USE OF PRP THERAPY IN SKIN and HAIR FOLLICLE REJUVENATION
Platelet rich plasma (PRP) application is a successful
catalyst in the healing process for wide varieties of conditions. PRP was first developed in the 1970s and first used in an open heart surgery procedure. PRP therapy began gaining popularity in the mid 1990s. Methods of harvesting and using platelet rich plasma are becoming widely practiced in the fields of sports medicine, orthopedics, traumatology, general surgery, dentistry, dermatology and cosmetology. Their main function is hemostasis by attaching to any breach in vessel where platelets aggregate, activate and release granules. The platelets organelle zone is rich in platelet granules. Alpha granules contain clotting mediators such as factor V, factor VIII, fibrinogen, fibronectin, platelet-derived growth factors, and chemotactic agents. Delta granules, or dense bodies, contain ADP, calcium, serotonin, which are plateletactivating mediators. Activated platelets release granules by exocytosis which contain not only clotting factors but more than sixty different biologically active substances that are involved in processes of tissue regeneration, angiogenesis, epithelialization, proliferation and differentiation of osteoblasts, and in synthesis of collagen and extracellular matrix of connective tissue.
Use in Androgenetic Alopecia and Alopecia
Areata: EGF and FGF in PRP activate the proliferation and trans-differentiation of hair follicle stem cells and product new follicular units or rejuvenate dormant follicles. PRP has mitogenic as well as antiapototic effect and prolong survival of dermal papillae. PRP as standalone or as an adjunct to surgical procedures (along with follicular transplantation) holds promising results. PRP is injected as interfollicular region as 0.1 ml/sq cm area. Follicles ready for transplantation can be dipped for 15 min before transplantation to improve survival and take rate. PRP Product to be used: Concentrated PRP preparations (typically 7-10 times concentration of platelets) are used in these conditions without any added stimulant. Quantity required varies depending on condition and 1-3 ml PRP may be needed for injection.
Use of PRP in skin Rejuvenation :
What to expect:
Skin aging is a unpreventable, irreversible process which
is influenced by both intrinsic and extrinsic factors. ROS damage, fragmentation of collagen and elastin, degradation of extracellular matrix are few of the intrinsic factors. Different growth factors in PRP including PGDF, TGF, VEGF and IGF stimulate dermal fibroblasts thus leading to deposition of new collagen. PRP works better than many other therapies based on inducing mild inflammatory response.
Initially after injection slight discomfort or increase
in pain is expected for first 1-3 days as injected platelets give some inflammatory response. It subsides rapidly and may require mild analgesics initially. The injected platelets release growth factors over next one week and rapid reversal of original symptoms.
Please contact Dr. S K Hayatnagarkar, Cryobank Fertility Research Centre, Kamgar Chowk, N2, CIDCO Aurangabad Cell & Whatsapp: 9422725000, 9890900585