Escolar Documentos
Profissional Documentos
Cultura Documentos
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Citoplasma
ADN
Pared celular
Membrana
celular
Ribosomas
Flagelo
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Caractersticas
Bacilos Gram
Tienen flagelos y fimbrias
Protena : MIP (potenciador infectividad
del Macrfago)
Legiolisina fosfolipasa C.
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Patogenia
Patgeno intracelular.
Ingresa por inhalacin fagosoma:
multiplicacin activa de bacteria
bronconeumona-neumona.
Otros. Rin, bazo, etc.
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Clnica
Infec. Subclnicas
Enf, Legionarios:L. Pneumophila
Fiebre de Pontiac
Infecciones extrapulmonares:
piel
Nefritis pericarditis
Absceso. Peritonieal.
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Epidemiologa
Microorganismo . ubicuos
- Relacionado al ambiente
- Factores de amplificacin,
- Mecanismos de diseminacin
- Factores de virulencia
- Susceptibilidad del husped
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Diagnstico
Mtodo directo
Deteccin de Ag por Inmunofluorescencia.
Deteccin de nucleicos.
Aislamiento: BCYE
Mtodo indirecto serolgicos
Inmunofluorencia . Indirecta Elisa.
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Consolidacin del
lbulo superior
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Tratamiento
Eritromicina
Rifampicina
Azitromicina
Claritromicina
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PSEUDOMONA
AURUGINOSA
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Morfologia
BACILOS GRAM NEGATIVOS 1-3, 0, 51 um
CAPA POLISACRIDA LIMO.
FLAGELO POLAR
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Determinantes de patogenecidad
FACTORES CELULARES
ACTIVIDAD BIOLGICA
Fimbrias (pili)
Adherencia al epitelio
Flagelo
Movilidad, invasividad
Polisacrido envoltura
Exopolisacrido mucoide
(alginato)
LPS (lpido A)
Antgeno O
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FACTORES EXTRACELULARES
Proteasas (elastasa,
proteasa alcalina).
Exotoxina A
Exoenzima SR
Citotoxina
Fosfolipasas
Ferripioquelina (fpq)
Captacin de hierro
Pioverdina
Captacin de hierro
Piocianina
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Cuadros Clnicos
Infecciones del
tracto respiratorio
Endocarditis
Infecciones
menngeas
Infecciones
urinarias
Bacteriemias
Infecciones
gastrointestinales
Infecciones
osteoarticulares
Infecciones
cutneas
Infecciones
oculares
Infecciones ticas
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Diagnostico microbiolgico
Aislamiento
Identificacin
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Tratamiento
Carboxipenicilinas
cefalosporinas de 3 y 4 generacin:
Batalactmico + aminoglicosido.
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Epidemiologa
UBICUO
OPORTUNISTA
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Profilaxis y control
1. En el hospital aislamiento
2. Higiene individual. Infeccin
endgena
3. Vigilancia y control de fmites
4. Comit de infecciones: supervisin
5. Vacunas: quemados
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KLEBSIELLA
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CARACTERISTICAS
Fermentan la
lactosa
Bacilos Gram-
Forman colonias
mucoides y
hmedas
Descarboxilan
lisina
No mviles
K. oxytoca
K. pneumoniae
Dos especies :
K. ozaenae
K.
rhinoscleromatis
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MECANISMOS DE
PATOGENICIDAD
Cpsula (K)
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KLEBSIELLA
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Enfermedades
K.
Neumoniae
K.
Azaenae
K.
Rhinoscleromatis
Rinoscleroma
Inicia con catarro comn. Inflamacin granulomatosa de vas
nasales. Masas tumorales.
Estudio anatomopatolgico, muestra macrfagos espumosos.
Clulas gigantes y bacilos encapsulados.
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Tratamiento
Ciprofloxacina
TMP SM X
Cefalosporina antiseudomnica de
tercera generacin.
Rifampicina
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HELICOBACTER
PYLORI
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Morfologa y fisiologa
- Bacilo gram Negativo: curvo o Espiralado
- 0.51 um de ancho y 2,5-4 um de largo.
- Tiene 4-6 flagelos unipolares
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No Gstricas
H. fennelliae
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Determinantes de Patogenicidad
Patogenia
Movilidad
Adhesinas
Ureasa
Citotoxina vacuolante
Otros: Protena CagA, dismutasa de
superxido, lipopolisacrido.
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lcera Duodenal
Carcinoma o
linfoma MALT
Colonizacin
Gastritis
lcera Gstrica
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Manifestaciones Clnicas
Gastritis aguda.
Intoxicacin
alimentaria
Gastritis Crnica
superficial difusa
Ulcera Gstrica o
Duodenal
Gastritis Crnica
Atrfica
Adenocarcinoma
Gstrico
Linfoma Gstrico
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GASTRITIS CRNICA
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GASTRITIS CRNICA
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Diagnstico
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Sensitivity/Specifity
(%)
Cost ($)
95/80 99
50-100
Special Stains
90/99
200
Culture
60-90/100
150
Ureasa tests
90/95
10
Quantitative ELISA
85-90/85-90
500-100
Qualitative serum
90/90
10-15
85-90/90
10-15
95/95
280
95/95
60
Nonendoscopic Test
Antibody tests
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Tratamiento
Antibacterianos, bismuto y
antiulceroso.
Epidemiologa
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