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To cite this article: Justin B. Miller , Bradley N. Axelrod , Lisa J. Rapport , Scott R. Millis , Sarah VanDyke ,
Christian Schutte & Robin A. Hanks (2012) Parsimonious prediction of Wechsler Memory Scale, Fourth Edition scores:
Immediate and delayed memory indexes, Journal of Clinical and Experimental Neuropsychology, 34:5, 531-542, DOI:
10.1080/13803395.2012.665437
To link to this article: http://dx.doi.org/10.1080/13803395.2012.665437
Research on previous versions of the Wechsler Memory Scale (WMS) found that index scores could be predicted
using a parsimonious selection of subtests (e.g., Axelrod & Woodard, 2000). The release of the Fourth Edition
(WMSIV) requires a reassessment of these predictive formulas as well as the use of indices from the California
Verbal Learning TestII (CVLTII). Complete WMSIV and CVLTII data were obtained from 295 individuals.
Six regression models were fit using WMSIV subtest scaled scoresLogical Memory (LM), Visual Reproduction
(VR), and Verbal Paired Associates (VPA)and CVLTII substituted scores to predict Immediate Memory
Index (IMI) and Delayed Memory Index (DMI) scores. All three predictions of IMI significantly correlated with
the complete IMI (r = .92 to .97). Likewise, predicted DMI scores significantly correlated with complete DMI
(r = .92 to .97). Statistical preference was indicated for the models using LM, VR, and VPA, in which 97% and
96% of the cases fell within two standard errors of measurement (SEMs) of full index scores, respectively. The
present findings demonstrate that the IMI and DMI can be reliably estimated using two or three subtests from
the WMSIV, with preference for using three. In addition, evidence suggests little to no improvement in predictive
accuracy with the inclusion of CVLTII indices.
Keywords: Memory; Wechsler Memory Scale; Short form; Parsimonious prediction; Concordance correlation
coefficient; Immediate memory; Delayed memory.
This research was supported by a grant from the National Institute on Disability and Rehabilitation Research, Department of
Education (H133A080044), the Del Harder Foundation, and the Wayne State University Graduate School. The contents of this study
do not necessarily represent the policies of the funding agencies. Justin B. Miller is now at the Semel Institute for Neuroscience and
Human Behavior, University of California, Los Angeles, CA, USA.
Address correspondence to Bradley N. Axelrod, John D. Dingell Department of Veterans Affairs, Psychology Section, Detroit, MI,
USA (E-mail: bradley.axelrod@va.gov).
2012 Psychology Press, an imprint of the Taylor & Francis Group, an Informa business
http://www.psypress.com/jcen
http://dx.doi.org/10.1080/13803395.2012.665437
532
MILLER ET AL.
METHOD
Participants
Archival data for the present study were obtained
from the John D. Dingell Department of Veterans
Affairs (VA) Medical Center in Detroit, Michigan
and the Rehabilitation Institute of Michigan (RIM)
in Detroit. The VA sample was drawn from the
clinical archives of persons evaluated on an outpatient basis during the course of routine clinical
care. The primary diagnostic concerns included
dementia, mood disorders, traumatic brain injury,
learning disability, attention deficit hyperactivity
disorder, and other medical concerns, such as cognitive declines related to Parkinsons disease and
vascular events.
The sample from RIM was collected as part
of a research study investigating the ability of
the WMSIV to differentiate cognitive impairment resulting from actual moderate to severe
Materials
For all cases, the entire WMSIV and CVLTII
were administered and scored according to
the standardized procedures. The sample from
RIM also completed several stand-alone symptom validity measures (e.g., Test of Memory
Malingering; Tombaugh, 1996) and embedded
measures of response bias (e.g., Reliable Digit
Span; Greiffenstein, Gola, & Baker, 1995). The VA
sample also completed the full WMSIV as part of
a comprehensive assessment of cognitive functioning in the context of a standard outpatient clinical
evaluation.
Procedure
This study was reviewed and approved by the
Human Investigation Committee at Wayne State
University and the Veterans Affairs Clinical
Investigation Committee. Persons recruited for the
study conducted at RIM were contacted via telephone (Southeastern Michigan Traumatic Brain
Injury System participants) or responded to printed
advertisements and posted fliers (simulator participants); all persons in this sample who agreed
533
Analyses
The primary analytic strategy entailed use of linear
regressions with one of two index scores as the outcome and a combination of several subtest scores
as predictors. The primary index scores of interest
included the Immediate Memory Index (IMI) and
the Delayed Memory Index (DMI). The individual predictors included scaled scores from the
Visual Reproduction (VR), Logical Memory (LM),
and Verbal Paired Associates (VPA) as well as
scaled scores generated from substituting CVLTII
indices for VPA. The Design Memory subtest
was not included as part of the analysis to focus
the present study on those subtests that are most
frequently administered. Six separate models were
evaluated, three predicting IMI(a) VR and LM
(IMI2); (b) VR, LM, and VPA (IMI3W); and (c)
VR, LM, and CVLTT (IMI3C)and three comparable models predicting DMI(a) VR and LM
(DMI2); (b) VR, LM, and VPA (DMI3W); and
(c) VR, LM, and CVLTZ (DMI3C). Predicted
values were calculated using the unstandardized
regression coefficients from each resulting equation.
Model performance was evaluated by comparing R-squared values, and the contribution of
individual predictors was assessed based on standardized regression coefficients. Predicted values
from each regression equation were correlated
with observed index score values using Pearson
correlation coefficients to determine the association
534
MILLER ET AL.
between actual and predicted values. The percentage of predicted index scores that fell within 1 standard error of measurement (SEM) of observed
index scores was computed. As reported in the technical and interpretive manual for the WMSIV, the
average SEM for the adult battery (i.e., 1669 years
of age) is 3.53 points for the IMI and 3.71 points for
the DMI (Wechsler, 2008a). Thus, for the present
study, the SEM was rounded to 4 points for both
indexes. To provide a clinically relevant metric, the
percentage of scores falling within a full standard
deviation (SD; 15 index points) was also computed. The Pearson correlations between predicted
WMSIV scores and obtained WMSIV scores
were compared across the different models, and
the differences in correlations between models were
evaluated using t tests following r-to-z transformations of the correlations.
To evaluate the rate of agreement between
the original value and predicted values, Lins
Concordance Correlation Coefficient (CCC; King
& Chinchilli, 2001; Lin, 1989) was also calculated.
The CCC is a method for measuring agreement
on a continuous measure obtained by two persons
or methods; it measures both precision and accuracy to determine how far the observed data deviate
from the line of perfect concordance (i.e., the line
at 45 on a square scatter plot). Lins coefficient is
expressed as the product of the Pearson correlation
coefficient, which is a quantification of precision
(i.e., the distance of each data point from the fitted model), with the added incorporation of a bias
correction factor (Cb) that measures accuracy (i.e.,
the distance of the resulting model from the optimal 45 diagonal originating at the origin; King
& Chinchilli, 2001; Lin, 1989). Unlike using standard Pearson statistics or paired-sample t tests, the
CCC is capable of detecting systematic bias that
may be present among comparisons (e.g., over or
under prediction) and is thus a preferred statistic
for evaluating agreement between continuous variables. Bias correction factor values that differ from
1.00 indicate the presence of bias, with greater deviation indicating stronger bias (Lin, 1989). Values of
the CCC can range from 1.0, indicating poor concordance, to 1.0, which would be observed in the
presence of perfect agreement between values.
RESULTS
Descriptive statistics for predicted index score values for all six models are presented in Table 1,
and model summary statistics for the three IMI
and three DMI prediction equations are presented
in Table 2. All regression coefficients in each of
535
TABLE 1
Descriptive statistics for full and short-form predicted WMSIV Immediate and Delayed Memory Indexes
Model
SD
Range of difference
Actual IMI
IMI2 (LM1, VR1)
IMI3C (LM1, VR1, CVLTII1)a
IMI3W (LM1, VR1, VPA1)
83.0
82.9
83.2
82.9
18.0
16.7
16.9
17.6
NA
17.5 to 21.7
16.4 to 20.8
10.7 to 14.4
Actual DMI
DMI2 (LM2, VR2)
DMI3C (LM2, VR2, CVLTII2)b
DMI3W (LM2, VR2, VPA2)
82.6
82.4
82.7
82.6
16.3
15.0
15.0
15.8
NA
16.1 to 17.5
15.4 to 16.3
10.7 to 11.8
Note. WMSIV = Wechsler Memory ScaleFourth Edition; IMI = Immediate Memory Index; DMI = Delayed Memory Index;
LM1 = Logical MemoryImmediate; LM2 = Logical MemoryDelayed; VR1 = Visual ReproductionImmediate; VR2 = Visual
ReproductionDelayed; CVLTII1 = California Verbal Learning TestIIImmediate; CVLTII2 = California Verbal Learning Test
IIDelayed; VPA1 = Verbal Paired AssociatesImmediate; VPA2 = Verbal Paired AssociatesDelayed.
a IMI3C employed a substitution of CVLTII Trials 15 t score for Verbal Paired Associates (Immediate).
b DMI3C employed a substitution of CVLTII Long-Delay Free-Recall z score for Verbal Paired Associates (Delayed).
TABLE 2
Regression summary statistics for short-form prediction models of Immediate and Delayed Memory Indexes
Predictors
Model summary
SEB
R2
SEE
IMI2
Logical Memory 1
Visual Reproduction 1
Constant
2.78
2.61
43.76
0.14
0.13
1.05
0.54
0.52
.92
.85
7.00
IMI3C
Logical Memory 1
Visual Reproduction 1
Substitution 1
Constant
2.32
2.48
1.13
39.48
0.15
0.13
0.17
1.18
0.44
0.49
0.18
.93
.87
6.49
IMI3W
Logical Memory 1
Visual Reproduction 1
Verbal Paired Associates 1
Constant
1.83
2.25
2.16
36.77
0.09
0.08
0.09
0.67
0.35
0.45
0.39
.98
.95
4.04
DMI2
Logical Memory 2
Visual Reproduction 2
Constant
2.76
2.55
46.55
1.22
0.12
0.99
0.57
0.55
.92
.84
6.49
DMI3C
Logical Memory 2
Visual Reproduction 2
Substitution 2
Constant
2.39
2.35
0.85
44.43
0.13
0.13
0.13
1.02
0.49
0.50
0.18
.93
.86
6.10
DMI3W
Logical Memory 2
Visual Reproduction 2
Verbal Paired Associates 2
Constant
1.98
2.02
1.94
40.43
0.08
0.07
0.08
0.63
0.41
0.43
0.39
.97
.95
3.75
Model
Note. SEB = Standard error of beta weights; SEE = Standard error of the estimate; IMI = Immediate Memory Index; IMI3C =
predicted IMI using LM, VR, and California Verbal Learning Test, 2nd edition (CVLTII); IMI3W = predicted IMI using LM,
VR, and Verbal Paired Associates (VPA); DMI = Delayed Memory Index; DMI2 = predicted DMI using LM and VR; DMI
3C = predicted DMI using LM, VR, and CVLTII; DMI3W = predicted DMI using LM, VR, and VPA. Substitution refers to use
of California Verbal Learning TestII indices in place of verbal paired associates.
536
MILLER ET AL.
TABLE 3
Accuracy of predicted WMSIV index scores in relation to the standard error of measurement and standard deviation of the
indexes
Predicted IMI
Range of discrepancy
Predicted DMI
IMI2
IMI3C
IMI3W
DMI2
DMI3C
DMI3W
12.6
16.6
40.0
19.3
10.8
9.9
18.7
44.9
16.3
10.2
1.0
15.8
65.4
15.4
2.4
9.6
19.5
43.8
15.1
12.0
10.3
14.9
49.8
13.9
11.0
1.4
12.7
71.1
12.4
2.4
Standard deviation
(Predicted > actual) 15 points
(Predicted > actual) within 15 points
(Predicted < actual) within 15 points
(Predicted < actual) 15 points
1.4
49.7
47.6
1.4
0.7
47.1
51.4
0.7
0.0
52.7
47.3
0.0
0.7
49.8
49.1
0.3
0.0
50.7
48.9
0.4
0.0
48.8
51.2
0.0
Note. WMSIV = Wechsler Memory ScaleFourth Edition; IMI = Immediate Memory Index; IMI2 = predicted IMI using Logical
Memory (LM) and Visual Reproduction (VR); IMI3C = predicted IMI using LM, VR, and California Verbal Learning Test, 2nd
edition (CVLTII); IMI3W = predicted IMI using LM, VR, and Verbal Paired Associates (VPA); DMI = Delayed Memory Index;
DMI2 = predicted DMI using LM and VR; DMI3C = predicted DMI using LM, VR, and CVLTII; DMI3W = predicted DMI
using LM, VR, and VPA.
a Standard errors of measurement (SEMs) for IMI = 3.5 and 3.7 points for IMI and DMI, respectively. Cutpoints rounded to nearest
whole points of SEM = 4. Standard deviations (SDs) for IMI and DMI = 15 points.
537
TABLE 4
Measures of agreement between observed and predicted index scores
Precision (Pearson
correlation coefficient)
Accuracy
(bias factor)
Concordance correlation
coefficient (CCC)
95%
Confidence
interval
IMI2
IMI3C
IMI3W
.92
.93
.98
1.00
1.00
1.00
.92
.93
.97
[.90, .94]
[.92, .95]
[.97, .98]
DMI2
DMI3C
DMI3W
.92
.93
.97
1.00
1.00
1.00
.91
.92
.97
[.89, .93]
[.91, .94]
[.97, .98]
Model
140
120
100
IMI
80
60
40
Note. IMI = Immediate Memory Index; IMI2 = predicted IMI using Logical Memory (LM) and Visual Reproduction (VR);
IMI3C = predicted IMI using LM, VR, and California Verbal Learning Test, 2nd edition (CVLTII); IMI3W = predicted IMI
using LM, VR, and Verbal Paired Associates (VPA); DMI = Delayed Memory Index; DMI2 = predicted DMI using LM and VR;
DMI3C = predicted DMI using LM, VR, and CVLTII; DMI3W = predicted DMI using LM, VR, and VPA.
40
60
Reduced major axis
80
IMI2
100
120
Figure 1. Scatter plot of observed Immediate Memory Index (IMI) values and predicted IMI values using Logical Memory and Visual
Reproduction subtests (IMI2).
MILLER ET AL.
40
40
60
80
IMI3C
100
120
60
80
IMI
100
120
140
Figure 2. Scatter plot of observed Immediate Memory Index (IMI) values and predicted IMI values using Logical Memory, Visual
Reproduction, and California Verbal Learning Tests, 2nd Edition subtest scaled scores (IMI3C).
40
60
80
IMI
100
120
140
538
40
60
Reduced major axis
80
IMI3W
100
120
Figure 3. Scatter plot of observed Immediate Memory Index (IMI) values and predicted IMI values using Logical Memory, Visual
Reproduction, and Verbal Paired Associates subtest scaled scores (IMI3W).
539
40
60
80
100
DMI2
120
140
60
80
DMI
100
120
140
Figure 4. Scatter plot of observed Delayed Memory Index (DMI) values and predicted DMI values using Logical Memory and Visual
Reproduction subtests (DMI2).
40
60
80
DMI
100
120
140
40
60
80
DMI3C
100
120
140
Figure 5. Scatter plot of observed Delayed Memory Index (DMI) values and predicted DMI values using Logical Memory, Visual
Reproduction, and California Verbal Learning Tests, 2nd Edition subtest scaled scores (DMI3C).
MILLER ET AL.
40
60
80
DMI
100
120
140
540
40
60
80
100
120
140
DMI3W
Reduced major axis
Figure 6. Scatter plot of observed Delayed Memory Index (DMI) values and predicted DMI values using Logical Memory, Visual
Reproduction, and Verbal Paired Associates subtest scaled scores (DMI3W).
DISCUSSION
The findings provide strong support for estimating WMSIV index scores using parsimonious
subsets of the most frequently administered subtests. The three primary subtests of the WMSIV
that are most familiar and most frequently used
(Logical Memory, Visual Reproduction, and
Verbal Paired Associates) serve remarkably well
to estimate both the Immediate Memory Index
(IMI) and Delayed Memory Index (DMI) of the
WMSIV. Furthermore, the present findings
demonstrate that the IMI and DMI can be reliably
estimated with a level of predictive accuracy that
is considered acceptable for use in clinical practice.
Estimations that used the CVLTII substitution
generally performed less well than did estimations
using the WMSIV subtests. Although the most
accurate model uses three of the four original
541
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MILLER ET AL.
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