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Sezione di Ingegneria Biomedica, Dip. di Metodologia Clinica e Tecnologie Medico-Chirurgiche, Universita` degli Studi di Bari, Policlinico- P.zza G. Cesare 11, I-70124 Bari, Italy
ARTS Lab, Scuola Superiore SantAnna, V.le Rinaldo Piaggio 34, I-56025 Pontedera, Italy
U.O. Ortopedia e Traumatologia, Dip. di Metodologia Clinica e Tecnologie Medico-Chirurgiche, Universita` degli Studi di Bari, Policlinico- P.zza G. Cesare 11, I-70124 Bari, Italy
A R T I C L E I N F O
A B S T R A C T
Article history:
Received 18 March 2010
Received in revised form 6 March 2011
Accepted 9 March 2011
In order to verify whether orthostatic posturography (OP) can support clinical assessment of total hip
(THA) and knee arthroplasty (TKA), 81 subjects with THA and 100 with TKA were recruited and
compared with 59 healthy volunteers. All patients were tested one or two days prior to surgery; 42
subjects (20 THA and 22 TKA) were tested again after six months, and 34 (14 THA and 20 TKA) yet again
after 12 months. OP was performed using a Kistler 9286A piezoelectric force plate and the following
postural parameters (PPs) were adopted on account of their functional meaning: mean velocity and the
root mean square of the distance of the centre of pressure (CoP), sway area, and 95% of the CoP power
frequency. Eye condition and fatigue related to the test duration were also examined. The three most
meaningful PPs were identied and a logarithmic transformation was then applied to these, as well as
standardization. Almost all the PP values were higher preoperatively in the patients as compared with
the healthy subjects and it was possible to detect many statistically signicant differences between
patients and healthy subjects. However, when examining the 181 subjects at the preoperative stage, the
PPs did not show congruence with the clinical scores as well as they did during follow-up. Therefore, the
use of the OP is not recommended to monitor patients undergoing THA or TKA.
2011 Elsevier B.V. All rights reserved.
Keywords:
Postural control
Clinical evaluation
Hip
Knee
Prostheses
1. Introduction
Objective outcomes are needed to support an evidence-based
approach, as well as for medico-legal purposes [1]. Total hip (THA)
and knee arthroplasty (TKA) procedures are widely adopted. THA is
the second most commonly performed surgical procedure, with an
estimated number of more than one million operations each year
worldwide [2]. It is estimated that in the Unites States alone, by
2030 the demand for THA and TKA will have grown by 174% and
673%, respectively [3]. Orthostatic posturography (OP) is used to
evaluate the trajectory of the centre of pressure (CoP) with the
patient in upright stance [4]. Accepting the hypothesis that the CoP
planar migration is stationary, about 40 posturographic parameters (PPs) are commonly adopted to describe the statistical
properties of the CoP, in the time and frequency domains [58]. The
robustness of PPs has been clearly assessed [911], but there are
contrasting conclusions in literature about the sensitivity and
clinical signicance of PPs in subjects affected by osteoarthritis
(OA), THA or TKA [1219].
* Corresponding author. Tel.: +39 080 5478617; fax: +39 080 5565425.
E-mail address: l.quagliarella@bioingegneria.uniba.it (L. Quagliarella).
0966-6362/$ see front matter 2011 Elsevier B.V. All rights reserved.
doi:10.1016/j.gaitpost.2011.03.010
A total of 240 subjects, 98 males and 142 females, took part in the study (Table 1).
One hundred and eighty-one subjects (81 THA and 100 TKA) belonged to the two
experimental groups (EGs) and 59 to the control group (CG); 42 patients (20 THA
50
Table 1
Anthropometric and posturographic parameters in the total hip arthroplasty, total knee arthroplasty and control groups.
AP
Age (yr)
Height (cm)
PP
MV (mm/s)
RMSDRD (mm)
RMSDAP (mm)
RMSDML (mm)
SA (mm2/s)
PF95AP (Hz)
PF95ML (Hz)
THA
Session
Mean SD
Range
TKA
Mean SD
Range
CG
Pre-op.
6m
1y
Pre-op.
6m
1y
Pre-op.
6m
1y
64.1 11.3
62.9 11.7
66.6 10.9
160.8 9.3
159.8 7.5
159.9 9.1
75.7 13.2
79.0 11.4
79.2 14.8
4080
4080
4280
143185
146180
146185
48106
63109
51112
68.8 6.8
67.7 8.0
68.7 7.3
154.6 8.1
155.2 7.9
152.9 7.0
77.7 12.3
79.6 12.5
75.9 10.4
4880
4880
4879
133178
142175
142165
37103
55105
62104
TKA
Mean SD
Group
THA
Test cond.
Eyes open
Session
Q1
Med.
Q3
Q1
Med.
Q3
Q1
Med.
Q3
Q1
Med.
Q3
Q1
Pre-op.
6m
1y
Pre-op.
6m
1y
Pre-op.
6m
1y
Pre-op.
6m
1y
Pre-op.
6m
1y
Pre-op.
6m
1y
Pre-op.
6m
1y
8.84
9.23
8.06
4.50
4.81
3.81
3.24
3.11
2.70
2.73
3.12
2.31
12.50
12.25
9.52
0.65
0.68
0.74
0.58
0.56
0.65
12.20
12.40
12.47
5.52
5.62
5.90
3.95
3.97
3.32
3.27
3.99
3.76
17.62
19.48
14.83
0.83
0.99
0.92
0.81
0.72
0.83
14.81
17.60
17.67
6.92
6.89
6.82
5.55
4.84
5.47
4.62
4.89
4.87
28.33
34.17
32.81
1.02
1.18
1.03
1.01
0.79
1.04
13.00
12.88
11.65
5.25
5.10
4.41
4.02
3.88
3.03
3.08
3.27
2.73
17.98
19.50
14.41
0.86
0.75
0.87
0.76
0.75
0.81
16.00
15.43
16.22
6.55
5.94
5.12
4.95
4.37
4.20
3.93
3.96
3.23
29.26
25.57
22.24
1.05
1.24
1.16
0.98
0.88
0.96
22.38
18.92
20.63
8.23
7.29
7.34
6.40
5.88
6.03
5.48
4.46
3.97
53.73
35.32
34.32
1.31
1.43
1.26
1.24
1.07
1.13
8.94
9.12
9.59
4.15
4.43
4.47
3.03
3.42
3.17
2.53
2.70
2.71
11.06
12.31
12.42
0.67
0.59
0.67
0.51
0.44
0.49
11.27
10.88
10.79
5.04
6.01
5.64
3.53
3.82
4.16
3.34
4.07
3.54
16.63
21.25
19.45
0.85
0.80
0.86
0.73
0.72
0.58
14.21
14.54
15.32
6.13
7.19
6.61
4.32
5.51
5.27
4.14
5.10
4.20
22.88
27.00
24.31
1.11
0.99
0.95
0.94
0.90
0.85
11.68
12.82
10.91
4.81
4.60
4.67
3.36
3.65
3.14
2.65
2.77
2.74
16.37
17.38
17.58
0.87
0.75
0.87
0.64
0.62
0.58
14.49
14.98
14.65
5.54
6.39
5.94
4.21
4.79
4.87
3.74
3.55
3.45
22.51
24.30
21.07
1.06
0.90
1.05
0.90
0.78
0.70
19.67
16.79
20.02
6.77
7.12
7.11
5.01
5.52
5.61
4.61
4.57
3.91
34.50
32.58
31.66
1.39
1.21
1.28
1.13
0.96
1.00
7.56
Eyes closed
Range
67.4 5.9
4876
162.3 10.5
142184
75.8 12.4
46100
CG
Eyes open
Eyes closed
Eyes open
Eyes closed
Med.
Q3
Q1
Med.
Q3
9.09
10.11
8.99
11.19
13.02
3.61
5.05
6.07
4.02
4.79
5.98
2.86
3.99
5.43
3.17
4.12
4.88
1.89
2.39
3.19
1.74
2.47
3.33
9.18
11.36
14.91
9.67
12.53
17.80
0.44
0.61
0.78
0.73
0.87
1.03
0.59
0.79
0.98
0.64
0.91
1.14
AP, anthropometric parameters; PP, posturographic parameters. THA, total hip arthroplasty; TKA, total knee arthroplasty, CG, control group. For the THA and TKA patients, the data are referred to the three trial sessions: preoperative
(pre-op.), six months (6 m), one year (1 y), whereas for the CG they refer to a single session. Since the PP data were not normally distributed they are reported as rst quartile (Q1), median and third quartile (Q3).
Group
Before data analysis, normalization of the PPs was done by quadratic detrending
[8,27], to eliminate any inuence of the main anthropometric features of each
subject, namely body mass and height, when the correlation coefcients were
signicantly (p < 0.05) higher than 0.1 with either body mass or height. The
normalization process produced data uncorrelated with body size, and magnitudes
and units comparable with the original ones.
Each subject was assumed to share body weight on the legs asymmetrically
when the averaged ML component of the CoP was outside an uncertainty range
(assumed as equal to the standard deviation of the distances between the middle
point of the segment joining the medial malleoli projection and the AP platform
51
3. Results
3.1. Statistical signicance
The PPs were analysed by non parametric statistics since they
did not show a normal distribution. RMSDRD was normalized for
the subjects body mass, and RMSDAP and PF95AP were normalized
for height.
The angle of misalignment between the subjects AP axis and
the platform-related AP axis was 3 28 (mean standard deviation) and the coefcient of variation of the distances between the
medial malleoli was less than 10%. Therefore, it could be assumed that
all subjects were similarly orientated and located with respect to the
platform.
After normalization, no statistically signicant differences
(SSD) due to age were found in the PPs after subdividing the CG
and the EGs (for each trial session) into two subgroups (under/over
60 years), but SSD due to gender were found for MV in TKA
(p = 0.001) and for PF95AP both in THA (p = 0.01) and in TKA
(p = 0.007). For these parameters comparisons were carried out
separately for males and females. The PP values in the EGs and CG
are reported in Table 1.
Comparing the PPs calculated in the interval T1 with those
obtained in T2 no SSD (MannWhitney) were found in either the
EGs or the CG.
Table 2
Statistically signicant differences in the posturographic parameters (PP) between
the total hip arthroplasty (THA) and total knee arthroplasty (TKA) groups as
compared to the controls (CG).
Groups
PP
Trial sessions
Pre-op.
6m
Gender
EO
EC
EO
EC
CG vs THA
MV
RMSDRD
RMSDAP
RMSDML
SA
PF95AP
M+F
M+F
M+F
M+F
M+F
M
F
M+F
M
F
M+F
M+F
M+F
M+F
M
F
M+F
z
y
z
z
CG vs TKA
PF95ML
MV
RMSDRD
RMSDAP
RMSDML
SA
PF95AP
PF95ML
z
z
z
z
y
z
1y
EO
EC
Trial sessions: preoperative (pre-op), after six months (6 m) and after one year (1 y)
from surgery. EO, eyes open; EC, eyes closed. p-Values: y, 0.01 p < 0.005; z,
0.005 p < 0.0005; , p < 0.0005. When SSD were present between males (M) and
females (F), the comparisons were made separately by gender.
52
TKA (88%) patients. Also MV, RMSD (as resultant and in the AP and
ML directions) and PF95AP were higher in THA (43% for MV, 36% for
RMSDRD, and 21% for PF95AP) and in TKA (30% for MV, 18% for
RMSDRD, and 22% for PF95AP) than in the CG.
During the follow-up, the number and signicance of SSD
declined markedly (Table 2). Only in the THA group was there a
steady reduction toward normal values in RMSDRD, RMSDAP and
SA, whereas the variations between sessions of the other PPs did
not present a clear trend. There were no SSD among sessions for
either THA or TKA patients.
When comparing THA and TKA, at the same follow-up session,
only in the preoperative session did a single SSD emerge for
RMSDAP (p = 0.004), which presented higher values in THA.
1,0
1,0
0,8
0,8
0,6
0,6
0,4
0,4
0,2
0,2
0,0
21
41
61
81
1,0
0,0
0,8
0,6
0,6
0,4
0,4
0,2
0,2
21
41
61
81
1,0
0,0
0,8
0,6
0,6
0,4
0,4
0,2
0,2
21
41
21
61
81
0,0
41
61
81
21
41
61
81
1,0
0,8
0,0
1,0
0,8
0,0
21
41
61
81
Fig. 1. Comparison of the clinical scores (white square) with the posturographic parameters (PP black dot) for the pre-operative session, THA (left side) and TKA (right side).
The posturographic parameters reported are MV (top), RMSDRD (centre) and R (bottom). The values of the clinical scores (Harris Hip Score for THA and the Knee Society Score
for TKA) are related to the maximum possible value (100 for the Harris Hip Score and 200 for the Knee Society Score). The posturographic parameters are related to the
maximum values obtained in the patients group (THA or TKA) in the preoperative session. Higher scores indicate a better clinical condition, while higher values of MV indicate
a higher cost of maintaining the balance control, higher values of RMSDRD indicate greater oscillation widths and higher values of R indicate a higher frequency of intervention
of the control system.
1,5
1,0
0,5
0,0
6 12
0 6 12
THA
TKA
MV*
6 12
0 6 12
THA
TKA
RMSD*
6 12
THA
6 12
TKA
R*
Fig. 2. Mean values, with upper and lower bounds of the 95% condence interval for
the mean, of the standardized variables (MV*, RMSD* and R*), in patients subjected
to total hip arthroplasty (THA) and total knee arthroplasty (TKA), over the three
sessions (preoperative: 0; six months: 6; one year: 12). The difference from zero
indicates variations with respect to the mean values of the control group. During
follow-up the parameters did not show a clear trend toward a return to normal
conditions in both the experimental groups.
53
Table 3
Classication of the subjects with respect to the normality region.
Classication
Parameter
Trial session
Pre-operative
Severe impairment
RMSD*
R*
CG
THA
THA
TKA
x
x
x
x
x
0
0
0
0
2
1
1
55
1
11
4
0
12
3
0
50
0
4
6
0
12
4
4
70
0
1
1
0
4
1
0
13
0
1
0
0
1
1
0
19
0
2
0
0
2
0
1
9
0
1
1
0
3
0
1
14
59
81
100
20
22
14
20
x
x
x
x
x
Normal
Total
TKA
1y
MV*
x
Mild impairment
6m
THA
TKA
Groups: CG, control; THA, total hip arthroplasty; TKA, total knee arthroplasty. Parameters: MV*, standardized mean CoP velocity; RMSD*, standardized root mean square of
CoP distances, R* = standardized MV to RMSD ratio. Classication: severe impairment when at least two parameter values were above the threshold; mild impairment
when only one was higher; and normal when no parameter exceeded the threshold. For each parameter, the threshold is equal to twice the standard deviation of the CG.
54
of the THA group and 71% of the TKA group examined were within
the normality range. This means that pain and limited walking
endurance did not cause anomalous control of the standing
posture in most of the patients.
At follow-up evaluations, after six and twelve months from
surgery, the PP values did not show a clear trend toward
improvement in either of the EGs (Fig. 2), whereas a general
and signicant reduction in pain and functional improvements was
observed during the follow-up.
The OP evolution of each patient in the follow-up was then
examined. The summary index K showed that at both six months
and one year there was an evident impairment of the standing
balance of some patients, although this was not related with the
clinical parameters. This disagreement may be due to the lack of
items of the clinical evaluation related to balance control and/or to
the evolution of the contralateral limb conditions. Orthostatic
posture is the effect of a synergy of different sensorial afferences
whose efciency depends on various factors (age, co-morbidities,
psychological aspects) [30], and also depends on the action of both
limbs, that are often affected by the same disease. The tendency to
unload the impaired limb did not occur systematically during the
preoperative session, whereas six months after surgery it was
present in THA subjects, as also reported in a recent study [19].
Pain relief and better walking capacities are the essential goals
of hip and knee joint prostheses, therefore the congruence of PPs
with these parameters is the rst condition that needs to be
satised in order to adopt OP for clinical assessment of THA or TKA.
Examining the 181 subjects in the preoperative stage, the PPs did
not show congruence with pain and walking capacities. Neither
was this apparent during follow-up. After surgery there were
several cases of worsening in the standing performance and
improvement in the clinical condition or vice versa.
Therefore, while the use of OP was able to detect differences
among groups of patients and healthy subjects, it seems to be unable
to monitor patients who must undergo THA or TKA. This conclusion
is due not only to the lack of congruence with the clinical parameters
but also to the inclusion inside the normality range of more than 60%
of the patients evaluated before surgery. In addition, it was found
that, for THA and TKA patients, OP can be conducted in a simplied
mode both by reducing the time to 60 s and by avoiding the OE trial.
The presence of SSD in the postural control between THA and TKA
patients and the CG is still an open question.
Acknowledgement
This study has been supported by grants from Universita` degli
Studi di Bari (Finanziamento progetti di ricerca, Ateneo). The study
sponsors had no involvement in the study design, collection, nor
the decision to submit this manuscript for publication. The authors
wish to thank all the participants in the study.
Conict of interest statement
None of the authors have any nancial and personal relationships with other people or organizations that could inappropriately inuence (bias) their work.
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