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10/9/2014

ONLY MRCP MCQs

Md Uzzal
2 mins

Carotid sinus vs. carotid body function


carotid S inuS : measures preSSure.
carotid bO2dy measures O2.

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Md Uzzal
4 mins

Tetracycline: teratogenicity
TEtracycline is a
TEratogen that causes staining of
TEeth in the newborn.

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Md Uzzal
5 mins

Teratogenic drugs: major non-antibiotics


TAP CAP:
Thalidomide
Androgens
Progestins
Corticosteroids
Aspirin & indomethacin
Phenytoin

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Md Uzzal
6 mins

Teratogenic drugs
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1/10

10/9/2014

ONLY MRCP MCQs

"W/ TERATOgenic":
Warfarin
Thalidomide
Epileptic drugs: phenytoin, valproate, carbamazepine
Retinoid
ACE inhibitor
Third element: lithium
OCP and other hormones (eg danazol)

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Md Uzzal
8 mins

Respiratory depression inducing drugs


"STOP breathing":
S edatives and hypnotics
Trimethoprim
Opiates
Polymyxins

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Md Uzzal
9 mins

Pulmonary infiltrations inducing drugs


"Go BAN Me!":
Gold
Bleomycin/ Busulphan/ BCNU
Amiodarone/ Acyclovir/ Azathioprine
Nitrofurantoin
Melphalan/ Methotrexate/ Methysergide

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2/10

10/9/2014

ONLY MRCP MCQs

Md Uzzal
10 mins

Zero order kinetics drugs (most common ones)


"PEAZ (sounds like pees) out a constant amount":
Phenytoin
Ethanol
Aspirin
Zero order
Someone that pees out a constant amount describes zero order kinetics (always the same amount out)

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Md Uzzal
12 mins

Torsades de Pointes: drugs causing


APACHE:
Amiodarone
Procainamide
Arsenium
Cisapride
Haloperidol
Eritromycin

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Md Uzzal
13 mins

Therapeutic dosage: toxicity values for most commonly monitored medications \\


"The magic 2s":
Digitalis (.5-1.5) Toxicity = 2.
Lithium (.6-1.2) Toxicity = 2.
Theophylline (10-20) Toxicity = 20.
Dilantin (10-20) Toxicity = 20.
APAP (1-30) Toxicity = 200.
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3/10

10/9/2014

ONLY MRCP MCQs

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Md Uzzal
14 mins

Quinolones [and Fluoroquinolones]: mechanism


"Topple the Queen":
Quinolone interferes with Topoisomerase II.

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Md Uzzal
15 mins

Microtubules: drugs that act on microtubules.


"The MicroTubule Growth Voiding Chemicals":
Thiabendazole
Mebendazole
Taxol
Griseofulvin
Vincristine/ Vinblastine
Colchicine

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Md Uzzal
16 mins

Metabolism enzyme inducers


"Randy's Black Car Goes Putt Putt and Smokes":
Rifampin
Barbiturates
Carbamazepine
Grisoefulvin
Phenytoin
Phenobarb
Smoking cigarettes
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4/10

10/9/2014

ONLY MRCP MCQs

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Md Uzzal
17 mins

Etoposide: action, indications, side effect


"eTOPoside":
Action:
Inhibits TOPoisomerase II
Indications:
Testicular carcinoma
Oat cell carcinoma of lung
Prostate carcinoma
Side effect:
Affects TOP of your head, causing alopecia

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Md Uzzal
18 mins

Disulfiram-like reaction inducing drugs


"PM PMT" as in Pre Medical Test in the PM:
Procarbazine
Metronidazole
Cefo (Perazone, Mandole, Tetan)

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Md Uzzal
19 mins

Cisplatin: major side effect, action


"Ci-Splat-In":
Major side effect: Splat (vomiting sound)--vomiting so severe that anti-nausea drug needed.
Action: Goes Into the DNA strand
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5/10

10/9/2014

ONLY MRCP MCQs

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Md Uzzal
21 mins

Busulfan: features
ABCDEF:
Alkylating agent
Bone marrow suppression s/e
CML indication
Dark skin (hyperpigmentation) s/e
Endrocrine insufficiency (adrenal) s/e
Fibrosis (pulmonary) s/e

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Md Uzzal
22 mins

Bleomycin: action
"Bleo-Mycin Blows My DNA to bits":
Bleomycin works by fragmenting DNA (blowing it to bits).
My DNA signals that its used for cancer (targeting self cells)

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Md Uzzal
23 mins

Antibiotics contraindicated during pregnancy


MCAT:
Metronidazole
Chloramphenicol
Aminoglycoside
Tetracycline

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6/10

10/9/2014

ONLY MRCP MCQs

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Md Uzzal
24 mins

Tricyclic antidipressents (TCA): side effects


TCA'S:
Thrombocytopenia
Cardiac (arrhymia, MI, stroke)
Anticholinergic (tachycardia, urinary retention, etc)
S eizures

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Md Uzzal
26 mins

SSRIs: side effects


SSRI:
S erotonin syndrome
Stimulate CNS
Reproductive disfunctions in male
Insomnia

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Md Uzzal
28 mins

Sodium valproate: side effects


VALPROATE:
Vomiting
Alopecia
Liver toxicity
Pancreatitis/ Pancytopenia
Retention of fats (weight gain)
Oedema (peripheral oedema)
Appetite increase
Tremor
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7/10

10/9/2014

ONLY MRCP MCQs

Enzyme inducer (liver)

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Md Uzzal
29 mins

Serotonin syndrome: components


Causes HARM:
Hyperthermia
Autonomic instability (delirium)
Rigidity
Myoclonus

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Md Uzzal
30 mins

Pupils in overdose: morphine vs. amphetamine


"MorPHINE: Fine. AmPHETamine: Fat":
Morphine overdose: pupils constricted (fine).
Amphetamine overdose: pupils dilated (fat).

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Md Uzzal
31 mins

Phenytoin: adverse effects


PHENYTOIN:
P-450 interactions
Hirsutism
Enlarged gums
Nystagmus
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8/10

10/9/2014

ONLY MRCP MCQs

Yellow-browning of skin
Teratogenicity
Osteomalacia
Interference with B12 metabolism (hence anemia)
Neuropathies: vertigo, ataxia, headache

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Md Uzzal
33 mins

Parkinsonism: drugs
SALAD:
S elegiline
Anticholinenergics (trihexyphenidyl, benzhexol, ophenadrine)
L-Dopa + peripheral decarboxylase inhibitor (carbidopa, benserazide)
Amantadine
Dopamine postsynaptic receptor agonists (bromocriptine, lisuride, pergolide)

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Md Uzzal
35 mins

Myasthenia gravis: edrophonium vs. pyridostigmine


eDrophonium is for Diagnosis.
py RIDostigmine is to get RID of symptoms

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Md Uzzal
37 mins

Morphine: effects
MORPHINES:
Miosis
Orthostatic hypotension
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9/10

10/9/2014

ONLY MRCP MCQs

Respiratory depression
Pain supression
Histamine release/ Hormonal alterations
Increased ICT
Nausea
Euphoria
S edation

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Md Uzzal
41 mins

Lithium: side effects


LITH:
Leukocytosis
Insipidus [diabetes insipidus, tied to polyuria]
Tremor/ Teratogenesis
Hypothyroidism

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10/10