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Introduction
Aerent
Tracheabronchial tree
Eerents
Modulation at
CNS cortex
CNS Center
Eector organ
Larynx, trachea
and bronchi
Vagus
Vagus
Cough Center:
Medulla,
Nucleus
tractussolitarius
Phrenic
Diaphragm
Spinal
motor
Expiratory muscles
10
11
12
Table 2 : Patients who achieved the clinical endpoint (improvement of >75%) for various parameters during the study period
CS1 (n=132)
CS2 (N=131)
CS3 (N=104)
Day3
Day7
Day3
Day7
Day3
Day7
36 (27.48)
102 (77.86)
37 (33.94)
109 (100)
Cough Frequency
44 (33.33)
111(84.09)*
85 (64.89)
124 (94.6)
69 (63.3)
105 (96.3)
Frequency of Night Awakenings
85 (64.39)
117 (88.64)$
Playing activity score
64 (48.48)
101 (76.52)
68 (47.71)
96 (75.23)
52 (46.85)
82 (73.87)
Appetite Score
59 (44.71)
97 (73.48)
56 (40.37)
96 (71.56)
44 (39.64)
78 (70.27)
Behavior Score
69 (52.27)
105 (79.5)
73 (55.73)
100 (76.34)
59 (53.15)
91 (81.98)
Global Assessment of Wellbeing
56 (42.42)
70 (53.03)
46 (35.11)
57 (43.51)
38 (34.86)
63 (57.8)
#
Figures in parentheses indicate the percentages; *p<0.05, comparison versus CS-3 for day 7; $p<0.05, comparison versus CS-2 and CS-3 for day 7;
p>0.05, for all other individual comparisons of CS-1 with CS-2/Cs-3 for respective days.
Parameter#
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