Maritza J. Romero-Lucas, M.D./D.Sc.

1. Lucas R, Fulton D, Caldwell RW, Romero MJ. Arginase in the vascular endothelium:
friend or foe? Front Immunol. 2014 Nov 17;5:589. doi: 10.3389/fimmu.2014.00589.
eCollection 2014
2. Cassuto J, Dou H, Czikora I, Szabo A, Patel VS, Kamath V, Belin de Chantemele E,
Feher A, Romero MJ, Bagi Z. Peroxynitrite disrupts endothelial caveolae leading to
eNOS uncoupling and diminished flow-mediated dilation in coronary arterioles of diabetic
patients. Diabetes. 2014 Apr;63(4):1381-93. doi:10.2337/db13-0577.
3. Romero MJ, Yao L, Sridhar S, Bhatta A, Dou H, Ramesh G, Brands MW, Pollock DM,
Caldwell RB, Cederbaum SD, Head CA, Bagi Z, Lucas R, Caldwell RW. L-Citrulline
Protects from Kidney Damage in Type 1 Diabetic Mice. Front Immunol. 2013 Dec
24;4:480. doi: 10.3389/fimmu.2013.00480.
4. Romero MJ. Home blood pressure variability: a new target to monitor in chronic kidney
disease patients with low eGFR? Hypertens Res. 2013 May 23. doi: 10.1038/hr.2013.53.
[Epub ahead of print].
5. Lucas R, Czikora I, Sridhar S, Zemskov EA, Oseghale A, Circo S, Cederbaum SD,
Chakraborty T, Fulton DJ, Caldwell RW, Romero MJ. Arginase 1: an unexpected
mediator of pulmonary capillary barrier dysfunction in models of acute lung injury. Front
Immunol. 2013 Aug 7;4:228. doi: 10.3389/fimmu.2013.00228. eCollection 2013.
6. Toque HA, Nunes KP, Rojas M, Bhatta A, Yao L, Xu Z, Romero MJ, Webb RC, Caldwell
RB, Caldwell RW. Arginase 1 mediates increased blood pressure and contributes to
vascular endothelial dysfunction in deoxycorticosterone acetate-salt hypertension. Front
Immunol. 2013 Jul 29;4:219. doi: 10.3389/fimmu.2013.00219. eCollection 2013.
7. Lucas R, Czikora I, Sridhar S, Zemskov E, Gorshkov B, Siddaramappa U, Oseghale A,
Lawson J, Verin A, Rick FG, Block NL, Pillich H, Romero M, Leustik M, Schally AV,
Chakraborty T. Mini-review: novel therapeutic strategies to blunt actions of pneumolysin
in the lungs. Toxins (Basel). 2013 Jul 15;5(7):1244-60. doi: 10.3390/toxins5071244.
8. Lucas R, Yang G, Gorshkov B, Zemskov EA, Sridhar S, Umapathy NS, Jezierska-Drutel
A, Alieva IB, Leustik M, Hossain H, Fischer B, Catravas JD, Verin AD, Pittet JF, Caldwell
RB, Mitchell TJ, Cederbaum SD, Fulton DF, Matthay MA, Caldwell RW, Romero MJ and
Chakraborty T. Protein kinase C- and Arginase I mediate Pneumolysin-induced
pulmonary endothelial hyperpermeability. Am J Respir Cell Mol Biol. 2012
Oct;47(4):445-53. doi: 10.1165/rcmb.2011-0332OC.
9. Romero MJ, Caldwell RW. The proximal tubule in progressive diabetic nephropathy: Are
tubular polyamines a new paradigm for developing therapies?. J Autacoids. 2012
May;1:e115. doi:10.4172/2161-0479.1000e115.
10. Romero MJ, Iddings JA, Platt DH, Ali MI, Cederbaum SD, Stepp DW, Caldwell RB,
Caldwell RW. Diabetes-induced vascular dysfunction involves arginase I. Am J Physiol
Heart Circ Physiol. 2012 Jan 1;302(1):H159-66. doi: 10.1152/ajpheart.00774.2011.
11. Chandra S, Romero MJ, Shatanawi A, Alkilany A, Caldwell R, Caldwell R. Oxidative
Species Increase Arginase Activity in Endothelial Cells through RhoA/Rho Kinase
Pathway. Br J Pharmacol. 2012 Jan;165(2):506-19. doi:
10.1111/j.14765381.2011.01584.x.
12. Shatanawi A, Romero MJ, Iddings JA, Chandra S, Umapathy NS, Verin AD, Caldwell
RB, Caldwell RW. Angiotensin II-induced vascular endothelial dysfunction through
RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathway. Am J Physiol
Cell Physiol. 2011 May;300(5):C1181-92. doi: 10.1152/ajpcell.00328.2010.
13. Yao L, Romero MJ, Toque HA, Yang G, Caldwell RB, Caldwell RW. The role of
RhoA/Rho kinase pathway in endothelial dysfunction. J Cardiovasc Dis Res. 2010
Oct;1(4):165-70. doi: 10.4103/0975-3583.74258.
14. Toque HA, Romero MJ, Tostes RC, Shatanawi A, Chandra S, Carneiro ZN, Inscho EW,
Webb RC, Caldwell RB, Caldwell RW. p38 Mitogen-Activated Protein Kinase (MAPK)
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Maritza J. Romero-Lucas, M.D./D.Sc.

Increases Arginase Activity and Contributes to Endothelial Dysfunction in Corpora
Cavernosa from Angiotensin-II-Treated Mice. J Sex Med. 2010 Dec;7(12):3857-67. doi:
10.1111/j.1743-6109.2010.01996.x.
15. Yang G, Lucas R, Caldwell RB, Romero MJ and Caldwell RW. Novel mechanisms of
endothelial dysfunction in diabetes. J Cardiovasc. Dis Res. 2010 Apr;1(2):59-63. doi:
10.4103/0975-3583.64432.
16. Rojas M , Zhang W, Lee D, Romero MJ, Nguyen T, Al-Shabrawey M, Tsai N-T, Liou G,
Brands M, Caldwell RW , Caldwell RB. Role of IL-6 in Angiotensin II-induced Retinal
Vascular Inflammation. Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1709-18. doi:
10.1167/iovs.09-3375.
17. Caldwell RB, Zhang W, Romero MJ, Caldwell RW. Vascular dysfunction in retinopathy
An emerging role for arginase. Brain Res Bull. 2010 Feb 15;81(2-3):303-9. doi:
10.1016/j.brainresbull.2009.08.025.
18. Chamberlain S, Lee JR, Romero MJ, Patel J, Hall JD, Sridhar S, Labazi M, Caldwell
RW, Marcus DM, Bartoli M. Protective effects of the carotenoid zeaxanthin in
experimental non-alcoholic steatohepatatis. Dig Dis Sci. 2009 Jul;54(7):1460-4. doi:
10.1007/s10620-009-0824-2.
19. Zhang W, Baban B, Rojas M, Tofigh S, Virmani SK, Patel C, Behzadian MA, Romero
MJ, Caldwell RW, Caldwell RB. Arginase activity mediates retinal inflammation in
endotoxin-induced uveitis. Am J Pathol. 2009 Aug;175(2):891-902. doi:
10.2353/ajpath.2009.081115.
20. Romero MJ, Platt D, Tawfik H, Labazi M, El-Remessy AB, Bartoli M, Caldwell RB,
Caldwell RW. Diabetes-induced coronary vascular dysfunction involves increased
arginase activity. Circulation Research. 2008; 102: 95-102.
21. Mosquera J, Romero MJ, Viera N, Rincn J, Pedreaez A. Could streptococcal
erythrogenic toxin B induce inflammation prior to the development of immune complex
deposits in poststreptococcal glomerulonephritis? Nephron Exp Nephrol. 2007; 105 (2):
e41-4.
22. Romero MJ, Platt D, Caldwell RB, Caldwell RW. Therapeutic Use of Citrulline in
Cardiovascular Disease. Cardiovascular Drug Reviews. 2006; 24 (3-4): 275-290.
23. Viera NT, Pedreanez A, Romero MJ, Rincon JC, Mosquera JA. Increased expression of
apoptosis-associated proteins in puromycin aminonucleoside nephrosis. Invest Clin.
2005 Sep;46(3):273-87.
24. Rincon J, Romero MJ, Viera N, Pedreanez A, Mosquera J. Increased oxidative stress
and apoptosis in acute puromycin aminonucleoside nephrosis. Int J Exp Pathol. 2004
Feb;85(1):25-33.
25. Pedreanez A, Rincon J, Romero MJ, Viera N, Mosquera J. Melatonin decreases
apoptosis and expression of apoptosis-associated proteins in acute puromycin
aminonucleoside nephrosis. Nephrol Dial Transplant. 2004 May;19(5):1098-105.
26. Rincon J, Viera NT, Romero MJ, Mosquera JA. Increased production of chemotactic
cytokines and elevated proliferation and expression of intercellular adhesion molecule-1
in rat mesangial cells treated with erythrogenic toxin type B and its precursor isolated
from nephritogenic streptococci. Nephrol Dial Transplant 2003; 18(6): 1072 1078
27. Fernandez L, Romero M, Rincn J, Mosquera J. Increased expression of CD54, CD18,
MHC class II molecules and proliferating cell nuclear antigen in acute puromycin
aminonucleoside nephrosis. Nephron Exp Nephrol 2003; 94 (2): e55 65
28. Viera N, Romero M, Montero MK, Rincn J, Mosquera J. Streptococcal erythrogenic
toxin B induces apoptosis and proliferation in human leukocytes. Kidney International
2001; 59 (3): 950 958
29. Fernandez L, Romero M, Soto H, Mosquera J: Increased apoptosis in acute puromycin
aminonucleoside nephrosis. Experimental Nephrology 2001; 9(2): 99-108
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Maritza J. Romero-Lucas, M.D./D.Sc.

30. Romero M, Mosquera J, Novo E, Fernandez L, Parra G: Erythrogenic toxin type B and
its precursor isolated from nephritogenic streptococci induce leukocyte infiltration in
normal rat kidneys. Nephrol Dial Transplant 1999; 14(8): 1867-1874
31. Romero M, Mosquera J, Rodriguez-Iturbe B. A simple method to identify NBT-positive
cells in isolated glomeruli. Nephrol Dial Transplant 1997; 12(1): 174-9.
32. Parra G, Romero M, Henriquez La-Roche, Pineda R, Rodriguez-Iturbe B. Expression of
adhesion molecules in poststreptococcal glomerulonephritis. Nephrol Dial Transplant
1994; 9(10): 1412-7