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INTRODUCTION
962
DOI: 10.2319/011216-33.1
963
Surgery
A complete high-level Le Fort I osteotomy was
made, then the maxilla was downfractured softly
to ensure its mobility. Maxillary advancement was
performed using a RED device10 (KLS-Martin L.P.,
Tuttlingen, Germany) in combination with titanium
miniplates and screws for anchorage. Two titanium
miniplates were fixed with screws at both sides of
the anterior maxillary wall to be used for traction.
The RED device was applied immediately after
surgery using scalp screws. After a latency period of
5 days, distraction was performed at a rate of 1 mm/day
until a positive overjet was achieved. The distraction
device was left in place for 4 weeks for rigid retention.
Lateral cephalograms, nasometer, and nasopharyngoscopy were used for evaluating the patients at
three stages: preoperatively (T0), postdistraction (T1),
and 1 year after distraction (T2).
Cephalometric Analysis
All lateral cephalograms were manually traced.
Reference points were marked, yielding 22 linear and
seven angular measurements (Figures 1 and 2).14,18
964
TAHA, ELSHEIKH
RESULTS
Cephalometric Measurements
The parameters pertaining to the sagittal maxillary
changes were 9.67u at the SNA angle, 8.5 mm at A
point, 11 mm at ANS, and 9.5 mm at PNS.
The vertical treatment changes in the maxilla, at the
position of A, ANS, and PNS points relative to the
X-axis, were increased significantly (P 5 .0001, .0001,
and .017, respectively), whereas the mean increases
in SNB angle, FMA, MP to SN, and PP to SN angles
were not statistically significant (P 5 .900, .749, .538,
and .493, respectively; Table 1). Significant increases
were observed in the nasopharyngeal and oropharyngeal dimensions (P 5 .0001), while the hypopharynx
(V-IPW) showed a nonsignificant change (P 5 .878).
Statistically significant results were recorded for the
velar angle and the need ratio (P 5 .0001). However,
the soft palate revealed no significant changes
(Table 2). Regarding the follow-up cephalometric
changes from T1 to T2, there were no significant
changes during this period except for the velar angle
(P 5 .005).
Nasometer
Nasopharyngoscope
The Karl Storz fibroptic naso-pharyngo-laryngoscopy model 11001 RP was used. Commenting on the
video record reply of all assessment aspects was done
with three judges.
Angle Orthodontist, Vol 86, No 6, 2016
965
SNA
SNB
ANB
FMA
MP to SN
PP to SN
A-X
ANS-X
PNS-X
A-Y
ANS-Y
PNS-Y
T1
T2
Mean
6 SD
Mean
6 SD
Mean
6 SD
P1
P2
71.33
75.33
24.42
33.83
42.92
11.83
50.92
43.58
41.58
58.42
61.67
17.33
3.85
2.90
3.50
3.41
4.85
2.59
6.01
5.07
4.38
6.86
9.32
4.42
81.00
75.42
5.58
34.17
43.83
12.50
57.00
48.75
43.67
66.92
72.67
26.83
4.26
3.42
3.60
4.63
4.47
3.63
5.03
5.50
3.20
8.66
8.18
4.80
78.67
74.22
5.67
34.11
44.22
13.11
56.22
47.78
44.00
64.78
71.67
24.89
4.58
4.06
2.87
3.72
4.09
3.41
6.91
4.55
3.46
7.40
6.42
4.26
.0001
.900
.0001
.749
.538
.493
.0001
.0001
.017
.005
.012
.0001
.134
.202
.915
.105
.233
.844
.831
.824
.629
.094
.535
.419
T0 indicates before distraction; T1, after distraction; T2, after retention; P, probability test used: paired t-test; P1, significance between T0 and
T1; and P2, significance between T1 and T2.
DISCUSSION
Lateral cephalometric films and computed tomography are used to assess velopharyngeal status, providing observation of soft and hard tissues, although
the reliability of the two-dimensional image has been
questioned as a valid representation of the actual
nasopharyngeal anatomy. Some studies23 have shown
that pharyngeal airway space measured by cephalograms offers good agreement with a three-dimensional
computed tomography scan.
Cephalometric analysis of the sagittal and vertical
positions of the maxilla showed significant changes,
which were expected as a result of distraction. When
the maxilla was brought forward by DO, the depth of
the nasopharynx and oropharynx were increased
significantly (13.75 mm and 3.5 mm, respectively).
This is due to the forward movement of the posterior
PNS-ad1
ad1-Ba
PNS-Ba
PNS-ad2
Ad2-H
PNS-H
Ptm-Ba
PNS-UPW
U-MPW
V- IPW
PNS-U
SPT
ANS-PNS-U
PNS-V
T-V
TGH
Need ratio
T1
T2
Mean
6 SD
Mean
6SD
Mean
6 SD
P1
P2
20.83
23.00
45.08
17.08
12.83
29.92
44.83
20.58
14.83
15.50
29.33
7.83
125.00
65.58
76.58
34.42
.70
3.41
4.13
4.23
3.96
3.69
4.32
4.61
3.03
3.10
3.15
2.02
1.19
3.88
8.24
2.50
2.54
.13
34.25
22.83
57.00
29.75
12.17
41.92
44.58
34.33
18.33
15.33
30.58
6.67
140.25
66.92
76.75
34.58
1.14
3.05
2.33
3.95
4.33
2.92
4.10
3.68
3.20
4.01
4.25
2.07
.98
5.22
8.69
3.02
2.39
.13
32.78
23.22
56.00
29.89
10.89
40.67
44.33
33.00
17.33
13.56
30.00
6.33
136.67
64.89
76.56
34.11
1.06
1.99
2.95
3.46
4.88
2.32
4.50
4.80
2.00
4.69
3.84
2.92
1.00
4.39
8.08
4.50
3.02
.13
.0001
.877
.0001
.0001
.526
.0001
.855
.0001
.0001
.878
.183
.06
.0001
.358
.854
.867
.0001
.094
.650
.012
.763
.855
.700
.877
.184
.305
.531
.763
.195
.005
.894
.928
.912
.157
T0 indicates before distraction; T1, after distraction; T2, after retention; P, probability test used: paired t-test; P1, significance between T0 and
T1; and P2, significance between T1 and T2.
Angle Orthodontist, Vol 86, No 6, 2016
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TAHA, ELSHEIKH
Table 3. Changes in the Nasometer Measurements Before Distraction (T0), After Distraction (T1), and After Retention (T2)
Nasal text
Oral text
T0
T1
T2
P1
P2
54.86 6 15.94
35.10 6 15.54
67.13 6 9.62
44.03 6 17.15
67.84 6 12.05
42.10 6 13.54
.008
.044
.787
.348
P1 indicates t-test between T0 and T1; P2, t-test between T1 and T2.
Table 4. Judgments of Nasal Resonance Using a 5-Point Scale (0 5 Normal; 1 5 Mild; 2 5 Moderate; 3 5 Severe; 4 5 Very Severe)
Hypernasality
Hyponasality
Patient No.
T0
T1
T2
Direction
T0
T1
T2
Direction
1
2*
3
4*
5
6
7
8
9
10
11*
12*
13
14
15
16*
17*
18
19
20*
21
22
23
24*
25
26
27
28
29
30
Mean
3
0
1
2
1
2
3
3
3
0
3
1
2
1
2
2
3
0
1
0
0
3
3
1
3
1
1
2
2
1
1.8
3
0
3
2
4
1
3
4
4
4
3
2
2
4
1
2
3
0
2
0
4
4
4
2
3
4
3
1
1
1
2.4
3
0
3
2
4
1
3
4
4
4
3
2
2
4
1
2
3
0
2
0
4
4
4
2
3
4
3
1
1
1
2.4
Same
Same
Deteriorated
Same
Deteriorated
Improve
Same
Deteriorated
Deteriorated
Deteriorated
Same
Deteriorated
Same
Deteriorated
Improve
Same
Same
Same
Deteriorated
Same
Deteriorated
Deteriorated
Deteriorated
Deteriorated
Same
Deteriorated
Deteriorated
Improve
Improve
Same
3
1
0
0
0
0
0
0
0
3
0
0
0
0
0
3
0
0
0
1
0
0
0
0
0
3
0
0
0
0
0.46
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0.06
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0.06
Improve
Same
Same
Same
Same
Same
Same
Same
Same
Improve
Same
Same
Same
Same
Same
Improve
Same
Same
Same
Same
Same
Same
Same
Same
Same
Improve
Same
Same
Same
Same
T0 indicates before distraction; T1, after distraction; and T2, after retention.
* : patient with pharyngeal flap.
Angle Orthodontist, Vol 86, No 6, 2016
967
Palate
Right pharyngeal wall
Left pharyngeal wall
T0
T1
T2
P1
P2
2.43 6 0.43
2.43 6 0.62
2.48 6 0.55
2.71 6 0.62
2.64 6 0.77
2.57 6 0.47
2.64 6 0.14
2.62 6 0.43
2.53 6 0.47
.104
.272
.671
.189
.67
.165
P1 indicates t-test between T0 and T1; P2, t-test between T1 and T2.
indicated decreased speech intelligibility and subsequent speech worsening. This effect might be
attributed to the greater increase in the pharyngeal
depth than the velar length resulting in compromised
VP closure and coupling between the oral and nasal
cavities. An increase in hypernasality after maxillary
distraction in cleft patients was reported in other
studies as well.1416 In agreement with our results,
previous studies4,6 also reported a similar deterioration
of hypernasality in the patients who experienced
abnormal preoperative hypernasality before advancement. This indicates that maxillary advancement as
performed in this study may contribute to the worsening of a previously existing hypernasality in subjects
with cleft.
It was very obvious that the presence of a predistraction pharyngeal flap decreased the degree of
resultant postdistraction hypernasality, and these
findings were found to coincide with the results of Ko
et al.,14 Guyette et al.,15 and Harada et al.,16 in whose
studies the flap is a soft tissue obturator of the
pharyngeal space.
Twelve patients maintained the same degree of
hypernasality, and four patients showed some
improvement, from moderate to mild hypernasality;
thus, compensation in the VF mechanism might be
assumed in these patients. The small, consistent
increase in velar length and the significant increase
in velar angle achieved some form of muscular
compensatory activity in these patients. The increase
in the velar angle was the result of stretching of the soft
palate, which is aided in maintaining the vertical
position of the soft palate and is considered to be
a part of the compensation occurring in the VP
mechanism.14 Through a gradual bone distraction
procedure, the surrounding soft tissues may have
a better chance to adapt to the structural changes,
in contradiction to the sudden changes elicited by
the Le Fort I osteotomy.
Warren and Drake26 reported that 60% of their
subjects with cleft had nasal airway obstruction. In our
PNS-UPW
U-MPW
V-IPW
PNS-U
SPT
ANS-PNS-U
Hyper
Endos
.695
.012
2.021
.947
2.404
.193
2.526
.079
2.056
.863
.361
.249
.587
.026
2.080
.806
r indicates Pearsons correlation coefficient; P, probability; Hyper, postdistraction hypernasality; and Endos, postdistraction endoscopic
results.
Angle Orthodontist, Vol 86, No 6, 2016
968
A comprehensive speech evaluation is an important
component of treatment planning for maxillary DO,
especially if done in cleft patients. If VP closure
cannot be compensated for, pharyngoplasty and
pharyngeal flap procedures should be considered to
correct the VPI.
CONCLUSIONS
N The maxilla was moved forward by gradual distraction, causing an increase in nasopharyngeal depth
and compromising VPF.
N There was a positive correlation between the amount
of maxillary advancement and the increase in
hypernasality and pharyngeal depth.
N No significant relapse was encountered in maxillary
skeletal position, nasopharyngeal measurements, or
function during the follow-up period.
TAHA, ELSHEIKH
12.
13.
14.
15.
16.
17.
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