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1.1 ......
1.2
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1.3
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1.4
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1.5

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23.

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. 30.12.2014 2782- ( . 26.12.2015)
58.


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: 18 2006 .
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59.

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. 30 1998 . 681.
60.

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61.

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62.

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63.

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64.


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68.

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77.

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79.

- 18.02.1997 59.
80.

034-2014 ( 2008):
31 2014 . 14-.
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07 2011 . 420-).

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2014 : . . 19 2013
. 2427-.
83.

.. , ,

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.: - , 2006. 456.
84.

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18771878 .. ., 1879. .
1. 416 .
126

85.

.., .., .., ..,

.. Nutrition Day .
. . 2011.
86.

09.01.1996 2.
87.

17.09.1991 (. 18.04.1995).
88.

23 2010 . 706.
89.

/ . [ .]. (); .(), 1997.


100 .
90.

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, 1959. 432 .
91.

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XXI . 2010. . 12.
4. . 414-416.
92.

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93.

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- .
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94.

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(22). . 179184.
95.

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. : - . 2005. 255 .
127

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. 1998. 4. .8081.
97.


/ . . 2015. 480 .
98.

( ). .: ,
2000. .I. 975.
99.

( ). .: , 2005. .VI.
968.
100.

( ). .: , 2006. .VII.
1000.
101.
( ). : . ..
. 2010. 148 .
102. (5-
.). .: .. , 2013. 178 .
103.
) / .
.. .., . . 2014.
244.
104.
/
. . 2015. 324 .
105. , .. .
/ .. , .. . .: , 2003. 221 .
128

106. .. / .. ;
.. .. . ., 2000. C. 316 348.
107. .., .., .. :
// . . . 1999. . 7. 15.
108. ,

..

/ .. , .. , .. // . 1999. 12
. 535
109. , .. -
/ .. , .. , . , .. , . // .
1999. 7 . 1
110. ..
/ .. , .. // . 1998. 5.
.610.
111. .., ..
(ESPEN)
. . 2009.
112. .., ..
. . 2010. . 2
.12-18.
113. , ..
/ .., .., .. // :
. 2015. . 3. 4. . 7-14.
114. , ..
/
.., .. // : . 2015. . 1.
3. . 7-16.
115. , .. -
/ .., ..,
.. // .
. 2012. . 5. 4. . 3-8.
129

116. , .. :
/ .., .. // .
. 2011. 2. . 912.
117. ,

..

..,

..,

..

//

: . 2014. . 2. 1. . 5-20.
118. ,

..

/ .., .. // . 2007. 9. .
73-78.
119. , .. : / ..
// - . ..
. 2008. 1. . 130137.
120. , .. : / ..
// - . ..
. 2007. 3. . 182189.
121. Adherence to longterm therapies. Evidence for action. Geneva, World
Health

Organization,

2003.

].

http://www.who.int/chp/knowledge/publications/adherence_report/en/
122. American Medical Association. AMA policy on drug formularies and
therapeutic interchange in inpatient and ambulatory patient care settings. Am J Hosp
Pharm. 1994; 51:180810.
123. American Society of Hospital Pharmacists, American Hospital Association,
American Pharmaceutical Association et al. Statement of guiding principles on the
operation of hospital formularies. Am J Hosp Pharm. 1964; 21:401.
124.

American Society of Hospital Pharmacists. Minimum standard for

pharmacies in hospitals. Am J Hosp Pharm. 1958; 15:9924.

130

125. ASHP Guidelines on the Pharmacy and Therapeutics Committee and the
Formulary

System

].

http://www.ashp.org/doclibrary/bestpractices/formgdlptcommformsyst.pdf
126. Australian pharmaceutical formulary 23rd edition available [
]. :

https://ajp.com.au/news/australian-pharmaceutical-

formulary-23rd-edition-available/
127. Base des Medicaments et Informations Tarifaires [ ].
: http://www.codage.ext.cnamts.fr/codif/bdm_it
128. Briggs

AH.

Handling

uncertainty

in

cost-effectiveness

models.

Pharmacoeconomics. 2000;17(5):479-500.
129. British National Formulary [ ]. :
http://www.bnf.org/about/
130. British National Formulary: The Essential Reference Books [
]. : http://www.bnf.org/products/books/
131. Budget Impact Analysis Good Practices [ ].
: http://www.ispor.org/budget-impact-health-study-guideline.asp
132. Canadian Agency for Drugs and Technology in Health. Health Technology
Assessment.

].

www.cadth.ca/index.php/en/hta..
133. Codd E.F. The Relational Model for Database Management Version 2.
Reading, Mass.: Addison-Wesley, 1990.
134. Department of Veterans Affairs National Acquisition Center. Federal
supply schedule service pharmaceuticals. [ ]. :
www1.va.gov/oamm/oa/nac/fsss/pharmfss.cfm.
135. Drug Effectiveness Review Project. Home page. [ ].
: www.ohsu.edu/ohsuedu/research/policycenter/DERP/index.cfm
136. Drug promotion: what we know, what we have yet to learn [
]. : http://apps.who.int/medicinedocs/pdf/s8109e/s8109e.pdf

131

137. Drummond MF, Sculpher MJ, Torrance GW, OBrian BJ, Stoddart GL.
Methods for the economic evaluation of health care programmes. 3rd Ed. Oxford:
Oxford University Press; 2005.
138. Essential medicines and health products [ ].
: http://www.who.int/medicines/areas/rational_use/en/
139. France G, Taroni F, Donatini A. The Italian health-care system. Health
Econ. 2005 Sep;14(Suppl 1): S187-202.
140. German

Institute

of

Medical

Documentation

and

Information

[ ]. : http://www.dimdi.de/static/en/index.html
141. Health Affairs Policy 04-032. TRICARE Pharmacy Benefit Program
Formulary

Management.

].

www.ha.osd.mil/policies/2004/04-032.pdf.
142. Holloway, K. editor. (2003) Drug and therapeutics committees: a practical
guide. Geneva: World Health Organization. Department of Essential Drugs and
Medicines

Policy.

].

http://apps.who.int/medicinedocs/pdf/s4882e/s4882e.pdf
143. Home of Common European Drug Database [ ].
: http://cedd.oep.hu/
144. Janknegt R., Steenhoek A. The System of Objectified Judgment Analysis
(SOJA): a tool in rational drug selection for formulary inclusion. Drugs. 1997; 53:550
562.
145. Karr A. Improving the drug evaluation process. Pharm J. 1994; 252:576
577.
146. Karr A. The Comparative Utilisation of Resources Evaluation Model-a
CURE for all disease. Pharm J.2000; 265:610621.
147. Lammy PP, Flack HL. Pharmacy and therapeutics committee, consent, and
the hospital formulary. Am J Hosp Pharm. 1966; 23:66272.
148. Mauskopf J, Earnshaw S, Mullins CD. Budget impact analysis: review of
the state of the art. Expert Rev Pharmacoeconomics Outcomes Res. 2005;5(1):65-79.
132

149. May JR. Formulary systems. In: DiPiro JT, ed.Encyclopedia of clinical
pharmacy. New York: Marcel Dekker; 2002.
150. MEDLINE/PubMed Resources Guide [ ].
: https://www.nlm.nih.gov/bsd/pmresources.html
151. Ministry of Defense Pharmacoeconomic Center. Future meetings of the
DoD

P&T

Committee.

].

www.pec.ha.osd.mil/PT_Committee.html.
152. Oxford Centre for Evidence-based Medicine. Levels of evidence.
[ ]. : www.cebm.net.
153. Pettiti DB. Meta-analysis, decision analysis, and cost-effectiveness
analysis. Oxford: Oxford University Press; 2000: 264-71.
154. Promoting Quality and Efficient Health Care in Federal Government
Administered or Sponsored Health Care Programs. Presidential Executive Order No.
13410,

C.F.R.

].

:http://edocket.access.gpo.gov/cfr_2007/janqtr/pdf/3CFR13410.pdf.
155. Pubmed

search

].

www.ncbi.nlm.nih.gov/pubmed
156. Rational Use of Medicines: Activities [ ].
: http://www.who.int/medicines/areas/rational_use/rud_activities/en/
157. Russell LB, Siegel JE, Daniels N, Gold MR, Luce BR, Mandelblatt JS.
Cost-effectiveness analysis as a guide to resource allocation in health: roles and
limitations. In: Gold MR, Siegel JE, Russell LB, Weinstein MC, editors. CostEffectiveness in Health and Medicine. New York: Oxford University Press; 1996:3-24.
158. Shana Trice, Joshua Devine, Harsha Mistry, Eugene Moore, Andrea
Linton. Formulary Management in the Department of Defense. JMCP March 2009 Vol.
15, No. 2
159. Social Security Administration. Conditions of participation for hospitals.
Am J Hosp Pharm. 1966; 23:179 180.
160. The Cochrane Collaboration. Home page. [ ].
: www.cochrane.org.
133

161. The Pursuit of Responsible Use of Medicines: Sharing and Learning from
Country

Experiences

].

http://apps.who.int/iris/bitstream/10665/75828/1/WHO_EMP_MAR_2012.3_eng.pdf?u
a=1
162. TRICARE Management Activity. Homepage of the Uniform Formulary
Beneficiary

Advisory

Panel.

].

www.tricare.mil/pharmacy/BAP/.
163. TRICARE Management Activity. TRICARE Pharmacy web site.
[ ]. : www.tricare.mil/pharmacy.
164. U.S. Code of Federal Regulations. Civilian health and medical program of
the Uniformed Services: pharmacy benefits program (32 C.F.R.Sect. 199.21).
[

].

http://edocket.access.gpo.gov/cfr_2007/julqtr/32cfr199.21.htm.
165. Veterans Health Care Act of 1992, Pub. L. No. 102-585, Sect. 603.
[ ]. : www.hrsa.gov/opa/pl102585.html.
166. WHO Model Lists of Essential Medicines [ ].
: http://www.who.int/medicines/publications/essentialmedicines/en/
167. Willcox AM. The legal basis of the formulary system.Am J Hosp Pharm.
1960; 17:6038.

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