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PROLIFERATIVE ACTIVITY
Labile tissue
Adult stem cells
Proliferate throughout life
Surface epithelia, lining of GIT , uterus
Hematopietic tissue
STEM CELLS
Self renewal
Bone marrow
Skin
POTENCY OF CELLS
Totipotent stem cells
Differentiate into embryonic & extraembryonic cell types
Cells produced by the first few divisions of the fertilized egg
TRANSDIFFERENTIATION
CELL CYCLE
G1- presynthetic
S - DNA synthesis
G2 - Premitotic
M - Mitotic
G0- Quiescent
Restriction point
G1/S transition
DNA replication
Cyclins
CDK inhibitors
EXTRACELLULAR MATRIX
Provides structural and biochemical support to the surrounding cells
Cell adhesion
Cell-cell communication
Growth & differentiation of cells
Scaffolding for tissue renewal
Storage & release of regulatory subtances
Interstitial matrix
Found between cells, in connective tissue
Basement membrane
Associated with cell surface
COLLAGEN
Most abundant protein
27 types of collagen
Fibrillar collagens
COLLAGEN
mRNA
Pre pro chains trimers
Hydroxylation of proline & lysine residues (VIT C)
Procollagen
Cleaved by proteases
Oxidation of lysine&hydroxylysine
Crosslinking