Escolar Documentos
Profissional Documentos
Cultura Documentos
Short communication
Bismuth subcarbonate nanoparticles fabricated by water-in-oil microemulsionassisted hydrothermal process exhibit anti-Helicobacter pylori properties
Rong Chen a,b,*, Gang Cheng a, Man Ho So b, Jiliang Wu a, Zhong Lu a, Chi-Ming Che b, Hongzhe Sun b,**
a
Key Laboratory for Green Chemical Process of Ministry of Education and School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Xiongchu Street, Wuhan,
PR China
b
Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong,
Pokfulam Road, Hong Kong, PR China
A R T I C L E I N F O
A B S T R A C T
Article history:
Received 4 July 2009
Received in revised form 9 December 2009
Accepted 24 December 2009
Available online 11 January 2010
Keywords:
A. Inorganic compounds
A. Nanostructures
C. Electron microscopy
C. X-ray diffraction
1. Introduction
Bismuth compounds such as colloidal bismuth subcitrate (CBS)
and ranitidine bismuth citrate (RBC) have widely been used in
clinic for the treatment of gastrointestinal disorders and Helicobacter pylori (H. pylori) infection together with antibiotics [1,2].
Bismuth subcarbonate (BSC) has also been shown to be effective
against this bacterium [3].
Recently, there has been an increasing interest in biological
applications of various nanoparticles. Near infrared (NIR) sensitive
nanoparticles such as AuAu(2)S nanoparticles are intensively being
developed for biomedical applications including drug and gene
delivery [4,5]. The uses of nanoparticles as antibacterial agents such
as silver based nanoparticles which are found to be effective against
E. coli, S. aureus and Ps. aeruginosa have been reported [69]. The
proteomic analysis of the mode of antibacterial action of silver
nanoparticles was also investigated [10,11]. Metal oxide based
nanoparticles, e.g. magnesium oxide and titanium dioxide have also
NH2 2 CO 3H2 O!CO2 2NH
4 2OH
(1)
(2)
655
(3)
656
Fig. 1. Powder XRD spectrum of (BiO)2CO3 nanoparticles (a) and XPS spectra of (BiO)2CO3 nanoparticles at low resolution and high resolution (b) at bismuth (Bi(4f), c), carbon
(C(1s), d) and oxygen (O(1s), e) region.
657
Fig. 2. TEM (a and b) and HRTEM (c and d) images of (BiO)2CO3 nanoparticles. The insets of (b) and (c) show the corresponding SAED pattern of the selected area of
nanoparticles and individual nanoparticle, respectively.
658
References
[1]
[2]
[3]
[4]
[5]
[6]
[7]
[8]
[9]
[10]
[11]
[12]
[13]
[14]
[15]
[16]
[17]
[18]
[19]
[20]
[21]
[22]
[23]
[24]
Acknowledgements
This work was supported by the National Natural Science
Foundation of China (Grant 20801043), Wuhan Chenguang
Scheme (Grant 200850731376) established under Wuhan Science
and Technology Bureau and the Area of Excellence Scheme (AoE/P10/01) established under the University Grants Committee of the
Hong Kong Special Administrative Region China.
Appendix A. Supplementary data
[25]
[26]
[27]
[28]
[29]
[30]
[31]
[32]
[33]
[34]
[35]
[36]