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UNIVERSITY OF BELIZE

FACULTY OF NURSING AND ALLIED HEALTH


Course Title: Pharmaceutical Calculations
Course code: Phar 102
Department/Program: Allied Health/ Pharmacy
Required for Degree Completion: yes, with C+ or better
Repeatability Limit: 4
Prerequisites: MATH 101,121 and PHAR 101
Lecturer: Y.I. Abubakar, BPharm., MSc., RPh
Day and Time: TU9.30-10.45
Consultation time: TBA

Catalog Description:
3 Cr.
This is the Arithmetic course based on calculations in the different areas of pharmacy practice.
Its a core requirement for second year students of pharmacy program. It includes a review of
arithmetic fundamentals with which the students should be strongly acquainted. The course
deals with such important issues as different systems of weights and measures, calculations on
doses, expression of strength in many forms such as %, ppm, millimoles and milli equivalence
and isotonicity of electrolyte solutions, density, specific gravity, reducing and enlarging
formulae in compounding etc. The students calculate the quantities of ingredients to
compound pharmaceutical and medicinal products. The course will cover interpretation of
prescriptions and medication orders. The student is expected to demonstrate knowledge of
these calculations in subsequent courses such as dispensing and in the practice of Pharmacy
after graduation
Lecture/Lab Hours:
The lecture will be offered twice a week; 3HRS.
PREREQUISITE / CO-REQUISITE: Phar101/Math 121
.
Course Objectives:
After the completion of this course, the students should be able to:
1. Show proficiency in elementary fundamentals of Pharmaceutical Calculations
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2. Explain relationships between metric and common measures.


3. Have the pre-requisite knowledge for correct interpretation of prescriptions and
medications order.
4. Explain the significance of accuracy in pharmaceutical computations and
measurements.
5. Recognize the degree of sensitivity of different instruments used in dispensing.
6. Demonstrate competence in calculating processes involving Pharmaceutical
formulation of varying strength and quantities.
7. Perform dosage computations using Age, weight, body substance area etc.
Sections II: Course Content & Scope
Unit I Introduction
1. Importance of pharmaceutical calculations to the overall
performance of
B.
C.

E.

Pharmacist
Use of numerals: roman, significant figures, and estimations.
Percentage errors, different systems of weights and measures (Apothecary,
Avoirdupois and metrics), and the relevance to Pharmacy calculations.
4. Conversion within the different systems of weights and
measures using
conversion factors.
Practice Questions

Students will be given a set of questions covering the topics in unit I to practice
Unit II Interpretation of Prescription and Medication Orders; Calculations of Doses
A. Interpreting a prescription (quantitative aspects only)
B. Dose for adult, children, using Youngs, Clarks and Frieds rules including using
Body surface area (BSA)
C. Calculating doses using household equivalent measures
D. Calculations based on the calibration of droppers practice questions related to
topic in Unit II.
TEST 1 covers UNITS I & II
Unit III

Reducing and Enlarging Formulae

A. Reduce and Enlarge formulae that specify amounts of ingredients


B. Reduce and enlarge formulae that specify proportional parts
C. Calculations based on density, specific gravity and specific volume and how they
relate to pharmacy.
Assignment I: Students will be given some questions covering UNIT III as assignment to be
submitted for grading.
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Unit IV

Expression of Concentration

A. Explain the concept of percent and percentage


B. Define percent weight in volume (% w/v)
C. Define percent volume in volume (% v/v)
D. Define percent weight in weight (% w/w)
E. Calculations relevant to pharmacy using these expressions
F. Discuss ratio strength (R.S), conversion of R.S. to percentage strength and vice versa
TEST 2 Covers UNITS III & IV
UNIT V

Dilution and Concentration

A. Explain stock solutions and their importance to pharmacy


B. Calculations on dilution of stock solutions
C. Determination of dilution of alcohol by calculations
D. Solve problems involving dilution and concentration of solids
E. Calculations of strengths of a preparation when diluted with another preparation
F. Define triturations and calculate triturations for powder
G. Differentiate between MFt and MFt DTD and relevant calculations related to these
signas
H. Define aliquots and calculations based on aliquot way of measuring.
Assignment 2
Unit VI
Alligation
A. Define Alligations
B. Utilization of alligation medial to calculate final percentage of a mixture, given
preparation of different percentages
C. Utilize the alligation alternate to calculate proportions of preparations of known
strength to make a preparation of desired strength.
TEST 3 Covers Unit V & VI
Unit VII

Calculation in electrolyteSolutions
A. Explain the differences between electrolyte and non electrolyte solutions
B. Define Isotonicity and sodium chloride equivalent (Na Cl Eq)
C. Calculate quantity of salt/substance to be used ensure isotonicity using its
Sodium chloride equivalence.
D. Express the concentrations of an electrolyte solution ( Mmoles,mEq0

Unit VIII

Miscellaneous
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Calculations relevant to pharmacy in


A. Parental admixtures
- Parental Additives
- Rate of flow for intravenous fluids
B. Solubility Ratios
C. Use of existing dosage form in extemporaneous compounding
D. Reconstitution of drugs using diluents.
E. Unit of potency

Assignment 3: Students will be given assignment based on Unit VII and VIII
Texts & References:
Pharmaceutical Calculations: Stoklosa, M.J.& Ansel, H.C.; Lea & Febiger (latest Edition).
Pharmaceutical Practice: Winfield Richards; Churchill Livingstone (Latest Edition)
Remingtons Science and Practice Pharmacy.Vol. I & Vol. II
METHODS OF INSTRUCTION:
Will include but not limited to:
a. Lecture and discussion
B. Student lead problem solving
(students will be expected to study the appropriate chapters before each lecture to
actively participate in class discussions or problem solving)
METHODS OF EVALUATION:
Students will be evaluated based on Assignments, Class participation and final exam. :
Assignments (3)
Class work (5)
Tests (3)
Attendance
Final Exam (cum)

15%
10%
30%
5%
40%

Test and Exams will consist of :


A. Multiple Choice Questions
B. Essay (Problem Solving) Questions
No make up exams will be given for unexcused absence. LATE assignments will result in 5
points deduction daily. Absences should be notified through the secretary or the lecturer before
the class.
Please set your phone on vibration, and no phone use during tests and exam
UB policy on academic dishonesty applies. See UB catalogue
UB GRADING SCALE will be used. See UB catalogue
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