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Janet Yu-Yahiro
Union Memorial Hospital, Baltimore, Maryland
William Hawkes, Ph.D., Michelle Shardell, Ph.D., and J. Richard Hebel, Ph.D.
University of Maryland School of Medicine
Justine Golden, M.S., Michele Werner, B.S., and Jay Magaziner, Ph.D.
University of Maryland School of Medicine
ABSTRACT
Background: Exercise is an important strategy with
potential to improve recovery in older adults following a
hip fracture. Purpose: The purpose of this study was to test
the impact of a self-efficacy based intervention, the Exercise
Plus Program, and the different components of the intervention, on self-efficacy, outcome expectations, and exercise
behavior among older women posthip fracture. Methods:
Participants were randomized to one of four groups: exercise
plus, exercise only, plus only (i.e., motivation), or routine
care. Data collection was done at baseline (within 22 days
of fracture), 2, 6, and 12 months posthip fracture. Results:
A total of 209 women were recruited with an average age of
81.0 years (SD 6.9). The majority was White (97.1%),
was widowed (57.2%), and had a high school education
(66.7%). Generalized Estimating Equations were used to
perform repeated measures analyses. No differences in trajectories of recovery were observed for self-efficacy or outcome expectations. A statistically significant difference in
the overall trajectory of time in exercise was seen
(p < .001), with more time spent exercising in all three
treatment groups. Conclusions: The study demonstrated that
2007, 34(1):6776)
INTRODUCTION
In 2003 there were more than 309,500 hospital admissions for hip fractures, and by the year 2030 over 650,000
hip fractures will occur annually in older adults (1). In
the 1st year of their fracture, approximately 30% of these
individuals will die (1), 25% will have significant functional
decline in activities of daily living such as bathing and
dressing (2), 20% will need help with lower extremity dressing, and 90% will require help climbing the stairs (3). Individuals who have had a hip fracture are noted to be
impaired in their ability to independently rise from an armless chair or to step symmetrically (4), and approximately
38% to 50% need assistance to walk or are unable to walk
at 12 months posthip fracture (5).
An important strategy with potential to improve
recovery in older adults following a hip fracture is exercise
training. Regular exercise, even at low levels of intensity,
can improve mental and physical health in older adults
(6). Despite the well-documented benefits of exercise, only
23% to 35% of men engage in regular exercise, and this is
even lower in women ranging from 17% to 32% (7,8).
Developing successful interventions to help motivate individuals after a hip fracture to adhere to regular exercise
programs has the potential to improve recovery and overall
quality of life.
67
68
Resnick et al.
factors and environmental influences all operate interactively as determinants of each other, incorporates the
factors that most consistently influence exercise behavior
(911). Social cognitive theory considers (a) self-efficacy
expectations, which are the individuals beliefs in their
capabilities to perform a course of action to attain a desired
outcome, and (b) outcome expectations, which are the
beliefs that a certain consequence will be produced by personal action. Exposure to enactive mastery experiences,
such as participation in an exercise class, is the most common intervention used to strengthen efficacy expectations
in older adults (1215). Verbal encouragement from a
trusted, credible source in the form of counseling and education has been used alone, and with enactive mastery, to
strengthen efficacy expectations (16,17). Less frequently,
vicarious experience (15,18), self-modeling (19), or
implementation of interventions to decrease the unpleasant
sensations or augment the pleasant sensations associated
with exercise have been used to strengthen self-efficacy
and increase adherence to exercise (18,20,21).
Behavior can also be altered by the outcome expectations the individual maintains, with expected outcomes
being physical or mental health changes, social effects, or
personal evaluations of behavior. In cross-sectional studies
with older adult samples, outcome expectations related to
exercise have had a significant influence on exercise behavior (2224) and seem to be particularly important to the
prediction of exercise behavior over time (25,26).
Several researchers (15,16,18,27) have utilized a variety
of sources of efficacy information to increase exercise
among older adults. These included verbal encouragement,
education about the benefits of exercise, social support,
manipulation of affective states, self-modeling, and cueing.
McAuley et al. (15,27) noted that the social environment
and affective states of the participants directly and
indirectly influence self-efficacy expectations and exercise
behavior, beyond the effects of enactive mastery. Cumulatively, these studies suggest that in healthy community
dwelling older adults there may be some benefit to adding
sources of efficacy information, in addition to enactive
mastery, when trying to strengthen the individuals beliefs
about their ability to exercise and increase exercise behavior. It is not clear, however, if exposing older individuals
who have sustained an acute medical event (i.e., a hip fracture) to multiple sources of efficacy information will
strengthen self-efficacy and outcome expectations or
increase time spent in exercise over the first 12 months
posthip fracture.
The purpose of this study, therefore, was to test the
Exercise Plus Program and the separate components of
the Exercise Plus Program (exercise only and plus only
components) using a four-group repeated measure design.
Specifically, the following was hypothesized:
1. Participants who were exposed to exercise only (exercise
trainer exercising with the individual) spent more time in
METHODS
Study Design
This study was a randomized controlled trial using a
repeated measure design with participants randomized to
one of four groups: exercise plus, exercise only, plus only,
or routine care. Baseline testing was conducted within the
first 22 days posthip fracture and random assignment
was done after baseline testing was complete. Follow-up
data collection was done at 2, 6, and 12 months posthip
fracture.
Sample
Participants were recruited from nine hospitals in the
greater Baltimore area (see Figure 1). Eligible participants
were female, were 65 years of age or older, were community
dwelling at the time of fracture, had a nonpathologic fracture within 72 hr of admission, had surgical repair of the
hip fracture, and were free of medical problems that would
potentially put them at particular risk for falls when exercising alone at home alone (e.g., neuromuscular conditions). Participants also had to be walking without
human assistance prior to the fracture and score 20 or
higher on the Folstein Mini Mental State Examination
(28). Institutional Review Board approvals were obtained
from the University of Maryland School of Medicine as
well as the study hospitals, and all enrolled participants
provided their own informed consent. Recruitment was
initiated in August 2000, and data collection on the final
participant was completed in September 2005. A Data
and Safety Monitoring Board met quarterly and reviewed
all adverse events and safety reports.
The Intervention: The Exercise Plus Program
The Exercise Plus Program incorporates the exercise
only and plus only components of the intervention
(described next). The theoretical premise of the Exercise
Plus Program has been described in detail elsewhere (29,30).
69
FIGURE 1 Flow of participants through the trial: Testing the effectiveness of the Exercise Plus Program.
70
Resnick et al.
to interventions to decrease the unpleasant sensations associated with exercise such as relieving or decreasing pain
with prescribed medications or use of heat=ice treatment,
and cueing with posters describing the exercises, a Goal
Form, and a calendar of daily exercise activities (29). A
detailed description of the plus component is available
from the first author upon request.
Descriptive Variables
Age, marital status, educational level, and living situation prior to hip fracture (whether they live alone or with
others) were obtained. Chart reviews were done to describe
medical history, surgical intervention, and hospital course
(see Table 1).
Statistical Analysis
The intention-to-treat principle was followed in all
analyses used for assessing the effect of treatment on
outcome, that is, all participants who were randomized
were included. Generalized Estimating Equations (39)
(GEEs) were used to perform repeated measures analyses
with the outcome measures described previously as dependent variables. The independent variables included dummy
variables to indicate the exercise plus, exercise only, and
plus only interventions (the control condition serving as
the reference). Additional dummy variables were used to
indicate the 2-, 6-, and 12-month time points (baseline serving as the reference). Interactions between the intervention
and time variables were also included as fixed effects in the
longitudinal model. This model was used to estimate the
mean and standard error of the outcome measure at each
time point for each of the four treatment groups. Robust
standard error estimates were obtained using a technique
described by Huber (40). A global p value for the differences in longitudinal trajectories among the four groups
was obtained from a test of the null hypothesis that all
the Intervention Time interaction coefficients in the
model are simultaneously zero.
Time-specific between-group contrasts were tested at
the 5% level using Wald statistics derived from the linear
combination of model coefficients used to estimate the dif-
71
TABLE 1
Descriptive Data for Participants by Treatment Group
Variable
No.
Age
Race
White
African American
Marital status
Never married
Married
Widowed
Divorced
Separated
Education
None
Elementary
High (712)
College
Postgraduate
Fracture site
Intertrochanteric
Subcapital
Subtrochanteric
Other
Anesthesia risk rating
Physical Therapy (PT) sessions
Length of hospital stay
Charlson Co-Morbidity Index
Residence at discharge
Community
Skilled nursing
Rehabilitation
Nursing home: No rehab
Unknown
Exercise Only
Plus Only
Exercise Plus
Routine Care
All Participants
51
82.4 7.9
54
80.6 6.9
52
81.4 5.8
51
79.7 6.7
208
81.0 6.9
51 (100.0%)
0
51 (94.4%)
3 (5.6%)
50 (96.2%)
2 (3.9%)
50 (98.0%)
1 (2.0%)
202 (97.1%)
6 (2.9%)
1 (2.0%)
17 (33.3%)
30 (58.8%)
2 (3.9%)
1 (2.0%)
1 (1.9%)
20 (37.0%)
31 (57.4%)
1 (1.9%)
1 (.9%)
4 (7.7%)
19 (36.5%)
27 (51.9%)
2 (3.9%)
0
1 (2.0%)
15 (29.4%)
31 (60.8%)
3 (5.9%)
1 (2.0%)
7 (3.4%)
71 (34.1%)
119 (57.2%)
8 (3.9%)
3 (1.4%)
0
2 (4.0%)
32 (64.0%)
12 (24.0%)
4 (8.0%)
0
0
37 (68.5%)
13 (24.1%)
4 (7.4%)
0
2 (3.9%)
33 (63.5%)
11 (21.2%)
6 (11.5%)
0
2 (3.9%)
36 (70.6%)
10 (19.6%)
3 (5.9%)
0
6 (2.9%)
138 (66.7%)
46 (22.2%)
17 (8.2%)
23 (45.1%)
22 (43.1%)
5 (9.8%)
1 (2.0%)
2.5 .5
4.3 3.2
3.8 .9
.7 1.3
16 (29.6%)
38 (70.4%)
0
0
2.7 .6
4.9 6.4
4.2 1.1
1.3 1.3
22 (42.3%)
27 (51.9%)
2 (3.9%)
1 (1.9%)
2.6 .6
5.1 4.6
4.3 1.6
1.1 1.1
27 (52.9%)
22 (43.1%)
1 (2.0%)
1 (2.0%)
2.6 .6
6.0 5.9
4.4 1.5
1.6 1.6
88 (42.3%)
109 (52.4%)
8 (3.9%)
3 (1.4%)
2.6 .6
5.1 5.2
4.2 1.3
1.2 1.4
4 (7.8%)
29 (56.9%)
18 (35.3%)
0
0
4 (7.4%)
25 (46.3%)
24 (44.4%)
1 (1.9%)
0
1 (1.9%)
22 (42.3%)
29 (55.8%)
0
0
1 (2.0%)
20 (39.2%)
29 (56.9%)
0
1 (2.0%)
10 (4.8%)
96 (46.2%)
100 (48.1%)
1 (.5%)
1 (.5%)
Note. Patients with angina, myocardial infarction, stroke, transient ischemic attack, deep venous thrombosis, seizures, and gastrointestinal
hemorrhage in the 6 months before admission were not eligible for the study.
years old (SD 6.9), all were female, and 97.1% were
White. The majority (57.2%) was widowed and had a
high school education (66.7%). Of the 209 initially
recruited into Testing the Effectiveness of the Exercise
Plus Program, 165 women (79%) were available for 2month assessments, 169 (81%) were available for 6-month
follow up, and 155 (75%) were available for the 12-month
follow up visits. One case was deleted postrandomization
due to being ineligible (no surgery was performed post
hip fracture). Reasons for loss to follow up are shown
in Table 2.
The time from fracture to first intervention visit from
the trainer ranged from 28 to 200 days. Participants generally were not willing to have a visit occur prior to 60 days
postfracture, and only 1 participant had her first visit at 28
days postfracture, 22 (31%) of the participants had their
first visit by 60 days postfracture, 44 (62%) of the participants had their first visit by 90 days postfracture, and
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Resnick et al.
TABLE 2
Reasons for Loss to Follow-up by Treatment Group
Follow-Up Point
Two monthe
Scheduling=unable to contact
Illness
Refusal of study (cumulative)
Refusal of measures
Death (cumulative)
Other
Six monthf
Scheduling=unable to contact
Illness
Refusal of study (cumulative)
Refusal of measures
Death (cumulative)
Other
Twelve monthg
Scheduling=unable to contact
Illness
Refusal of study (cumulative)
Refusal of measures
Death (cumulative)
Other
Usual Carea
2
2
2
3
0
0
(4%)
(4%)
(4%)
(6%)
(0%)
(0%)
4
0
3
0
1
0
(8%)
(0%)
(6%)
(0%)
(2%)
(0%)
1
0
3
2
3
1
(2%)
(0%)
(6%)
(4%)
(6%)
(2%)
Exercise Onlyb
Plus Onlyc
Exercise Plusd
0 (0%)
0 (0%)
4 (10%)
6 (15%)
0 (0%)
0 (0%)
0 (0%)
1 (3%)
10
(26%)
0 (0%)
0 (0%)
1 (3%)
2
0
2
5
1
0
(5%)
(0%)
(5%)
(11%)
(2%)
(0%)
1
3
5
4
0
0
(3%)
(8%)
(13%)
(10%)
(0%)
(0%)
0
0
2
3
1
2
(0%)
(0%)
(4%)
(7%)
(2%)
(4%)
1
0
5
4
1
0
(2%)
(0%)
(12%)
(10%)
(2%)
(0%)
2 (6%)
1 (3%)
10
(29%)
0 (0%)
2 (6%)
1 (3%)
3
0
2
4
1
1
(7%)
(0%)
(5%)
(9%)
(2%)
(2%)
4
0
5
5
2
0
(11%)
(0%)
(14%)
(14%)
(5%)
(0%)
a
n 51. bn 51. cn 54. dn 52. eUsual care, n 42; exercise only, n 40; plus only, n 44; exercise plus, n 39. fUsual care, n 43; exercise only, n 39; plus only, n 46; exercise plus, n 41. gUsual care, n 41; exercise only, n 35; plus only, n 43; exercise plus, n 36.
Treatment Fidelity
Treatment fidelity was considered with regard to study
design, training, delivery of treatment, and receipt of treatment (43). Training of the interventionists was completed
as delineated in the procedure manual, and retraining
was ongoing through monthly meetings of the trainers with
the investigators who developed the exercise only and plus
only interventions. The exercise only group on average
received 45% of the total possible visits, the plus only
group received 63% of the total possible visits, and the
exercise plus group received 55% of the total possible visits. Seventy direct observations (five different interventionists) of the interventionists were completed by two of the
investigators. Overall, there was a 90.8% adherence to
delivery of the intervention across all of the treatment
groups, and in 92% of the observed visits the participants
73
TABLE 3
Predicted Means (SE) and Sample Sizes for Outcome Measures for Each Treatment Group
Exercise Only
Variable
Self-efficacy expectations
Baseline
2 month
6 month
12 month
Outcome expectations
Baseline
2 month
6 month
12 month
Exercise time in hours
Baseline
2 month
6 month
12 month
Plus Only
Exercise Plus
Routine Care
SE
SE
SE
SE
5.24
6.61
7.35
7.84
0.36
0.45
0.40
0.28
51
40
38
35
5.33
6.30
7.20
7.14
0.34
0.42
0.33
0.45
54
44
46
42
5.54
6.63
7.14
7.30
0.32
0.45
0.45
0.39
52
39
41
36
5.31
6.45
5.89
6.35
0.37
0.36
0.47
0.51
51
42
43
40
.28
3.92
3.91
3.97
4.07
0.10
0.11
0.09
0.09
51
40
39
35
3.99
3.84
3.93
3.89
0.10
0.11
0.09
0.11
54
44
46
42
3.92
4.07
3.86
3.94
0.10
0.09
0.10
0.10
51
39
41
36
3.95
3.88
3.84
3.73
0.08
0.09
0.10
0.10
51
42
43
40
.13
1.21
1.77
2.27
3.34
0.25
0.36
0.29
0.66
51
40
39
35
0.92
1.49
2.91
3.00
0.35
0.28
0.48
0.55
54
44
46
43
0.76
2.08
2.59
3.10
0.25
0.42
0.63
0.65
52
39
41
36
0.66
1.70
1.02
0.92
0.20
0.36
0.25
0.23
51
42
43
40
< .001
Note. n 208.
DISCUSSION
Partially supporting the stated hypotheses, this study
demonstrated that exposure to the full Exercise Plus Program, the exercise only component, or the plus only
component increased reported time in exercise activities
among older women posthip fracture. This subjective
report was further supported by the objective data from
the SAM for the exercise only and motivation only interventions, but not for exercise plus. As has been suggested
FIGURE 2 Longitudinal trajectories of time (hours) spent exercising as measured by the Yale Physical Activity Survey.
FIGURE 3 Longitudinal trajectories of activity (steps) as measured by the Step Activity Monitor (SAM).
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Resnick et al.
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