Nipro Europe Headquarters

Weihoek 3H
1930 Zaventem
Belgium
T +32-(0)2-7255533
F +32-(0)2-7257041
www.nipro-europe.com
Nipro Europe - France
Bipole Clermont-Limagne
63360 Gerzat
France
T +33 (0)473 33 41 00
F +33 (0)473 33 41 09
Nipro Europe - Netherlands
Regus Business Center
Verlengde Poolseweg 34-36
NL-4818 CL Breda
Netherlands
T: +31-(0)76-524 50 99
F: +31-(0)76-524 46 66
Nipro Europe - Turkey
Akasyali Sok. Mine Palas Apt.No.10/4
Bostanci
34744 Istanbul
Turkey
T +90 (0)216 445 16 88
F +90 (0)216 445 41 27
Nipro Europe - UK
Ground Floor - Unit 7
The Forum - Minerva Business Park
Lynchwood
Peterborough PE2 6FT
United Kingdom
T: +44-(0)173-322 4300
F: +44-(0)173-323 4310

Nipro Europe - Poland

Ul. Aleja Jana Paw a II, 23
00-854 Warsaw
Poland
T +48 (0)22 653 85 98
T +48 (0)22 653 85 06
Nipro Europe - Italy
Centro Direnzionale Milanafiori
Strada 1 - Palazza F/1
I-20090 Assago
Italy
T: +39-02-575 000 57
F: +39-02-575 181 11
Nipro Europe - Spain
Avda. Castilla 2
San Fernando Henares
SP-28830 Madrid
Spain
T: +34-91-672 1834
F: +34-91-672 1917
Nipro Europe - Russia
12 Krasnopresnenskaya
Nab. Office nr. 1017
10th Floor - entrance nr. 6
World Trade Center
RF-123610 Moscow
Russia
T: +7-495 258 1364
F: +7-495 258 1367

Specifications

Back To Basics

ELISIO
90H 110H 130H 150H 170H 190H 210H 250H
Effective Surface Area (m2)

1,1

1,3

1,5

1,7

1,9

2,1

Priming Volume (ml)

70

85

95

105

115

130

Effective Length (mm)

228

245

259

271

281

290

Inner Diameter (m)

200

200

200

200

200

200

Membrane Thickness (m)

40

40

40

40

40

40

Maximum TMP (mmHg)

500

500

500

500

500

500

Materials

When we designed this dialyser, we once again

reviewed the human kidney function. The
human kidney is an assembly of nephron elements. Therefore, as a starting point, we
looked at a single nephron before designing a
single hollow fibre. From there, we focused on
the overall human kidney functions by
redesigning the dialyser housing and its inside
structure.

Membrane

PolynephronTM

Housing

Polycarbonate

Header

Polycarbonate

Potting Compound

Polyurethane

Sterilization Method

Dry Gamma

Package

24 pcs/box

Dialyser Design
Polynephron inside
TM

The redesigned housing and its inside structure improves

removal of small molecules as well as low molecular weight
proteins, while conserving such essential proteins as albumin.
The ELISIO dialyser might look similar to competing products. Our exclusive POLYNEPHRON membrane and the
other dialyser elements have been finely tuned based on
years of experience and expertise, and this distinguishes our
product. The ultra-smooth PU cut surface and the finelyfinished inner lumen of hollow fibres will not damage blood
cells. The inner design of the fibre ensures smooth blood flow.
Consequently, the return of blood is easier and there will be
minimum residual blood in the dialyser.
The ELISIO dialyser with its POLYNEPHRON membrane
is state of the art and unique dialyser ready for the current dialysis demands.

Optimized use of m
Optimized dialysa
Perfect d
This dialyser uses less priming solution
than other dialysers currently
on the market.

Treatment
for all patients
The ELISIOTM dialysers are available
from 0,9 -2,5 m2.

Weight reduction
During the development of the ELISIOTM dialyser
we also looked at the environmental impact.
This resulted in a significant weight reduction.

membrane quantity
ate flow dynamics
degassing
Improved
header
shape
The caps have been redesigned
to reduce channeling
at the blood side.

Ultra-smooth
PU-cut surface

ELISIOTM

Competitor

ELISIOTM

Competitor

During the production of the dialyser

the cutting of the potting is done
in such away that the surface is mirror-like,
making it smoother and less damaging for blood cells.

Improved fibres with

POLYNEPHRON membrane
TM

The new rippled structure of the membrane fibres

makes spacer yarns unnecessary, resulting in a more
homogeneous dialysate flow and a slimmer dialyser design.

3D-structure of the membrane

The well-balanced mix of hydrophobic (reddish) and
hydrophilic (bluish) domains reduces membrane fouling.

Optimised asymmetric structure

and wall thickness

Improved mechanical strength

of the fibres
Reduces the risk of fibre leakage

Better contact between dialysate

and blood compartment
and higher package density
Resulting in higher performances .

Uniform distribution of pore sizes

Pore sizes are optimized to have the highest possible clearances
for low molecular weight proteins, like 2m, whilst avoiding albumin
loss.

In-vitro
Clearances
Urea

Phosphate

ELISIO H
Polyflux H
Fx-series
HI-PS

In-vivo
Clearances
Best 2m Clearances in HD and HDF
Independently of the treatment mode, the Nipro ELISIO 190H dialyser demonstrated
much better performances than the reference filters, with regard to 2 microglobulin
Remarks : Qb400/Qd700 /Qs 80 mL/min

Excellent biocompatibility
The POLYNEPHRONTM membrane showed an excellent biocompatibility (WBC, C5a) and
thrombogenicity (Platelet count, TAT) as could be expected from a synthetic membrane.
White Blood Cell count

Clinical data obtained in Germany, 8 patients, Jan 2008

C5a generation

SERIES

Performance Qf=0
ELISIO
Clearances (mL/min)1

Qb/Qd(mL/min)

90H

Urea

200/500
300/500
400/500
400/800
500/800

189
243
274
300
332

192
253
291
325
363

195
263
311
344
388

197
270
323
357
406

198
275
332
362
417

199
280
343
370
427

200
284
346
377
432

200
293
361
385
457

Creatinine

200/500
300/500
400/500
400/800
500/800

175
213
237
265
282

183
228
252
294
320

191
240
273
316
346

194
252
288
331
363

196
259
299
342
383

197
268
309
349
404

198
269
319
355
410

200
282
337
375
426

Phosphate

200/500
300/500
400/500
400/800
500/800

160
195
220
235
254

164
209
240
254
282

170
224
255
280
315

176
233
271
298
333

179
245
288
313
352

183
251
296
325
368

188
256
304
330
373

193
274
322
346
400

Vitamin B12

200/500
300/500
400/500
400/800
500/800

114
128
132
141
151

125
145
153
171
178

137
161
174
193
204

148
173
188
209
223

156
185
202
227
242

162
195
215
240
259

165
198
219
250
264

177
219
242
270
291

Inulin

200/500
300/500
400/500
400/800
500/800

77
84
86
91
94

82
86
90
92
97

90
97
100
106
112

97
109
116
120
122

105
117
126
128
135

115
127
137
140
148

120
138
145
150
158

149
166
176
185
203

Myoglobin

200/500
300/500
400/500
400/800
500/800

55
58
61
64
65

61
64
70
71
81

70
78
82
84
90

78
89
92
95
104

88
96
104
106
110

94
101
110
111
117

98
103
113
116
124

112
123
132
137
141

53

59

64

67

74

76

82

93

KUF (mL/hr/mmHg)2
Sieving Coefficient3

Vitamin B12
Inulin
Myoglobin
Albumin

0,989
0,926
0,223
0,002

110H 130H 150H 170H 190H 210H 250H

1 In Vitro Test Condition(EN1283) : Qf 0mL/min

2 KUF (EN1283) : Bovine Blood (Hct 322%, Protein 60g/L, 37C), Qb 300mL/min
3 SC(EN1283) : Qb 300mL/min, Qf 60mL/min

Specifications

Back To Basics

ELISIO
90H 110H 130H 150H 170H 190H 210H 250H
Effective Surface Area (m2)

0,9

1,1

1,3

1,5

1,7

1,9

2,1

2,5

Priming Volume (ml)

62

70

85

95

105

115

130

149

Effective Length (mm)

210

228

245

259

271

281

290

302

Inner Diameter (m)

200

200

200

200

200

200

200

200

Membrane Thickness (m)

40

40

40

40

40

40

40

40

Maximum TMP (mmHg)

500

500

500

500

500

500

500

500

Materials

When we designed this dialyser, we once again

reviewed the human kidney function. The
human kidney is an assembly of nephron elements. Therefore, as a starting point, we
looked at a single nephron before designing a
single hollow fibre. From there, we focused on
the overall human kidney functions by
redesigning the dialyser housing and its inside
structure.

Membrane

PolynephronTM

Housing

Polycarbonate

Header

Polycarbonate

Potting Compound

Polyurethane

Sterilization Method

Dry Gamma

Package

24 pcs/box

Nipro Europe Headquarters

Weihoek 3H
1930 Zaventem
Belgium
T +32-(0)2-7255533
F +32-(0)2-7257041
www.nipro-europe.com
Nipro Europe - France
Bipole Clermont-Limagne
63360 Gerzat
France
T +33 (0)473 33 41 00
F +33 (0)473 33 41 09
Nipro Europe - Netherlands
Regus Business Center
Verlengde Poolseweg 34-36
NL-4818 CL Breda
Netherlands
T: +31-(0)76-524 50 99
F: +31-(0)76-524 46 66
Nipro Europe - Turkey
Akasyali Sok. Mine Palas Apt.No.10/4
Bostanci
34744 Istanbul
Turkey
T +90 (0)216 445 16 88
F +90 (0)216 445 41 27
Nipro Europe - UK
Ground Floor - Unit 7
The Forum - Minerva Business Park
Lynchwood
Peterborough PE2 6FT
United Kingdom
T: +44-(0)173-322 4300
F: +44-(0)173-323 4310

Nipro Europe - Poland

Ul. Aleja Jana Paw a II, 23
00-854 Warsaw
Poland
T +48 (0)22 653 85 98
T +48 (0)22 653 85 06
Nipro Europe - Italy
Centro Direnzionale Milanafiori
Strada 1 - Palazza F/1
I-20090 Assago
Italy
T: +39-02-575 000 57
F: +39-02-575 181 11
Nipro Europe - Spain
Avda. Castilla 2
San Fernando Henares
SP-28830 Madrid
Spain
T: +34-91-672 1834
F: +34-91-672 1917
Nipro Europe - Russia
12 Krasnopresnenskaya
Nab. Office nr. 1017
10th Floor - entrance nr. 6
World Trade Center
RF-123610 Moscow
Russia
T: +7-495 258 1364
F: +7-495 258 1367