THIOCOLCHICOSIDE

Molecular formula and molecular mass:

Structural Formula:

Formula: C27H33NO10S
Mol. mass: 563.618 g/mol

CAS number: [602-41-5]

Melting point: Starts to decompose at 1900C to 1980C.

Solubility: Soluble in water & Alcohol
Crystallinity: Crystalline Powder.
pH Values: 0.5% aqueous solution pH between 6.5-7.5.
Hygroscopicity: Free flowing crystalline powder.

S.NO
1
2
3
4

Physical Characteristics
Identification
Appearance
Colour
Odour

Specification
By IR, UV & TLC
Fine Crystalline dry Powder
Yellowish
Characteristic

Chemical Characteristics
5
6
7
8
9

Assay (HPLC Purity)

Loss on drying at 105C for 4.0 Hours (% w/w)
Specific Optical Rotation @ 23 C
pH (0.5% aq. Solution)
Sulphated Ash

98 102 w/w
NMT 2% w/w
-550 to -580
6 7.5
NMT 0.1%

Solubility
10

Soluble in water, Ethanol

THIOCOLCHICOSIDE
Molecular formula and molecular mass:

Structural Formula:

Formula: C27H33NO10S
Mol. mass: 563.618 g/mol

CAS number: [602-41-5]

Melting point: Starts to decompose at 1900C to 1980C.

Solubility: Soluble in water & Alcohol
Crystallinity: Crystalline Powder.
pH Values: 0.5% aqueous solution pH between 6.5-7.5.
Hygroscopicity: Free flowing crystalline powder.

Related Substance
11
12
13

N-Deacetyl N-formyl Thiocolchicoside

Colchicoside
Total of all impurities

NMT 0.5%
NMT 0.5%
NMT 0.5%

Residual Solvents
14
15
16

17
18
19
20

Methanol
Chloroform
Ethanol
Microbiology
Total Plate Count
Yeast & Mould
Escherichia coli
Salmonella

NMT 3000 ppm

NMT 60 ppm
NMT 5000 ppm

NMT 1000 cfu/gm

NMT 100 cfu/gm.
Absent
Absent

THIOCOLCHICOSIDE
Molecular formula and molecular mass:

Structural Formula:

Formula: C27H33NO10S
Mol. mass: 563.618 g/mol

CAS number: [602-41-5]

Melting point: Starts to decompose at 1900C to 1980C.

Solubility: Soluble in water & Alcohol
Crystallinity: Crystalline Powder.
pH Values: 0.5% aqueous solution pH between 6.5-7.5.
Hygroscopicity: Free flowing crystalline powder.

21
22
23

Stapphylococcus
Pseudomonas
Bacterial Endotoxin

Absent
Absent
NMT 87.5 Eu/mg.

Thiocolchicoside is a muscle relaxant that has been claimed to possess GABA-mimetic and glycinergic
actions. It is used in the symptomatic treatment of painful muscle spasm.