in the

skin decreases.
Cells responsible for healing wounds
act more slowly and decrease in
number

Difficulty
adjusting to
changes in
temperature

The fat layer under the skin, which

helps conserve body heat, thins.
The number of sweat glands decrease,
and the sweat glands produce less
sweat. Sweat helps cool the body.
The number of blood vessels
decreases, and blood flow in the deep
layers of the skin decreases. As a
result, the body cannot remove heat
from body as well.

Decreased
sensation and
sensitivity to
pain

The number of nerve endings in the

skin decreases.

Grey or white hair The hair follicles produce less

pigment (melanin).
Thinning or loss
of hair

Hairs, which must be replaced

periodically, grow more slowly, and
some hair follicles stop producing
new hair.

Sexual function
Dryness of the
vagina

Less oestrogen is produced.