SYLLABUS

PATHOLOGY

Total number of hours (per semester) in the

curriculum
( 17h course + 38 h LP SEM II)
MORPHOPATHOLOGY

Name of Discipline

Year of study

III

Semester *

II

Type of final evaluation (E / V / C)

The regime of the discipline (C - Compulsory , O - Optional, F Facultative)

Total hours of curriculum

Titular of the discipline

Total hours of individual

study
Conf.Dr. Sergiu Teleman
55

Ob

Number of credits

75

Total hours per

semester

* If discipline has more semesters of study, should

Faculty

Medicine

Department

Morphofunctional Sciences

Profile
Specialisation

fill in for each semester

Total

C**

55

17

38

Medicine
Medicine

Discipline objectives
1. Learning the morphological changes that characterize specific disease on systems
2. Establishing etiopathogenic and clinical connections with prognostic factors of specific entities
3. The correct interpretation of the histo or cytodiagnostic bulletins

E1
8
130

Course content - 17 HOURS

Course content - 17 HOURS

1. LIVER, BILLIARY TRACT, EXOCRINE PANCREAS (3 hours)
Liver: Jaundice and cholestasis. Acute and chronic viral hepatitis. Bacterial, parasitic and
helminthic infections. Autoimune hepatitis. Drug and toxic induced liver diseases. Alcoholic liver
disease. Inborn errors of metabolism: hemochromatosis, Wilson disease, 1 antitrypsin deficiency,
neonatal hepatitis. Hepatic cirrhosis. Portal hypertension. Benign and malignant tumors.
Biliary tract: Cholelitiasis. Acute and chronic cholangitis and cholecystitis. Carcinoma of the
gallbladder and extrahepatic ducts.
Exocrine Pancreas: Mucoviscidosis. Acute and chronic pancreatitis. Tumors.
2. HEMATOPOETIC AND LYMPHATIC SYSTEMS (3 hours)
Anemias. Polycytemia. Leukemias and myeloproliferative disorders: acute leukemias, chronic
myeloid leukemia, chronic lymphoid leukemia. Plasma cell neoplasms.
Reactive lymphadenitis. Lymphomas: Non-Hodgkin lymphomas and Hodgkin Disease.
Spleen: morphological basis of splenomegaly.
3. GENITAL MALE PATHOLOGY (1 hour)
Testis and prostate tumors
4. FEMALE GENITAL TRACT (4 hours)
Morphological methods of diagnosis
Cervix: acute and chronic cervicitis; endocervical polyps; cervical intraepithelial neoplasia and
squamos cell carcinoma. Body of uterus: endometriosis, endometritis, functional disorders,
tumors. Fallopian tubes: inflammations, tumors. Ovaries: inflammations, polycystic ovaries,
pseudotumors, tumors. Gestational and placental disorders: placental inflammations, ectopic
pregnancy, gestational trophoblastic disease. The breast: disorders of development, inflammations,
fibrocystic changes, tumors. Morphological methods of diagnosis in breast carcinoma.
5. ENDOCRINE PATHOLOGY (3 hours)
Pathology of pituitary gland: adenoma.
Thyroid pathology: hypothyroidism (cretinism, myxedema), hyperthyroidism (thyrotoxicosis),
Graves disease, acute and chronic thyroiditis, diffuse nontoxic simple goiter, multinodular goiter,
benign and malignant tumors.
Pathology of parathyroid glands: primary and secondary hyperparathyroidism.
Adrenal gland pathology: hyperadrenal syndrome (Cushing sdr.}, primary aldosteronism,
Adrenogenital sdr., 21-hydroxylase deficiency, primary acute adrenocortical insufficiency
(Waterhouse-Friderichsen sdr.), primary chronic insufficiency (Addison's disease). Adrenocortical
tumors.
Pathology of the adrenal medulla: pheochromocytoma, neuroblastoma.
6. PATHOLOGY OF SKELETAL DISORDERS (30 minutes)
Pathology of Bone: Diseases associated with impaired mineral homeostasis: rachitism and
osteomalacia. Infections: pyogenic osteomyelitis. Bone tumors.
7. PATHOLOGY OF SKELETAL MUSCLE (30 minutes)
Inflammatory myopathies, toxic myopathies. Neuromuscular junction diseases: myasthenia gravis.
8 CENTRAL NERVOUS SYSTEM PATHOLOGY (2 hours)
Malformations. Traumatic vascular injuries: subdural and epidural hematoma. Cerebrovascular
disease: cerebral infarction, intracerebral hemorrhage and subarachnoid hemorrhage. Hypertensive
encephalopathy. Infections: acute bacterial and viral meningitis. Focal suppurated acute infection:

Laboratory content -38 hours

1. HEART AND BLOOD VESSELS (6 hours)
Necropsy of the heart. Congenital heart disease. Atherosclerosis (coronary, aorta). Aneurysms.
Ischemic heart disease. Systemic hypertension. Rheumatic fever. Infective endocarditis. Pathology of
the myocardium. Heart failure.
1. RESPIRATORY TRACT (4 hours)
Lobar pneumonia. Interstitial pneumonia. Bronchopneumonia. Bronchiectasis. Lung abscess. Pulmonary
tuberculosis. Pneumoconiosis. Emphysema. Bronchogenic carcinoma.
2. URINARY TRACT (4 hours)
Glomerular disease: minimal change disease, acute postinfectious proliferative glomerulonephritis.
Crescentic glomerulonephritis, chronic glomerulonephritis, diabetic glomerulosclerosis. (PAS staining).
Tubulointerstitial disease: acute tubular necrosis, acute pyelonephritis, phenacetin nephropathy and
papillary necrosis. Obstructive uropathy: hydronephrosis. Congenital anomalies: horse shoe kidney,
polycystic kidney, double renal pelvis, double ureteres. Tumors: Grawitz, Willms, secondary tumors.
Urinary bladder: papilloma and carcinoma.
4. GASTROINTESTINAL TRACT (4 hours)
Esophagus: malformations, diverticulum, carcinoma
Stomach: acute gastritis, acute ulcer, chronic peptic ulcer and complications. Tumors
Bowel: Meckel diverticulum, pseudomembranous colitis, tumors
5.LIVER, BILIARY TRACT AND PANCREAS (4 hours)
Liver: acute viral hepatitis, chronic hepatitis. Cirrhosis: types, complications. Primary and secondary
tumors.
Billiary tract: lythiasis, colecistitis, carcinoma.
Pancreas: acute pancreatitis with cytosteatonecrosis. Carcinoma.
6.HEMATOPOIETIC AND LYMPHATIC SYSTEMS (2 hours)
The processing of the lymph node biopsy for the histopathological diagnosis. Visceral changes in
chronic leukemia. Non-Hodgkin lymphomas. Hodgkin disease: nodular sclerosis and mixed cellularity
7.FEMALE GENITAL TRACT (2 hours)
Cervix: inflammations, tumors. Body of the uterus: endometrial hyperplasia, benign and malignant
tumors of the endometrium and myometrium. Fallopian tubes: inflammations
8.GESTATIONAL PATHOLOGY; BREAST PATHOLOGY (2 hours)
Abortion, Ectopic pregnancy, placental tumors
Breast : tumors
ANATOMO-CLINICAL AUTOPSY (6 hours)
RECOVERY (4 hours)

Bibliography
1. Atlas and textbook of pathology. Doina Butcovan, Ed.Universitas XXI Iasi, 2005 ISBN
978-606-538-019-6
2. Pathology course. Doina Butcovan, Ed.Universitas XXI Iasi, 009, ISBN 978-606-538-019-6

SSkills
S1. Learning of recommendations for morphological methods [cyto and histopathological diagnosis on
smears and biopsies] used in clinical diagnosis and patient therapy.
2. 2. Theoretical characterization and identification of the morphological substrate [macroscopical and
microscopical findings] of pathological processes and diseases presented on systems.
3.3. Learning of pathology concepts which help the student to correlate anatomo-clinical and
laboratory data in medical and surgical pathological conditions.
4. 4. Learning of basic morphological concepts that allow understanding and interpreting of the
anatomo- pathologic bulletin by physician.

In establishing of the final mark we take in

consideration:
- exam answers / colloquium responses (final
evaluation):

Share in scoring in percent

(Total = 100%)
50%
35%

- practical exam

- final answers to practical laboratory

- periodical testing by control tests
- continuous testing during the semester

15%

- activities like homework / referrals / essay /

translation / projects

- other activities (please specify): colloquium

Describe the practical modality for the final evaluation:
Written exam MCQ
Practical exam oral

Estimate the total time (hours per semester) for the individual activities of the student
(fill with 0 activities not required)
0
1. . Read-in and learning the course notes
8. Preparing for oral presentations
2. Learning using the textbook, courses
3. The study of the minimal suggested
bibliography

4. Additional documentation in library

5. Specific activity for Seminars and / or
laboratory
6. Achieving of homework, report, essay,
translation

25

9. Preparing the final examination

16

10. Consultation

11. Reference material

10

12. Reference material on Internet

13. Other activities ...

7. Preparing for tests

14. Other activities ...

Total hours of individual study (per

semester) = 75
Date of filling in: 2012
The signature of the titular:

Conf.Dr. Sergiu Teleman