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BANGALORE, KARNATAKA.
DR. BABITHA M C
Post graduate in obstetrics and gynecology
Department of Obstetrics and Gynecology
Mysore Medical College and Research institute
Mysore 570001
31-5-2012
Amniotic fluid volume is the sum of inflow and outflow of fluid into the amniotic space and as such reflects fetal
fluid balance. Early on the gestation Amniotic Fluid is thought to be derived directly from the mother across
amnion, fetal surface of placenta and fetal body surface. In later half main source is fetal urine, lung liquid
secretion; major routes of resorption are fetal swallowing and intramembranous pathways.
The amniotic fluid volume at each week of pregnancy is variable. It increases from 20ml at 10 weeks to 770ml
at 28 weeks, remains at a steady state till 39 weeks, after which decreases dramatically. The average Amniotic
fluid volume in third trimester is 700-800 ml.2
Clinical assessment of amniotic fluid volume including bimanual palpation, symphysio fundal height is
unreliable. Diagnosis is generally made by measuring the Amniotic fluid compartment using ultrasound.
Definition of increased and decreased Amniotic fluid volume are based on the sonographic criteria2
Polyhydramnios is diagnosed when the deepest vertical pool of amniotic fluid is 8cm or greater, amniotic fluid
index measured by Phelans technique above 25cm/ 95th percentile. Incidence is around 1% of all pregnancies.
The etiology of polyhydramnios is diverse and involves many maternal and fetal conditions including diabetes
mellitus, congenital anomalies, isoimmunisation, multiple gestation and placental abnormalities. Half of cases
are found to be idiopathic1. Premature labour complicated 40% of polyhydramnios patients3.
Oligohydramnios is diagnosed when ultrasonographically the AFI is <=5cm/ 5th centile, or a single deepest pocket
of 2cm1. It affects 3-5% of pregnancies.2 Oligohydramnios is associated with high risk adverse perinatal outcome
1
like fetal distress, meconium staining, low apgar and neonatal resuscitation/ NICU admission but is a poor
predictor. Oligohydramnios is often used as an indicator for delivery.
So assessment of amniotic fluid volume is a helpful tool in determining who is at risk for potentially adverse
obstetric and perinatal outcome.
Therefore this study is conducted to determine the maternal and perinatal outcome in pregnancies with abnormal
AFI
2. Nazlima et al. (2012)4 studied 78 singleton pregnancies with gestational age of 28-42 weeks with low AFI for
perinatal outcome in jan-dec 2009, concluded that isolated Oligohydramnios is associated with high rate of
pregnancy complications and increased perinatal mortality and morbidity. Such women should be managed in a
special unit to combat complications effectively.
3. Ott W J et al (2005)5 studied AFI and its impact in 4753 high risk pregnancies and 1153 low risk pregnancies
and concluded that AFI is a weaker predictor of perinatal outcome than has been classically suggested. Although
the AFI identification of polyhydramnios was helpful in identifying LGA fetuses and fetuses at risk for
congenital abnormalities, oligohydramnios was a rather weak predictor of poor perinatal outcome.
4. Casey and colleagues (2000)6 in a retrospective analysis of 6423 pregnancies, AFI<5cm was associated with
increased perinatal morbidity and mortality.
5. Locatelli et al (2004)7 studied 413 women with uncomplicated pregnancies and AFI<5, concluded that
oligohydramnios is independently associated with a higher risk of low birth weight centile
6. Cunningham et al (2010)1. Excessive amniotic fluid is identified in 1% of pregnancies. Polyhydramnios is
usually associated with fetal malformation especially of CNS and GI system. Idiopathic hydramnios occurs in
approximately half of the all cases, even when sonography and radiography shows normal fetus, prognosis is still
guarded. Maternal complications are placental abruption, uterine dysfunction, Post partum hemorrhage,
malpresentation and operative interventions.
Oligohydramnios developing early in pregnancy is rare and frequently associated with poor prognosis.
Management of Oligohydramnios in late pregnancy depends on clinical situation. Oligohydramnios detected
before 36 weeks of pregnancy in presence of normal fetal anatomy and growth may be managed expectantly in
conjunction with fetal surveillance.
7. William Gilbert et al8. Severe Oligohydramnios has an increased PMR later in the third trimester. Studies have
reported increase in perinatal mortality associated with Oligohydramnios but most have not corrected for other
underlying medical conditions. Many clinicians believe that induction is indicated for oligohydramnios at or
close to term.
Polyhydramnios in third trimester is usually mild and not assosciated with structural defect. Vast majority of
cases cause cannot be found and are termed as idiopathic. Transient polyhydramnios has favorable outcome,
persistent cases the fetus and mother should be closely monitored.
8.Pankaj desai et al (2004)9 studied 55 women with low risk pregnancies with AFI<5 cm. concluded that reduced
liquor amnii in high risk pregnancies carries an increased risk of intrapartum complications but in low risk
pregnancies it has no adverse effect on labour or perinatal outcome.
9. Rainford et al (2001)10 in 232 women with uncomplicated pregnancies at term an AFI< 5 cm increases the
incidence of induction of labour.
10. Rukhsana et al (2010)11 50 women with AFI<5cm were compared with 50 with AFI>5cm for induction of
labour, mode of delivery, meconium stained liquor and fetal outcome measures such as APGAR score and
admission to NICU. AFI<5cm was associated with adverse pregnancy and perinatal outcome. However perinatal
mortality was not affected.
11. Pri-Paz S et al (2012)12 in a retrospective chart review of 524 singleton pregnancies diagnosed with
polyhydramnios and delivered in a single tertiary referral center between 2003 and 2008, There was an
association between the frequencies of a variety of adverse pregnancy outcomes and the severity of
polyhydramnios as reflected by the maximal AFI.
12. Naser omar et al (2005)13, a retrospective study of 65 singleton pregnancies with idiopathic polyhydramnios
and concluded that adverse perinatal outcome are less in idiopathic polyhydramnios than the one with a known
cause.
13. Kuang-Chao Chen et al(2005)14.Polyhydramnios carried a higher incidence of adverse perinatal outcomes,
such as low Apgar scores, fetal death, fetal distress in labor, NICU transfer and neonatal death, despite exclusion
of congenital anomalies from the study population. Detailed antepartum fetal well-being surveillance, intensive
intrapartum monitoring and further attention postpartum are warranted in
Patients with this condition.
14. Panting- kemp et al (1999)15, conducted a study in 150 women with singleton pregnancies and idiopathic
polyhydramnios concluded that in contrast to polyhydramnios with specific causes, idiopathic polyhydramnios is
not associated with higher rates of poor perinatal outcome.
Characteristic
Parameter
Method
Set-up
Birth weight of
Mean=2781 gm
Hypothesis
T-test,
the neonate in
S.D= 619 gm
testing
oligohydramnio
s patients
error=10%,
Power= 80%
Sample size
Due to the singleton clause we decide the maternal sample size based on the the birthweight parameter. Thus noligo
is a minimum of 60.
As mentioned earlier, the incidence of oligohydramnios and polyhydramnios is in 3:1 proportion 1,2. Thus the
sample size for the study will be a minimum of n= 60+20 i.e n=80
B. Exclusion criteria:
Maternal outcome i.e. complications and mode of delivery, Perinatal outcome i.e. meconium staining, APGAR at
1 minute,5 minutes,birth weight, NICU admission to be assessed.
8. LIST OF REFERENCES:
1. Cunningham, leveno, Bloom hauth, Rouse, Spong, Williams Obstetrics- 23rd,edition, chapter 21, 490-499.
7
2. D K James, P J Steer, CP Weiner, B Gonik- High risk Pregnancy and management options, 4th edition,
chapter 12, 197-207.
3. Guin Gita, Punekar Shweth, Lele Arvind, Khare Shashi. A prospective clinical study of feto-maternal outcome
in pregnancies with abnormal liquor volume. The journal of Obstetrics and gynecology of India (NovemberDecember 2011) 61(6); 652-655.
4. Nazlima n, Fatima b. Oligohydramnios at third trimester and perinatal outcome. Bangladesh journal of
medical science vol11.no.01 january 2012.
5. Ott W J. Reevaluation of the relationship between amniotic fluid volume and perinatal outcome. Am JOG,
2005 Jun;192(6):1803-9.
6. Casey B M, Mcintire DD, Donald D et al. Pregnancy outcome after diagnosis of Oligohydramnios. Am J
Obstet Gynecol 2000;182;902-12.
7. Anna Locatelli, Patrizia Vergani, Laura Toso, Maria Verderio, JohnC. Pezzullo and Alessandro Ghidini.
Perinatal outcome associated with oligohydramnios in uncomplicated term pregnancies. Archives of Gynecology
and Obstetrics Volume 269, Number 2 (2004), 130-133.
8. Steven G gabbe, Jennifer R. Niebyl, Joe Leigh Simpson. Obstetrics, Normal and Problem pregnancies, 5th
edition, chapter 31, 834-845.
9. Desai Pankaj, Patel purvi, Gupta Anjali. Decreased amniotic fluid index in low risk pregnancy: any
significance? J Obstet Gynecol Ind Vol 54, No.5: September/October 2004; 464-466.
10. Rainford M, Adiar R, Scialli AR, Ghidini A.Spong CY. Amniotic fluid index in uncomplicated term
pregnancy. Prediction of outcome. J. Reprod- Medicine, June 2001;46(6); 589-92.
11. Rikhsana karim, Sadaqat jabeen, fawad Pervaiz, Samdana wahab, Sumaira Yasmeen, Mehnaz raees.
JPMI2010 vol 24, No.04:307-311.
12. Pri-Paz S ; Khalek N ; Fuchs KM ; Simpson LL. Maximal amniotic fluid index as a prognostic factor in
pregnancies complicated by polyhydramnios. Ultrasound Obstet Gynecol. 2012; 39(6):648-53.
13. Naser omar Mustafa, Tameem makzen, Mohammed Fehmi, WAel Odeh Mahmood. Perinatal outcome in
idiopathic polyhydramnios. Bahrain medical Bulletin Vol27. No.1. March 2005.
14. Kuang-Chao Chen, Jui-Der Liou, Tai-Ho Hung,Dong-Ming Kuo, Jenn-Jeih Hsu, Ching-Chang Hsieh,T'sangT'ang Hsieh et al (2005)Outcomes of Polyhydramnios without Associated congenital anomalies after gestational
age of 20 weeks . Chang Gung Med J Vol. 28 No. 4. April 2005.
15. Andrea Panting-Kemp, Tuan Nguyen,Elaine Chang, Ed Quillen and Lony Castro. Idiopathic
Polyhydramnios and perinatal outcome. Am J Obstet gynecol 1999; 181; 1079-82.
9.
SIGNATURE OF CANDIDATE
10.
oligohydramnios/polyhydramnios on
maternal and fetal outcome in low risk
pregnancies
11.4 Signature
12.
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12.
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