Escolar Documentos
Profissional Documentos
Cultura Documentos
by
David Karaba, OMD, LAc
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3.
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Tissue Response
Simplified Explanation
Technical Neuro-endocrine-immune response
Basic Neurological Activation and Response
8 hour course
Detailed Neuro pathways and responses
Effects on Autonomics
Understanding the physiology of Master Tungs
method of distal pts and how to explain how they
work.
And More (Reviewed and expanded at conclusion)
Patient Question:
So
Usually after:
Does It Hurt?
Puncture Wound
Acupuncture is a Puncture Wound.
A puncture wound is a serious threat to the Body.
It is a breach of the skin barrier system
The body mounts a major response to neutralize any potential
pathogens
Puncture Wound
The Body responds to investigate and
neutralize any Pathogens or Toxins
Vasodilation / Inflammation (initial part of healing)
Allow WBCs to migrate out of vessels to find any bacteria,
venom, or poison.
Mast cells, basophils
Histamine
Heparin
Leukotrienes
Arachidonic Acid
Prostaglandins
Immune compliment
Chemotaxis (i.e. tells WBCs where to go)
Venom
Snake bite
Insect bite
Bacteria
Abrasion
Nail
Poison
Plant thorn, Animal, etc.
Puncture Wound
The Body doesnt find any pathogens or toxins
Only a Stainless Steel Sterilized - One-Time Use Needle
Puncture Wound
These anti-inflammatory substances circulate in local
tissue and reduce inflammation that may be present
Muscle Injuries
Arthritis
Tendonitis
Etc.
Puncture Wound
Further still, the body creates natural pain
killers (opioids, endorphins, enkephalins, etc.)
to turn off the False Alarm signal as well.
Puncture Wound
Note:
Alternatively Occasionally there are pathogens in the body as is
the case when someone is sick with a cold or flu.
(Provided the Root is Strong)
Needle Manipulation
Characteristics of treatment controlled by
strength of needling, insertion depth, and
retention time
Stronger stimulation produces more needle
induced tissue damage products
Longer needle retention time favors restorative
anti-inflammatory response
Muscle Spasms
Muscle Spasms
Muscle Spindles
and Golgi Tendon
Organs
Muscle Spasms
Resetting of muscle spindle cells allows
stretch and consequent progress towards
restoration of full range of motion
Spinal Reflexes
Spinal Reflexes
3. Gamma-loop reflex
Puncture Wound
Muscle spindles
It has been calculated that only 1/3 of the
fibers of a muscle nerve consists of motory
axons conducing to the muscle fibers, while
more than an half consists of fibers conveying
signals from the neuromuscular spindle to the
spinal marrow and vice versa.
The neuromuscular spindle is richly supplied
with nerve fibers and blood vessels.
Visceral
Relationships
|
Recognized in terms of
organ referred pain
reflecting in certain body
regions
Viscerovisceral
relationships occur as well
where function or treatment
stimulation of one organ
produces autonomic
reflexes in another organ
Puncture Wound
Basically, Acupuncture is an ingenious way to
trick the body into healing itself by bringing
blood flow to the region and related areas
Providing Oxygen, nutrients, defensive substances,
and endocrine substances to these regions
Fine Vessels-Sunmai
Arterioles, Venules
and Capillaries
Critical Nodes-Jie
Propagated Sensation Pathway
Fire Alarm
Fire Drill at school (or accidental)
Everybody moves to designated spaces
Fire fighters come to investigate
Fire fighters dont find a fire
May find other areas of concern and remedy
Superficial
Lymphatics
Skin
Muscle
Tissue
Veins
Arteries
Longitudinal Distribution
Vessels-Jingmai
Collateral Vessels-Luomai
at each Node
Connecting-Luomai
Between Paired Zangfu
Vessels in the Extermeties
and Other Regions of Body
Needling Therapy
Needling therapy
effects the body first
at the capillary /
cellular level
Sun Mai
Second sensory
nerves that affect the
CNS
Needling Mechanisms
Kinin Generating
Protease
Kallikrien
Complement Anaphylatoxin
C3a, C5a, or C4a
C5a
CA++
IGE
NA+
Heparin
+
Histamine
IGE
Receptors
Granules
Mast Cells
& Basophils
Selected
Phospholipids
Mast Cells
and Baosophils
Other Cell
Types
Arachidonic
Acid
Cyclooxygenase (3)
5-HPETE
Leukotriene A4
PGG2
5-HETE
SRS-A
Pathway
LTB4
Cleaved by
Aryl
Arly Sulfatase B
LTC4
LTD4
100X
1000X
100X
100X
LTE4
Prostaglandin H2
Causes dissagregation
of platelets
PGI2
PGE2
Powerful bronchial
constrictor
PGF2
Potent vasodilator
preferently in human
lung
PGD2
Potent regulators
of blood coagulation
and homeostasis
1. Blocked by steroidal antiinflamatory drugs
2. Blocked by 5-LOX inhibiters
3. Blocked by selective and non-selective non-steriodal antiinflamatory
drugs (NSAIDs) as COX-1 and COX-2 inhibiters
Selected Phosopholipids
Leukotrine (LT A, B)
SRS-A (LT C, D, E)
Prostaglandins
PGE1
GGE2
PGF2a
PGD2
PGI2 - PGF1a
Thromboxane A2
Thromboxane B2
Platelet Activating Factor
Leukotrienes
Phospholipase A2 or
Phospholipase C + Diglyceride Lipase (1)
5 - Lipoxygenase (2)
Histamine
Heparin
ECF-A
NCF-A
Arylsulfatase A&B
Thromboxane A2
Thromboxane B2
Prostaglandins
PGI2: causes disaggregation of platelets
PGE2: potent broncho and vaso dilators that
regulate tissue microenvironment
PGF2: potent bronchial constrictor
PGD2: potent vasodilator in human lung
Mast Cell
Are heavily granulated wandering cell found
in connective tissue beneath epithelial
surfaces
Granules contain histamine, heparin, and
many proteases
Have IgE receptors and like basophils they
degranulate when IgE coated antigens bind
to their surfaces
Mast Cell
Also participate in non-specific natural immunity
activated by Complement
Marked mast cell degranulation produces
allergic reactions and can produce anaphylaxis
Eosinophil
Have a short half life in circulation and
attracted to surface of endothelial cells
Like neutrophils, they release proteins,
cytokines, and chemokines producing
inflammation
Capable of killing off invading organisms
Basophil
Also enters tissue and release cytokines and
proteins
Resemble but are not identical to mast cells,
but do contain histamine and heparin
Participate in immediate-type hypersensitivity
Ranges from mild urticaria, rhinitis, and to
severe anaphylactic shock
Eosinophil
Abundant in mucosa of gastrointestinal tract to
defend against parasites
Circulating eosinophils increased in allergic
reactions
Includes asthma, other respiratory diseases,
and gastrointestinal diseases
Platelets
Platelets
Nociceptive Activation
Needle Insertion
Slide Title
Collagen, Microfibrils
and Basement Membrane
Text
XIIa
Text
Kinin Protease
from Mast Cells
& Basophils
Text
Plasmin
Plasmingen
Text
Text
Inhibited by Heparin
XIIa
Prothrombin
Thrombin
XIIa
Blood Coagulation
System Provokes
Needling Response
Kallikrien
Chemotaxis
Plasma Kininogen
Bradykinin
Potent Vasodilation and
Smooth Muscle Contraction
Nociceptive
Excitation
Immune
Compliment System
Classical Pathway
involves attack by C1 when
antibody bound to antigen in
an antigen-antibody complex
is encountered
Alternative Pathway
C3
Plasmin
C3b
Factor B
C3b,B
Fractor D
Thrombin
Amplification
C3b,Bb
C3
Activated by Plasmin
to Provoke Immune
Response to Needling
Anaphylatoxin
C3bn,Bb
Properdin
C3bn,P,Bb
C5
C6
C7
C8
C9
Anaphylatoxin
Chemotaxis
Lysis, Cytotoxicity
Complement Alternative
Pathway
+ =
C3 activated by Plasmin
immediately forms C3b
binding with Factor B
which then activates more C3
in a feed-forward amplification
Combined Action
Blood coagulation system and alternative
pathway immune complement system interact
to amplify response
C3 causes mast cell and basophils
degranulation and release of kinin protease
This preferentially causes more production of
bradykinin to stimulate nociceptive fibers
Complement Alternative
Pathway
Plasmin activates C3 provoking the immune
complement system
Complement proteins C3 and C5 cause potent
vasodilatation by degranulating mast cells and
plasma basophils
Released heparin inhibits thrombin
Needling Mechanisms
Needle
Insertion
Hageman
Factor XII
Microfibrils and
Basement Membrane
Damage Products
Factor XIIa
Plasminogen
Kininogen
Plasmin
Activates C3
Prothrombin
(Inhibited by
Heparin from
Mast Cells)
C3
Immune
Complement System
Alternative Pathway
Blood Coagulation
System
Kinin
Protease
Bradykinin
C3
C5
Amplification
Loop
C3b,Bb
Nociceptive Excitation
Via B2 Receptors
ECF-A
NCF-A
LT C, D & E
PGE2
Potent Local
Vasodilation
Immune Cell
Attraction
Spinal Chord
Dorsal Horn
I, II, III, IV, V, VI
Intermediate Zone
VII
Ventral Horn
VIII, IX
Grey Matter
(surrounding
central canal)
X
Neuroanatomy through Clinical Cases. Blumenfeld, 2002
Nociceptive Fibers
C-Fiber
Myelinated, Large
Non-Myelinated, small
May be sensitized
May be sensitized.
Nociceptive Fibers
Neurogenic Inflammation
10
Somatosensory Pathways
Posterior Column
Medial Lemnisical
Pathway
Sensory
Vibration
Joint Position
Proprioceptive
Muscle Spindle
Golgi Tendon
Fine Touch
A-alpha, I
A-beta, II
Ascending Pathways
ALT comprised of spinothalamic (STT),
spinorecticular (SRT), and spinomesencephalic
(SMT) tracts
Somatic and visceral nociceptive signals
synapse on ALT crossed fibers
Major portion of SRT and SMT fibers project to
the pons, midbrain, and medulla
A small portion of STT fibers projects to the
thalamus, which sends fibers to sensory cortex
Proprioception
Sherrington: defined proprioceptors as
sensory receptors for stimuli that "are
traceable to actions of the organism itself, and
since the stimuli to the receptors are delivered
by the organism itself, the deep receptors may
be termed proprioceptors...
(1906) Brain 29:467-482
Proprioception Receptors
Joint receptors: sensory endings in joint
Cutaneous receptors: movements and
postures cause deformations of skin
(mechanoreceptors)
Specialized muscles receptors:
Muscle spindles respond to stretch
Golgi tendon organs sensitive to changes in tension
Essential Properties
Proprioception
Amount of muscle activity mobilized by
proprioceptive inputs is small
Adequate stimuli for proprioceptors arise from
actions of organism itself
System can be stimulated by needling
superficial body
Slide Title
Anterior Lateral
Pathways
Sensory
Pain
Temperature
Crude Touch
Pressure
A-delta, III
C, IV
11
Corticospinal
Tract
Descending
Motor
Pathway
Text
Text
Text
Text
Text
Somatotopic Organization of
Spinal Chord
Motor:
85%
Descending
Corticospinal
Cross over
pyramidal
decussation to
form:
Lateral
Corticospinal
Tract.
Remaining
Make Anterior
Corticospinal
Tract.
Blue:
Ant. Cortico Red:
Rubrio Note:
Assoc.
Neurons
Crossing to
opposing sides
Neuroanatomy through Clinical Cases. Blumenfeld, 2002
Somatic Afferents
Nociceptive (1)
Needle
Insertion
Skin and
Superficial
Tissue
Gamma
Loop
Ascending
(4)
Pathways (3)
Motor (5)
Muscle
Autonomic
Motor (6)
Blood
Vessels
Inhibition (9)
Spinal Cord
Dorsal Horn
Proprioceptive
(2)
Spinal Cord
Ventral Horn
Brain
Response (8)
Autonomic
Motor (7)
Visceral
Afferent (10)
Internal Organs
12
Proximal
Nodes
Descending
Inhibition
Detailed schematic
shows specific neural
pathways along with
specific
neurotransmitters
Brain
Stem
Segemental
Level
Area Proximal
to Problem
Afferent
Signals
Local and
Adjacent
Nodes
Region of
Problem
Segemental
Level
Distal
Nodes
Area Distal
to Problem
Segemental
Level
Dao of Chinese Medicine, Figure 15.1,
Oxford University Press 2002
CNS Descending
control is shown as
separate from stress
analgesia which
utilizes
norepinephrine rather
than natural opiates
Dao of Chinese Medicine. Kendall, Oxford University Press, 2002
Propagated
Sensation
Sensations of energy
moving up or down the
arm (or leg) are properly
known as propagated
sensation
SENSORY CORTEX
Norepinephrine
Neurons
Dorsal Root Ganglia
A- and C Nociceptive Neurons
& Group II Static Load Neurons
Node 3
PS
Automatic reflexes
occurring in the spinal
cord levels reverse the
flow of sensory nerves
and activate adjacent
areas of skin along the
longitudinal pathway of
related vessels and
nerves
Node 2
Antidromic
Pathway
THALAMUS
PERIAQUEDUCTAL GRAY
DORSAL RAPHE
PS as Neural Reflex
Serotonergic
Neurons
Enkephalin
Interneuron
Anterior
Lateral
Tract
Propriospinal
Pathways
DRR
Tract of Lissauer
and DLF
Antidromic
Pathway
DRR
Dorsal
Columns
PS
Node 1
Needling Sensation &
Proprioceptive Signals
Ventral
Funiculi
Spinal Cord
Segment
Saturday Lecture
CNS / Brain pathways
Acu Mechanisms and pathways
Significance to Tx
HDNJ
(LAPD)
Proprioception
Embryology
13
Questions /Comments
Parasympathetic
Relaxation Restoration
Chronic conditions
Inflammation
PENS Perspectives
14