Escolar Documentos
Profissional Documentos
Cultura Documentos
1647
Epithelial-mesenchymal
signalling regulating
tooth morphogenesis
Irma Thesleff
Institute of Biotechnology, University of Helsinki,
00014 Helsinki, Finland
(e-mail: irma.thesleff@helsinki.fi)
Journal of Cell Science 116, 1647-1648
2003 The Company of Biologists Ltd
doi:10.1242/jcs.00410
Differentiation
and mineralization
Morphogenesis
Dental lamina
Bud
Cap
Bell
Root formation
and eruption
Late bell
Enamel
Ectoderm
Dentin
Dental placode
Mesenchyme
Cervical loop
Msx1-/Enamel knot
Pax9-/Lef1-/Secondary enamel knots
Activin A-/Runx2 -/-
Dentin
Enamel
Pulp
Root
Jaw bone
Oral ectoderm
BMP
FGF
SHH
Pitx2
WNT
TNF
Odontogenic
mesenchyme
Dental placode
p21
Msx2
Lef1
Edar
BMP
ACTIVIN
Bud ectoderm
BMP
TNF
FGF
SHH
WNT
Enamel knot
p21
Msx2
Lef1
Edar
Condensed dental
mesenchyme
BMP
FGF
SHH
WNT
Secondary
enamel knots
p21
Msx2
Lef1
BMP
FGF
SHH
WNT
Differentiation
and mineralization
Dental papilla
mesenchyme
1648
References
Jernvall, J. and Thesleff, I. (2000). Reiterative
signaling and patterning in mammalian tooth
morphogenesis. Mech. Dev. 92, 19-29.
Salazar-Ciudad, I. and Jernvall, J. (2002). A
gene network model accounting for development
and evolution of mammalian teeth. Proc. Natl.
Acad. Sci. USA 99, 8116-8120.
Thesleff, I. and Mikkola, M. (2002). The role of
growth factors in tooth development. Int. Rev.
Cytol. 217, 93-135.