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List of vaccine ingredients

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This list of vaccine ingredients indicates the culture media used in the production of common vaccines and the excipients they contain. Most vaccines listed are produced on cultures containing either egg, which are allowed to contain 0.05
mg/Kg glyphosate residues,[1] or Bovine serum albumin, which are from cows allowed to eat fodder that contain 500 mg/Kg glyphosate residues.[2] Also listed are substances used in the manufacturing process.[3]

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To read the prescribing information for each individual vaccine, see List of Licensed Vaccines

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Culture media

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Adenovirus vaccine

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Anthrax vaccine
(Biothrax)

Page information

BCG (Bacillus

Wikidata item

Calmette-Gurin)

Cite this page

(TICE BCG)

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DTaP (DAPTACEL)

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38)

Acetone, alcohol, anhydrous lactose, castor oil, cellulose acetate phthalate, dextrose, D-fructose, D-mannose, FD&C Yellow #6
aluminum lake dye, fetal bovine serum, human serum albumin, magnesium stearate, micro crystalline cellulose, plasdone C, Polacrilin
potassium, potassium phosphate, sodium bicarbonate, sucrose

Puziss-Wright medium 1095, synthetic or semisynthetic

Aluminum hydroxide, amino acids, benzethonium chloride, formaldehyde, inorganic salts and sugars, vitamins

Synthetic or semisynthetic

Asparagine, citric acid, lactose, glycerin, iron ammonium citrate, magnesium sulfate, potassium phosphate

Cohen-Wheeler or Stainer-Scholte media, synthetic or semisynthetic

Aluminum phosphate, formaldehyde, Glutaraldehyde, 2-phenoxyethanol

Cohen-Wheeler or Stainer-Scholte media, Lathan medium derived from bovine

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Excipients

Dulbecco's Modified Eagle Medium, human diploid fibroblast cell culture (WI-

DTaP (Infanrix)

casein, Linggoud-Fenton medium derived from bovine extract, synthetic or

Aluminum hydroxide, bovine extract, formaldehyde, glutaraldhyde, polysorbate 80

semisynthetic

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Aluminum potassium sulfate, ammonium sulfate, bovine extract, formaldehyde, gelatin, peptone, polysorbate 80, sodium phosphate,

DTaP (Tripedia)

Cohen-Wheeler or Stainer-Scholte media, synthetic or semisynthetic

DTaP/Hib (TriHIBit)

Synthetic or semisynthetic

Aluminum potassium sulfate, ammonium sulfate, bovine extract, formaldehyde or formalin, gelatin, polysorbate 80, sucrose, thimerosal[4]

DTaP-IPV (KINRIX)

Vero (monkey kidney) cell culture, synthetic or semisynthetic

Aluminum hydroxide, calf serum, formaldehyde, glutaraldehyde, lactalbumin hydrolysate, neomycin sulfate, polymyxin B, polysorbate 80

Bovine protein, Lathan medium derived from bovine casein, Linggoud-Fenton

DTaP-HepB-IPV

medium derived from bovine extract, Vero (monkey kidney) cell culture,

(Pediarix)

synthetic or semisynthetic

DtaP-IPV/Hib

Aluminum hydroxide, aluminum phosphate, calf serum, lactalbumin hydrolysate, formaldehyde, glutaraldhyde, neomycin sulfate,
polymyxin B, polysorbate 80, yeast protein
Aluminum phosphate, bovine serum albumin, formaldehyde, glutaraldhyde, MRC-5 cellular protein, neomycin, polymyxin B sulfate,

Synthetic or semisynthetic

(Pentacel)

thimerosal[4]

polysorbate 80, 2-phenoxyethanol

DT (diphtheria
Synthetic or semisynthetic

Aluminum potassium sulfate, bovine extract, formaldehyde, thimerosal (multi-dose) or thimerosal[4] (single-dose)

DT (Massachusetts)

Synthetic or semisynthetic

Aluminum hydroxide, formaldehyde or formalin

Hib vaccine (ActHIB)

Synthetic or semisynthetic

Ammonium sulfate, formaldehyde, sucrose

Hib (PedvaxHib)

Synthetic or semisynthetic

Aluminum hydroxyphosphate sulfate

Hib (Hiberix)

Semisynthetic

Formaldehyde, lactose

Hib/Hep B (Comvax)

Synthetic or semisynthetic, yeast or yeast extract

vaccine plus tetanus

vaccine) (Sanofi)

Hepatitis A vaccine
(Havrix)
Hepatitis A vaccine
(VAQTA)
Hepatitis B vaccine
(Engerix-B)
Hepatitis B vaccine
(Recombivax HB)
HepA/HepB vaccine
(Twinrix)

Amorphous aluminum hydroxyphosphate sulfate, amino acids, dextrose, formaldehyde, hemin chloride, mineral salts, nicotinamide
adenine dinucleotide, potassium aluminum sulfate, sodium borate, soy peptone, yeast protein

Human diploid tissue culture (MRC-5)

Aluminum hydroxide, amino acid supplement, formalin, MRC-5 cellular protein, neomycin sulfate, phosphate buffers, polsorbate 20

Human diploid tissue culture (MRC-5)

Amorphous aluminum hydroxyphosphate sulfate, bovine albumin or serum, formaldehyde, MRC-5 cellular protein, sodium borate

Yeast or yeast extract

Aluminum hydroxide, phosphate buffers, yeast protein

Amorphous aluminum hydroxyphosphate sulfate, amino acids, dextrose, formaldehyde, mineral salts, potassium aluminum sulfate, soy

Yeast or yeast extract

peptone, yeast protein

Human diploid tissue culture (MRC-5), yeast or yeast extract

Human
papillomavirus (HPV)

protein L1, vitamins

Human

Amino acids, amorphous aluminum hydroxyphosphate sulfate, carbohydrates, L-histidine, mineral salts, polysorbate 80, sodium borate,

Yeast or yeast extract

vitamins, yeast protein

(Gardasil)
Influenza vaccine

Beta-propiolactone, calcium chloride, dibasic sodium phosphate, egg protein, monobasic potassium phosphate, monobasic sodium

Chicken embryo

(Afluria)
Influenza vaccine

phosphate, neomycin sulfate, polymyxin B, potassium chloride, sodium taurodeoxychoalate, thimerosal (multi-dose vials only)

Chicken embryo

(Agriflu)
Influenza vaccine

Egg proteins, formaldehyde, polysorbate 80, cetyltrimethylammonium bromide, neomycin sulfate, kanamycin
Formaldehyde, octoxynol-10 (Triton X-100), -tocopheryl hydrogen succinate, polysorbate 80 (Tween 80), hydrocortisone, gentamicin

Chicken embryo

(Fluarix)
Influenza vaccine

sulfate, ovalbumin, sodium deoxycholate, sucrose, phosphate buffer

Monobasic sodium phosphate, dibasic sodium phosphate, polysorbate 20, baculovirus and host cell proteins, baculovirus and cellular

insect cell line (expresSF+)

(Flublok)
Influenza vaccine

DNA, Triton X-100, lipids, vitamins, amino acids, mineral salts

Madin Darby Canine Kidney (MDCK) cell protein, MDCK cell DNA, polysorbate 80, cetyltrimethlyammonium bromide, -propiolactone,

Madin Darby Canine Kidney (MDCK) cell protein

(Flucelvax)
Influenza vaccine

phosphate buffer

Chicken embryo

(Flulaval)
Influenza vaccine

Formaldehyde, -tocopheryl hydrogen succinate, polysorbate 80, sodium deoxycholate, thimerosal, ovalbumin
Beta-propiolactone, egg protein, neomycin, nonylphenol ethoxylate, polymyxin, thimerosal (multi-dose containers), thimerosal[4] (single-

Chicken embryo

(Fluvirin)
Influenza vaccine

dose syringes)
Egg protein, formaldehyde, gelatin (standard formulation only), octylphenol ethoxylate (Triton X-100),sodium phosphate, thimerosal

Chicken embryo

(Fluzone)
Influenza vaccine

(multi-dose containers only)

Arginine, dibasic potassium phosphate, egg protein, ethylene diamine tetraacetic acid, gentamicin sulfate, hydrolyzed porcine gelatin,

Chicken kidney cells, chicken embryo

(FluMist)

yeast protein
Aluminum hydroxide, amino acids, lipids, mineral salts, sodium dihydrogen phosphate dehydrate, type 16 viral protein L1, type 18 viral

Trichoplusia ni cells

(Cervarix)

papillomavirus (HPV)

Aluminum hydroxide, aluminum phosphate, amino acids, formalin, MRC-5 cells, neomycin sulfate, phosphate buffers, polysorbate 20,

monobasic potassium phosphate monosodium glutamate, sucrose

Japanese
encephalitis vaccine

Mouse brain culture

Formaldehyde or formalin, gelatin, mouse serum protein, polysorbate 80, thimerosal

Vero (monkey kidney) cell culture

Aluminum hydroxide, bovine serum albumin, formaldehyde, protamine sulfate, sodium metabisulphite

(JE-Vax)
Japanese
encephalitis vaccine
(Ixiaro)
Meningococcal
vaccine (Menactra)
Meningococcal
vaccine (Menomune)
Meningococcal
vaccine (Menveo)
MMR vaccine (MMRII)

Modified Mueller-Miller medium, Mueller Hinton agar, Watson Scherp medium

Formaldehyde (Each 0.5 mL dose may contain residual amounts of formaldehyde of less than 2.66 g (0.000532%), by calculation),
phosphate buffers[5]

Watson Scherp media, Mueller Hinton agar

Lactose, thimerosal (multi-dose vial only)

Franz complete medium

Amino acids, formaldehyde, yeast extract

Amino acids, fetal bovine serum, glutamate, hydrolyzed gelatin, neomycin, recombinant human serum albumin, sodium phosphate,

Human diploid tissue culture (WI-38), Medium 199

sorbitol, sucrose, vitamins

Bovine calf serum, dibasic potassium phosphate, dibasic sodium phosphate, human albumin, human serum albumin, hydrolyzed gelatin,

MMRV vaccine

Human diploid tissue cultures (MRC-5, WI-38), Medium 199

(ProQuad)

monobasic potassium phosphate, monosodium L-glutamate, MRC-5 cellular protein, neomycin, sodium bicarbonate, sorbitol, sucrose,
potassium chloride

Pneumococcal
vaccine (Pneumovax)
Pneumococcal
vaccine (Prevnar)
Polio vaccine (IPV IPOL)
Polio vaccine (IPV Poliovax)
Rabies vaccine
(Imovax)
Rabies vaccine

Bovine protein

Phenol

Soy peptone broth

Aluminum phosphate, ammonium sulfate, casamino acid, polysorbate 80, succinate buffer, yeast

Vero (monkey kidney) cell culture, Medium 199

Calf serum protein, formaldehyde, neomycin, 2-phenoxyethanol, polymyxin B, streptomycin

Human diploid tissue culture (MRC-5)

sodium chloride

Human diploid tissue culture (MRC-5)

Albumin, MRC-5 cells, neomycin sulfate, phenol

Amphotericin B, beta-propiolactone, chicken protein, chlortetracycline, human serum albumin, neomycin, ovalbumin, polygeline

Rhesus fetal lung tissue culture, chicken embryo

(RabAvert)
Rotavirus vaccine

(processed bovine 14 gelatin), potassium glutamate

Vero (monkey kidney) cell culture

fetal bovine serum, sodium citrate, sodium phosphate monobasic monohydrate, sodium hydroxide, sucrose, polysorbate 80

Dulbecco's Modified Eagle Medium (DMEM)

Amino acids, calcium carbonate, dextran, sorbitol, sucrose, vitamins, xanthan

Mueller & Miller medium, synthetic or semisynthetic

Aluminum potassium sulfate, bovine muscle tissue, formaldehyde, peptone, thimerosal[4]

Td vaccine (Mass)

Modified Mueller's media, synthetic or semisynthetic

Aluminum phosphate, ammonium phosphate, bovine extracts, formaldehyde, thimerosal (some multi-dose vials)

Tdap vaccine

Mueller's growth medium, Mueller-Miller casamino acid medium(without beef

(Adacel)

heart infusion), synthetic or semisynthetic

(RotaTeq)
Rotavirus vaccine
(ROTARIX)
Td vaccine
(Decavac)

Aluminum phosphate, ammonium sulfate, formaldehyde, glutaraldehyde, 2-phenoxyethanol

Fenton media with bovine casein, Lathan medium derived from bovine casein,

Tdap vaccine

Linggoud-Fenton medium derived from bovine extract, Stainer-Scholte liquid

(Boostrix)

Aluminum hydroxide, bovine extract, formaldehyde, glutaraldehyde, polysorbate 80

medium, synthetic or semisynthetic

Typhoid vaccine
(inactivated

Synthetic or semisynthetic

Disodium phosphate, monosodium phosphate, phenol, polydimethylsiloxane, hexadecyltrimethylammonium bromide

TYPHIM Vi)
Typhoid vaccine (oral

Amino acids, ascorbic acid, casein, dextrose, galactose, lactose, sucrose, yeast extract

Ty21a/Vivotif)
Vaccinia

Vero (monkey kidney) cell culture

(ACAM2000)

Dibasic sodium phosphate, ethylenediamine tetraacetic acid sodium (EDTA), fetal bovine serum, gelatin, glutamate, monobasic

Varicella vaccine

Human diploid tissue cultures (MRC-5 and WI-38)

(Varivax)

potassium phosphate, monobasic sodium phosphate, monosodium L-glutamate, MRC-5 DNA and cellular protein, neomycin, phosphate,
potassium chloride, sucrose

Yellow fever vaccine

(YF-Vax)
Zoster vaccine

Chicken embryo

Egg protein, gelatin, sorbitol

Bovine calf serum, dibasic sodium phosphate, hydrolyzed porcine gelatin, monosodium L-glutamate, MRC-5 DNA and cellular protein,

Human diploid tissue cultures (MRC-5 and WI-38)

(Zostavax)

See also

Glycerin, human serum albumin, mannitol, neomycin, phenol, polymyxin B

monobasic potassium phosphate, neomycin, potassium chloride, sucrose

[ edit ]

Vaccine types
Vaccination schedule
Adjuvant
Preservative
Cell culture
Growth medium

References

[ edit ]

The initial list is based on information from the Centers for Disease Control and Prevention (CDC) and the Food and Drug Administration (FDA) and thus limited to US-approved vaccines.
1. ^ Template:Citehttp://www.fao.org/fao-who-codexalimentarius/standards/pestres/pesticide-detail/en/?p id=158
2. ^ Template:Citehttp://www.fao.org/fao-who-codexalimentarius/standards/pestres/pesticide-detail/en/?p id=158
3. ^ "Vaccine Excipient & Media Summary"
4. ^ a

bc de

(PDF).

Note: Thimerosal content less than 0.3 g.

5. ^ Menactra package insert. Sanofi Pasteur. 26 August 2014 v0.12.

Categories: Vaccination

Vaccines

This page was last modified on 7 December 2016, at 18:21.

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