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in observational studies
Jiannong Liu, PhD, Eric Weinhandl, MS, Wendy L St. Peter, Pharm D, FCCP, FASN, BCPS
United States Renal Data System, Minneapolis Medical Research Foundation, University of Minnesota Twin Cities
Introduction
Methods
Figure 1: Immortal
time illustration
Results
Immortal Time
Exposed
Starting date
of exposure
Event date
Study
start date
Study
end date
Unexposed
Event date
Distribution
Lambda
Exponential
800
Alpha
1000
500
1000
1500
Censor
(%)
50
23
40
1300
Weibull
Treatment
(%)
35
0.5
0.33
40
75
40
35
Bias
Measurement
Method 1
Method 2
Method 3
Method 4
Mean RR
0.414
0.183
0.951
1.002
RR Range
(0.35, 0.50)
(0.14, 0.23)
(0.80, 1.24)
(0.80, 1.28)
Significance (%)
100.0
100.0
6.2
5.4
Mean RR
0.585
0.295
0.966
1.000
RR Range
(0.43, 0.77)
(0.23, 0.39)
(0.70, 1.26)
(0.66, 1.39)
Significance (%)
100.0
100.0
5.2
5.6
40
Mean RR
0.717
0.366
1.020
1.009
RR Range
(0.51,0.90)
(0.27, 0.46)
(0.71, 1.29)
(0.66, 1.34)
30
Significance (%)
Mean RR
93.4
0.164
100.0
0.072
3.8
0.477
5.6
1.008
RR Range
(0.14, 0.20)
0.05,0.10
0.40,0.57)
0.72, 1.39)
Significance (%)
100.0
100.0
100.0
4.5
Mean RR
0.526
0.133
1.969
1.002
RR Range
(0.45, 0.61)
(0.11, 0.16)
(1.55, 2.56)
0.76, 1.32)
Significance (%)
100.0
100.0
100.0
4.6
Mean RR
0.155
0.110
0.320
1.005
RR Range
Significance (%)
(0.11, 0.20)
100.0
(0.08, 0.14)
100.0
(0.23, 0.41)
100.0
(0.61, 1.50)
6.4
35
45
Lambda and Alpha are the parameters of exponential and Weibull distributions for life time.
Conclusions
References:
1) Suissa S. Pharmacoepid Drug Safety 2007; 16: 241249
2) Kovesdy CP. Kidney International 2008; 73, 12961302