Sample Name: Poly (ethylene oxide -b- lactide)

(DL form)
Sample #: P8913-EOLA (DL form)

1H-NMR

Spectrum of the block copolymer:

700

Structure:

600

CH3

CH

500

CH2

Composition:
Mn x 103
PEO-b-PLA
2.0-b-12.5

P8913-EOLA(DL form)
400

300

PDI

200

1.2

100

Tg for PLA block

26oC

Tg, Tc & Tm for PEO block

Not observed

0
3.67

CH2

1.04

1.00

CH3

-100
6.0

5.0

4.0

3.0

2.0

1.0

ppm (f1)

Synthesis Procedure:
Poly(ethylene oxide -b- lactide) is prepared by living
anionic polymerization of ethylene oxide and
coordination polymerization of lactide.
Characterization:
An aliquot of the anionic poly(ethylene oxide) block
was terminated before addition of lactide and
analyzed by size exclusion chromatography (SEC) to
obtain the molecular weight and polydispersity index
(PDI). The final block copolymer composition was
calculated from 1H-NMR spectroscopy by comparing
the peak area of the ethylene oxide protons at about
about 3.6 ppm with the lactide protons at about 5.1
ppm.

SEC of the block copolymer:

P8913- EOLA (DL form)

0.2

0.0

12

14

16

18

20

22

24

26

28

30

Ve (ml)

Solubility:
Poly(ethylene oxide -b- lactide) is soluble in
chloroform, THF, DMF, toluene and precipitates
from ethanol, ether and hexane.

Size exclusion chromatography:

Poly(ethylene glycol), Mn=2000, Mw=2100, PI=1.03
Block Copolymer PEO(2000)-b-PLA(12500), PI=1.2
H
Composition from
NMR
Dp: EO(45 units)-b-LA (174 units)

DSC thermogram for PLA block:

-0.15

19.37C

-0.20

Heat Flow (W/g)

Thermal analysis of the sample:

Thermal analysis of the samples was carried out on a
TA Q100 differential scanning calorimeter at a
heating rate of 10oC/min.The midpoint of the slope
change of the heat flow plot of the second heating
scan was considered as the glass transition
temperature (Tg).

-0.25

26.35C(T)

-0.30

31.58C

-0.35
0
Exo Up

10

20

30

Temperature (C)

40

50
Universal V4.2E TA Instruments

v.R-1