Escolar Documentos
Profissional Documentos
Cultura Documentos
02/12/15 7:58 pm
Using this site means you're happy for us to use a few essential cookies to keep it going. Full details can be found here.
Hydrolysis of ATP
Written by Tim Sheppard MBBS BSc. Last updated 9/11/10
Follow blobs.org |
Share this page
Print
Facebook
Gmail
Favorites
Twitter
Email
More... (272)
AddThis
http://www.blobs.org/science/article.php?article=30
Page 1 of 2
02/12/15 7:58 pm
Next consider the phosphate group. It is amphoteric which means that it can both
donate and accept protons. This is clear from its structure. If the solution it is in
has a low pH (i.e. lots of hydrogen ions kicking about) then it doesn't need to offer
any, and it will keep them for itself - i.e. there will be no negatively charged
oxygens, only -OH groups. However, if the pH is high (i.e. very few hydrogen ions
kicking about) then the phosphate will donate some to the solution, and will end up
with no hydrogen ions, only negatively charged oxygens.
Physiological pH (i.e. the pH that exists in most cells in the body) is about 7.4 which is fairly neutral.
This means that a phosphate group will exist with just one hydrogen ion attached, and the remaining
oxygens all free.
In the hydrolysis of ATP, as shown in the animation at the top, there is a hydrogen ion left over at the
end. This is because at physiological pH, the phosphate group only wants its one hydrogen atom. Since
it has that, the other hydrogen atom just has to float about. Therefore, at physiological pH, the
hydrolysis of ATP will produce 3 things, despite only starting with two. This means that the system has
become more disordered (because 3 is more disordered than 2) and there has been an increase in
entropy
entropy, which means that the free energy will become even more negative.
Other factors which are considered include the presence of magnesium ions in most cells; since they
have a 2+ charge, they reduce the repulsion between the negative charges on the phosphate groups,
which means that instead of such a large enthalpy change, it is left at 30.5kJ/mol.
Finally, however, consider that the whole system is an equilibrium
equilibrium. According to Le Chatelier's
Principle
Principle, if there is a build up of a particular chemical involved, then the equilibrium will shift to oppose
that change. Imagine that there was a build up of ATP; the equilibrium would shift to oppose that
change, meaning that more ADP would be produced.
In the body, this is exactly what happens. All the processes of metabolism are
set up to produce more and more ATP, which means the reaction will want to
happen to produce more ADP from the ATP - put in basic terms, there will be
more energy released from the ATP ADP reaction, because it wants this to
happen more.
When we consider the amount of energy produced by the hydrolysis of ATP, we
consider all of these factors together. Although the textbooks will tend to
quote 30.5kJ/mol or 7.3kcal/mol for the value of energy released upon
hydrolysis, if you take into account the high concentration of ATP that
accumulates in human cells, the energy released from hydrolysis of ATP may be
given as about 49kJ/mol, or 11.7kcal.mol. Which is, obviously, a lot!!
Essentially, it's best to look beyond the bond enthalpies to explain why ATP releases so much energy
upon hydrolysis. It's not simply a case of considering formation of different bonds, but of considering
that the formation of the products is favourable - it creates a system that is much 'happier', which
means the reaction will release energy.
Further Reading
Unfortunately some of the articles are currently missing a bibliography. This is being rectified as quickly
as possible, so do check back again soon.
http://www.blobs.org/science/article.php?article=30
Page 2 of 2