Ranitidine Drug Study

In making a Drug Study, the following elements must be present: Generic Name and the
Brand name (not all brands, just the brand used by the patient), Action, Indication,
Pregnancy Category, Drug Classification, and Contraindication, Adverse Effect, Drug
interaction and Nursing Consideration/Intervention. Most clinical instructors preferred this
to be in a long bond paper in printed or handwritten with paper in landscape.

Ranitidine hydrochloride
Brand Name: Alti-Ranitidine (CAN), Novo-Ranidine (CAN), Nu-Ranit (CAN),
Zantac, Zantac EFFERdose, Zantac GELdose, Zantac 75
Pregnancy Category B
Drug class: Histamine2 (H2) antagonist
Therapeutic actions
Competitively inhibits the action of histamine at the histamine 2 (H2)
receptors of the parietal cells of the stomach, inhibiting basal gastric acid
secretion and gastric acid secretion that is stimulated by food, insulin,
histamine, cholinergic agonists, gastrin, and pentagastrin.
Indications
Short-term treatment of active duodenal ulcer
Maintenance therapy for duodenal ulcer at reduced dosage
Short-term treatment of active, benign gastric ulcer
Short-term treatment of gastroesophageal reflux disease
Pathologic hypersecretory conditions (eg, Zollinger-Ellison syndrome)
Treatment of erosive esophagitis
Treatment of heartburn, acid indigestion, sour stomach
Contraindications
Contraindicated with allergy to ranitidine, lactation.

 Use cautiously with impaired renal or hepatic function.

Adverse effects
Headache, malaise, dizziness, somnolence, insomnia, vertigo,
Tachycardia, bradycardia, PVCs (rapid IV
administration), Rash, alopecia, Constipation, diarrhea, nausea, vomiting,
abdominal pain, hepatitis, increased ALT levels, Gynecomastia, impotence or
decreased libido, Leukopenia, granulocytopenia,
thrombocytopenia, pancytopenia, Pain at IM site, local burning or itching at
IV site, Arthralgias
Drug Interactions:
Increased effects of warfarin, TCAs
Decreased effectiveness of diazepam
Decreased clearance and possible increased toxicity
of lidocaine, nifedipine
Nursing considerations
Administer oral drug with meals and at bedtime.
Decrease doses in renal and liver failure.
Provide concurrent antacid therapy to relieve pain.
Administer IM dose undiluted, deep into large muscle group.
Arrange for regular follow-up, including blood tests, to evaluate
effects.