To investigate the association between HLA-DRB1* alleles and post-streptococcal acute

glomerulonephritis (PSAGN) in Egyptian children, 32 unrelated patients with PSAGN and 380
healthy individuals from the same locality were typed for DRB1* alleles using the polymerase
chain-reverse hybridization technique. Patients with PSAGN had significantly increased
frequency of both DRB1* 03011 (46.9 vs. 19.2% in controls, P=0.00025) and DRB1* 1105
(31.1 vs. 15.6% in controls, P=0.0097) alleles. However, after correction of P values, only the
difference for DRB1* 03011 allele remained significant (Pc =0.025). Their relative risks were
significantly high (3.71, confidence interval [CI]=1.87.8, and 3.57, CI=1.48.9 respectively).
No significant differences in the frequency of the two alleles were observed among patients with
different grades of hypertension or proteinuria. In conclusion, DRB1* 03011, and possibly 1105,
alleles confer susceptibility to PSAGN. However, the severity of the disease is not determined by
these two alleles.8
Sibling contacts have increased risk for the development of clinical/subclinical poststreptococcal glomerulonephritis compared with their parents. Sibling contacts with unexplained
urinary abnormalities might have subclinical nephritis in evolution; their complement levels
normalized before occurrence of nephritis in index cases. 7
Kontak saudara memiliki peningkatan risiko terhadap terjadinya GNAPS klinis dan subklinis
dibandingkan dengan orang tua. Kontak saudara dengan kelainan urin yang tidak dapat
dijelaskan mungkin merupakan nefritis subklinis. Alel HLA DRB1* 03011 dan mungkin HLA
DRB1* 1105 berpengaruh pada kerentanan terhadap GNAPS.

1. Rodriguez B, Mezzano S. Acute postinfectious glomerulonephritis. Dalam: Avner ED,

Harmon WE, Niaudet P, Yashikawa N, penyunting. Pediatric nephrology. edisi ke-6. Berlin:
Springer; 2009. h. 743-55.
2. Smith JM, Faizan MK, Eddy AA. The child with acute nephritis syndrome. Dalam: Webb N,
Postlethwaite R, penyunting. Clinical paediatric nephrology. edisi ke-3. New York: Oxford;
2003. h. 367-80.
3. Rauf S, Albar H, Aras J. Konsensus Glomerulonefritis Akut Pasca Streptokokus. Unit Kerja
Nefrologi. Ikatan Dokter Anak Indonesia. Jakarta: Badan Penerbit Ikatan Dokter Anak
Indonesia. 2012. h. 1-17.
4. Alatas H, Tambunan T, Trihono P, Pardede S. Buku Ajar Nefrologi, edisi ke-2. Jakarta: Balai
Penerbit FKUI; 2002. h. 323-359.
5. Pardede SO, Puspaningtyas NW. Kriteria RIFLE pada Acute Kidney Injury. Majalah
Kedokteran FK UI. Vol. XXVIII, No.2. 2012. h. 92-9.
6. Permono B, Sutaryo, Ugrasena IDG, Windiastuti E, Abdulsalam M. Buku Ajar HematologiOnkologi Anak. Jakarta: Balai Penerbit IDAI; 2006. h. 58 63.

7. Layrisse Z, Rodriguez-Iturbe B, Garcia-Ramirez R, Rodriguez A, Tiwari S. Family studies of

the HLA system in acute post-streptococcal glomerulonephritis. Human Immunology. 1983. 7
(3): 177-185.
8. Bakr A, Mahmmod LA, Al-Chenawi F, Salah A. HLA-DRB1* alleles in Egyptian children
with post-streptococcal acute glomerulonephritis. Pediatr Nephrol. 2007. 22: 376-379.
9. Kaspadia AS, Panda M, Fogo AB. Case Report: Postinfectious Glomerulonephritis: Is there
a role for steroid?. Indian Journal of Nephrology. 2011. 21 (2): 116-119.
10. Zeledon JL et al. Glomerulonephritis causing acute renal failure during the course of
bacterial infection: Histological varieties, potential pathogenetic pathways and treatment.
Int Urol Nephrol. 2008. 40 (20): 461-70.
11. Jovanovic D, Kovacevic Z, Rabrenovic V, Skataric V. Acute post streptococcal
glomerulonephritis in adults corticosteroid therapy, yes or no? Vojnosanitetski Pregled.
2001. 58 (2): 161 166.
12. Chan JC, Williams DM, Roth KS. Kidney Failure in Infants and Children. Pediatrics in
Review. 2002. 23(2): 47-59.
13. Rang HP, Dale MM, Ritter JM, Flower RJ, Henderson G. Rang and Dales Pharmacology.
Edisi 7. 2011. Churchill Livingstone, Elsevier. h. 626-9.
14. Ljutic D, Perkovic D, Rumboldt Z, Bagatin J, Hozo I, Pivac N. Comparison of ondansetron
with metoclopramide in the symptomatic relief of uremia-induced nausea and vomiting.
Kidney Blood Press Res. 2002: 25(1):61-4.
15. Coca G, Yusuf B, Shlipak MG, Garg AX, Parikh CR. Long-term risk of mortality and other
adverse outcomes after acute kidney injury: A systematic review and meta-analysis. Am J
Kidney Dis. 2009. 53:96173.
16. Goldstein SL, Devarajan P. Progression from acute kidney injury to chronic kidney disease :
A pediatric perspective: An invited review for Advances in Chronic Kidney Disease. Adv
Chronic Kidney Dis. 2008. 15:27883.