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ROSE PHARMACY JAIPUR
GPAT / NIPER (JEE) / DI

Model Test Paper 8

Max. Marks: 300

ROSE PHARMACY GPAT

Time: 3 hours

JA
IP

UR

(Subject:- Pharm. Analysis)

Instructions
1. All questions are multiple choice objective, you have to select one correct answer.
2. There are 100 questions in question paper. Each question contains three marks.
3. There will be (one third) negative marking for each wrong answer.

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Q.1
Calculate the max of the given structure.
a) 250
b) 320
c) 348
d) 387
Q.2 What will be the effect of hydrogen bonding on vibrational frequency in I.R spectra?
a) Increase the wave number b) decrease the wave number c) decrease the wave
length d) Does not effect the wavelength
Q.3 In I.R. bending vibrations (Deformations), the movement of atoms takes place in the
same direction is known as
a) Scissoring
b) Rocking
c) Wagging
d) Twisting
Q.4 Which one of the following factors does not affect the chemical shift?
a) Inductive effect b) Anisotropic effect c) Concentration d) hydrogen bonding
Q.5 Bathochromic shift is also known as
a) Hypochromic shift b) Hyper chromic shift c) Red shift d) hypsochromic shift
Q.6 Which one of the following drugs is assayed by dissolving in glacial acetic acid and
titrated with standard perchloric acid using orcet blue as indicator
a) Paracetamol IP b) Salbutamol sulphate IP c) Isoniazid IP d) Aspirin IP
Q.7 One of these detectors is not used in gas chromatography
a) Flame Ionization b) Thermal conductivity c) Golay
d) Electron capture
Q.8 Nuclear magnetic movement is shown by
a) 12C
b) 16O
c) 32S
d) 15N
Q.9Which types of radiation has the wavelength between 2.5-50 m in electromagnetic
Spectrum?
a) UV light
b) Near IR
c) Mid-IR
d) Far IR
Q.10 Free radical substances showing paramagnetism due to the magnetic movement of
unpaired electron, Which spectroscopy is applied for its determination?
a) NMR
b) ESR
c) IR
d) PMR
Q.11 Conductance cells for conductivity measurements can be made from one of the
Following metal
a) Potassium
b) Sodium
c) Platinum
d) Stainless Steel
Q.12 The Scientists were awarded Noble Prize in Physics for Phenomenon of NMR
a) Henery and Moseley
b) Flix Bloch and Edward M. Purcell
c) Beer and Lambert
d) Frederic William Herschel
Q.13 Absorption band originates due to n-* transition of a single chromophoric group is
a) K-band
b) B-band
c) E-band
d) R-band
Q.14 What will be the wave number of infrared light of wavelength 10 m?

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a) 100 cm-1
b) 1000 cm-1
c) 104 cm-1
d) 105 cm-1
Q.15 A detector woks on the principle that if wires of two dissimilar metals are joined
head to tail, then a difference in temperature between both causes a current to flow
a) Bolometer
b) Photovoltaic
c) thermocouple
d) pneumatic
Q.16 Calculate the molar absorptivity, , for a solution containing 1.0 mmol dm-3
(1.0 10-3 mole per liter) of solute, when the absorbance of 1cm cell was 1.5
a) 1200
b) 1500
c) 900
d) 5000
Q.17 Mass-Mass spectrometer is also known as
a) Double focusing b) Electrospray desorption c) Tandem d) Quadrupol
Q.18 If Molecular weight of parent ion is 77 and further it breaks in Metastable ion and
daughter ion of molecular weight 51. Then calculate metastable ion.
a) 48.2
b) 33.4
c) 63.2
d) 48
Q.19 If analytical work has to be carried out in UV region, cuvette must be made up of
a) Gelatin
b) Glass
c) Plastic
d) Quartz
Q.20 The source of radiation used in I.R. spectroscopy
a) Nernst glower b) sodium lamp c) Deuterium lamp d) Tungsten lamp
Q.21 Reduction in the intensity of fluorescence is called as
a) Suppression
b) Depression
c) Sedation
d) Quenching
Q.22 In TLC plates, which one spraying agent is used for alkaloid sample?
a) 2,4-dinitrophenyl hydrazine b) Mercuric nitrate
c) Antimony trichloride
d) aniline phthalate
Q.23 The transition between a triplet excited state and singlet excited state is known as
a) allowed
b) forbidden
c) both
d) none of these
Q.24 The time from point of injection of sample to the time of elution of separated
Component from the column is known as
a) Retention time
b) Retardation time
c) separation time
d) mean time
Q.25 Silver-silver chloride reference electrode is made up of
a) copper wire coated with copper chloride b) Sodium wire coated with sod. chloride
c) Mercury with calomel
d) Silver wire coated with silver chloride
Q.26 In polarography any change in diffusion current is denoted by
a) Ilkovic equation b) Nernst Equation c) Arrhenius equation d) Stock equation
Q.27 In acid base titration ..electrode is used as indicator electrode.
a) Platinum
b) Glass
c) Mercury
d) Silver
Q.28 is used as supporting material in column in size exclusion chromatography.
a) ODS
b) TMS
c) Agarose
d) none of these
Q.29 Sulpha drugs are assayed by diazotization method, the titrant is used
a) Sodium nitrate
b) Sodium nitrite
c) Silver nitrite
d) Silver nitrate
Q.30 Captopril IP is assayed by titration
a) against 0.1N sodium hydroxide using phenolphthalein indicator b) of a solution in
dimethyl- formamide with 0.1M of tetrabutyl ammonium hydroxide. c) of a solution
in anhydrous formic acid and acetic anhydride with 0.1N perchloric acid
d) of a
solution containing 1.8M sulphuric acid and potassium iodide with 0.025M potassium
iodate using starch solution.
Q.31 Platinum foil is coated with platinum black in which type of electrode?
a) Hydrogen
b) Glass
c) Mercury
d) Silver
-1
Q.32 The equation = Sin (n 2d) is known as

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a) Nernst equation b) Iikovic equation c) Braggs equation d) Arrhenious equation

Q.33 The angle between the direction of the incident beam and that of the diffracted
Beam is
a)
b) 2
c) 3
d) 4
Q.34 The wave number 3000-3100 cm-1 is characteristic for the band
a) C=O
b) O-H
c) C-H (aromatic) d) C N
Q.35 A dilute sulphuric solution is treated with 0.1 N ceric ammonium sulphate using
ferrotin indicator is used for titration of
a) Sulfadiazine tablet I.P. b) Salbutamol sulfate I.P. c) Riboflavin tablets I.P.
d) Ascorbic acid tablet I.P.
Q.36 If molecule size is greater than 2000 than it can be separated by
a) HPLC b) HPTLC c) Size exclusion chromatography
d) Gas-mass
Q.37 In reverse phase HPLC
a) Stationary phase is polar and mobile phase is non polar b) stationary phase is non
polar and mobile phase is polar c) both phase are polar d) both phase are non polar
Q.38 The current remains zero and graph is plotted between E versus volume of titrant in
a) Amperometric titrations
b) Potentiometric titrations
c) Conductometric titrations
d) Voltametry
Q.39 Re-emission of previously absorbed radiation is phenomenon of
a) Scattering
b) Flame Photometry
c) Luminescence
d) Absorbance
Q.40 Ferrous ion is very weakly colored for colorimetric analysis. It can be converted
Into a highly colored complex using
a) H2SO4
b) PDAB
c) Thymol blue
d) 1:10-Phenanthroline
Q.41 -* and n-* electronic transitions are possible in
a) Benzene
b) Toluene
c) Bromine
d) Naphthalene
Q.42 the number of peaks shown by Iso propyl alcohol in an NMR spectrum is
a) Four
b) Two
c) three
d) Five
Q.43 In flame photometry, the flame temperature is attained by
a) Acetylene
b) Hydrogen
c) Propane
d) all
Q.44 If the induced field reinforces the applied field the proton will be in NMR
a) Shielded
b) deshielded
c) no effect
d) red shift
Q.45 A mixture of the following gases can be used in flame photometry to get a
Temperature 31400C
a) Hydrogen& nitrous oxide b) Acetylene & oxygen c) Hydrogen & air
d) Hydrogen & oxygen
Q.46 Tesla is a unit used to express
a) Frequency
b) Pressure
c) Voltage
d) Magnetic field strength
Q.47 A Polychromatic light source is used in
a) UV spectrometer b) FT-IR spectrometer c) Spectroflurimeter d) IR spectrometer
Q.48 E1% 1cm (Absorptivity) of paracetamol is 740 and molecular weight is 151.6 than calculate
molar absorption cofficient,
a) 1121.84
b) 11218.4

c) 112.184

d) none of these

Q.49 Calculate max for 2, 4 pentadiene

a) 215
b) 220
c) 217
d) 222
Q.50 Calculate the max for the p-hydroxybenzaldehyde in nm. Base value for
Benzaldehyde in ethanol is 250 nm
a) 253
b) 275
c) 261
d) 270
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Q.51 the B.P. assay of Nifedipine is by titration of a

a) solution in anhydrous acetic acid with 0.1M perchloric acid b) solution in
previously neutralized acetone with 0.1N sodium hydroxide; end point by
potentiometry c) solution in previously neutralized acetone against standard
potassium dichromate solution d) A solution in 2-methyl- 2- propranol and
perchloric acid with 0.1M cerium sulphate using ferroin as indicator
Q.52 Which one of equation is related to column chromatography
a) id = 708 nCD m2/3 t1/6 b) VR = tR Fc c) E = E0 RT log [H+]/n F d) A = bc
Q.53 Polarography can be used for the
a) To study fluorescent material b) Study of resistance of a solution c) Study of
current potential relationship d) Study of optical activity of organic molecules
Q.54 Derivatization is done in gas chromatography for
a) Improve the thermal stability of compounds b) Change the separation properties
of compounds by the purposeful adjustment of their volatility c) introduce a detector
oriented tag into a molecule d) All of these
Q.55 How many signals are produced by methyl cyclopropane?
a) two
b) three
c) four
d) five
Q.56 Hydrogen absorbency index and nitrogen rules are related to
a) UV Spectroscopy b) IR Spectroscopy c) NMR Spectroscopy d) Mass Spectroscopy
Q.57 The Flame ionization detector is the most popular detector because of its
a) High sensitivity b) Short range of linearity c) Low reliability d) Universal response
Q.58 Which one of these is not a hyphenated technique?
a) GC-MS
b) GC-IR
c) FT-IR
d) MS-MS
Q.59 A thermistor detector functions by changingwhen heated
a) Frequency
b) Pressure
c) Voltage
d) Resistance
Q.60 In NMR if the atom contains three nearby protons then these will produce
a) Doublet
c) Triplet
c) Quartet
d) Sestet
Q.61 0.25 g of a compound C10H15NO.HCl was titrated with 0.1 M HClO4.it consumed
12.5 ml of the titrant, Calculate the percentage purity of given sample
a) 98.3
b) 99.25
c) 94.72
d) 100.75
Q.62 Erichrome black T is used indicator in which type of titration?
a) Neutralization b) Precipitation
c) Redox
d) Complexometric
Q.63 PYRIDOXINE HCl IP is dissolved in glacial acetic acid and then the inorganic
reagent is added. What is the name of inorganic agent?
a) Potassium Methoxide solution
b) Mercuric acetate solution
c) Tetra butyl ammonium hydroxide solution d) Ceric ammonium sulphate solution
Q.64 Which one of the following solvent is not used in NMR Spectroscopy?
a) Carbon di sulfide b) Deuterated chloroform c) Carbon tetra chloride d) Water
Q.65 The reference material used in NMR Spectroscopy is
a) Trimethyl silane
b) Tetramethyl silane
c) Both of these d) None of these
Q.66. produced in the fragmentation cannot be detected in the mass spectrometer.
a) Neutral molecules b) Molecular ions
c) Metastable ions d) Parent ions
Q.67 The pyroelectric detectors use ferroelectric materials operating below Curie point
temperature is composed of
a) Oxides of Mn, Co and Ni b) Bi-Sb c) Xenon d) Triglycin sulphate
Q.68 The most widely used material for preparing infrared cells for liquid samples and

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discs for solid samples is

a) Potassium bromide b) Potassium chloride c) Sodium bromide d) Calcium bromide
Q.69 The main sources of infrared radiation used in spectrophotometers are except
a) the Nernst glower
b) Nicrome wire wound on ceramic support c) Mercury
vapour lamp d) The Globar, a bonded silicon carbide rode
Q.70 The wave number 1720-1740 cm-1 for carbonyl group is characteristic band for
a) Aldehyde
b) Ketone
c) acid
d) Esters
Q.71 What is approximate wavelength of green color?
a) 450-500 nm b) 500-570 nm c) 570-590 nm
d) 590-620 nm
Q.72 Sorensen apparatus is used for determination of
a) Crystal growth b) pH scale
c) HLB value d) Interparticular force
Q.73 Chlormbucil is assayed as per IP by titrating a dilute acetone soln of the drug with
a) 0.1 M sodium hydroxide
b) 0.1 M hydrochloric acid
c) 0.2 M perchloric acid
d) 0.1 M silver nitrate
Q.74 Official assay for the Glibenclamide is by titration using a standard solution of
a) Sodium nitrite b) Iodine c) Potassium permanganate d) Sodium hydroxide
Q.75 what will be the range of finger print region in cm-1 (wave number)
a) 5000-1600
b) 8000-1600
c) 1600-600
d) 3000-1600
Q.76 In Fluorescence, the energy is emitted by
a) Singlet
b) triplet
c) radical
d) none
Q.77 The Potential at the point on the polarographic wave where the current is equal to
one half of the diffusion current is termed as
a) Half wave current b) full wave Current c) half wave Potential d) full wave Potential
Q.78 Which one is not a reference electrode
a) Silver-silver chloride b) Mercury- calomel c) Dropping mercury d) hydrogen
Q.79 What will be the unit of molar conductivity?
a) mho
b) -1cm-1
c) -1cm2mol-1
d) -cm
Q.80 In Conductometric titrations, one of the following is evaluated by calibration with
0.1M potassium chloride
a) distance between two electrodes b) Cell constant c) area of cross section of each
electrode
d) Platinum wire of electrode
Q.81 In Mass spectroscopy, positive charged in can be produced by
a) Heating the sample
b) Bombarding the sample with high energy electrons
c) Bombarding the sample with high energy protons d) Bombarding the sample with
high energy photons
Q.82 If a proton is coupled with N other equivalent protons the number of peaks in
multiplet is N+1 and the relative intensities of these multiplets are determined by
a) Cram's rule
b) Pascal's triangle
c) Chemical shift
d) Bedth's rule
Q.83 Parts per million (PPM) is unit for measurement of
a) Coupling constant b) Wave number
c) Base peak d) Chemical shift
Q.84 In Mass Spectra, the peak that has highest relative abundance (100%) is know as
a) Base
b) Metastable ion
b) Fragment ion d) Rearrangement ion
Q.85 What is the mechanism of liquid liquid chromatography for seperation of samples
a) Adsorption
b) Partition
c) Absorbtion
d) None of these
Q.86 Octadecyl silane (C-18) column is used in.............chromatography.
a) Ion Pair
b) Size Exclusion
c) Bonded Phase d) Ion exchange

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Q.87 Pulse damper is used with which type of reciprocating piston pumps
a) Single head
b) Dual head
c) Triple head
d) None of these
Q.88 A sample is injected onto a given column and mobile phase is unchanged throughout
the time required for sample components to elute from the column is known as
a) Gradient elution b) Solvent programming c) Mobile phase elution d) Isocratic elution
Q.89 The simplest form of preparative thin layer chromatoghraphy is to use
a) glass plate
b) aluminium plate
c) coated plate
d) Uncoated plate
Q.90 What is the use of T.L.C.
a) To establish the purity and authenticity of starting material b) To monitor the reaction
c) To check the isolation and purification procedures d) All of these
Q.91 The energy absorbed in............produces changes in rotational, vibrational, and elctronic
energy of the molecule
a) U.V. region
b) I.R. region
c) NMR region d) Microwave region
Q.92 What is the wave length of microwave that are used to produce electron spin resonance
a) 10 nm-100 nm
b) 100 nm-1000 nm
c) 1 mm-30 cm
d) 100 cm-500 cm
Q.93 Ionic mobility is denoted by
a) cm/sec
b) degree Celcius/sec
c) mg/sec
d) none of these
Q.94 Which is used for dispersing the incident radiation in UV spectroscopy?
a) Nicol Prism b) Diffraction grating c) Both of these d) none of these
Q.95 The Work of Heyrovsky is related to the discovery of .........technique for which he
received the Noble prize in 1959.
a) Potentiometry
b) Polarimetry
c) Polarography
d) Amperometry
Q.96 When the potential applied across two electrode is maintained at some constant
value, the current is measures and plotted against the volume of the titrant is known as
a) Potentiometry
b) Conductometry
c) Polarography
d) Amperometry
Q.97 The substituent that delocalizes the pi electrons and enhances the fluorescence is
a) -Cl
b) -NO2
c) -NH2
d) -COOH
Q.98 Which one of these is not a emission spectroscopy
a) Fluorimetry
b) Fluorescence
c) Phosphorescence
d) Infrared
Q.99 Which one is not used as oxidant in Flame emission spectroscopy?
a) Air
b) Nitrous oxide
c) hydrogen
d) Oxygen
Q.100 The ratio of cell constant and resistance in Conductometric titration is known as
a) EMF b) Specific conductance c) Standard potential d) none of these

Answer Key (Pharma analysis) Model Test paper-8

4.c
19.d
34.c
49.d
64.d
79.c
94.c

5.c
20.a
35.d
50.b
65.b
80.b
95.c

6.b 7.c
21.d 22.b
36.c 37.b
51.d 52.b
66.a 67.d
81.b 82.b
96.d 97.c

SE

3.b
18.b
33.b
48.b
63.b
78.c
93.a

RO

1.c 2.b
16.b 17.c
31.a 32.c
46.d 47.b
61.d 62.d
76.c 77.c
91.a 92.c

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8.d
23.b
38.b
53.c
68.a
83.d
98.d

9.c 10.b 11.c 12.b 13.d 14.b

24.a 25.d 26.a 27.b 28.c 29.b
39.c 40.d 41.c 42.c 43.d 44.b
54.d 55.c 56.d 57.a 58.c 59.d
69.c 70.a 71.b 72.b 73.a 74.d
84.a 85.b 86.c 87.a 88.d 89.c
99.c 100.b

15.c
30.d
45.b
60.c
75.c
90.d