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Brand Name:
Apo-Ranitidine (CAN),
CO Ranitidine (CAN),
Gen-Ranitidine (CAN),
Novo-Ranitidine, (CAN),
Nu-Ranit (CAN),
ratio-Ranitidine (CAN),
Zantac,
Zantac EFFERdose,
Zantac GELdose,
Zantac 75,
Zantac 150
Classification:
Pregnancy Category B
Adults
Active duodenal ulcer: 150 mg bid PO for 48 wk. Alternatively, 300 mg PO once
daily at bedtime or 50 mg IM or IV q 68 hr or by intermittent IV infusion, diluted to
100 mL and infused over 1520 min. Do not exceed 400 mg/day.
Pediatric
For creatinine clearance < 50 mL/min, accumulation may occur; use lowest dose
possible, 150 mg q 24 hr PO or 50 mg IM or IV q 1824 hr.
Therapeutic actions
Ranitidine blocks histamine H2-receptors in the stomach and prevents histamine-mediated
gastric acid secretion. It does not affect pepsin secretion, pentagastrin-stimulated factor
secretion or serum gastrin.
Indications
Adverse effects
Contraindications
Porphyria.
Nursing considerations
Assessment
Physical: Skin lesions; orientation, affect; pulse, baseline ECG; liver evaluation,
abdominal examination, normal output; CBC, LFTs, renal function tests
Interventions
Teaching points
Take drug with meals and at bedtime. Therapy may continue for 46 weeks or
longer.
If you also are using an antacid, take it exactly as prescribed, being careful of the
times of administration.
You may experience these side effects: Constipation or diarrhea (request aid from
your health care provider); nausea, vomiting (take drug with meals); enlargement
of breasts, impotence or decreased libido (reversible); headache (adjust lights
and temperature and avoid noise).
Report sore throat, fever, unusual bruising or bleeding, tarry stools, confusion,
hallucinations, dizziness, severe headache, muscle or joint pain.