Characterization of Cytokine Production by LCH Cells

Raymond Yu MD
Royal Post Graduate Medical School - London, United Kingdom

Award Amount: $10,000

Possible Viral Etiology of Langerhans Cell Histiocytosis

Kenneth McClain MD, PhD

Texas Childrens Hospital - Houston, Texas USA

Award Amount: $10,000

A Genetic Marker for FHL

Jan-Inge Henter MD, PhD

Karolinska Hopital - Stockholm, Sweden

Award Amount: $10,000

Isolationand Culture of Human Fetal Dendritic/Langerhans Cells

Ronald Jae MD

Childrens Hospital of Pittsburgh - Pittsburgh, Pennsylvania USA

Award Amount: $10,000

Ultrastructural Studies in Langerhans Cell Histiocytosis: Evidence of Cytological

Changes Reflecting Eects of Virus

Gary Mierau PhD

Childrens Hospital of Denver - Denver, Colorado USA

Award Amount: $9,650

Transient & Stable Expression of the CD1a Molecule in Human Cell Lines

Raymond Yu MD

Royal Post Graduate Medical School - London, United Kingdom

Award Amount: $10,000

Investigations of Immunotherapy of LCH Using Monoclonal Antibodies to CD1a

Tony Chu FRCP

Page 1 of 25

Royal Post Graduate Medical School - London, United Kingdom

Award Amount: $10,000

Cytokines in Langerhans Cell Histiocytosis: A Molecular Biology Study

Pauline Chou MD

Childrens Memorial Hospital - Chicago, Illinois USA

Award Amount: $10,000

Gangliosides and the Pathogenesis of FEL

Stephan Ladisch MD
Childrens National Medical Center - Washington, District of Columbia USA

Award Amount: $10,000

Pathogenesis & Biological Behavior of Langerhans Cell Histiocytosis

Wim Timens MD, PhDand Willem A. Kemps MD, PhD

Groningen University Hospital - Groningen, The Netherlands

Award Amount: $7,500

Determination of Clonality in Langerhans Cell Histiocytosis (LCH)

Cheryl Willman MD

University of New Mexico - Albuquerque, New Mexico USA

Award Amount: $40,000

Cytokine Production in Langerhans Cell Histiocytoses

George Kannourakis MD, PhD

Royal Childrens Hospital - Victoria, Australia

Award Amount: $10,000

Characterization of the Presence and Activation of Growth Factorsand Their

Receptors in LCH Cells

Christian NezelofMD (PI) and Sylvette Barbey PhD

Hospital Saint-Louis - Paris, France

Award Amount: $10,000

Page 2 of 25

A SCID Mouse Model of LCH

Kenneth McClain MD, PhD

Baylor College of Medicine - Houston, Texas USA

Award Amount: $10,000

A Molecular Study of Histiocytic Disorders in Children: A Search for Bacteria or

Viral Agents, Identification of a T-cell Clonal Response

Cliord C Bailey FRCP; Ian J Lewis; Sally E Kinsey MD; Caroline R Shiach MD
St. James Memorial Hospital - Leeds, United Kingdom

Award Amount: $10,000

Molecular Analysis of LCH: Clonality, Genetics, and Drug Resistance

Cheryl Willman MD
University of New Mexico Cancer Center - Albuquerque, New Mexico USA
Award Amount: $40,000

Molecular Studies on the Aetiologyand Clonality of LCH

George Kannourakis MD, PhD

Royal Childrens Hospital - Victoria, Australia

Award Amount: $40,000

Identification of Specific T-cell Receptor: Rearrangements in LCH L:esions

Jack Gorski PhD

Blood Center of Southwest Wisconsin - Milwaukee, Wisconsin USA

Award Amount: $20,000

Gangliosides and the Pathogenesis of FEL

Ruixiang Li PhD and Stephan Ladisch MD

Childrens National Medical Center - Washington,District of Columbia USA
Award Amount: $10,000

Page 3 of 25

Pathogenesis & Biological Behavior of Langerhans Cell Histiocytosis: The Role of

Cytokines and Cytokine Receptors
Wim Timens MD, PhD

Groningen University Hospital - Groningen, The Netherlands

Award Amount: $5,500

Pediatric Immunodeficiency Fund

Alexandria Filipovich MD
UniversityHospital and Clinic of Minnesota - Minneapolis, Minnesota USA

Award Amount: $1,000

Comparative Genomic Hybridization in Langerhans Cell Histiocytosis

Mary Haag PhD

All Childrens Hospital - St. Petersburg, Florida USA

Award Amount: $10,000

Development of a Mouse Xenograft Model to Examine the Localization, Binding &

Killing of CD1a Positive Cells by Monoclonal Antibodies & Single Chain Fvs
Samuel Murray
Royal Post Graduate Medical School - London, United Kingdom

Award Amount: $10,000

Characterization of T-cellsandLangerhans Cellsin LCH

Eric Classen MD and Maarten Egeler MD
Sophia Childrens Hospital - Rotterdam, The Netherlands

Award Amount: $10,000

Role of GM-CSF in the Pathogeny of Langerhans Cell Histiocytosis

Nicole Brousse MD

Hopital Necker Enfants Malades - Paris, France

Award Amount: $10,000

Page 4 of 25

Tumor Necrosis Factor-Alphaand Interferon-Gamma Gene Structure in Children

with Histiocytosis
Kenneth McClain MD, PhD
Baylor College of Medicine - Houston, Texas USA

Award Amount: $10,000

Immune Dysregulation During the Response to Murine Malignant Histiocystosis

Angela Panoskaltsis-Mortari PhD

University of Minnesota - Minneapolis, Minnesota USA

Award Amount: $10,000

Bone Marrow Involvement in Patients with Multi-System Langerhans Cell

Histiocytosis
Michael Dworzak MD andNicole Grois MD
St. Anna Childrens Hospital - Vienna, Austria

Award Amount: $10,000

Phase II Trial of 2 Chlorodeoxyadewosine in the Management of the Histiocytic

Syndromes
Alan Saven MD
Green Cancer Center - La Jolla, California USA

Award Amount: $10,000

Juvenile Chronic Myelogeous Leukemia: Purificationand Characterization of the

Leukemic Stem Cells In Vitro & In Vivo
Melvin Freeman MD
Hospital for Sick Children - Toronto, Canada

Award Amount: $9,700

Studies on Cytokines, Clonality & Apoptosis in HLH Cells

Shinsaku Imashuku MD
Kyoto City Institute of Health & Environmental Science - Kyoto, Japan

Award Amount: $10,000

Page 5 of 25

A Study of Clonality of LCH in Female Patients by Identification of the Inactive X

Chromosomes in Single LCH Cells

Jon Pritchard FRCP; Marilyn Monk PhD; Marian Malone FRCP

Hospital for Sick Children - London, United Kingdom

Award Amount: $10,000

Clonality & Cytogenetic Abnormalities in Patients with Langerhans Cell

Histiocytosis of Varying Clinical Severity

Tony Chu FRCP

Royal Post Graduate Medical School - London, United Kingdom

Award Amount: $10,000

HLH Clinical Trial/ NK Cell Activity

Jan-Inge Henter MD, PhD

Karolinska Hopital - Stockholm, Sweden

Award Amount: $2,000

Defects of Apoptosis as a Cause of Hemophagocytic Lymphohistiocytosis

Syndromes

Keith Elkon MD
The Hospital for Special Surgery - New York, New York USA
Award Amount: $50,439

Histiocytosis and Familial Erythrophagocytic Lymphohistiocytosis (FEL) Research

Diane Komp MD and Joel Rappeport MD

Yale Medical School - New Haven, Connecticut USA
Award Amount: $30,000

Langerhans Cell Histiocytosis I & II Studies - North Americanand European

Regional Studies

Stephan Ladisch MD; H. Stacy Nicholson MD; Helmut Gadner MD, FRCP

Childrens National Medical Center - Washington, District of Columbia USA

Award Amount: $40,000

Page 6 of 25

Chromosomal Localization of the Genetic Lesion in Familial Hemophagocytic

Lymphohistiocytosis

Jan-IngeHenter MD, PhD and Gosta Holmgren MD, PhD

Karolinska Hopital - Stockholm, Sweden

Award Amount: $10,000

Molecular Basis of NK Cell Dysfunction in Familial Haemophagocytic

Lymphohistiocytosis

E. Marion Schneider PhD

University of Dusseldorf - Dusseldorf, Germany

Award Amount: $9,065

T-cell Receptor VB Analysis in Histiocytosis Syndromes: Role of Superantigens

Murali Chintaqumpala MD

Texas Childrens Hospital - Houston, Texas USA

Award Amount: $10,000

T-cell Receptor Vo & Vs Diversity in Langerhans Cell Histiocytsis

Jonna Hvas PhD and George Kannourakis PhD

Royal Childrens Hospital - Victoria, Australia

Award Amount: $10,000

Rosai-Dorfman Disease (RDD) Biology

Marco Paulli MD

Institute of Surgical Pathology - Pavia, Italy

Award Amount: $10,000

Generation of Immortalized Cell Lines of Langerhans Cell and Langerhans Cell

Histiocytosis Cells

Tony Chu FRCP

Royal Post Graduate Medical School - London, United Kingdom

Award Amount: $25,000 (paid over two years)

Isolation, Identification,and Studies on the Biology of a Transmissible Agent

Involved in the Causation of Langerhans Cell Histiocytosis: Implications for
Future Treatment Strategies for Disseminated LCH
George Kannourakis PhD

Page 7 of 25

Royal Childrens Hospital - Victoria, Australia

Award Amount: $72,000

Generation of Immortalized Cell Lines of Langerhans Cell and Langerhans Cell

Histiocytosis Cells
Tony Chu FRCP
Royal Post Graduate Medical School - London, United Kingdom
Award Amount: $25,000

Investigation of Possible Associations of Histocompatibility and/or Tumor

Necrosis Factor Types with Susceptibility to LCH or Particular Clinical
Manifestations of this Disease
Marilyn Pollack PhD and Kenneth McClain MD, PhD

Texas Childrens Hospital - Houston, Texas USA

Award Amount: $20,000

Immune Dysregulation in Canine Langerhans Cell Histiocystosis; An Animal

Model for the Human Disease
Peter Moore PhD

University of California, School of Veterinary Medicine - Davis, California USA

Award Amount: $20,000

The Role of Apoptosis (Programmed Cell Death) in the Pathogenesis of LCH

Michael Weintraub MD
Hadassah-Hebrew University Medical School - Jerusalem, Israel

Award Amount: $20,000

Defects of Apoptosis as a Cause of Hemophagocytic Lymphohistiocytosis

Keith Elkon MD

Hospital for Special Surgery - New York, New York USA

Award Amount: $49,464

Cell-Associatedand Soluble Macrophage Mannose Receptor: A Potential New

Marker for Langerhans Cell Histiocytosis

Page 8 of 25

Siamon Gordon PhD

Sir Williams Dunn School of Pathology - Oxford, United Kingdom

Award Amount: $50,000

Polypeptide Receptors for Dendritic Cell Function and Recruitment

Svetlana Mojsov PhD and Ralph M. Steinman MD

The Rockefeller University - New York, New York USA

Award Amount: $50,000

Association of HHV-8 with Langerhans Cell Histiocytosis

Frank Jenkins PhD

University of Pittsburgh Cancer Institute - Pittsburgh, Pennsylvania USA

Award Amount: $16,609

Genetic Mapping in Familial Haemophagocytic Lymphohistiocytosis

D. Mark Layton and Michel R.A. Lalloz PhD

Kings College - London, United Kingdom

Award Amount: $19,960

Molecular Analysis of the Cells in Histiocytosis

Ralph Steinman MD and Svetlana Mojsov MD

The Rockefeller University - New York, New York USA

Award Amount: $30,000

Dynamics of Calcium Fluxes in Lymphocytes and Histiocytes Analyzed by

Confocal Laser Scanning Microscopy

E. Marion Schneider PhD

Universitatsklinik fur Anasthesiologie - Ulm, Germany

Award Amount: $19,964

Design for a Mouse Model of Langerhans Cell Histiocytosis

Kenneth McClain MD, PhD

Texas Childrens Hospital - Houston, Texas USA
Award Amount: $30,000

Page 9 of 25

Immune Function Studies in Family Members of Patients with Hemophagocytic

Lymphohistiocytosis

Alexandra Filipovich MD
Cincinnati Childrens Hospital MedicalCenter - Cincinnati, Ohio USA

Award Amount: $19,923

Study of Dierentiationand Clonality of Langerhans Cell Precursors in Patients

with LCH

Nicole Brousse MD

Hospital Necker Enfants Malades - Paris, France

Award Amount: $20,000

Development of a Single Chain Monoclonal Antibody to CD1a for

Immunoimagingand Treatment of Patients with Langerhans Cell Histiocytosis

Tony Chu FRCP

Royal Post Graduate Medical School - London, United Kingdom

Award Amount: $22,755

Novel Genes in Histiocytosis

Jacques Banchereau PhD
Baylor Institute for Immunology Research - Dallas, Texas USA

Award Amount: $30,000

Targeted Imaging & Therapy with Humanized Anti-CD1a ScFv Antibody

Conjugates for Langerhans Cell Histiocytosis
Robert Arceci MD, PhD

Cincinnati Childrens Hospital Medical Center - Cincinnati, Ohio USA

Award Amount: $30,000

Blood Dendritic Cells in Histiocytosis

A. Karolina Palucka MD, PhD
Baylor Institute for Immunology Research - Dallas, Texas USA
Award Amount: $30,000

Page 10 of 25

Evaluation of the 2B4 Pathway in XLP & HLH

Kim E. Nichols MD

Childrens Hospital of Philadelphia - Philadelphia, Pennsylvania USA

Award Amount: $30,000

RNA Array Analysis for Normal Development of Dendritic Cells

Mikhail M. Dikov PhD
Vanderbilt University - Nashville, Tennessee USA

Award Amount: $30,000

Analysis of T-cell Dysfunction in Childhood Hemophagocytic Lymphohistiocytosis

Eiichi Ishii MD, PhD
Hamanomachi Hospital - Fukuoka, Japan
Award Amount: $29,100

Assessment of Risk Factor for the Development of Diabetes & Other Central
Nervous System Abnormalities in LCH
Nicole Grois MD
St. Anna Childrens Hospital - Vienna, Austria

Award Amount: $30,000

HLH-94 Clinical Trial

Jan-Inge Henter MD, PhD

Karolinska Hopital - Stockholm, Sweden

Award Amount: $25,000

LCH-II Clinical Trial

Helmut Gadner MD,FRCP (PI) and Nicole Grois MD

St. Anna Childrens Hospital - Vienna, Austria

Award Amount: $25,000

CNS Clinical Trial

Page 11 of 25

Helmut Gadner MD,FRCP and Nicole Grois MD

St. Anna Childrens Hospital - Vienna, Austria

Award Amount: $48,500

Epidemiology Study of LCH in Children in a Special Population Group

Jonathan Ducore MD
University of California, Davis Medical Center - Davis, California USA
Award Amount: $5,500

A Mouse Model of Langerhans Cell Histiocytosis

Pieter Leenen PhD (PI); Karel Hahlen MD, PhD; R. Maarten Egeler MD, PhD
Erasmus University - Rotterdam, The Netherlands

Award Amount: $30,000

Evaluation of Thalidomide for Treatment of Resistant Langerhans Cell

Histiocytosis
Kenneth McClain MD, PhD
Texas Childrens Hospital - Houston, Texas USA

Award Amount: $30,000

Genetic and Functional Studies on the Pathogenesis of FHL

Jan-Inge Henter MD, PhD (PI) and Bengt Fadeel MD
Karolinska Hopital - Stockholm, Sweden

Award Amount: $30,000

Analysis of the Tumor Necrosis Factor Receptor Pathway in LCH

Manfred B. Lutz PhD and Jens Oliver Funk MD

University of Erlangen - Erlangen, Germany

Award Amount: $30,000

Analysis of Gene Expression in HLH Patients Using DNA Microarrays

Janos Sumegi MD
University of Nebraska Medical Center - Omaha, Nebraska USA

Page 12 of 25

Award Amount: $30,000

Cytotoxic Cell Studies in Family Members of Patients with Hemophagocytic

Lymphohistiocytosis (HLH) and Patients with Macrophage Activation Syndrome
(MAS)
Alexandra Filipovich MD
Cincinnati Childrens Hospital MedicalCenter - Cincinnati, Ohio USA

Award Amount: $30,000

A Revised International Treatment Protocol for HLH-94 Clinical Trial

Jan-Inge Henter MD, PhD
Astrid Lindgren Children's Hospital - Stockholm, Sweden

Award Amount: $30,000

LCH-III Clinical Trial

Nicole Grois MD

St. Anna Childrens Hospital - Vienna, Austria

Award Amount: $30,000

Investigation of Molecular Mechanisms Underlying LCH: Characterization of a

Disease Specific DNA Library

Tony Chu FRCP

Hammersmith Hospital - London, United Kingdom

TotalAmount of Award: $30,000

An Animal Model of Hemophagocytic Lymphohistiocytosis

Michael Jordan MD

Howard Hughes Medical Institute - Chevy Chase, Maryland USA

TotalAmount of Award: $60,000 (paid over two years)

FLT3 Ligand in LCH

Anna Paluka MD, PhD

Baylor Institute for Immunology Research - Dallas, Texas USA

TotalAmount of Award: $60,000 (paid over two years)

Page 13 of 25

Role of Dectin-1 (Beta Glucan Receptor) in the Interactions of T-cells with

Langerhans and Antigen Presenting Cells

Siamon Gordon PhD

Sir Williams Dunn School of Pathology - Oxford, United Kingdom

TotalAmount of Award: $30,000

Biologic Correlates of Response to Therapy in LCH

Kenneth McClain MD, PhD

Baylor College of Medicine - Houston, Texas USA

TotalAmount of Award: $30,000

Investigating Chemokine Receptor Usage as an Explanation for the Aberrant

Behaviour of CD1a Cells in LCH

Nicola Annels MD

Leiden University Medical Center - Leiden, The Netherlands

TotalAmount of Award: $60,000 (paid over two years)

An Investigation Using DNS Microarrays of the Expression of Matrix

Metalloproteinases in Normal and Langerhans Cells

Stephen Jolles PhD

National Institute for Medical Research - London, United Kingdom

TotalAmount of Award: $30,000

Construction of a Viral Vector Containing the Human Perforin Gene

Cesare Danesino MD

Umana Ed Ereditaria - Pavia, Italy

TotalAmount of Award: $60,000 (paid over two years)

HLH-94 Clinical Trial

Jan-Inge Henter MD, PhD

Karolinska Hopital - Stockholm, Sweden
TotalAmount of Award: $15,000

LCH-III Clinical Trial

Page 14 of 25

Nicole Grois MD
St. Anna Childrens Hospital - Vienna, Austria
TotalAmount of Award: $45,000 (paid over two years)

Targeted Imaging and Therapy with Humanized Anti-CD1a Monoclonal Antibody

Conjugates for LCH

Robert Arceci MD, PhD

Johns Hopkins - Baltimore, Maryland USA

TotalAmount of Award: $60,000 (paid over two years)

$45,000 of total award paid by the Histiocytosis Association of Canada

Study of the Genetic Defects Underlying HLH: Investigation of Cellular

Abnormalities Associated with Defective NK Cell Function and Resultant
Dysregulation of T-cell Populations

Alexandra Filipovich MD
Cincinnati Childrens Hospital MedicalCenter - Cincinnati, Ohio USA

TotalAmount of Award: $60,000 (paid over two years)

Total amount paid by the Histiocytosis Association of Canada

Genetic Characterization of Langerhans Cell Dierentiation in LCH

Kelvin Lee MD

University of Miami School of Medicine - Miami, Florida USA

Development of a Murine Model for LCH Using Binary Knock-in Mice

Frederic Geissmann MD, PhD

Necker-Enfants Malades Hospital - Paris, France

Novel Photoconvertable Florescent Proteins to Trace Hemophagocytes in Whole

Blood
Marion Schneider PhD

University of Ulm - Ulm, Germany

Page 15 of 25

A New Transgenic Mouse Model for Skin LCH: Probing the Disease Mechanisms
Hans Acha-Orbea PhD
University of Lausanne - Epalinges, Switzerland

Genome-Wide Detection of Possible Chromosomal Imbalances in LCH Lesional Cells

Using BAC Microarrays
Nicola Elizabeth Annels MD
Leiden University Medical Center -Leiden, The Netherlands

Identification of Lytic Granule Exocytosis-Related Candidate Genes Involved in

Pathogenesis of
Hemophagocytic Lymphohistiocytosis
Sasa Radoja PhD and E. Marion Schneider PhD
Children's Research Institute- Washington, District of Columbia USA

Cigarette Smoking and TSLP in the Pathogenesis of Pulmonary LCH

Robert Vassallo MD
Pulmonary and Critical Care Medicine, Mayo Clinic -Rochester, Minnesota USA

Gene Expression in Langerhans Cell Histiocytosis

Kenneth L. McClain MD, PhD
Baylor College of Medicine,Texas Children's Cancer Center - Houston, Texas USA

Study of Dendritic Cell-Derived Multinucleated Giant Cells in Langerhans Cell

Histiocytosis
Christine Servet-Delprat PhD
Molecular Immunobiology Clinic; INSERM - Lyon, France

LCH-III Clinical Trials

Nicole Grois MD

St. Anna's Children's Hospital - Vienna, Austria

Structure/Function Relationships in the MUNC13-4 Protein: Molecular Consequences

of Familial Hemophagocytic Lymphohistiocytosis Associated Mutations
Janos Sumegi MD

Cincinnati Children's Hospital Medical Center - Cincinnati, Ohio USA

The Mechanism of Regulation of Dendritic Cell Dierentiation by Adenosine

Page 16 of 25

Mikhail M. Dikov PhD

Vanderbilt University Medical Center - Nashville, Tennessee USA

Homozygozity Mapping for Identification of a Novel Genetic Defect in Patients with

Familial Hemphogocytic Lymphohistiocytosis
Udo zur Stadt MD
University Medical Center Hamburg Eppendorf - Hamburg, Germany

Analysis of T-cell Function in Langerhans Cell Histiocytosis

Kenneth L. McClain MD, PhD and Carl E. Allen MD, PhD
Texas Children's Hospital, Baylor College of Medicine -Houston, Texas USA

Langerhans Cell and Dendritic Cell Homeostasis in Human Skin

Matthew Collin MD
Newcastle University - Newcastle upon Tyne, United Kingdom

Genomic Array and Expression Analysis of Frequent Amplifications in CD1a+LCH

Cells
Nicola Elizabeth Annels MD
Leiden University Medical Center - Leiden, The Netherlands

Cigarette Smoking Promotes Dendritic Cell Survival and Resistance to Apoptosis

Through HEME-Oxygenase-1 Dependant Mechanisms
Robert Vassallo MD

Mayo Clinic - Rochester, Minnesota USA

Genetic Studies on the Pathogenesis of FHL

Magnus Nordenskjld MD, PhD
Karolinska University Hospital - Stockholm, Sweden

Homozygosity Mapping to Reveal Novel Genetic Defects in Patients with Familial

Hemophagocytic Lymphohistiocytosis
Maurizio Aric MD

Osoedale dei Bambini "G. Di Cristina" - Palermo, Italy

Page 17 of 25

Ganglioside-Induced Defective Granule Exocytosis-Mediated Cytotoxicity in

Hemophagocytic Lymphohistiocytosis
Sasa Radoja PhD
Children's National Medical Center Washington, District of Columbia USA
Lymphocyte Trafficking in Langerhans Cell Histiocytosis
Kenneth McClain MD, PhD and Carl Allen MD, PhD

Texas Childrens Cancer Center/Hematology Service - Houston, Texas USA

Investigations into the Clinical and Molecular Pathogenesis of XIAP Deficiency
Rebecca Marsh MD; Jack J. H. Bleesing MD, PhD; Kimberly Risma MD, PhD;
Lisa Filipovich MD
Cincinnati Children's Hospital Medical Center Cincinnati, Ohio USA
A Transgenic Mouse Model Mimicking Abnormal Langerhans Cell Trafficking in
Langerhans Cell Histiocytosis
Barrett J. Rollins MD, PhD; Barbara Brandner PhD; Gayane Badalian MD, PhD
Dana-Farber Cancer Institute, Harvard Medical School
Boston, Massachusetts USA
Role of the Granzyme Inhibitor Proteinase Inhibitor-9 (PI-9) in Langerhans Cell
Histiocytosis
Carl F. Classen MD
University Childrens Hospital Rostock - Duisburg, Germany
Biomarker Monitoring of Central Nervous System Disease in Langerhans Cell
Histiocytosis
Jan-Inge Henter MD, PhD
Karolinska Institutet Stockholm, Sweden

Mechanisms of IL-17A-Dependent Dendritic Cell Long-Term Survival and Fusion in

Langerhans Cell Histiocytosis
Christine Delprat MD, PhD
INSERM Lyon, France

A Knock-In Mouse Model Mimicking Abnormal Langerhans Cell Trafficking in

Langerhans Cell Histiocytosis
Barrett J. Rollins MD, PhD

Dana-Farber Cancer Institute, Harvard Medical School - Boston, Massachusetts USA

Page 18 of 25

Accumulation of Misguided Lymphocytes and Dendritic Cells: A New Model for LCH
Carl E. Allen MD, PhD and Kenneth L. McClain MD, PhD

Texas Childrens Hospital/Baylor College of Medicine - Houston, Texas USA

Revisiting the Candidate Regions for Familial Hemophagocytic Lymphohistiocytosis
(FHLH): Loss-of-Function-Screening Search for the Missing Disease Causing Genes
Janos Sumegi MD, PhD
Cincinnati Childrens Hospital Medical Center - Cincinnati, Ohio USA
Proteolytic Maturation of Perforin: Determining the Requirements for Cytotoxic Function
in Patients with Hemophagocytic Lymphohistiocytosis
Kimberly Risma MD, PhD

Cincinnati Childrens Hospital Medical Center - Cincinnati, Ohio USA

Mechanisms of Interferon Gamma-Induced Hemophagocytosis
Michael Jordan MD
Cincinnati Childrens Hospital Medical Center - Cincinnati, Ohio USA
Interrogating Disease Mechanisms in a Novel Mouse Model of Hemophagocytosis
Michelle Hermiston MD, PhD

University of California, San Francisco - San Francisco, California USA

Origin of the LCH Cell
Miriam Merad MD, PhD; Matthew Collin MD; Kenneth McClain MD, PhD; Carl Allen MD,
PhD

Mount Sinai School of Medicine - New York, New York USA

The Pathogenesis of XLP Due to XIAP Deficiency
Rebecca A. Marsh MD; Jack J. H. Bleesing MD, PhD; Alexandra Filipovich MD

Cincinnati Childrens Hospital Medical Center - Cincinnati, Ohio USA

Histiocyte Society Clinical Trials Database System
LCH-IV Treatment Protocol Study
LCH Study Reference Center - Vienna, Austria

Histiocyte Society International Rare Histiocytic Disorder Registry

Oussama Abla MD
Page 19 of 25


The Hospital for Sick Children - Toronto, Ontario, Canada

Proteolytic Maturation of Perforin: Determining the Requirements for Cytotoxic

Function
Kimberly Risma MD, PhD
Cincinnati Childrens Hospital Medical Center - Cincinnati, Ohio USA

Exploring Coexisting Maternal Microchimeric Cells and Host T-cells in LCH Lesions
A.G.S. van Halteren PhD and R. Maarten Egeler MD, PhD

Leiden University Medical Center - Leiden, The Netherlands

Myeloid Dendtritic Cell Developement in Langerhans Cell Histiocytosis

Carl E. Allen MD, PhD; Kenneth L. McClain MD, PhD; Chris Man Tsz-Kwong PhD

Baylor College of Medicine - Houston, Texas USA

A Transcriptome Analysis of the Monocytes in Erdheim-Chester Disease

Julien Haroche MD, PhD

Hpitaux de Paris, and Universit - Paris, France

Biomarker Profiles in Hemophagocytic Diseases - A Systems Biology Approach

E. Marion Schneider PhD

Universittsklinikum Ulm - Ulm, Germany

Osteopontin Expression and Function in Langerhans Cell Histiocytosis

Carl E. Allen MD, PhD; Tricia L. Peters MD, MS; Kenneth L. McClain MD, Ph
Baylor College of Medicine - Houston, Texas USA

Assesment of PTPN6 (SHP-1) in Langerhans Cell Line

Ichiro Murakami MD, PhD and Takashi Oka PhD

Tottori University - Yonago-shi, Japan

Histiocyte Society Clinical Trials Database System

LCH-IV Treatment Protocol Study
LCH Study Reference Center - Vienna, Austria

Page 20 of 25

Proteolytic Maturation of Perforin: Determining the Requirements for Cytotoxic

Function
Kimberly Risma MD, PhD

Cincinnati Childrens Hospital Medical Center Cincinnati, Ohio USA

Hybrid ImmunoTherapy (ATG/Dexamethasone/Etoposide) for Hemophagocytic

Lymphohistiocytosis: The HIT-HLH Trial
Michael Jordan MD

Cincinnati Childrens Hospital Medical Center Cincinnati, Ohio USA

The Role of BRAF V600E in the Pathogenesis of Langerhans Cell Histiocytosis

Gayane Badalian Very MD, PhD

Dana-Farber Cancer Institute Boston, Massachusetts USA

Flow Cytometric and Secretomic Analysis of LCH Lesions

Matthew Collin MD
Institute of Cellular Medicine Newcastle upon Tyne UK

A Gene Expression Strategy to Identifiy the Cell of Origin in Langerhans Cell

Histiocytosis
Carl E. Allen MD, PhD

Texas Childrens Hospital Houston, Texas USA

Mechanistic Studies of Defects in Lymphocyte Cytotoxicity Underlying HLH

Yenan Bryceson PhD

Center for Infectious Medicine Stockholm, Sweden

Gene-Expression Profiling of Peripheral Blood Mononuclear Cells in Hemophagocytic

Lymphohistiocytosis
Janos Sumegi MD, DSc, PhD

Cincinnati Childrens Hospital Medical Center Cincinnati, Ohio USA

Page 21 of 25


Identifying Familial Associations in Langerhans Cell Histiocytosis Using the Utah
Population Database
Mark Fluchel MD

Primary Childrens Hospital Salt Lake City, Utah USA

Histiocyte Society Clinical Trials Database System LCH-IV Treatment Protocol Study
Histiocyte Society Executive Board

LCH Study Reference Center Vienna, Austria

International Rare Histiocytic Disorders Registry (IRHDR)

Oussama Abla MD
The Hospital for Sick Children - Toronto, Ontario, Canada

A BRAF V600E-Drive Mouse Model of Langerhans Cell Histiocytosis

Gayane Badalian Very MD, PhD
Dana-Farber Cancer Institute - Boston, Massachusetts USA

Mechanistic Studies of Defects in Lymphocyte Cytotoxicity Underlying HLH

Yenan Bryceson PhD
Karolinska Institutet Center for Infectious Medicine - Stockholm, Sweden

Perforin Gene Transfer into Human Cytotoxic Lymphocytes

Kimberly Risma MD, PhD
Cincinnati Children's Hospital Medical Center - Cincinnati, Ohio USA

Biomarkers in Primary and Secondary Hemophagocytic Lymphohistiocytosis

Janos Sumegi MD, PhD
Cincinnati Children's Hospital Medical Center - Cincinnati, Ohio USA

Histiocyte Society Clinical Trials Database System LCH-IV Treatment Protocol Study
Histiocyte Society Executive Board
LCH Study Reference Center Vienna, Austria

M1 Versus M2 Polarization of the Hemophagocyte: Insight into Biologic Function

Edward Behrens MD
The Children's Hospital of Philadelphia - Philadelphia, Pennsylvania, USA

Improving Diagnostics of and Gaining Mechanistic Insights into Defects in Lymphocyte

Page 22 of 25

Cytotoxicity Underlying HLH

Yenan Bryceson PhD
Karolinska Institutet Center for Infectious Medicine - Stockholm, Sweden

Analysis of Jagged2 Signaling in Langerhans Cell Histiocytosis

Caroline Hutter MD, PhD
Children's Cancer Research Institute/St. Anna Kinderspital - Vienna, Austria

Focused Screening of Novel Therapies for HLH Using an Animal Model

Michael Jordan MD
Cincinnati Children's Hospital Medical Center - Cincinnati, Ohio USA

Research Infrastructure for Clinical and Translational Research in Langerhans Cell

Histiocytosis (LCH)
Carlos Rodriguez-Galindo MD
Dana-Farber Cancer Institute - Boston, Massachusetts USA

Whole Exome Sequencing of Langerhans Cell Histiocytosis

Barrett Rollins MD, PhD; Astrid G.S. van Halteren PhD
Dana-Farber Cancer Institute - Boston, Massachusetts USA
Leiden University Medical Center - Leiden, The Netherlands

Histiocyte Society Clinical Trials Database System LCH-IV Treatment Protocol Study
Histiocyte Society Executive Board
LCH Study Reference Center - Vienna, Austria

Gene Therapy in a Mouse Model of Virus-triggered X-linked lymphoproliferative

Disease (XLP1):
Control of Infection and Disease Progression
Peter Aichele, PhD
University Medical Center Freiburg, University of Freiburg - Freiburg, Germany

Dysregulation of Dendritic Cell Development in Langerhans Cell Histiocytosis

Matthew Collin, MD
Newcastle University - Newcastle upon Tyne, United Kingdom
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Unraveling the Pathophysiological Role of the BRAFV600E Mutation in Langerhans Cell
Histiocytosis (LCH) and its Therapeutical Implications with Murine Models of High Risk
LCH
Miriam Merad, MD, PhD
Icahn School of Medicine at Mount Sinai - New York, New York USA

Janus Kinase Inhibition as a Novel Treatment for Hemophagocytic Lymphohistiocytosis

Kim E. Nichols, MD
The Children's Hospital of Philadelphia - Philadelphia, Pennsylvania USA

Histiocyte Society Clinical Trials Database System LCH-IV Treatment Protocol Study
Histiocyte Society Executive Board
LCH Study Reference Center - Vienna, Austria

International Registry of Rare Histiocytic Disorders

Oussama Abla, MD
The Hospital for Sick Children, Toronto, Ontario Canada

Gaining Insights into the Mechanisms of Lymphocyte Cytotoxicity Underlying

Hemophagocytic Lymphohistiocytosis
Yenan Bryceson, PhD
Karolinska Institutet, Stockholm, Sweden

Novel Animal Model for LCH

Sergio Lira, MD, PhD
Icahn School of Medicine at Mount Sinai, New York, New York USA

Accumulation of Heterozygous Mutations on HLH Pathogenesis

Fernando Sepulveda, PhD
Imagine Institute, Paris, France

Comprehensive mRNA/miRNAs Expression Analysis in Familial Hemophagocytic

Lymphohistiocytosis Type 2, Using the C57BL/6-Prf1tm1Sdz/J Murine Model
Janos Sumegi,MD, DSc, PhD
Cincinnati Children's Hospital Medical Center,Cincinnati, OH USA

Exploring CD8+ T cell-LCH-cell Interactions in Langerhans Cell Histiocytosis: A Three

Center Study

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Astrid van Halteren, PhD

Leiden University Medical Center,Leiden, Netherlands

MEK Inhibition in the Therapy of Histiocytic Neoplasms

Omar Abdel-Wahab, MD
Memorial Sloan Kettering Cancer Center, New York, New York USA

Dysregulation of Dendritic Cell Development in Langerhans Cell Histiocytosis II:

Langerin Induction and Comparative Gene Expression Studies
Matthew Collin, MD
Newcastle University, Newcastle Upon Tyne, United Kingdom

Deciphering the Underlying Molecular Defects in CTL and NK Cell Cytotoxicity in FHL
Patients
Claudio Giraudo, PhD
The Children's Hospital of Philadelphia,University of Pennsylvania,Philadelphia,
Pennsylvania USA

Identification of Molecular Mechanisms Underlying Defective Cytotoxic Lymphocyte

Function in Chediak-Higashi Syndrome, a Histiocytic Lysosomal Storage Disorder with
Immunodeficiency
Konrad Krzewski, PhD
National Institute of Allergy and Infectious Diseases, National Institutes of
Health,Rockville, Maryland USA

LCH-IV Clinical Trial Stratum I Patient Registration Reimbursement for North

American Institutions
Carlos Rodriguez-Galindo, MD
St. Jude Children's Research Hospital, Memphis, Tennessee USA

The Interplay of NOTCH and MAPK Pathway in LCH

Raphaela Schwentner, MSc, PhD
Children's Cancer Research Institute,Vienna, Austria

Genetic Dissection of the Exocytic Machinery in Cytotoxic Lymphocytes

Matthias Voss, PhD
Karolinska Institutet,Stockholm, Sweden

Page 25 of 25