Common Drugs and Antidotes

Substance

Antidote

Acetaminophen/ Tylenol/ Paracetamol

acetylcysteine (Mucomyst)

Non-specific poisons except cyanide, iron, lithium, caustics and

alcohol.

Activated charcoal

Potassium

albuterol inhaler, insulin & glucose,

NaHCO3, kayexalate

Neuromuscular blockade (paralytics)

anticholinesterase agents

Anticholinesterase

atropine sulfate or pralidoxime

Amanita phalloides (Death cap mushroom)

Benzylpenicillin

Fluoride ingestion

Calcium salts

Iron

deferoxamine

Digoxin

digibind
digoxine immune fab

Lead

dimercapol, edetate calcium, disodium,

Extrapyramidal symptoms (EPS)

diphenhydramine (Benadryl)

Benzodiazepines

flumazenil

Ethylene glycol

fomepizole

Beta blockers and calcium channel blockers

glucagon

Insulin reaction

Glucose (Dextrose 50%)

Ergotamine

Heparin

Cyanide

Hydroxocobalamin

Fluorouracil

leucovorin calcium

calcium gluconate

Magnesium sulfate

Cyclophosphamide

mesna

Chemical producing severe methemoglobinemia. Ifosamide-induced

encephalopathy.

Methylene blue

Opioid analgesics

nalmefene or naloxone

Narcotics

naloxone (Narcan)

Anticholinergics

Neostigmine

Cyanide

Nitrite, sodium and glycerytrinitrate

Copper, gold, lead, mercury, zinc, arsenic

Penicillamine

Dopamine

phentolamine (Regitine)

Tricyclic antidepressants

phyostigmine or NaHCO3

Coumadin/Warfarin

Phytomenadione (Vitamin K.)

Heparin

protamine sulfate

Isoniazid, theophylline, monomethyl hydrazine. Adjunctive therapy in

ethylene glycol poisoning.

Pyridoxine

Cobra bite

Snake anti-venin

Iron

Sodium Bicarbonate

Cyanide

Sodium thiosulphate

Alcohol, Wernicke-Korsakoff Syndrome

Thiamine

Chemicals causing methemoglobinemia in patients with G6PD

deficiency

Vitamin C

Toxin
Acetaminophen
(Paracetamol)
Salicylates
Anticholinesterases,
organophosphates
Antimuscarinic,
anticholinergic agents
Beta blockers
Digitalis

Iron (Ferrous Sulfate)

Lead
Arsenic, mercurym gold
Copper, arsenic, gold
Cyanide
Methemoglobin
Carbon Monoxide
Methanol, ethylene glycol
(antifreeze)
Opioids, Narcotic Analgesics:
Demerol and Morphine
Sulfate
Benzodiazepines
Tricyclic antidepressants
(Anafranil, Tofranil)
Anticoagulant: Heparin
Anticoagulant: Warfarin
Thrombolytics: t-PA,
(Streptokinase, Urokinase)
Lithium Carbonate (Eskalith)
Calcium Channel Blocker
(Verapamil)
Magnesium Sulfate

Antidote / Treatment
N-acetylecysteine
Alkalinize urine, dialysis
Atropine, Pralidoxime
Physostigmine salicylate
Glucagon
Stop digitalis, normalize K;
lidocaine, anti-dig FAB
fragments ( Digitoxin) Digitalis
Immune FAB
Deferoxamine
CaEDTA, dimercaprol, succimer,
penicillamine
Dimercaprol (BAL), succimer
Penicillamine
Nitride, Hydroxocobalamin
Methelyn blue
100% O2, hyperbaric O2
Ethanolm dialysism fomepizole
Naloxone Hydrochloride
(Narcan), Naltrexone
Flumazenil (Romazicon)
NaHCO3 (nonspecific)
Protamine Sulfate
Vitamin K, fresh frozen plasma
Aminocaproic Acid ( Amicar)
Sodium Bicarbonate
Calcium
Calcium Gluconate