Escolar Documentos
Profissional Documentos
Cultura Documentos
Parasitologi- FK UGM
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Innate immunity
Adaptive immunity
Humoral
Immune
response
Cellular
Immune
response
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Mucosal
Immune
response
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Protozoa
Helminth
Arthropod
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Antigen E. histolitica
20-32 component
Soluble
Un-soluble
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Attachment
Lectin
Surface Ag:
-Lectin
-Cystein proteinase
-Amebaphore
Amoebas surface Ag bind
to fibronectin & Laminin
Attachment &
Migration into
solid tissue
Matrix extracell:
- Collagen
- Fibronectin
- Laminin
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Amoeba
cysteine
proteases
manipulate
and destroy
host
defences to
facilitate
nutrient
acquisition,
parasite
colonization
and/or
invasion.
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Invasion of
intestinal
epithelial
Ulcus Ameba
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Lytic activity
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Chemotaxis:
Locomotion toward target cells
Contact/ adhesion
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LPPG:lipopeptidophosphoglycan
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Antibody respons
Rapid
1week
Intestinal
Circulating
ELISA
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Antibody in Amebiasis
Resistance to
Complement lysis
Ab against surface Ag
-Immobilization
Shedding of
Ag-Ab complex
Evade Humoral
Immune response
Ab against lectin :
-inhibit adhesion
-phagocytosis (+)
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M
A
L
A
R
I
A
Ab
Ab
Ab
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Jean Langhorne, Francis M Ndungu, Anne-Marit Sponaas
& Kevin Marsh
Nature Immunology 9, 725 - 732 (2008) doi:10.1038/ni.f.205
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Host
immune
responses
against
Plasmodium
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Vaccine against
malaria
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Sporozoite
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BRADIZOITE FORMATION
Immunocompetent host : CMI cyst
formation
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Protozoa
Helminth
Arthropod
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Immune
Response
against
Intestinal
Nematode
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Eosinophils use
FcgR1 Receptor
to mediate to kill
helminth
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Protozoa
Helminth
Arthropod
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Venomous Arthropods
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Arthropods Venom:
Hypersensitivity reactions
are mediated by
immunological mechanism
that cause tissue damage
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Mast-cell activation
has different
effects on different
tissues
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