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BMED 3100 Systems Physiology

Problem Set 3, Due Thursday, October 27, 2016


See syllabus for homework guidelines.
1. a) What is the partial pressure of oxygen in atmospheric air? Show how you got this answer.
b) What is the partial pressure of oxygen at 100% humidified air at 37C? Show your work.
a. 760 mmHg/1 atm * 0.21 = 160 mmHg
b. it is reduced. (760-47) mmHg * 0.21 = 150 mmHg (vapor pressure is higher moisture in air
takes space; gas is more soluble in air than liquid liquid vapor pressure displaces oxygen)
2. According to the Fick principle, the oxygen consumption rate of an organ is equal to the blood flow
through that organ times the amount of oxygen extracted from the blood as it flows through the
organ:
Oxygen consumption rate = cardiac output * (arterial oxygen content venous content)
Donald has a total body oxygen consumption rate of 250 mL O2 consumed per minute. The O2
content of blood in his aorta is 200mL O2/L. The O2 content of pulmonary artery blood is 140mL
O2/L blood.
a) What is his cardiac output?
b) What is the rate of O2 transport from his left ventricle?
c) What is the rate of O2 transport returning to his right atrium?
a) blood flow = CO = 250 mL O2/min / (200-140 mL O2/L) = 4.167 L/min (4167 mL/min)
b) 4.17 L/min*200 mL O2/L = 833 mL O2/min
c) 4.17 L/min*140 mL O2/L = 583.8 mL O2/min
3. Hillary had complications from pneumonia and her left lung collapsed. Her Hb concentration is 12
g/dl and alveolar PO2 is 50 mm Hg
a) What is her arterial PO2?
b) What is the concentration of dissolved O2 in her blood?
c) What is the total O2 content?
a) 50 mmHg (same as PAO2)
b) 50 mmHg * 0.003 ml O2/dl blood /mmHg = 0.15 ml O2/dl blood
c) total = soluble + bound = 0.15 ml O2/dl blood + (12 g/dl * 1.34 ml O2/g Hb * 0.8) = 13 ml O2/dl
blood (if read over 80% saturation value will be slightly higher.)
4. Gary just got a new hybrid car and it has a keyless ignition. He forgets to turn off the car when he
comes home one night and carbon monoxide builds up in the garage and leaks into the adjacent living
room where he is watching TV. He feels light headed and disoriented and calls 911. When the
ambulance arrives they figure it out and turn off the car and bring him to the hospital while
administering oxygen. Upon arrival it is found that his hemoglobin concentration is 14 g/dl, his PaO2 is
100 mm Hg, and 80% of the Hb is carboxyhemoglobin (i.e. bound to CO).
a) what is his O2 -binding capacity?
b) what is total oxygen content?
c) When Gary was in the ambulance receiving O2 did it help? Why or why not?
d) Draw an oxyhemoglobin dissociation curve for this situation.
a) If 80 % of the hemoglobin is bound to CO, only 20% is available for O2, so
Hb-O2 capacity = 14 g Hb/dl blood * 1.34 ml O2/g Hb * 20% = 3.75 mlO2 / dL blood

BMED 3100 Systems Physiology


Problem Set 3, Due Thursday, October 27, 2016
See syllabus for homework guidelines.
b) Total O2 content is the amount bound to Hb + the O2 dissolved in blood. We know the first
value, but need to calculate the dissolved O2, which isnt affected by the CO that is bound to
O2.
Dissolved O2 = 100 mm Hg * 0.003 mLO2 / dl blood / mm Hg = 0.3 mLO2 / dl blood
Total O2 content = 3.75 mLO2 / dl + 0.3 mLO2 / dl = 4.05 mLO2 / dl
c) Yes, the O2 in the ambulance helped! The relative percentage of O2 that is dissolved versus
bound is much higher (0.3 / 4 ~ 7.5 %) versus the normal situation (0.3 / 19 ~1.6%), therefore it is
important to keep the level as high as possible. Other reasonable answers accepted, but must be
based in physiology (i.e. not just its better than nothing).
Similar to this, but plateaus at 20%:

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