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Overview
If you are fascinated by the effects chemicals can have on the human body, this may be the career for
you. Forensic toxicologists perform scientific tests on bodily fluids and tissue samples to identify any
drugs or chemicals present in the body.
As part of a team investigating a crime, a forensic toxicologist will isolate and identify any substances
in the body that may have contributed to the crime, such as:
Alcohol
Other chemicals
Poisons
Metals
Working Conditions
Most forensic toxicologists work in labs run by law enforcement agencies, medical examiners or private
drug testing facilities. They often must sit or stand for long periods of time. The tests they perform
require very fine motor skills and a dogged commitment to following rigorous scientific protocols.
Working with bodily fluids and tissue samples can be messy and smelly. The forensic toxicologist is also
exposed to details about crimes, which can be emotionally difficult.
The workload can be significant, and when the samples come from a crime scene, the pressure to
perform tests faster can be strong. The forensic toxicologist must be able to resist this pressure, work
efficiently without rushing and prioritize effectively
Cyanide toxicity is generally considered to be a rare form of poisoning. However, cyanide exposure occurs
relatively frequently in patients with smoke inhalation from residential or industrial fires. In addition, intensive
treatment with sodium nitroprusside or long-term consumption of cyanide-containing foods is a possible source
of cyanide poisoning. Historically, cyanide has been used as a chemical warfare agent, and it could potentially
be an agent for a terrorist attack.[1, 2]
Cyanide exists in gaseous, liquid, and solid forms. Hydrogen cyanide (HCN, also known as prussic acid) is a
volatile liquid that boils at 25.6 C (78.1 F). Potassium and sodium cyanide salts are water soluble; mercury,
copper, gold, and silver cyanide salts are poorly water soluble.
In addition, a number of cyanide-containing compounds, known as cyanogens, may release cyanide during
metabolism. These include, but are not limited to, cyanogen chloride and cyanogen bromide (gases with potent
pulmonary irritant effects), nitriles (R-CN), and the vasodilator nitroprusside sodium, which may produce
iatrogenic cyanide poisoning during prolonged or high-dose intravenous (IV) therapy (>10 mcg/kg/min). (See
Etiology.)
Industry widely uses nitriles as solvents and in the manufacturing of plastics. Nitriles may release HCN during
burning or when metabolized after absorption by the skin or gastrointestinal tract. A number of synthesized and
natural compounds produce HCN when burned. These combustion gases likely contribute to the morbidity and
mortality from smoke inhalation. Finally, long-term consumption of cyanide-containing foods, such as cassava
root or apricot seeds,[3] may lead to cyanide poisoning.
Depending on its form, cyanide may cause toxicity through inhalation, ingestion, dermal absorption, or
parenteral administration. Clinical manifestations vary widely, depending on the dose and route of exposure,
and may range from minor upper airway irritation to cardiovascular collapse and death within minutes.
(See Clinical Presentation.) In severe cases, rapid, aggressive therapy consisting of supportive care and
antidote administration can be lifesaving. (See Treatment andMedication.)