Happyco Broch GB

THE SOURCE
of our
NATURAL
WELL-BEING
WORLD PATENTS
AND
EXCLUSIVENESS
TABLE OF
CONTENTS
02/03
Dear
Friends
..............................................
05
60/65
DAY&NIGHT .................................................. 66/71
Conclusion .................................................................................. 72/73
PROTEOX
......................................................
Our Mission ................................................................................ 06/07

The vision ...................................................................................... 08/09
Story of a man ............................................................................ 10/13
Maintenance of the source of our life
is our responsibility .................................................................. 14/15
presents a world exclusivity :
Orochronodietology
How and why ? ................................................................................ 18
The cell .................................................................................................. 19
The chrono cycle of the cell .................................................... 20
The orogranule ................................................................................ 21
Orality and orobioavailability ........................................................ 22
Conclusion .......................................................................................... 23
RENEW .............................................................. 24/29
FLEX ...................................................................... 30/35
RELAX .................................................................. 36/41
ENERGY ............................................................ 42/47
SLIM ...................................................................... 48/53
NOToBACKo .................................................. 54/59
04/05
Dear
The international structure organized for a rapid and straight enlargement

worldwide, the HAPPY.CO software, easy and user friendly, the back office
complete and skilled, are all some of our main benefits.
The marketing program is very attractive and easy to understand, making
it possible for everyone to reach a fast success and offer the opportunity to
build a lasting and satisfactory personal improvement through a fantastic
mission.
Friends
A very important project of new Orochronodietology and dermo dietology

products launching is already planned for the next few years.
and
As Chairman of the Scientific Committee
Im very proud and glad to share with you
the launch of HAPPY.CO and
Orochronodietology worldwide.
At the end of 2011, as the chairman of LGZ and responsible for the
development and diffusion of Orochronodietology, I was approached by a
group of professionals and experts who offered us the exclusivity rights for
Orochronodietology in the segment of Network Marketing.
We were all really fascinated by the conviction, the motivation and the
happiness of these people, which goal was to create a new Company
dedicated to Orochronodietology, and to the future development of this
fantastic and very promising new natural therapy.
With this in mind, It seemed obvious to all of us that we should call this new
Company HAPPY.CO, which mission would be to give the opportunity for
people to be HAPPY and help them through Orochronodietology, both
from a health as well as an ethical development point of view.
Starting a new Company with such an innovation in such a turbulent
moment is not easy, but our roots are strong and our branches ready to
grow quickly.
Orochronodietology : a NEW, BUT

ALREADY STRONG AND LASTING
HAPPINESS OPPORTUNITY!!!
The most innovative and revolutionary
offer in the MLM segment ever
proposed for a HAPPY World!
A good reason to join us
immediately!!!
Our
mission
Happiness
with
06/07
The human being can be defined as a complex of intelligent cells with
memory, each providing a specific function which work all together in
a perfect synergy.
A genius of cinema, Woody Allen, defined Health as a state of
transition that doesnt promise anything good: just a minimum
unbalance can modify our general health status .
Even the World Health Organization (WHO) uses this definition in its
Constitution preamble of 1946, which hasnt been modified since.
Health is a complete state of physical, mental and social wellness, and
is not defined as the simple absence of illness or infirmity. It implies
that the possibility to satisfy the basic and fundamental needs of the
person, whether those needs would be emotional, health related,
nutritional, social or cultural, starting from the embryo stage to the
elderly ones of our life.
Paraphrasing this definition, we can also say that happiness is a
transition state that doesnt promise anything good: just a small
physical or psychological or even emotional problem makes us face a
reality that is no longer the ideal one we were living just a few
moments before.
And the more time passes without happiness, the harder it is to find it
again.
HAPPY.CO wanted to look for natural tools that can help us find
happiness in our body, our soul and our
global life.
If we were happy at some point in our life, lets look inside ourselves !
If we did it once, what prevents us from being happy again? lets look
inside ourselves ! We ask you this: could we have "unconsciously"
locked our way to happiness? Is it because we dont want to make a
choice? Our state of mind impacts our health. Lets look inside
ourselves ! Be positive!
Our little inner voice always speaks to us but we are deaf. We just dont
want to listen to it. Yet our cells constantly send us messages that
would enable us, if we listened to them, to regain our balance more
easily, feel stronger and therefore more willing to take concrete action
and believe in our projects and ambitions.
Happiness is also to DARE. IF YOU WANT IT, YOU OBTAIN IT, as we

were told by our elders when we were children, and how true it was
then. BUT now that we definitely have a better control of ourselves,
we do not believe in that anymore. Whats stopping us?
Our body is a vehicle of happiness. In order to be happy, we need to be
in full control of our vehicle. Our body is telling us something
constantly using the language of the cells.
Orochronodietology helps to rebuild the bridge towards the cells,
helping them to reach again their active complexity and their integrity.
Following their biological, nutritional and functional cycle,
Orochronodietology leads them out of the stress condition where we
were putting them through our behaviour and lifestyle. When free from
stress, cells can just communicate their happiness and their message
will finally be heard by our whole being, for a global happiness.
With exclusive concepts and results

of Orochronodietology , we cannot
set lower goals!
R EB U IL D Y OU R H A P P INE SS
WIT H
It's a g re a t a mb i ti o n,
ITS OU R MIS S ION
VISION:
The main target of the company
is to help people find their own
way to happiness and help them
live their life in the right way
through the rediscovery
of natural health.
08/09
We want to be:
The reference MLM company in the field of natural health
in the next 5-10 years;
The company that has the trust and the fidelity of all its
customers;
A constantly forward looking company;
An extraordinary team to work and cooperate with.
GOALS:
We can make this real, together with the HAPPY.CO friends, through the following:
1. The development and diffusion, both in scientific and geo graphical terms, of Orochronodietology and HAPPY.CO
products starting from Europe and then moving to the rest of the continents.
2. The continuous innovation of the HAPPY.CO products as natural tools

available to everybody and for everybody.
3. The continuous development and maintaining of the ethical, quality and

safety value of the HAPPY.CO products and of the entire HAPPY.CO project, already
guaranteed by the whole of the company and by every single HAPPY.CO friend.
4. The involvement and participation
of all the HAPPY.CO friends in the

HAPPY.CO children charity programs all over the world, through the financing and/or
the realization of CHILD HOSPITALS, SCHOOLS, EDUCATIONAL CENTERS and
EDUCATIONAL PROGRAMS.
If you share these values, youre already a happy friend !
Its time to be happy !
Story
of a Man
Nature always
expresses itself :
you only need
to know how
to understand
it and observe
it with humility
10/11
Behind my passion for natural medicine
there are experiences of my life.
Ive always believed that man and nature both possess remedies to
the unbalances that manifest in man as diseases.
He who knows the sick well, also knows how much talking and
giving attention can help resolve many of their problems.
He who knows nature also knows how much the study of its language
and correct utilization of its fruit can be used to cure the sicknesses
of man.
All of this is the foundation of my belief and my personal and professional experiences.
Venetian, descendant of a dynasty of doctors, chemists and pharmacists
for five generations, I had the opportunity, since my youth, to also live
both the scientific spirit of the familys chemical pharmaceutical group
and the simplicity of another great family tradition : the love of nature,
earth and the agricultural world.
Actually, I grew up among the grape vines agricultural farm in the
hills of Vicenza where my parents brought me to life. Here, since I was
a boy, among farmers and farm animals, I was fascinated by
the alchemy of vine production and the medicine of simple folk.
I tried to understand the secrets of medicinal herbs prepared by old
farmers according to the tradition of folk medicine.
I have always been sensitive to the stories of the elderly on their use
of popular medicine. I was fascinated by their capacity to instinctively
individualize, in spite of their diagnostic ignorance and medical
therapy, good natural remedies : there was always one available and
immediately efficient. Nature always expresses itself : you only need
to know how to understand it and observe it with humility as I was
told as a medical student, but I was over enthusiastic with a hunger to
learn the great scientific theories.
These strong memories and this apparent contrast between science
and nature, had a lot of importance on my professional life.
After graduating in medicine and surgery at the University of Padova
in Italy with specialization in General surgery, Anesthesia, Reanimation
and clinical pharmacology, I dedicated my first fifteen years of medical
profession alternating surgical practice with teaching at the university
and research in medicine and pharmacology. The desire for research
and creativity oriented me toward the management of international

projects in my family pharmaceutical group created by my grandfather.
Within Zambon Laboratories, was a maturation of fundamental
experiences of research and pharmaceutical industrial development
that lead me to France at Sophia Antipolis in the early 1990s.
It was then that I found the meeting point of my experiences and my
aspirations: France, in Europe, is a country where phytotherapeutic
research is at the avant-garde and the south of France is rich in culture
and tradition of the natural world.
It was impossible not to find my roots and wings in this environment:
my first laboratory of Research and Development is in some way the
union of my experience in research, my medical practice and the
competence that I developed through the great knowledge of plants
and aromatic herbs in this French region. Twenty years as head of a
formidable staff of experts in phytoaroma- therapy allowed me to open
doors to innovation I found what Id looked for in a long time in my
research in this field. Thanks to this innovation, confirmed by
worldwide patents obtained today, I was able to transfer my
competences, my medical and clinical culture and my experiences of
pure research and applied research in a new enterprise reality.
I founded Laboratoires Docteur Zannini where nature-sciencecreativity-innovation-efficient and pharmaceutical quality found their
realm in offering everybody the benefits that nature made available.
In collaboration with international Research Centers, world famous
universities, and profiting of medicine and pharmacology researchers
skills and experiences, we finally created in 2009 orodietology and
in 2010 Orochronodietology, which development and exclusiveness
diffusion are from now on ensured by HAPPY.CO international, in
perfect synergy and synchrony with Laboratoires Docteur Zannini.
... which
had its reflectings
In the research unity, development

and production realization.
The innovation
and ethic, through
the respect
of nature and
environment
When I began reflecting on the creation of Laboratoires Docteur
Zannini, the syntony between the creation of natural remedies and
respect of nature in the entire chain of the fabrication process seemed
inevitable to me. My objective has always been to conceive a means of
production where the pharmaceutical quality and technology
naturally get united with respect to the environment and protection
of natural energetic sources.
It was in Saint Raphael, south east of the french riviera, that I found the
right place. On an old improved refuse site, the technological park
Epsilon offered me the opportunity to construct an industrial structure
whose composted foundation already respected nature.
We then decided to identify and apply to our project the most modern
technology in the field of sustainable development, with particular
regards to energy.
Coherent with this philosophy, our center of production is still today

the first industrial establishment in the world to utilize solar energy
as a source for all energetic needs, for both air treatment and the
nourishing of the industrial process, thanks to a new system that
utilizes solar air-conditioning by desiccation. Enough of consuming
gas and other energetic sources and make way to a more natural
system of production.
Sun is sufficient for heating, cooling or climatizing the production cycle
to the ideal temperature making it capable of maintaining the best
characteristics of our raw plant material and nourishing our whole
fabrication process.
More than 1800 square meters of high natural technology was built on
a terrain of more than 4000 square meters where we wanted to
maintain the vegetation that spontaneously grew in this region :
lavender, rosemary, thyme, sage, eucalyptus and... grape vines.
Innovation, quality and respect for the

environment are guaranteed at
Laboratoires Docteur Gaetano Zannini who
placed at the disposal of HAPPY.COTM
International all these wonders of nature !
12/13
14/15
Maintenance of
the source of our life
is our responsibility
Nutrition is the source of our lives,
since the first cell of the new born
is created in the womb of the mother.
The new scientific disciplines are more and more interested in the
relationship between nutrition and cellular memory. Recent studies
(for example of epigenetic) tend to demonstrate that food can interfere
with the cells behaviour, even with changes to the chromosomal level.
The food supply is supposed to bring to the body all the nutrients
necessary for its proper functioning, and therefore to the maintenance
of good health. The nutrients are the elementary components
contained in the food, or from the ambient nature. They are used by
the body to cover its physiological needs, including for growth and
development. Water is the main element of our functioning; the
carbohydrates, lipids, proteins have a particular energetic function, a
function of constitution and of maintenance of tissues; vitamins,
essential amino acids, essential fatty acids, the mineral elements (Na,
K, Ca, P, Mg, S, Fe, Zn, etc. ), the oligo-elements (I, Cu, Co, Cr, Mn, V,
Mo, Ni, Pb, etc. ) have a role in the regulation of metabolism and,
finally, the dietary fiber have a function primarily of mechanical type.
Nature has created different food,

rich in essential nutrients, with a daily
and seasonal rhythm, to allow us to be
constantly well fed and therefore to be
able to respond to the demands of
our life and respect what should be
our normal life cycle, on daily and
in the course of the years basis.
However, progressively industrialized, food is paradoxically far from
the basic objective and has become poor and toxic. Indeed, the food
extracted of intensive practices, whether they are of plant or animal
origin, is subject to multiple changes. For reasons of storage,
conservation, sustainability, it undergoes aggressive transformation.
It is refined, heated to high temperature, irradiated...
At equal weight, food contains fewer nutrients than when extracted
from traditional agriculture, which has led to an incomplete food
supply:
- For the food of plant origin: the vitamins and nutrients are
affected.
- For the food of animal origin: the protein content is reduced in favor
of water and fat primarily composed of saturated fatty acids.
Various substances are incorporated at various stages of production
of the modern food, making it less effective for the organism:
- The chemical fertilizers and pesticides are an integral part of the
intensive agriculture.
- confectionery, dairy desserts and many industrial food products
contain refined white sugar in large quantities ;
- food additives (salts, dextrin, colourings, preservatives, flavour
enhancers, flavourings, agents of palatability ...) are used in
abundance
The food of today is

therefore no longer
capable of providing
us all in good time
the nutrients that
our body needs.
In addition to the defects of the industrialized food impeding the
physiological well being, the negative points of the modern way of life
of the general population are added, such as stress, smoking,
pollution, fatigue ... which are generators of oxidative stress at the
cellular level.
Our food has therefore become constantly stricken.
To maintain a good health, we would ideally need to associate a food
supply with an intact natural quality, a perfect mastery of cooking,
follow the seasonality of natural foods and of the food as it is known by
our cellular memory for centuries and centuries, a regular physical
activity, manage daily stress, eliminate tobacco, a good sun
protection all conditions hardly do-able simultaneously.

If, years ago, food supplementation was recommended, today, we may
well say that it must be mandatory. To fill the existing deficiencies in
vitamins and essential nutrients, the use of nutritional supplements
capable of providing a true complete cellular Micronutrition becomes
inevitable.
Orochronodietology is the first cellular

nutritional supplement which has proven
to be able to supply to the body
the essential elements to its proper
functioning.
In agreement with the needs of the bodys
rhythm, it provides nutrition and cellular
protection while reviving the impaired
functions. Thus properly nourished,
protected and supported, the body
can perform its vital functions more easily
and regain its balance and therefore
its ideal functioning.
16/17
presents a world exclusivity:

OROCHRONODIETOLOGY
TM
A new and unique product which

acts at the source of our natural
wellbeing, 100% of natural origin,
and allows to restore, maintain
and stabilize very quickly the global
balance of the cell with the result of
restoring a healthy and happy life.
Orochronodietology is a new science (LOGY) that studies the cellular
dietary (DIETO) through mouth assimilation (ORO: from latin Os, oris
mouth) respecting the natural daily biorhythm.
Orochronodietology follows in its action the internal biological clock
and the rhythmic operation of the various cellular reactions in order
to optimize the nutritional and functional effectiveness of the various
natural complexes included into the Happyco Programs.
Each new complex resulting from the Orochronodietology is going to

be supplied to the cells at the time, depending on their cycle, when
they are most capable of profiting.
Orochronodietology is the first and only natural scientific

discipline that acts :
1.Simultaneously and immediately on all the sources
of the imbalance to be treated.
2.At the global cellular level (in active synergy on nutrition,
antioxidant protection and functional recovery).
3.Through buccal assimilation,
4.Respecting the natural biological clock.
ITS 5 SOURCES OF WELLBEING:

- POWER: the only one that acts on all sources of the problem thanks
to its synergistic multi-target action.
- GLOBALITY: the only one that has a complete and simultaneous
action on all cells, including the three elements essential to the cell:
the nutrition, protection, and its specific function.
- RAPIDITY: the only one that is absorbed immediately and directly
in the mouth, which allows the direct passage of natural principles in
the organism and then into the cells.
- BALANCE: the only one respecting the 24 hours cellular biological
rhythm.
- SAFETY: the only one that has no envelope, no capsule, no excipients,
no gelatin, no cellulose, no conservatives, no alcohol and its totally
GMO-free.
The Happy.co Orochronodietology

programs : natural efficacy at its top proven
in hours and days and not anymore
in weeks and months !
How and Why ?

Thanks to the technology of the orogranules:
- The only ones who are "built" one by one, by the gradual and
simultaneous progressive integration of the active ingredients from
the center to the periphery. Thanks to this the active ingredients
become simultaneously content and container.
- The only ones who can integrate in the complex all kind of active
ingredients, regardless of their physical and chemical nature
(liquid, powder, solid oils, essential oils ...).
- The only ones that can so create a new natural complex providing a
synergy of multi-target simultaneous and immediate actions.
- The only ones where the content is also the container: no need of
envelope, of excipient, of capsule, of gelatin, of cellulose, of
preservatives. Alcohol and GMO-free.
18/19
- The only ones that, according to those factors, allow the orobioavailability : direct buccal assimilation ensures 100% absorption of
natural active ingredients in the organism, avoiding the classic
digestive way, without loss of quality and quantity of the multi-target
action.
The Cell
Our organism is a complex of intelligent cells, with a memory and
each of them having a specific function.
The cell and the wellbeing
The health of the cell depends

primarily on its metabolic
and nutritional balance, which
influence directly effectiveness
of its physiological function
>
I n c r e a s e d
N e e d
>
the cell is the source of our life.
The cell therefore needs its specific nutrients, that can be found in the
blood, that will be used depending on the need within the 24 hours
(enzymes, fatty acids, carbohydrates, proteins, trace elements ...).
increased operation
increased consumption
The role of the cells is essential to the life of

the organism. However, to ensure their role, the health
of cells depends on three key points:
Nutrition
Only well nourished and well protected cells can exercise at their best
all the different functions that are vital to the wellbeing of the organism.
Inactive cell
>
In order to effectively perform their Functions, cells must have a

correct Nutritional level and appropriate Protection capabilities.
Each disturbance of these levels, whatever the cause, will result
in a cellular suffering.
During such a disturbance, the cells are forced to temporarily
stop their function to be able to find a proper state of nutrition
and protection again: the dysfunction is installed. If the cells
are no longer able to react, the dysfunction will then be gradually
extended to other cells resulting in a state of imbalance in the
body, which may gradually evolve into a disease.
inefficiency of the cell

reduction in defenses
of the cell
>
- Their Nutrition: the cell must be nourished in order

to grow and reproduce.
- Their Protection: the cell must be well nourished
in order to defend and protect itself
- Their Function: the cell must be well nourished
and protected in order to exercise its specific
physiological function.
depletion of the reserves
Protection
All the metabolic activities of the cell are producing toxins and waste,
often in the form of free radicals. When they are produced in excess,
they become killers for the cell. Thanks to the nature, the cells have
their means to defend themselves, and thus ensure the smooth running
of their functions. This is going only to happen, anyway, when in a
condition of balance.
Unfortunately, the current living conditions, with poor diet, different
abuses (tobacco, alcohol ...), lack of exercise, sunlight, stress ... are
leading to an increased cellular production of free radicals, and therefore
lead to an increased consumption of the antiradical resources of the cell.
Nowadays we require to the cells a lot more than that for which they were
programmed. The cell specific defense systems are no longer sufficient
to ensure a proper protection. A cell inadequately fed and not protected
will be subject to the attack of free radicals, depleting its reserves, and
not being able to perform its function any longer. This could bring,
eventually, to the cell death. Just a single cell becoming inadequate
is able to cause a chain reaction leading to a general state of imbalance.
The provision of micronutrients able to provide cellular nutrition and

protection is then essential to allow the cells to be consistently efficient in carrying out their specific function.
However conventional treatments usually act only at the level of the
function, which will be stimulated by specific ingredients, so basically
by an horizontal action only. This helps to cover the surplus of demand
of the cells that are still active and only partially to cover the functional deficit of certain cells. This way no direct aid will be provided
to cells that are suffering as they need to first find their nutritional
status and their protection capability before being able to ensure their
function again.
100%
100%
100%
100%
0%
0%
0%
0%
0%
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FUNCTION
100%
<
ACTIVITY
<
ACTION OF OROCHRONODIETOLOGY APPLICATIONS
Action on the function only

(horizontal action)
10
PROTECTION
Overnight, the cell is resting as it does not have to worry about its specific function (that it carries during the day) and can therefore take care only of
its needs:
- The process of restoration, regeneration and cell renewal are taking
place;
- The detoxification reactions occur;
- The microcirculation is activated so to provide direct input of micronutrients to cells and the removal of waste from detoxification.
These cellular activities also generate free radicals, which production
reaches its maximum around 3am.
Thus, overnight, the cell uses:
- Nutrients available for its energy needs;
- Its defenses to protect against adverse effects of toxins and free radicals produced during the night.
NUTRITION
CELLS
Orochronodietology acts not only on the function, but also

simultaneously and synergistically on the protection and nutrition
of the cell, whatever the state of each cell would be, thereby
accelerating the global recovery process of cells and therefore the
100% recovery of cellular activity. It is then a global vertical action
and not only a horizontal one like in conventional treatments.
Combined and simultaneous

action on Nutrition, Protection
and Function
(vertical action)
CELLS
<
<
0%
<
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<
100%
<
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6
100%
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3
100%
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NUTRITION
100%
<
PROTECTION
<
FUNCTION
<
100%
ACTIVITY
<
ACTION OF OROCHRONODIETOLOGY APPLICATIONS
The chrono
cycle of the cell
10
In the morning, the cell has nearly exhausted its nutrition and
protection reserves, and therefore need nutrients to renew its reserves
in order to be found in the best conditions for carrying out its specific
functions in the day thats starting, hence The Morning Program of
Orochronodietology.
During the day, the cells perform their multiple specific functions and so they require the supply of nutrients not only to restore
their energy and defense, but also the availability of specific nutrients
to optimize their functions. During the day, the supply of nutrients is
needed to maintain cell nutrition and protection but mostly to promote
the specific functions of cells, hence The Daily Program of Orochronodietology.
In the evening, the cells must be prepared to support their
overnight renewal, regeneration and detoxification function. In the evening, the cells end their chrono cycle and must rebuild their reserves
and prepare themselves before starting their night activity, hence The
evening Program of Orochronodietology.
20/21
The orogranule
Orochronodietology is the only natural therapy that makes possible the

simultaneous and immediate availability of the nutritional principles
needed by the cell for its nutrition, protection and to revive its function
deficit, in the moment when they are most needed thanks to a new
biological complex, called Orogranule, where active ingredients are at
the same time content and container, allowing the buccal assimilation
and absorption (orobioavailability).
The Orogranule is the intake unit that makes the cellular action of
Orochronodietology possible.
Composition
Each Orogranule is born thanks to the simultaneous and progressive
integration from the center to the periphery, starting from a nucleus of
100 in diameter, of a complex of active ingredients of natural origin
coming from Phytotherapy, Aromatherapy and Micronutrition.
Two sets of actives are integrated simultaneously in order to create
the new complex specific to each program during the building process
of each Orogranule:
- The active ingredients that provide nutrition and protection of the cell,
grouped under the name of -Mditril, and common to every
program.
Thus, each Orogranule is characterized by the presence of this

nutritional complex in order to fill the deficiency of substances that are
essential to the cell, particularly for cell nutrition and protection but
also to simultaneously strengthen the specific action of plant extracts
and essential oils provided by:
- The complex of all natural active ingredients (herbs, oils, essential
oils, ...) specific to address the problem of functional impairment.
The Orogranule is the only and unique solid form that integrates
simultaneously Phytotherapy, Aromatherapy and Micronutrition in a
complex directly assimilated by mouth.
Manufacturing principle
The Orogranules are built one by one starting from a central core of
about 100 microns in diameter around which a set of liquid and solid
components, oils and essential oils (normally liquid and very volatile)
can be progressively integrated to form a single solid complex, each
specific for each Orogranule.
The importance of the complex compared to a simple association of
ingredients, typical of other solid forms (being it a mixture to be
enclosed in a capsule or tablet, for example ...) is demonstrated by the
results regarding the level of antioxidant power obtained by the simple
association where one can observe that the association may lead to
values well below the sum of the effect of the single component (table
1), while the complex created through the Orogranule produces a
result greater than the sum of the single components (table 2).
-Mditril is a unique phytonutritional formula that

contains two groups of integrated components:
2.
one, designed and built especially for increasing

cellular protection, consists of extracts of:
lycopene, olive, OPC grape marc. These
components are considered today to be the most
powerful anti-radical available in the natural
world;
the other, a complex of algae, designed and built
to increase the intake of natural micronutrients
(vitamins, trace minerals, oils ...), is made through
the integration of Spirulina, Fucus and sea
lettuce. gras essentiels), est constitu par
l'intgration de Spiruline, Fucus and sea lettuce.
100
>
50
0
SAMPLE
PRODUCT 1
PRODUCT 2
80
TEST KRL**
1.
EFFECTIVENESS (table 1)
Complex vs association
<
PRODUCT 3
PRODUCT
1+2+3
40
Orogranule
A
B
C
20
concentration (by g/l of reaction medium)
OROGRANULE
Antioxidant power of a finished Orogranule

compared to its single components
taken separately (table 2)
60
PRODUCT 1+2 PRODUCT 1+3
Each Orogranule is a small sphere, 100% of natural origin, made up

exclusively of the complex of the biological active principles
simultaneously and gradually integrated from the the center to the
periphery until the required diameter is reached in order to have the
needed dosage.
The active nutritional ingredients of the Orogranule are content and
container at the same time and, unlike other formulations, do not
require any envelope, excipient, gelatin, cellulose, alcohol ...
This feature is a indispensable prerequisite to allow orobioavailability,

that is to say, the direct assimilation and absorption of the new biological
complex through buccal way, bypassing the classic digestive way.
Orality and
Orobioavailability
A number of studies have proven the existence of relationship between
our mental and physical state, which controls our well-being on a daily
basis.
The first reaction of the organism in case of weakness of a function is
changing the relationship mind / body, causing the psycho-physical
imbalance, in response to the messages of cell failure (and hence of
the organ) that are sent to the brain.
Indeed, the cell deficiency or the insufficiency of a function have
consequences in terms of this relationship, which can be expressed in
different ways. The body responds immediately to restore the good
psyche-physical relationship.
If the organism fails to restore this balance, the relationship between
the two spheres is so narrow that a malfunction of one causes
important consequences on the other, and this happens in both
directions.
The disease, considered in the sense of imbalance, is nothing else than
the personalized expression of the suffering of this relation for any
individual.
However, orality has been shown to be a connection point, a point of

communication between the two spheres, memory of the buccal
relationship that we have acquired in our lives since the our
conception.
The Orochronodietology - says Professor Rufo - is characterized by
an extensive understanding of the patient and the disease, with the
inclusion of psychological elements of great importance in the
restoration of the psycho-physical balance, like for example orality
through Orogranules and the Orobioavailability excusive to
Orochronodietology.
The orobioavailability corresponds to the buccal

assimilation of the complex
The delivery via buccal route has many advantages
over the oral route:
- it allows the controlled delivery of substances for
a period that may be extended [SHOJAEI, 1998],
- it has both vascular and lymphatic drainage
[SHOJAEI, 1998 ; SZENTE, 2007], allowing
the rapid entry of the substance into the systemic
circulation,
- it gives the possibility of avoiding the hepatic first
pass metabolism and the pre-systemic elimination
[Shojaei, 1998; SZENTE, 2007; HAO, 2003], thus
avoiding any loss of activity,
- it offers better bioavailability [Keller-Stanislawski,
1992], gives the possibility to achieve higher plasma
concentrations of substance [Sasaki, 1998; FINN,
2005] in a shorter period of time [Sasaki, 1998]
(these conclusions are illustrated by the graph below)
and to significantly reduce exposure to metabolites
[Sasaki, 1998; FINN, 2005],
- it is well accepted by patients [Shojaei, 1998],
making treatment compliance easier.
22/23
In conclusion
More efficiency: only Orochronodietology acts by direct buccal
assimilation, respecting the cellular rhythm, immediately and
synergistically on all the different sources of the problem, thanks to
the exclusive opportunity to integrate into the Orogranule the actives
coming from Phytotherapy , Aromatherapy, the Micro Nutrition,
regardless of their physicochemical characteristics.
More speed: only the Orogranule can act simultaneously and at the
same time on nutrition, antioxidant protection and functional recovery
of the cell.
More safety: only the Orogranule has no envelope, no excipient, no

gelatin, no cellulose, no alcohol, no preservatives.
And additionally
it is user friendly
Ease of prescription: unique yet personalized,a single application
is covering several indications, because the complex is capable of acting
on several sources of the problems to be addressed.
Ease of dosage: 1 to 2 Orogranules to be sucked three times a day
Ease of intake:
sucking gradually in the mouth to help the direct

buccal assimilation and absorption.
Orochronodietology
is the only natural
treatment which brings you
all daily needs (24 hours)
to restore the cells
and their memory,
thus to restore
naturally the balance
of the organism.
renew
HAPPY.CO
TM
the only product that supports the
renewal of the cells,

mainly those exposed to the external aggressions
the most (skin, eyes,nails, hairs and other appendages)

and requiring
fast renewal rate (vascular cells),
while respecting the day and night cellular biorythm.
24/25
TM
renew
Study Conducted with Cell Cultures of Human Keratinocytes (skin cells)
Designed for :
Cell growth
- Hair imbalance (hair brittleness, loss, deadness )
- Eyes imbalance (tired eyes)
- Vascular imbalance (heavy legs, varicosity, pain, retention )
- Against stress of everyday life
- In case of higher demand for anti-oxidants
Concentration (g/l)
- Skin imbalance (wrinkles, decline, loss of flexibility )

<
+44% of cell growth

>
0,400
+35% of cell growth

<
>
0,025
0,000
0,200
0,400
0,600
0,800
1,000
Relative absorbance (proportional to the alive cells)
Morning
At night:
- All organism cells recover, regenerate and renew,
- Microcirculation is increased in order to ensure supply of nutrition
to the cells and removal of waste products from detoxification,
- These night activities of the cells produce free radicals and toxins;
the cell, therefore, uses its own instruments of anti-oxidation
protection in order to mitigate the killing effects of free radicals.
E Vitamin
witness without product
The stimulation of metabolic activity of cells (i.e. stimulation of their growth) provided by
the Renew complex is higher than Vitamine E (reference). [In Press, AJCM]
Daily
The skin performs various functions in defence against external
aggression, which produces free radicals.
Impact of Solar Exposure on Ability of Cell Defence against

Radicals
All these night activities consume energy, i.e. the nutrition reserves.
150
In the morning,
Without exposure/
occasional exposure
N = 26
N = 134
130
regular exposure
>
Te s t K R L
140
N = Number of studied cases
>
the cells, therefore, need to get back to a

correct nutrition level and to the optimum level of anti-oxidation
stamina in order to be able to ensure efficiency of their specific daily
tasks.
RENEW
120
110
Morning recharges the energy and defence reserves, which were

consumed during the night, and restores the cells, mainly the cells
exposed to the external aggression the most, to the best possible
condition for the new day and for ensuring their specific tasks.
100
N = 24
Exposure to sun impairs the cell defence ability in direct proportion to the exposure level
and duration.
P. Piccerelle, M. Prost, Actes Symposium - New 21st Century Health Challenges and
Pre-Medicine, Cassis (France), 21 Mars 2009.
26/27
The Daily Path continues providing for the needs of the cell
nutrition and protection, but it mainly acts on skin, capillary and eye
cells directly exposed to external hazard. The Daily Path provides for
nutrition, protection and support of specific functioning of these cells,
especially in the area of exposure to free radicals.
Anti-Oxidation Ability of Renew Daily and Each of Its Individual

Components
100
Orogranule
A
B
C
Te s t K R L
80
60
The conclusion is that the Renew

Program Daily Path improves
protection against radicals as
compared with the control sample
of blood by 71%.
40
20
0
0
Concentration (g/L of reaction medium)
P. Piccerelle, M. Prost, Actes

Symposium - New 21st Century
Health Challenges and
Pre-Medicine, Cassis (France),
21 Mars 2009.

after Exposure to Peroxides (inducing oxidation stress and thus release
of free radicals)
Effects of Renew on oxidant stress caused by H2O2
Concentration (g/l)
1,5
<
0,75
>
-58% of free radicals
0,38
<
0
5000
>
10000
fluorescence intensity (proportional to oxidant stress)

Renew
E Vitamin
[In Press, AJCM)
Good for:
- skin hydration improvement
- maintenance of skin consistence and resistance
- making the skin soft and firm
- helps mitigating the wrinkles
- strengthens hair
- mitigates the impact of free radicals
Evening
The skin cells regenerate at night (like all cells), including cell division
that achieves its peak at around 1 AM. Microcirculation also increases
in order to ensure the nutrition supply and removal of waste products
(cell renewal).The vascular cell restoration that occurs at night is
necessary for ensuring proper cell renewal process and thus proper
process of renewal of other cells, as well.
Evening continues the support of the cell demands for

nutrition and protection, however, it mainly acts on vascular cells,
which require fast renewal process.
>
<
Already in low concentrations, the Renew complex doubles the defensive anti-oxidation
capacity of the cells, whereas vitamin E (reference sample) does not reach such antioxidation effect even in high concentrations.
15000
renew
Therefore, Evening provides for:

- Cell nutrition protection that enables nutrition of the skin and
circulation cells,
- Support their correction process and mitigate the killing effects of
free radicals, production of which is very high at night,
- Strengthening and improvement of tissue microcirculation, mainly
the skin tissue,
- By active action on strengthening and protection of veins, with blood
flow strengthening, which results in supply of nutrition to cells, their
renewal and removal of waste products,
- Improvement of lymphatic drainage supporting removal of toxins
and waste products.
Good for:
- supporting removal of waste products
- activates microcirculation limiting varicose veins
- mitigates the feeling of swelling, especially in case of heavy
legs
Anti-Oxidation Effect of Renew Evening (KRL Test)

Antioxidation effect (% increase
of T1/2 of blood witness)
700
The conclusion is that the

Renew Evening Path has a very
significant anti- oxidation effect.
It improves blood protection
against radicals by almost 600%
as compared with the reference
sample.
600
500
400
300

Symposium - New 21st Century Health Challenges and
21 Mars 2009.
200
100
0
0
10
A clinical study lasting for 4 6 weeks has been conducted with 325
patients, who suffered from circulation problems (varicosity, varicose veins,
heavy legs) :
Improvement of circulatory troubles

100
100
90
90
91,9
80
Percentage of improvement
TM
70
80
68,7
70
60
60
>
50
40
50
40
30
30
23,2
20
20
8,1
10
0
10
0
Very significant
Significant
Non significatif
Very significant
+ Significant
The Renew Evening also allows for significant improvement of circulation system functioning
during the day. [In Press, Revue 37,2, 2009]
RENEW is the only treatment

program that deals with the overall
imbalance and that allows for
restoring the organism back
to balance as far as skin, eyes
and vessels are concerned while
respecting the daily cell rhythm.
28/29
Recommended Use:
Orogranules are to be dissolved mainly in mouth in
order to support
orobioavailability (instant absorption of active
components by buccal way).
- 1 Orogranule of Morning in the morning
- 2 Orogranules of Daily, one before noon and one
at the end of afternoon (or both at one time before
noon)
- 1 Orogranule of Evening before going to sleep.
Recommended dosage can be doubled, if required:
- 2 Orogranules of Morning in the morning
- 4 Orogranules of Daily, two before noon and two
eventually at the end of afternoon
- 2 Orogranules of Evening before going to sleep.
Other Supporting Studies

- KRL tests conducted with Renew Morning, Daily and Evening,
KIRIAL International a company of the Spiral group of laboratories
- KRL Patent - Michel Prost PCT/FR90/00061, 2009
- Proceedings of Symposium NEW 21ST CENTURY HEALTH
CHALLENGES AND PRE- MEDICINE, Cassis (France), 21 March
2009.
- AGNOLI A, MANFREDI M, MOSSUTO L, PICCINELLI A.,
Relationship between circadian rhythms and blood pressure and the
pathogenesis of cerebrovascular insufficiency. Rev Neurol (Paris). 1975;
131(9):597-606.
- DE COTRET LR, Sleep: Period of Intensive Activity. Passeport Sant,
6 October 2008.
- GRECO RM. et al., Hyaluronic acid stimulates human fibroblast
proliferation within a collagen matrix. J. Cell. Physiol., 1998;
177(3):465-73.
- HENRY F, ARRESE JE, CLAESSENS N, PIERARD-FRANCHIMONT
C, PIERARD GE., Skin and its daily chronobiological clock Rev Med
Liege. 2002; 57(10):661-5.
- NUTRANEWS, Nutranews, Science, Nutrition, Prevention and Health,
Natural Nutrition for
- Fighting Skin Aging, November 2008, 7-14.
- NUTRANEWS, Nutranews, Science, Science, Nutrition, Prevention
and Health, Collagen and
- Beauty of Skin, June 2009, 16.
- OESSER S et al., Stimulation of type II collagen biosynthesis and
secretion in bovine chondrocytes cultured with degraded collage. Cell.
Tissue Res.2003; 311:393-399.
flex
HAPPY.CO
TM
The only product that will ensure
a global action on disturbed

articular and bone balance
while respecting the day and night
cellular biorythm.
30/31
TM
flex
Designed for:
Good for:
- articular problems: pain, stiffness, weakness

- bone problems: pain, demineralization, fractures
- problems of sportsmen : trauma, muscle pain and fragility
of structures linked to hyperactivity
- supplying cells with nutrition and protection
The insufficient articular cell is exposed to very strong attack by

oxidants. In case of articular and bone problems, we often state
disturbance of the oxidant-antioxidant balance. These are really the
free radicals and oxidation stress, which induce that factor, which
contributes to osteoarthritis development a lot. The patients suffering
from osteoarthritis are subjected to major oxidation stress. In vitro
the free radicals can suppress synthesis of essential components in
the cartilage cells and the studies show that these are the antioxidants
that protect the cells from these attacks by radicals.
During the night, all cells in organism recover, regenerate

and renew.
The cell uses:
- nutrition that is available in the blood circulation for its own demand
for energy, as well as for its renewal and detoxification activities;
- its own means of protection against anti-oxidants in order to mitigate
the killing effects of free radicals produced during the night activities
of the cell.
In the morning, the cells, therefore, have the need to

restore their energy reserves and their anti-oxidation stamina in
order to be in the optimum state when performing the activities
of the organism during the day.
Morning restores the energy and defence reserves, which were
at the biggest exposure (mainly the articular cells), to the best
possible condition to face the daily demands and ensure their
specific tasks.

after Exposure to Peroxides (inducing oxidation stress and thus release
of free radicals)
Antioxidant protector effect

1,5
Concentration (g/l)
Morning
- restricts the impact of the oxidant-antioxidant

imbalance
<
0,75
>
<
0,38
>
>
<
0
2000
4000
6000
8000
10000
12000
14000

FLEX
E Vitamin
Conclusion: Even in low concentration, the action of the Morning program of flex complex
on anti- oxidation protection is bigger than action of vitamin E in high concentration.
[In Press, AJCM).
32/33
The articular cells fulfil specific functions. In case of articular

imbalance, the articular cells become deficient and we can observe
inflammation processes and gradual destruction of cartilages, which
causes pain, impaired mobility and flexibility. This is why the articular
cells in imbalance need nutrition for their energy demand and
mainly the need for self-defence, but also for supporting their
specific functional tasks.
Daily, therefore, compensates the need for the cell nutrition

and protection, but it mainly acts on articular cells in imbalance,
it has an anti-inflammatory, analgesic and regenerating effect.
Good for:
A complex clinical study conducted with 871 subjects (of which 542 within
a single treatment and 329 within complex treatment and other problems),
who were treated for 60 days, confirmed the effective action of Flex Daily
on articular problems:
Improvement of join pains

100
90
30
20

500
400
300
200
100
0
2
10

Symposium - New 21st Century
Health Challenges and
21 Mars 2009.
Rate of positive results
98%
6%
1st day
- Protecting the articulation, the bone and the muscle

from hyperactivity stress (overwork)
35%
40
5 days
10 days
Days of use
600
60 days
50
- strengthening cartilages
The conclusion is that Flex Daily

has a very significant
antioxidation effect. It improves
resistance to radicals by more
than 668% as compared to
the reference sample.
30 days
60
- improving mobility, reactivity and flexibility of joints
700
90,59%
65%
70
10
- mitigating and suppressing painful joints
Anti-Oxidation Effect of Flex Daily Path (KRL Test)
88,19%
80
Rate of positive results
Daily
% of positive results
Improvement of mobility
89,1%
93%
92,8%
88%
83%
78%
73%
68%
65,1%
63%
10 days
Days of use
30 days
60 days
% of positive results
The Flex Daily Path also acts fast on articular problems: 65,1% of patients noted reduced
pain and better articular mobility on day 10, of which 35,4% during the first week.
Significant reduction of pain and mobility improvement is noticed in 30 and 60 days.
[Phytothrapie Europenne, n43, Avril 2008).
TM
flex
Evening
Therefore, Evening reflects the demand for the cell nutrition and
protection, however, it mainly acts on bone cells, which need to
be renewed, replenished with minerals and strengthened, so that
they provide an efficient support to the joints.
A nt io x id a t ion ef fect (% increa s e

of T 1/2 of b lood wit nes s )
In the evening all cells, especially the articular ones, are exhausted by
their specific daily tasks and they need to recover during the night.
Nutrition and protection are important for ensuring the cell renewal
efficiency.
The bone cells play a critical role in supporting the joints, and therefore,
the comfort of the joints requires their renewal and reconstruction.
Anti-Oxidation Effect of Flex Evening (KRL test)

800
The conclusion is that the Flex

Daily Path has a very significant
anti-oxidation ability.
It improves resistance to
radicals by more than 672%
sample.
700
600
500
400

Symposium - New 21st
Century Health Challenges
and Pre-Medicine, Cassis
(France), 21 Mars 2009.
300
200
100
0
0
Evening provides for:

- A cellular nutri-protection providing bone cell nourishment,
- replenishment of minerals,
- strengthening of weakened bones
- effect against pain,
10
Concentration (by g/l of reaction medium)
Recommended Use:
Good for:
- accelerating the mineral replenishment
- strengthening the bone mass
- suppressing articular pain
Orogranules are to be dissolved mainly in mouth

in order to support orobioavailability (instant
absorption of active components by buccal way).
noon)
34/35
- KRL tests conducted with Flex Morning, Daily and Evening, KIRIAL
International a company of the Spiral group of laboratories - KRL Patent - Michel
Prost PCT/FR90/00061, 2009.
CHALLENGES ANDPRE-MEDICINE, Cassis (France), 21 March 2009.
- DE COTRET LR, Sleep: Period of Intensive Activity. Passeport Sant, 6 October
2008.
- YUDOH K, KARASAWA R, MASUKO K, KATO T., Water-soluble fullerene (C60)
- inhibits the development of arthritis in the rat model of arthritis,
Int J Nanomedicine - 2009; 4:217-25.
- MIRSHAFIEY A, MOHSENZADEGAN M. The role of reactive oxigen species
in immunopathogenesis of rheumatoid arthritis. Iran J Allergy Asthma Immunol.
2008; 7(4):195-202.
- KHAN IM, GILBERT SJ, CATERSON B, SANDELL LJ, ARCHER CW.,
Oxidative stress induces expression of osteoarthritis markers procollagen IIA
and 3B3(-) in adult bovine articular cartilage., Osteoarthritis Cartilage. 2008;
16(6):698-707.
FLEX is the only treatment

that acts on the overall
imbalance in joints
and bones while respecting
the daily cell rhythm
relax
HAPPY.CO
The only preparation that brings
a quiet night and thus

a clam day, while respecting
the day and night cellular biorythm.
TM
36/37
TM
relax
By night : During the night all cells of the organism recover,
regenerate and renew. The phase of an efficient sleep is, therefore, very
important for the organism well-being, as it enables the cells to restrict
their specific activities and be concerned with themselves.
The cell uses :
- Nutrition that is available in the blood circulation for energy it needs
for its restoration and detoxification activities;
- Its own means of protection against anti-oxidants in order to mitigate
the killing effects of free radicals produced during the night activities
of the cell.
Designed for:
- stressed individuals
- nervous strain
- difficulties with falling asleep
- insomnia
- stress in digestion
- weakened ability to defend against external effects
and infections
- problems upon change of seasons

restore their energy reserves and their ability to defend against
the radicals in order to get to an optimum state to support the
specific activities of the
organism during the day.
Morning
The mental and physical stress during the day brings higher pressure on
cells. The cells must deal with more intensive production of radicals
induced by more intensive response of the organism to stress.
Effect of Mental Stress on Overall Potential of Defence against

Radicals (KRL Test)
exposed to the external effects and stress the most, to an optimum
state so that they can efficiently defend and perform their specific
tasks for the entire day.
140
Work-related stress
130
>
Life stress
P < 0.001
Good for:
>
Te s t K R L
150
Morning restores the reserves of energy and defensive substances
120
>
P < 0.01
>
110
100
N = 77
Low
Low
N = 81
N = 26
moderate
moderate
N = 77
N = 81
N = 26
High
High
Stress impairs the cell ability to defend against radicals

- supplying the cells with nutrition and defensive

substances
- preparing the organism for better managing
of everyday stress
38/39
after Exposure to Peroxides (induces oxidation stress, i.e. production
of free radicals)
Daily also ensures effects of the cell nutrition protection,

which allows for maintaining an optimum energy and protection
capacity, has a soothing effect against cramps and easy digestion.
Anti-Oxidation protector effect

Good for:
Concentration (g/l)
1,5
<
0,75
>
<
0,38
>
>
<
0
2000
4000
- improving dealing with everyday stress

- shortening the required sleeping time
- improving quality of sleep
- bringing relief and relaxation
- making everyday activities easier
6000
8000
10000
12000
Anti-Oxidation Abilities of Relax Daily (KRL Test)
14000
800
RELAX
E Vitamin
Conclusion: Even in low concentration, the action of the Morning program of relax complex
[In Press, AJCM)
Daily
The nerve cells perform their specific tasks during the day, while they
have to respond to everyday mental and physical tasks in order to avoid
gradual weakening of the organism.

The Relax Daily Path has a very

significant Anti- Oxidation
Effect: it improves resistance
to radicals by almost 700% as
compared with the reference
blood sample
700
600
500
400

21 Mars 2009.
300
200
100
0
0

They need nutrition for their energy demands, for their protection,
as well as specific nutrition for their specific tasks.
Daily keeps satisfying the needs of the cell nutrition and

stamina, but it mainly acts on the nerve cells in imbalance, these
need specific nutrition with respect to their function.
relax
The clinical study conducted for a period of one month in a hospital

environment with 20 individuals proved efficient action of Relax on mood
and sleep disorders:
3
Waking up tired
2,5
2,5
1,5
1,5
-78%
0,5
0,5
0
Day 0
Irritation during the day
Day 30
-66%
Day 0
Anti-Oxidation Abilities of Relax Evening (KRL Test)

Antioxidation effect
(% increase of T1/2 of blood witness)
TM
800
600
500
400
300
200
100
0
0
2
5
10
1
Day 30
Relax enables reduction of irritation during the day.

The Relax Evening has a very

significant anti-oxidation effect:
it improves resistance
to radicals by almost 750%
blood sample.
700
Effect of Relax evening program on free radicals production after 1 hour

of lymphocyte culture
In the evening, the cell must get ready for correct performance
of their night function of restoration, regeneration and detoxification.
Stress exhausts the cells designated for defence. These cells
of the immune system activate and regenerate during the
night.
f lu orescen ce in ten sity
2 500 000
Evening
Antioxidant effect on
lymphocytes, in a dosedependant
fashion, allowing for
the most tested concentrations
a decrease of more than 50%
of free radicals produced
after 1 hour.
2 000 000
1 500 000
1 000 000
500 000
0
0=T
Evening continues to support the cell nutrition and

stamina, however, it mainly acts on the immune system cells,
which need to renew properly to ensure their efficiency during
the day, and in particular, to ensure response in stress
situations.
12
37
111
330
Concentration (mg/L)
Effect of Relax evening program on free radicals production after 24 hours

of lymphocyte culture
- mitigating the impact of stress on organism

- strengthening the organism defense
- improving resistance of organism to everyday attacks
from outside
- increasing tolerance to change of seasons
f luorescen ce in ten sity
2 000 000
Good for:

21 Mars 2009.
Antioxidant effect on lymphocytes,

in a dose-dependant fashion,
for a concentrations of 0,33g/l,
Relax Evening program generates
a decrease of 37% of free radicals
produced within 24 hours.
1 500 000
1 000 000
500 000
0
0=T
12
37
111
330
40/41
Recommended Use:
in order to support orobioavailability (instant absorption
of active components by buccal way).
at the end of afternoon (or both at one time before noon)

- KRL tests conducted with Relax Morning, Daily and Evening, KIRIAL
International a company of the Spiral group of laboratories - KRL Patent Michel Prost PCT/FR90/00061, 2009.
- Proceedings of Symposium NEW 21ST CENTURY HEALTH CHALLENGES
ANDPRE-MEDICINE, Cassis (France), 21 March 2009.
2008.
- MILLER AH., Depression and immunity: a role for T cells? Brain Behav Immun.
2010; 24(1):1-8.
RELAX is the only preparation that allows for dealing

with various stress situations the organism is exposed
to during the day and night, while respecting the daily
cell rhythm.
energy
HAPPY.CO
TM
The only preparation that
supplies
tone and energy while respecting

the day and night cellular biorythm.
42/43
TM
energy
Designed for:
- cases of decreased energy
- cases of insufficient vitality
- cases of physical and mental overload
- cases of insufficient resistance to load
- cases of long and difficult recovery
- cases of difficulties with falling asleep and sleeping disorders
Morning

restore their energy reserves and their anti-oxidation defense
ability, so that they get to the best possible form to support the
specific activities during the day.
Morning restores the reserves of energy and defensive
substances consumed during the night, and restores the cells,
mainly the cells that were exposed to hazard from the external
environment the most, to an optimum state so that they can
efficiently deal with the load of the entire day and ensure
fulfillment of their specific tasks.
Good for:
A strain, whether physical or mental, induces higher production of free

radicals.
- supplying the cells with nutrition and defense

- preparing the cells for better functioning during the day
Impact of Physical Exercise on Potential of Defence

against Radicals (KRL test)
P < 0.01
140

after Exposure to Peroxides (induces oxidation stress, i.e. production
of free radicals)
>
130
Protective and antioxidant effect
>
>
120
1,5
110
100
N = 46
Non athlete
N = 66
Amateur athlete
N = 72
Regular athlete
Although those who train on a regular basis feel more protected, the reduced general
potential of defense after strain is always directed against radicals.
This is why the cells need more to relax after a full day of strain.
At night the cell uses:

- nutrition that is available in the blood circulation for its demand for
energy, as well as for renewal and detoxification;
- its own means of anti-oxidation in order to restrict harmful effects of
free radicals produced during the night activities of the cell.
Concentration (g/l)
Time of half haemolysis

(in min)
150
<
0,75
>
<
0,38
>
>
<
0
2000
4000
6000
8000
10000
12000
14000

ENERGY
E Vitamin
Conclusion: Even in low concentration, the action of the Morning program of energy complex
[In Press, AJCM)
44/45
Daily
The muscle cells perform their specific functions.
They need nutrition for their demand for energy and defense, as
well as nutrition specific for its tasks.
Daily not only makes sure the permanently more intensive

cell processes and the level of anti-oxidants, which is impaired by
production of free radicals associated with everyday physical and
mental strain, are maintained, but it is efficient also at the level of
physical and intellectual performance by having adapting effect
on the central nervous system, stimulation of adrenal and
spermatic glands with stimulation of resistance to tiredness. It
also shortens the time required for recovery of strengths and
better mastering of physical and mental strain.
The clinical study conducted with 20 sportsmen for a period of 4 months

confirmed the efficient action of Energy (Daily) on tone, vitality and sporting
performance:
70
55
50
50
40
- 64%
20
10
+ 59%
35
30
0
T0
T4
Beginning of the study End of the study
T0
T4
Muscular Fatigue
Muscular pain
Improvement of concentration
+ 86%
50
45
40
35
25
+ 33%
40
- 88%
30
Antiradical power of Daily Energy Program (KRL Test)
improvement of recovery
and physical shape
45
30
55
- improving physical and intellectual vitality

- improving resistance to tiredness
- shortening of recovery time
- helping to manage stress
60
60
60
Good for:
Reduction of Fatigue
and muscular pain
T0
T4
Recovery after physical effort

Physical fitness
40
35
30
25
20
15
10
5
0
Sleep disorder
- 78%
T0
T4
Concentration
300
The Energy Daily Path has a very

good anti-oxidation ability: it
improves resistance to radicals
by almost 270% as compared
with the reference blood sample.
250
200
150
100
50
0
0
10

Energy Daily increases the sport and mental performance with the action on speed of strength
recovery, quality of sleep, significant improvement of sporting performance.
TM
energy
Clinical study conducted for a period of one month in a hospital
environment with 20 subjects:
Evening
All cells, in particular the muscle and nerve cells, must get ready to
perform their night functions of renewal, regeneration and detoxification
correctly. The sleeping phase must be efficient and strengthening.
The cells need nutrition in order to provide for their demand for energy and
defence. The organism must calm down in order to ensure efficiency the
recovery phase during the sleep, thus efficiency of specific daily tasks.
Evening keeps maintaining the needs of cell nutrition and
Period of replenishing (in min)
6,8
6,6
20
- 10 mn
10
6
Day 0
Day 30
Sleep disorder
2,5
2
1,5
- Shortening the required sleeping time

- Improving quality of sleep
- Ensuring night relax that regenerates
- Brings relief and relaxation for better natural ability
to respond to impulses
6,4
6,2
Good for:
+ 40 mn
7
30
protection, however, mainly acts on the nervous system cells.

Therefore, Evening will ensure the nutrition protection that will
enable the immune cells to optimize the energy reserves and
defense abilities, it has a soothing effect, sedative effect and anticramp effect with digestion easement.
Total sleep time (in hour)

7,2
40
- 60%
1
0,5
Day 0
Day 0
Day 30
The Energy Evening Path enables to

shorten the time of falling asleep,
to prolong the sleeping time
and to mitigate the sleeping
disorders. Subjects sleep better
and are less tired in the morning,
so they are less stressed during
the day: the subjects are quite at
night, allowing them to calm down
during the day and be more
resistant to daily aggressions.
Day 30
Anti-Oxidation Effect of Energy Evening (KRL Test)

800
Energy Evening has a very

it improves resistance
blood sample.
600
400
200
0
1
0
2
5

21 Mars 2009.
ENERGY is the only preparation

that brings optimum levels of
physical and mental energy
in both normal situations
and situations of higher demand
while respecting the daily rhythm
of the cell.
46/47
Other Supporting Studies:
Recommended Use:
in order to support orobioavailability (instant
absorption of active components by buccal way).
noon)
- 4 Orogranules of Daily, two before noon and
two eventually at the end of afternoon
- KRL tests conducted with Energy Morning, Daily and Evening, KIRIAL
International a company of the Spiral group of laboratories - KRL Patent Michel Prost PCT/FR90/00061, 2009.
- DE COTRET LR, Sleep: Period of Intensive Activity.
Passeport Sant, 6 October 2008.
slim
HAPPY.CO
The only preparation that
TM
enables
adjustment of the body
shapes while respecting the day
and night cellular biorythm
48/49
TM
slim
Designed for:
- cases of body weight increase
- cases of swelling feelings
- retention
- cellulite and incrassation
- accumulation of fat, localized masses of fat
- unaesthetic swelling
- loss of tone of muscles and tissue
resistance). These sugars first deposit in the form of muscle and liver
glycogen, then in the form of fats.
Therefore, it is required to have a sufficient amount of substances
supporting degradation of reserves during the morning supply of
nutrition during the slimming process.
Morning restores the reserves of energy and protection of fat

cells, acts on heat release, microcirculation activation, dewatering,
removal of waste products and detoxification.
Good for:
Morning
- supplying nutrition and protection to fat cells

- supporting release of fat reserves
- supporting fat mass reduction
- supporting mitigation of cellulite and incrassation.
A failure to cope with eating customs, lack of movement, stress these

are at the birth of deregulation of the biological clock of the cells, leading
to excessive weight and excessive fat deposition. The fact is that the
periods of activity and relaxation within a physiological cycle controlled by
the biological clock play the fundamental role in the cell metabolism and
for a balance between the fat deposition and consumption.
- nutrition that is available in the blood circulation for its own demand
for energy, as well as for its renewal and detoxification activities;
- its own means of protection against anti-oxidants in order to mitigate
the killing effects of free radicals produced during the night activities of
the cell.
In the morning, the cells need nutrition in order to restore

their energy reserve and ability to defend against oxidants so that
they can support the specific activities of the organism during the
day in an optimum condition.
In presence of excessive fat, the metabolism of fat cells is disturbed,
stressed, which leads to excessive production of free radicals.
The fat cells thus have an extraordinary need to strengthen the
anti-oxidation defence capacity.
Unlike the slow sugars, the fast sugars deposit more quickly in the
morning and at noon, as certain insulin receptors (supporting utilization
of sugars) are less sensitive in the morning (physiological insulin
Anti-Oxidation Effect of Slim Morning (KRL Test)

A nt io x id a tion ef fec t (% inc rea s e
of T 1/ 2 of b lood wit nes s )
At night the cell uses:
800
The Slim Morning Path has a

very significant anti-oxidation
effect: it improves resistance
as compared with the
reference blood sample.
700
600
500
400
300
200
100
0
0
2
5
1

21 Mars 2009.
Daily
In the weight reduction process, it is important to strengthen
removal of the waste from the cell metabolism and restrict the
water retention phenomenon, which are two factors impairing the
overall functioning of organism, feeling of swelling and gaining weight.
During the day the cells take care of dewatering and excretion and
perform their specific functions.
They need nutrition for their demand for energy and defense, as well as
nutrition specific for their functioning.
Reduction of measurements (cm)
50/51
keeps maintaining the cell needs for

nutrition and defense, acting mainly on the cells providing for
dewatering, which need nutrition specific for their functioning,
which results in improved process of detoxification and removal
of excessive water.
Reduction of personal measurements

with slim daily program
0
-0,2
-0,4
-0,6
-0,8
- 1 cm
-1
-1,2
- 1,3 cm
-1,4
- 1,3 cm
-1,6
Day 0
Day 15
Reduction of waist circumference

Reduction of thighs circumference
Reduction of hip circumference
Day 30
The Daily Path
Evolution of the swelling sensation and bulimic

impulses with Slim Daily program
Rating evaluation
2,3
Good for:
- reducing overweight
- getting slimmer
1,8
- 43%
1,3
- 29%
0,8
Day 15
The clinical study conducted with 30 women with IMC index between 24
and 30 proved efficient action of Slim (Daily) on reduction of weight,
number of measurements and feeling of gaining weight:
Efficiency of Slim Daily program

in the weight loss
0
Weight loss (in kg)
-0,4
-0,6
-0,8
-1
-1,2
- 1,5 kg
-1,6
Weight loss
Day 0
Day 15
IMC = Body weight rate.
Day 30
Day 30
After 30 days of use, Slim Daily achieved an average reduction of weight by 1,5 kg and
reduction in number of measurements, as well as reduced feeling of swelling and
bulimia recurrence.
-0,2
-1,4
Swelling sensation
Bulimic impulses
slim
In the evening the cells need nutrition for covering their night
demands for energy and defense, but also nutrition prioritizing the
fat burning, thus inhibition of the fat deposition.
Evening thus complements the daily action of HappyCo

Slim by maintaining the activity of cell nutrition and defense, but
also by improving the fat mass/non-fat mass ratio thanks to its
efficient action on fat burning with full preservation of the muscle
tissue, also acting on heat release and supporting excretion.
35
30
25
20
15
10
5
0
The Slim Evening Path has a very

it improves resistance to
radicals by almost 35% as
compared with the reference
blood sample.
0
2
1
66
Weight (kg)
- reinforcing the body shape
Reduction of waist
circumference
Reduction of body weight

65
Good for:

A clinical study, lasting 30 days, conducted on a target population of

30 women on hormonal contraception and overweight demonstrated
the effectiveness of Slim (Evening) on weight loss and bloating sensation
reduction.
- reducing the fat mass while prioritizing the muscle

mass preservation
64
63
- 2,9kg
62
61
60
- improving the tone of muscles and tissue
Day 0
Day 20
Waist circumference (cm)
The cells, in particular the fat cells, must get ready for proper
performance of their function of renewal, regeneration and detoxification
at night.
In addition, the evening metabolism differs from the daily metabolism, as
secretion to the digestive system occurs, which enables excessive
digestion of food. The glycogen synthesis peak (form of sugar deposition)
is at night.
Anti-Oxidation Effect of Slim Evening Path (KRL Test)
76,5
76
75,5
75
74
73,5
Day 0
Reduction of thighs
circumference
98
Weight (kg)
97,5
97
96,5
- 1,7cm
96
95,5
95
Day 0
Day 20
Day 30
- 1,7cm
74,5
Day 30
Day 20
Day 30
Reduction of hip
circumference
Waist circumference (cm)
Evening
A nt io x id a t ion ef fect
TM
58
57,8
57,6
57,4
57,2
57
56,8
56,6
56,4
56,2
56
- 1,5cm
Day 0
Day 20
Day 30
52/53
Reduction of swelling sensation

3
- KRL tests conducted with Slim Morning, Daily and Evening, KIRIAL
International a company of the Spiral group of laboratories - KRL Patent Michel Prost PCT/FR90/00061, 2009
Measure index
2,5
2

1,5
1
- 95%
0,5
0
Day 0
Day 20

Day 30
After 30 days of use, Slim Evening gave the result of an average weight loss of about
3 kg and a decrease in all measurements, correlated with a decrease of the bloating
sensation.
SLIM is the only preparation that

can give the organism repeated
lessons in proper balance
between weight and body line
while respecting the daily rhythm
of the cell.
Recommended Use:
Orogranules are to be dissolved mainly in mouth in
order to support orobioavailability (instant absorption
of active components by buccal way).
- 2 Orogranules of Evening before going to sleep
This dosage can be reduced in the stabilization phase
or after the desired results have been obtained
noon)

2008.
- LEUNG A. FOSTER S., Encyclopedia of common natural ingredients used in food,
drugs and cosmetics, John Wiley & Son, USA, 1996.
- MASON P., Dietary Supplements, Second ed, Pharmaceutical Press, London, 2001.
- WICHTL M., Herbs, Tradition, Medical Practice, Science and Therapy, Technique
et Documentation, 1999.
- HARGRAVE-BARNES KM, AZAIN MJ, MINER JL., Conjugated linoleic
acid-induced fat loss dependence on Delta6-desaturase or cyclooxigenase., Obesity
(Silver Spring). 2008 Oct;16(10):2245-52.
- RAWLINGS AV., Cellulite and its treatment. Int J Cosmet Sci. 2006 Jun; 28(3):
175-90.
- WHIGHAM LD, WATRAS AC, SCHOELLER DA. Efficacy of conjugated linoleic
acid for reducing fat mass: a meta-analysis in humans. Am J Clin Nutr.
2007; 85(5):1203-11.
- GAULLIER JM, HALSE J, HYE K, KRISTIANSEN K,
FAGERTUN H, VIK H, GUDMUNDSEN O.
Supplementation with conjugated linoleic acid for 24
months is well tolerated by and reduces body fat mass
in healthy, overweight humans. J Nutr. 2005;
135(4):778-84.
- JIANG ZY, ZHONG WJ, ZHENG CT, LIN YC,
YANG L, JIANG SQ. Conjugated linoleic acid
differentially regulates fat deposition in back fat
and longissimus muscle of finishing pigs. J Anim
Sci. 2010. Jan 29. [Epub ahead of print]
- NORRIS LE, COLLENE AL, ASP ML, HSU JC, LIU
LF, RICHARDSON JR, LI D, BELL D, OSEI K,
JACKSON RD, BELURY MA. Comparison of dietary
conjugated linoleic acid with safflower oil on body composition in
obese postmenopausal women with type 2 diabetes mellitus. Am J Clin Nutr.
2009; 90(3):468-76.
HAPPY.COTM
notobacko
TM
The only product which allows you to
take
into account all your personal
addictions during all day
54/55
00/00
TM
notobacko
TM
Each Step
Designed for people

who want to stop smoking
Each Step is presented in a box containing 4 smaller boxes, each with

6 blisters of 8 Orogranules : each blister of 8 Orogranules represents the
average daily dose and is made up of 3 different types of Orogranules ,
each having a specific action on the addictions.
The 8 Orogranules are to be sucked during the day in accordance with the
numbering indicated on the back of the blister, as a supplement to
balanced food and a healthy life style. The daily number of Orogranules is
adaptable depending on the results, but it is important to maintain a
minimal quantity of Orogranules sucked a day (minimum 4) so as not to
lose the benefit of controlling of the mouth busy with something.
TM
TM
TM
Notobacko has been specially designed and developed by our

researchers to accompany the resolve to counteract simultaneously the
3 types of dependence: physiological dependence, psychological
dependence and behavioural dependence.
Without the need to stop smoking suddenly and with the support of a
personal coach, Notobacko helps to readjust the organism gradually to
the absence of tobacco and thereby helps to resume completely the
control of the functions transformed by the cigarettes: stress, memory,
concentration, energy, the five senses...
Based on the exclusive concept of the Orochronodietology , Notobacko
acts at the heart of the cell, depending on the time of the day and the
degree of addiction. Thanks to the Orogranule to suck and dissolve
gradually in the mouth, Notobacko assures a triple cellular action:
nutrition, antioxidant protection and revival of the specific cellular
function.
TM
TM
TM
TM
TM
TM
Notobacko is a program of natural origin,

flexible and suitable for all, offered in 3 stages ("Steps") :
- Step 1: Stopping smoking
- Step 2: The consolidation
- Step 3: The detoxification
Steps 2 and 3 will be totally personalised depending on your
needs evaluated by means of a questionnaire to be completed
approximately a week before the end of each Step.
Note: As the subsequent Steps are determined individually
depending on the results of the previous ones, following the 3
stages successively is optional.
TM
TM
TM
TM
Each Step
- has a duration of 24 days,
- offers personal assistance of a coach,
- contains an evaluation questionnaire to be sent obligatorily a week before
the end of the Step so that the following Step can be adjusted to the
results and needs in a personalised manner,
- may be used in association with nicotine substitutes or other anti-tobacco
treatments.
56/57
I Step 1: Stopping smoking
When you try to stop smoking or reduce smoking, your body continues
to defend itself reacting habitually. The withdrawal symptoms
essentially include a lack of something in the mouth, physical
withdrawal symptoms and annoying gestures.
The 3 types of Orogranules contained in Step 1 help you to:
- Orogranule A (items 2 and 5 on the blister): purifier your mouth,
fight against the acid attacks of bacteria and whiten you teeth.
- Orogranule B (items 1, 4, 6, 8 on the blister): influence the taste of
the cigarette, reduce the wish to smoke, relieve irritation of the
mucous membrane and take away the sensation of hunger.
- Orogranule C (items 3 et 7 on the blister): ease the addiction and
relax during the day, improve the falling asleep and the quality of
sleep
.
III Step 3: The detoxification

Now it is necessary to purify the organism definitely of all the toxins
accumulated during the years of smoking cigarettes. At this stage
therefore the phase of general detoxification begins with maintenance of
active fight against the noxious effects of the tobacco.
Step 3 will be entirely personalised depending on the answers provided in
the second questionnaire.
TM
TM
This stage will revitalise the cells and will make gradually disappear
the marks of the tobacco. It will help the organism to resume naturally
the control of all bad habits related to sleep, stress, purity of the
organism as well as physical and psychological shape. It will help to
clean up the organism of all the toxins accumulated, to restore your
good shape and dynamism so that you find yourself finally and
definitely free from the tobacco.
TM
TM
First contact with

your coach
II Step 2: The consolidation

After the 1st month of stopping smoking, the products of the 2nd stage
aim at consolidating the detachment from the tobacco and helping the
organism to fight against putting on weight and stress, and to control
behavioural addiction (concentration, memory, irritability, fatigue...).
Step 2 will be entirely personalised depending on the answers provided
in the first questionnaire.
It will help you not to smoke any longer, prevent attacks of hunger or
bulimic urges and will maintain your weight restoring the normal
functioning of the organism.
It will help you to combat irritability and to sleep better.
Step 1: stopping smoking
Step 2: the consolidation
Standard, 24 days
Personalised, 24 days
Personalised, 24 days
>
>
Questionnaire 1
Step 3: the detoxification
Questionnaire 2
CO N T IN U O U S CO N TA C T WIT H YO U R PE R SO N AL CO A C H
>
Congratulations!
You have stopped
smoking!
TM
notobacko
TM
TM
Step by step, Notobacko acts gradually on all the personal sources of the tobacco
problem
Moreover, the following was shown clearly:
Clinical study of Notobacko: in total, 98 patients were observed (2/3 of

women, 1/3 of men). Independently of the degree of addiction and the
number of cigarettes smoked daily, the group was made up principally by
moderately and strongly addicted smokers.
- The importance of keeping the mouth busy and the role

of the Orogranule in controlling the lack of something
in the mouth
100
- The importance of free personalised coaching for good

course of the treatment and reinforcement of the
motivation, as confirmed by 87% of patients who had
participated
100
80
80
66,7%
60
60
40
40%
40
33,3%
20
20
11,7%
41,7%
Women
Men
0 cig/j
- Long-term non-smoking:
77.8% did not return to the addiction after 3 months,
6,7%
72.2% after 6 months and
0
2/3 of women, 1/3 of men
- The ease of using the treatment: Orogranules to suck,

with a pleasant taste
1-10 cig/j 10-20 cig/j >20 cig/j
Number of cigarettes/day
Predominance of smokers moderately
and strongly addicted.
50% after 12 months

- The absence of unpleasant side effects
Decrease of tobacco consumption by Step

100%
13%
18%
Rates decline
80%
38%
60%
30%
49,30%
41,70%
40%
48%
20%
35%
28,40%
Step 2
Step 3
More than 2
patients in 3
More than 7
patients in 8
0%
Step 1
Stopped or
reduced smoking
by 50-90%
almost 1
patient in 2
Reduction < 50%

50% < Reduction < 100%
100% and managed to stop smoking
Almost 1/3
of patients managed
to stop smoking at
the end of Step 3.
58/59
HAPPY.CO
proteox
The only product which ensures
a global action
on the natural defences and purification
of the organism in accordance with the
rhythm of cellular needs.
60/61
proteox
Designed to respond to:
A study conducted on cell cultures of human keratinocytes

(cells of the skin) after exposition to peroxides (inducing
oxidative stress and thus production of free radicals)
- Weakened natural defences

- Need to reinforce and detoxify the organism
- Disturbed hepatic and digestive equilibrium
- Increased need for antioxidants
Protective antioxidant effect
Le Morning Program
The production of free radicals produced naturally by the organism
increases in particular when the natural defences of the organism are
weakened. A disequilibrium is then observed between the production of
free radicals and their elimination by the organism. It is called oxidative
stress and is at the origin of numerous pathologies.
By the morning, the cells, particularly those of the liver, have practically
exhausted their nutritional and defence reserves, and thus need nutrients
to replenish their reserves and find themselves in the best conditions that
assure performance of their specific daily function.
The HAPPYCO PROTEOX Morning Program will act specifically in
order to restore the energy consumed during the night by the activity of
cellular regeneration and in order to satisfy daily needs of the cells for
energy and defence.
Concentration (g/l)
1,5
<
0,75
>
<
>
0,38
>
<
0
2000
4000
6000
8000
10000
12000
14000
Intensity of fluorescenece (proportional to the oxidative stress)

PROTEX (evening program)
Vit E
Already at low concentrations, the PROTEOX Morning Program doubles the ability of
antioxidant defence of the cells, while vitamin E (reference) does not achieve such
antioxidant effect even at a high concentration.
Conclusion: Even at a low concentration the action of the Morning Program on the
antioxidant protection is greater than that of vitamin E in a high concentration.
The Morning Program recharges the reserves of energy and defence
consumed during the night and puts the cells in the best conditions to
face the day and assure accomplishment of the function.
Benefits:
- Nutrition and protection of the cells
- Restoring of the good level of cellular energy and protection
- Preparation of the cells to make them more reactive during
the day
Le Daily Program
Every day the organism faces interior and exterior aggressions (season
changes, sudden weather modifications, periods of convalescence,
situations of stress, taking of medicines) which it has to resist in order
to maintain its balance.
62/63
Thus, during the day all cells of the organism, and particularly the cells
of the system of natural defences, exercise their specific function of
defence.
2 500 000
Intensity of fluorescence
The Daily Program continues to satisfy the needs for nutrition and
protection of the cells but acts particularly on the cells of the
immunologic system in order to reinforce their daily efficiency and above
all their reactivity to aggressions.
Effect on production of free radicals after an hours

in cultures of lymphocytes
The PROTEOX Daily Program has

a very significant antioxidant
effect: it increases the
resistance of the blood sample
to free radicals by more than
750%.
500
400
300
200
100
0
1
0
2
5
10
Concentration (in grams of the product
per litre of the reaction environment)
500 000
[P. Piccerelle, M. Prost, Actes

Symposium New 21st Century
Health Challenges And
Pre-Medicine, Cassis
(France), 21 Mars 2009]
12
37
111
330
Effect on production of free radicals after

24 hours in cultures of lymphocytes
2 000 000
Intensity of fluorescence
Antioxidant effect (% increase

of T 1/2 of the blood sample)
Antioxidant effect of the PROTEOX Daily Program

(Test KRL)
600
1 000 000
0=T
- Diminishes the impact of stress on the organism

- Reinforces the defence of the organism
- Improves the resistance of the organism to daily
aggressions
- Increases the tolerance to season changes
700
1 500 000
Benefits:
800
Antioxidant effect of the

PROTEOX Daily Program on
the lymphocytes is dose
dependent. In higher
concentrations it allowed a
decrease by more than 50%
of the production of free
radicals after an hour.
2 000 000
Antioxidant effect of the

PROTEOX Daily Program
on the lymphocytes is dose
dependent. At the
concentration of 0.33 g/l the
PROTEOX Daily Program
entails a reduction 37 % by
of free radicals produced in
24h.
1 500 000
1 000 000
500 000
0
0=T
12
37
111
330
Concentracin (mg/L)
Le Morning Program
The normal metabolic process, medicines, alcohol or nutritional
deficiencies and imbalances produce a broad range of toxins which must
be neutralised in the liver.
When the mechanisms of detoxification in the liver are overburdened,
the toxins accumulate in the organism and favour occurrence of chronic
proteox
health problems. They can harm numerous functions, especially the

immunologic system, making way for numerous pathologies. It is
therefore particularly important to protect and reinforce the liver and to
stimulate the mechanisms of detoxification.
During the night
- The processes of cellular recovering, regeneration and renewal take
place;
- The reactions of detoxification occur;
- The microcirculation is activated in order to assure direct supply of
micronutrients to the cells and removal of the residues of detoxification.
Thus, during the night, the hepatic cells use up:
- The available nutrients to satisfy their needs for energy;
- Their means of defence to protect themselves from the harmful effect
of the toxins and free radicals produced at night.
By the morning the hepatic cells have practically exhausted their
nutritional and defence reserves, so they need nutrients to replenish their
reserves and to find themselves in the best conditions to assure their
specific daily function.
The Evening Program recharges the reserves of energy and defence
consumed during the day and puts the cells, especially the hepatic cells,
in the best conditions to face the night and to assure the accomplishment
of their function during the day.
Benefits:
- Maintain the well-being of the hepatic cells
- Facilitate the functions of the liver
- Facilitate the digestion
- Support food transit and prevent the lazy bowel syndrome
Usage indications:
The granules should preferably be dissolved in the mouth
to favour their orobioavailability (immediate assimilation
of the active ingredients in the mouth).
- 1 Orogranule of the Morning Program in the morning
- 1 Orogranule of the Daily Program before noon and
1 Orogranule late in the afternoon (or 2 together before
noon)
- 1 Orogranule of the Evening Program before going
to sleep.
The dose can be doubled at the stage of intense treatment
or if the cellular needs are particularly increased:
- 2 Orogranules of the Morning Program in the morning
- 2 Orogranules of the u Daily Program before noon
(and possibly 2 Orogranules in the afternoon)
- 2 Orogranules of the Evening Program before going
to sleep.
PROTEOX is the only product able to respond to weakened defences

of the organism and consequences of this weakening and simultaneously
facilitate regeneration of the cells of the system of purification of the organism
from free radicals and toxins.
64/65
HAPPY.CO
day&night
contributes to the
pleasure of being with the others
The only product which
during the day and at night!
66/67
day&night
Designed to respond to:

- Difficult digestion
- Bad breath of food origin
- Problem of dental and mouth hygiene
- Snoring
- Problems related to snoring
By the morning the cells need to regain the right nutritional level and
their optimal ability of antioxidant and detoxifying defence in order to
assure the efficiency of their specific daily activity.
The Morning Program recharges the reserves of energy and defence
consumed at night and puts the cells, especially those of the mouth, in
the best conditions to face the day and assure the accomplishment of
their specific function.
Benefits:
During the night the salivary secretion diminishes, which leads to dryness
of the mouth, an unpleasant condition appearing in a quarter of the
population.
The saliva helps to clean the teeth from dental plaque and helps to clean
the mucous membrane of the mouth, allows the mouth to defend itself
from infections and constitutes the first stage of food digestion.
In addition to being one of the causes of bad breath, the decrease of the
saliva favours little wounds of the mouth (in particular close to dental
prostheses), of the langue and lips, as well as dental caries, gum
infections and candidiasis of the mouth.
Therefore it is necessary to optimise the well-being of the mouth from the
morning.
During the night:
- All cells of the organism recover, regenerate and renew,
- The microcirculation is intensified in order to assure the supply of
nutrients to the cells and removal of the residues of detoxification,
- This nightly activity of the cells produces free radicals and toxins. The
cell will therefore use its own means of antioxidant defence in order to
limiter the harmful effects of free radicals and to free itself from an
excess of toxins.
All these activities at night consume energy and the reserves of nutrients.
- Helps to neutralise the attacks of acids produced by

bacteria
- Optimises the decrease of dental plaque and caries
- Supports the protection and reinforcement of teeth enamel
- Contributes to purifying of the breath
- Restores cellular levels of nutrients and antioxidants
Test KRL - Antioxidant effect of Day&Night

Morning Program
Antioxidant effect (% increase
of T 1/2 in the blood sample)
Le Morning Program
60
50
40
30
20
10
0
1
3
4
2
Concentration (g/l of the reaction environment)
The Morning Program has a very strong antioxidant effect: it increases the resistance to
free radicals in the blood sample by over 55%.
[P. Piccerelle, M. Prost, Actes Symposium New 21st Century Health Challenges And
Pre-Medicine, Cassis (France), 21 Mars 2009]
68/69
Le Daily Program
LEvening Program
During the day the cells which assure the digestion and the well-being
of the mouth exercise their specific function. But very often an excess of
alcohol, a meal eaten too fast or food that is too heavy put a strain on the
cells, which find it hard to cope with digestion and that leads to
unpleasant consequences related to the sensation of heaviness and bad
breath.
From 3 and 5 people in 10 in the world suffer from bad breath and
digestive imbalance. There are many causes at the origin of this
discomfort, some directly related to the lifestyle (smoking, lack of mouth
and dental hygiene, gum or periodontal disease, taking of certain
medicines), others are directly related to the food eaten (garlic, onion,
alcohol) or to eating practices (diets, fasting). Unfortunately, it is often
the others who notice our digestive problem, especially when we eat
certain foods.
Snoring is a problem often wrongly evaluated which may have significant

consequences for the health and the psychophysical balance not only of
the people who snore but also for their partners and families.
The causes are multiple: the principal origin is linked to the natural
mechanism of relaxing of mouth muscles, which causes narrowing of the
respiratory tract. The tissues begin to vibrate and that entails the
phenomenon of snoring. The problem aggravates when the respiratory
tract is blocked due to overweight, smoking, alcohol, the position in which
one sleeps
Unable to rest, the cells are stressed and demand supplementary
energies to satisfy their needs for protection and defence at night, but also
for specific nutrients which might help the good functioning of the cells
involved in multiple origins of snoring.
The Daily Program will act at the same time in the mouth and in the
stomach to affect simultaneously various causes of bad breath related to
food and slow digestion.
The Evening Program will thus complete the daily action of HAPPYCO
Day&Night by acting for the benefit of comfort at night, maintaining the
cellular nutrition and protection but also by acting immediately on the
possible various causes of snoring.
Benefits:
Benefits:
- Provides antiseptic action and lasting purification

in the mouth
- Facilitates emptying of the stomach, reducing
the effects of excessive food and drink
- Helps to fight and reduce the origins of bad breath
at the source
- Effect of regeneration and tensing of the soft palate,

- Soothing and unblocking of the nose,
- Hydrating and humidifying of the mouth and throat,
- Regulating of the digestion and facilitating of falling
asleep.
CLINICAL STUDY
An open observational study was conducted, each participant being
his or her own reference. 20 persons affected by snoring, without
restriction of age or sex used the HALT-O-RONF product every evening
for 10 days. One observation of the snoring was made at the beginning
(T0) and then after 1, 2, 5 and 10 days of taking the product.
day&night
Results:
The intensity of snoring
At T0 the intensity of snoring ranged from level 2 to level 4 for the
majority of patients.
From the first day 90% of the patients noticed a lower intensity of
snoring, at least by 1 point on the scale of measurement. On the tenth
day 13 patients declared that they no longer snored. Out the 20 patients
in the study, 13 declared to have stopped snoring before T10: 4 from the
first day, 2 after two days, 6 after 5 days.
and continues to grow during the treatment. After 10 days 90% of the
patients declared they had good or very good sleep quality. It was
observed that the quality of sleep improved by 85% in 10 days.
The discomfort of the partner
At the beginning of the study 85% of the patients declared that their snoring
caused discomfort to their partners. After 2 days this discomfort concerned
only 50% of the patients. After 10 days of the treatment partners discomfort
related to snoring concerned no more than 20% of the patients.
Reduction of partners discomfort
5
100
85%
4
75%
80
3
Patients (%)
Intensity of snoring (scale from

0 to 5)
Intensity of snoring after 10 days of using the product
2
1
60
50%
40
25%
20
20%
0
0
0%
10%
20%
30%
40%
50%
60%
70%
TO
T1 jour
T2 jours
T5 jours
T10 jours
Patients (%)
The quality of sleep

The graph presents the percentage of patients who declared to have
good or very good sleep quality, depending on the number of days of
using Halt-O-Ronf. The percentage increases by 15% from the first day
Conclusion
The analysis of this preliminary study conducted with the HALT-O-RONF
product shows very positive results: 65% patients stopped snoring and
90% recognised an important benefit of decreased snoring, improved
sleep quality and reduced discomfort of the partner.
Evolution of the percentage of patients with good or

very good sleep quality
100
80%
Patients (%)
80
90%
60
45%
40
20%
20
5%
0
TO
T1 day
T2 days
T5 days
T10 days
DAY&NIGHT is the only product

which readjusts the organism to
maintain the right digestive balance
DURING THE DAY AND AT NIGHT,
in accordance with the daily rhythm
of the cells.
70/71
Usage indications:
The granules should preferably be dissolved in the mouth
to favour their orobioavailability (immediate assimilation
of the active ingredients in the mouth).
- 1 Orogranule of the Morning Program in the morning
- 1 Orogranule of the Daily Program after lunch and
- 1 Orogranule after dinner
- 1 Orogranule of the Evening Program before going to sleep.
The dose can be doubled if necessary:
- 2 Orogranules of the Morning Program in the morning
- 2 Orogranules of the u Daily Program after meals
- 2 Orogranules of the Evening Program before going to sleep.
conclusion
L'orochronoditologie
TM
ensures consistency between the function

and need of the cells
following the cellular biorhythm of the day and night.
The HAPPY.CO products will

also help to restore the natural
system in its entirety and at
the same time to restore the
disrupted function for a more
effective, fast and safe action.
72/73
These five scientific benefits are made possible thanks
to the proprietary exclusive and patented technology
of Orogranules:
- The only ones who are built one by one gradually from the center
to the periphery.
- The only ones who can integrate into their complex any kind of active
ingredient, regardless of their physicochemical nature (liquid,
powder, solid, oils, essential oils ...).
- The only ones that create a new complex of multi-target actives
ensuring a synergistic action.
- The only where the active ingredients are simultaneously content and
container: no need of shell, excipient, capsule, gelatin, cellulose,
conservatives.
- The only ones that allow orobioavailability (buccal direct
assimilation) to ensure 100% of quality and quantity of natural
actives "avoiding" the classic digestive track.
Orochronodietology is the base of HAPPYCO Products, all of

them being unique and innovative.
Its efficiency level, never reached until today, is based on

its five strengths:
- POWER: the only one that acts on all sources of the problem to be
solved thanks to its multi-target action
- SPEED: the only one that is immediately and directly absorbed in the
mouth, allowing the direct passage of the actives in the blood
- SAFETY: the only one that has no envelope, no capsule, no excipient,
no gelatin, no cellulose, no preservatives, no alcohol and is GMOfree
- COMPREHENSIVENESS: the only one that has a complete and
simultaneous action on the three essential elements for the cell: its
nutrition, its protection and its specific function
- BALANCE: the only one that respects the cellular biological day /
night rhythm
Each of the HAPPY.CO products consists of 3 programs to be taken

during the day in order to meet the needs of the cells, specific needs
at each stage of their daily cycle. Each complex will thus be supplied
to the cells at the time, depending on their life cycle, they need it most
and are most capable of profiting.
Each of the new complexes

that are part of the HAPPY.CO
natural products is going to be
immediately and simultaneously
act on all the sources
of the problem to be treated,
respecting the daily chronobiology
of the organism.
ITS TIME TO BE
HAPPY !
PHOTOS : L. LEFEVRE, THINKSTOCK & ISTOCKPHOTO
ITS TIME TO BE HAPPY !
myhappyco.com

Happyco Broch GB

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THE SOURCE

Our Mission ................................................................................ 06/07

The international structure organized for a rapid and straight enlargement

A very important project of new Orochronodietology and dermo dietology

Orochronodietology : a NEW, BUT

Happiness is also to DARE. IF YOU WANT IT, YOU OBTAIN IT, as we

With exclusive concepts and results

2. The continuous innovation of the HAPPY.CO products as natural tools

3. The continuous development and maintaining of the ethical, quality and

4. The involvement and participation

of all the HAPPY.CO friends in the

If you share these values, youre already a happy friend !

Its time to be happy !

and creativity oriented me toward the management of international

had its reflectings

In the research unity, development

Coherent with this philosophy, our center of production is still today

Innovation, quality and respect for the

Nature has created different food,

The food of today is

protection all conditions hardly do-able simultaneously.

Orochronodietology is the first cellular

presents a world exclusivity:

A new and unique product which

Each new complex resulting from the Orochronodietology is going to

Orochronodietology is the first and only natural scientific

ITS 5 SOURCES OF WELLBEING:

The Happy.co Orochronodietology

How and Why ?

The cell and the wellbeing

The health of the cell depends

the cell is the source of our life.

The role of the cells is essential to the life of

In order to effectively perform their Functions, cells must have a

inefficiency of the cell

- Their Nutrition: the cell must be nourished in order

depletion of the reserves

The provision of micronutrients able to provide cellular nutrition and

ACTION OF OROCHRONODIETOLOGY APPLICATIONS

Action on the function only

Orochronodietology acts not only on the function, but also

Combined and simultaneous

ACTION OF OROCHRONODIETOLOGY APPLICATIONS

Orochronodietology is the only natural therapy that makes possible the

Thus, each Orogranule is characterized by the presence of this

-Mditril is a unique phytonutritional formula that

one, designed and built especially for increasing

concentration (by g/l of reaction medium)

Antioxidant power of a finished Orogranule

PRODUCT 1+2 PRODUCT 1+3

Each Orogranule is a small sphere, 100% of natural origin, made up

This feature is a indispensable prerequisite to allow orobioavailability,

However, orality has been shown to be a connection point, a point of

The orobioavailability corresponds to the buccal

More safety: only the Orogranule has no envelope, no excipient, no

sucking gradually in the mouth to help the direct

the only product that supports the

renewal of the cells,

the most (skin, eyes,nails, hairs and other appendages)

fast renewal rate (vascular cells),

while respecting the day and night cellular biorythm.

- Skin imbalance (wrinkles, decline, loss of flexibility )

+44% of cell growth