Escolar Documentos
Profissional Documentos
Cultura Documentos
1) glucose fuel
a) blood sugar
b) all cells can use glucose for energy sometimes
c) some cells use glucose for energy all of the time
d) rate of oxidation regulated by demand, not supply
2) dietary glucose intake
a) oxidize for energy
b) excess stored as glycogen (liver and muscle)
c) extreme excess can be converted to fat (lipogenesis; liver)
d) outcome: lowers the rise in blood glucose following dietary intake
3) glucose (blood sugar):
a) predominate carbohydrate in the blood
b) not abundant in food
c) most digestible carbohydrates digested to glucose before absorption
4) sacchar meaning sweet, sugar
a) monosaccharide
b) disaccharide
c) oligosaccharide (3-10)
d) polysaccharide (many)
e) straight and branched chains of glucose residues
5) D&A
a) large carbohydrates must be digested to monosaccharides
b) only monosaccharides absorbed:
i) glucose
ii) galactose
iii) fructose
c) disaccharides digested by brush border enzymes
i) maltose:
(1) glucose-glucose
(2) 1,4 linkage
(3) maltase
ii) sucrose
(1) glucose-fructose
(2) 1,2 linkage
(3) sucrase
iii) lactose
(1) galactose-glucose
(2) 1,4 linkage
(3) lactase
(4) lactose intolerance: insufficient enzyme activity for hydrolysis of lactose
d) digestive enzymes use water to make and break bonds
page | 1
NTR-413
Fuel Intake Carbohydrates
NTR-413
Fuel Intake Carbohydrates
NTR-413
Fuel Intake Carbohydrates
9) liver glycogen
a) glycogen in liver and skeletal muscle; small amounts in many cells
b) polymer of glucose residues
c) synthesis regulated by the enzyme, glycogen synthase (GS)
d) mobilization (degradation) regulated by the enzyme, glycogen phosphorylase (GP)
e) glucose is added or removed from the glycogen tree at multiple ends simultaneously
f) activating GS, while inhibiting GP, greatly increases the rate at which glycogen is made
i) oppose also true, greatly increasing the rate of glycogen mobilization
g) insulin increases GS, while inhibiting GP; promoting synthesis
h) glucagon increases GP, while inhibiting GS; promoting mobilization
i) high blood glucose: insulin and glucagon
i) glycogen synthesis helps to lower circulating blood glucose
j) low blood glucose: insulin and glucagon
i) glycogen mobilization (degradation) helps to maintain circulating blood glucose
k) glucose-6-phosphatase (liver only) dephosphorylates glucose so it can leave the cell
l) mobilized glucose from liver glycogen is made available for the body to use
10) skeletal muscle glycogen
a) no glucagon receptors; does not mobilize glycogen when circulating blood glucose begins to fall
b) no G-6-phosphatase; does not release glucose to circulation
c) glycogen synthesis by similar mechanism as liver (insulin)
d) glycogen mobilization based on contraction (not glucagon)
e) mobilized glucose from muscle glycogen is made available only for the muscle to use
11) glucose transporters
a) facilitated glucose transporters on all cells; allows passage of glucose through cell membrane
b) multiple transporter isoforms on most cells; different transport characteristics
i) glut1 (most cells)
ii) glut2 (hepatocytes); transport at high concentration
iii) glut3 (neurons); transport even at low concentration
iv) glut4 (adipocytes, skeletal muscle, cardiac muscle); insulin-dependent
c) glut4
i) transporter located in intracellular vesicles
ii) insulin stimulates fusion of vesicles with cell membrane
iii) rapid increase in glucose transporters; rapid increase in glucose (muscle and adipocytes only)
iv) helps to lower elevated blood glucose
12) summary: high blood glucose (following meal; postprandial state)
a) insulin, glucose (I/G ratio)
i) promotes glycogen synthesis to a point (limits on how much glycogen can be made)
ii) promotes glucose uptake into three cell types
(1) glucose uptake can be stored as glycogen or oxidized (based on demand)
iii) increase glucose uptake and glycogen formation helps lower blood glucose
13) summary: low blood glucose (overnight fasting; post-absorptive state)
page | 4
NTR-413
Fuel Intake Carbohydrates
i)
ii)
iii)
iv)
14) fiber
a) all plant foods contain fiber
b) not all animal foods contain fiber
15) fiber classification (based on source):
a) dietary fiber - nondigestible carbohydrates and lignin found naturally in plants
b) functional fiber - nondigestible carbohydrates extracted from plant food and added to diet
c) total fiber: dietary fiber + functional fiber
16) fiber classification (water solubility):
a) soluble fiber
b) insoluble fiber
17) insoluble fiber:
a) cellulose, some hemicellulose, lignin
b) do not dissolve in water; pass through GI tract intact
c) hydrate and move waste through the intestine; prevents constipation
18) soluble fiber:
a) mucilage, glucans, pectin, gums, psyllium, resistant starch
b) attracts water; forms gel
c) slows digestion
d) delays gastric emptying
i) fullness weight control
ii) decreases postprandial rise in blood glucose
e) decrease absorption of dietary cholesterol
f) lowers LDL cholesterol (by preventing bile reabsorption, new bile made from cholesterol)
19) health benefits:
a) vary with fiber type
b) healthy diet rich in fruit, vegetables, whole grains, legumes, nuts and seeds
c) variety of soluble and insoluble fibers provides all of the health benefits
20) sweeteners
a) nutritive sweeteners:
i) digestible
ii) monosaccharides, disaccharides, sugar alcohols
iii) digested in small intestine to three monosaccharides before absorption
(1) monosaccharides and disaccharides (4 kcal/gm)
(2) sugar alcohol; chewing gums and candies; not fully digested (~2 kcal/gm)
iv) natural nutritive sweeteners
page | 5
NTR-413
Fuel Intake Carbohydrates
NTR-413
Fuel Intake Carbohydrates
page | 7