Abstrak

PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN GAHARU (Aquilaria microcarpa

Baill.) TERHADAP NILAI ACTIVATED PARTIAL THROMBOPLASTIN TIME DAN
PROTROMBIN TIME PADA TIKUS JANTAN

Daun gaharu (Aquilaria Microcarpa Baill.) memiliki kandungan senyawa flavonoid dan tanin yang
berpotensi sebagai antikoagulan. Penelitian ini bertujuan untuk membuktikan pengaruh pemberian
ekstrak etanol daun A. microcarpa terhadap nilai activated partial thromboplastin time dan
protrombin time pada tikus jantan. Dua puluh tikus jantan dibagi menjadi 5 kelompok. Kelompok 1
(kontrol normal), II (kontrol positif), III, IV, V (ekstrak etanol daun A.microcarpa dosis 125
mg/KgBB, 250 mg/KgBB dan 500 mg/KgBB). Hewan uji diberi perlakuan selama 14 hari. Hasil
penelitian menunjukan rata-rata nilai activated partial thromboplastin time berturut-turut yaitu
20,20; 32,05; 23,15; 22,85; 20,40, dan rata-rata nilai protrombin time berturut-turut yaitu 22,05;
39,55; 31,50; 23,27; 23,05. Hasil statistik menunjukan ada perbedaan nyata pada protrombin time,
namun tidak ada perbedaan nyata pada activated partial thromboplastin. Oleh karena itu dapat
disimpulkan bahwa ekstrak etanol daun A. microcarpa dapat memperpanjang nilai protrombin time
yang menunjukan adanya efek pada jalur ekstrinsik sementara pada activated partial
thromboplastin tidak mempengaruhi sehingga menunjukan tidak adanya efek pada jalur intrinsik.
Kata kunci : Ekstrak gaharu, activated partial thromboplastin time, protrombin time

Abstract
THE EFFECT OF ETHANOL EXTRACT OF GAHARU LEAVES (Aquilaria microcarpa Baill.)
ON THE VALUE OF ACTIVATED PARTIAL THROMBOPLASTIN TIME AND PROTROMBIN
TIME IN MALE RATS
Gaharu leaves (Aquilaria microcarpa Baill.) contains of flavonoid compound and tannin which is
potentially could heal the wounds. The objective of this research is to prove the effect of ethanol
extract of A. microcarpa on the value of activated partial thromboplastin time and protrombin time.
Twenty rat strains wistar are divided into 5 groups. Group I (negative control), II (positive control),
III, IV, V (ethanol extract of A. microcarpa leaves dosage 125mg/KgBB, 250mg/KgBB and
500mg/KgBB respectively). The subject is given the treatment for 14 days. The research result
shows mean of activated partial thromboplastin time 20,20; 32,05; 23,15; 22,85; 20,40, and the
research result shows mean of protrombin time 22,05; 39,55; 31,50; 23,27; 23,05.The statistic result
shows that there is a significant difference of protrombin time but there is no significant difference
of activated partial thromboplastin time. The results suggested that the ethanol extract of A.
microcarpa leaves prolonged protrombin time, suggesting its possible effects on the extrinsic
pathway, while activated partial thromboplastin time was not altered suggesting that it may have no
effects on the intrinsic pathway.

Keywords : gaharu extract, activated partial thromboplastin time, protrombin time