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Original Article
Amin et al.
Int J Pharm Pharm Sci, Vol 6, Issue 6, 89-93
adopted for FTIR experiment and samples were scanned over the
range of 4000400 cm-1.
X-Ray Diffraction
These results are consistent with previous studies [4] reporting that
the size of NaOH-water hydrates; which plays a primary role in
cellulose dissolution, is concentration-dependent. Native cellulose
chains are very dense with an inter-sheet distance of about 10 A
and a crystalline diameter of only 10 nm. Hence, at low NaOH
concentrations, these hydrodynamic diameters of NaOH-water
hydrates may be too large to penetrate the crystalline region;
alternatively, the quantity of NaOH may be insufficient to dissolve
the cellulose. By contrast, at higher concentrations, the NaOH
molecule may position itself more closely towards the cellulose
chain and form soda cellulose I. Soda cellulose I is capable of
absorbing more alkali solution and converting into soda cellulose II,
which is apparently water soluble [4].
Amin et al.
Int J Pharm Pharm Sci, Vol 6, Issue 6, 89-93
urea concentration increased, the band split into two absorption
peaks at 1665 and 1635 cm-1. The latter peak was allocated to the
OH of the water absorbed from the cellulose.
Fig. 2: X-ray diffraction data of regenerated bacterial cellulose treated with (a) different concentration of urea, (b) different concentration
of NaOH, (c) different concentration of NaOH/urea.
91
Amin et al.
Int J Pharm Pharm Sci, Vol 6, Issue 6, 89-93
Fig. 3: Comparative FTIR spectra of regenerated bacterial cellulose treated with (a) different concentration of urea, (b) different
concentration of NaOH, (c) different concentration of NaOH/urea.
Table 1: Formulation code for regenerated bacterial cellulose on the basis of solvent composition for bacterial cellulose and percentage
solubility of BC
Formulation code for regenerated cellulose
0-0
0-2
0-4
0-6
2-0
2-2
2-4
2-6
4-0
4-2
4-4
4-6
6-0
6-2
6-4
6-6
8-0
8-2
8-4
8-6
10-0
10-2
10-4
10-6
Solubility of BC
(%)
0
0
0
0
3.650.95
5.151.35
6.590.67
6.800.72
17.111.53
20.700.87
23.770.85
24.221.53
29.220.95
32.742.52
36.080.84
36.741.37
40.650.86
43.751.08
45.311.19
46.070.75
43.162.07
45.352.26
46.821.46
46.531.75
92
Amin et al.
Int J Pharm Pharm Sci, Vol 6, Issue 6, 89-93
Table 2: Relative crystallinity of regenerated cellulose
% w/v Ratio of NaOH/Urea
0/0
0/2
0/4
0/6
2/0
4/0
6/0
8/0
10/0
CONCLUSION
In summary, the work reports the effect of alkali treatment with
urea on bacterial cellulose solubility, structure and crystallinity,
along with the effect on hydrogel appearance and swelling
properties. From X-ray diffraction and FTIR analysis it was found
that sodium plays important role in transformation of cellulose I to
II more than 2% NaOH concentration. Urea doesnt affect structure
and crystallinity alone but in presence of NaOH it increased the
mercerisation process of BC.
CONFLICT OF INTERESTS
Declared None
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0.93
0.93
0.94
0.93
0.88
0.73
0.70
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