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Agenda:
Talk about all these crazy steps in cellular
respiration
compound
ADP + Pi ATP
phosphorylation
glucose
P
ADP
2 NAD+
2 NADH + 2H+
2 ATP
2H2O
2 pyruvate
(3-C)
C3H6O3
1/24/2017
ELECTRON TRANSPORT
CHAIN
Occurs in inner membrane
of mitochondria
Produces 26-28 ATP by
oxidative phosphorylation
via chemiosmosis
CHEMIOSMOSIS
Collection of molecules
embedded in inner membrane
of mitochondria
Tightly bound protein + nonprotein components
Alternate between
reduced/oxidized states as
accept/donate eDoes not make ATP directly
Ease fall of e- from food to O2
2H+ + O2 H2O
oxidative phosphorylation
uses
generates
Chemiosmosis = H+ gradient
across membrane drives cellular
work
Proton-motive force: use proton
(H+) gradient to perform work
ATP synthase: enzyme that makes
ATP
Use E from proton (H+) gradient
flow of H+ back across membrane
ATP
chemiosmosis
uses E
redox
reactions
of
which couples
proton
gradient
called
proton motive
force
ETC
in which
e- passed
down E levels
to final e- acceptor
drives
H+
through
ATP synthase
O 2 H2 O
1/24/2017
Without O2
O2 present
FERMENTATION
aerobic cellular
respiration
(with O2)
ALCOHOL FERMENTATION
Pyruvate Lactate
Ex. fungi, bacteria, human
muscle cells
Used to make cheese,
yogurt, acetone, methanol
Note: Lactate build-up
does NOT causes muscle
fatigue and pain (old idea)
RESPIRATION
Release E from
breakdown of food
with O2
Occurs in mitochondria
O2 required (final
electron acceptor)
Produces CO2, H2O and
up to 32 ATP
ENERGY
glycolysis
anaerobic
(without O2)
(cytosol)
Fermentation
mitochondria
(cytosol)
pyruvate
oxidation
ethanol + CO2
(yeast, some bacteria)
citric acid
cycle
ETC
chemiosmosis
lactic acid
(animals)
oxidative
phosphorylation