MEDICATION CLASS: Aminoglycosides

INDICATIONS/USES: Treatment of serious gram-negative bacterial infections and

infections caused by staphylococci when penicillins or less toxic drugs are contraindicated.
MECHANISM OF ACTION: Inhibits protein synthesis in bacteria, causing cell death.
SIDE EFFECTS: Ataxia, ototoxicity, nephrotoxicity, diarrhea, nausea, vomiting.
CONTRAINDICATIONS/BLACK BOX WARNINGS: Hypersensitivity to
aminoglycosides, most parenteral products contain bisulfates and should be avoided in
patients with a known intolerance. Products containing benzyl alcohol should be avoided
in neonates. Use cautiously in renal impairment.
ROUTES: IM, IV, IT, Topical, PO, Inhaln
ASSESSMENTS & TEACHING POINTS
-Assess patient for signs of infection. (fever, increased pulse, decreased BP, increased WBC)
-Obtain a specimen for culture and sensitivity.
-Inform patient medication should be taken as prescribed.
-Inform patient of common side effects. (nausea, vomiting, diarrhea) Also, inform patient of
more serious side effects such as hearing loss, specifically higher pitches, and renal
impairment.
-Instruct patient to get lab work done during treatment to determine efficacy of the
treatment, as well as to monitor electrolyte levels.
-Inform patient to drink plenty of fluids.
HOW TO DETERMINE EFFECTIVENESS
By evaluating patients vital signs and lab results during treatment.
TWO MEDS FROM THIS CLASS
1. Gentamicin
2. Neomycin
TWO REFERENCES ( include year)
1. Davis Drug Guide (2015)
2. Focus on Pharmacology (2013)
Students Name__Stacie Marlow_____________________