Exercise and immune crosstalk in breast cancer microenvironment

Supplemental Table 1. Risk of Bias (aka Quality Ratings)

Selection Bias

Performance Bias

(Measurment
Bias)

(Attrition
Bias)

Blinding of
outcomes assessors

Dropout

Allocation
Author, publication year Randomization concealed
(investigators)

Blinding
Groups similar Blinding of
of treating
at baseline
patients
providers

Fairey et al., 2005

NR

52/53 (98%)
Exercise: 24
Control: 28

Exercise: (1)
4.2%

National Cancer Institute

of Canada (NCIC), Canadian Cancer Society (CCS),
CCS/NCIC Sociobehavioral
Cancer Research Network.

Campbell P.T. et al., 2008

NR

108/112 (96%)
Exercise: 50
Control: 58

National Institutes of
Health

Arikawa et al., 2011

NR

319/391 (82%)
Exercise: 166
Control: 153

Exercise: (46)
21.7%
Control: (26)
14.5%

National Institutes of
Health/National Cancer
Institute

Horne et al., 1997

NR

Exercise: 4
Control: 5

NR

NR

Jimenez et al., 2007

NR

8/8 (100%)

NR

NR

Nehlsen-Cannarella et al.,
1991

NR

36/36 (100%)

NR

Steele Foundation grant

Campbell K.L. et al., 2008

NR

95/100
Control: 49
Exercise: 46

Overall: 3%
Exercise: (1)
2.08%
Control: (2)
3.92%

National Institutes of
Health

Friedenreich et al., 2012

NR

310/320 (97%)
Exercise: 154
Control: 156

Overall: 2.8%
Exercise: (5)
3.1%
Control: (4)
2.5%

Canadian Breast Cancer

Research Alliance, the
Alberta Cancer Foundation, Alberta Heritage for
Medical Research Health,
Canadian Institutes of
Health Research.

Lee et al., 2012

NR

22/27 (81%)
Control: 7
LI: 8
HI: 7

(5/27) 20%

Kyung Hee University

Imayama et al., 2012

NR

186/204 (91%)
Exercise:
106/117
Control: 80/87

Overall: 39.9%

National Cancer Institute

Sprod et al., 2012

NR

21/35 (60%)
Exercise: 9
Control: 10

Overall: 52%
Exercise: (6)
66%
Control: (4)
40%

Sally Schindel Cone Foundation (KMM), NCI

Completion of
study

Intention
Funding source
to treat

Exercise and immune crosstalk in breast cancer microenvironment

Nieman et al., 1995

NR

16/20 (80%)
Exercise: 8
Control: 8

Overall: 40%
Exercise: (2)
(10%)
Control: (2)
(10%)

National Institute of Aging

Payne et al., 2008

NR

18/20 (90%)
Exercise: 9
Control: 9

Overall: 10%
Exercise: (1)
(10%)
Control: (1)
(10%)

National Institute of Nursing Research

Ergun et al., 2013

NR

38/40 (95%)
Exercise: 18
Control: 20

2/40 (5%)
Exercise: 2

NR

Ege University Medical

Faculty BAP project

Jones et al., 2013

NR

67/68 (99%)
Exercise: 36
Control: 31

1/68 (1.5%)
Control: 1

American Cancer Society

Abbreviations: Y, yes; N, no; NR, not reported.