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painfully high, with the direct and indirect economic burden amounting to more than 336
billion euros per year2 more than the entire German national budget. The top three
culprits are dementia (105 billion), followed by stroke (64 billion) and headache and
migraine (43 billion). 122 billion euros is accounted for by treatment costs and direct nonmedical costs, respectively, while a further 93 billion euros is attributable to indirect costs
such as sick leave or early retirement.
Neurological disease also has a significant impact in terms of DALYs 3, a measure used to
determine the years lost through disease and premature death. In the EU alone 4, 2.2
million DALYs are attributable to dementia, 1.6 million to strokes, 640,000 to Parkinsons
disease and 260,000 to epilepsy. According to the WHO, worldwide DALYs due to
neurological disease will rise from 95 million in 2015 to 103 million in 2030, an increase of
more than nine percent. Alzheimers and other forms of dementia (up 37 percent), and
cerebrovascular disease (up 13 percent) will be among the main factors behind the
increase.