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Pulsating quality
Moderate or severe pain intensity
Aggravation by or causing avoidance of routine physical
activity (eg, walking or climbing stairs)
Third, during the headache the patient experiences at
least 1 of the following:
Vascular theory
In the 1940s and 1950s, the vascular theory was proposed
to explain the pathophysiology of migraine headache.
Wolff et al believed that ischemia induced by intracranial
vasoconstriction is responsible for the aura of migraine
and that the subsequent rebound vasodilation and
activation of perivascular nociceptive nerves resulted in
headache.
Magnesium deficiency
[24]
particularly in certain subsets of migraine patients.
Endothelial dysfunction
Vascular smooth muscle cell dysfunction may involve
impaired cyclic guanosine monophosphate and
hemodynamic response to nitric oxide.[25] Nitric oxide
released by microglia is a potentially cytotoxic
proinflammatory mediator, initiating and maintaining
brain inflammation through activation of the trigeminal
neuron system.
Etiology
Migraine has a strong genetic component. Approximately
70% of migraine patients have a first-degree relative with
a history of migraine. The risk of migraine is increased 4fold in relatives of people who have migraine with aura.[30]