Lidocaine has been used as a local anesthetic for over 50 years. It works by blocking sodium channels in neurons, inhibiting nerve impulses. Lidocaine is widely distributed after IV administration and can cross the blood brain and placental barriers. It is metabolized in the liver and excreted by the kidneys. While generally well tolerated, lidocaine can cause CNS excitation and at high doses, seizures, respiratory depression and cardiovascular collapse. Lipid emulsion therapy may be used to treat lidocaine toxicity. There is limited data on use of lidocaine patches or infusions for pain in children, but case reports use 1/8 to 2 patches or IV infusions of 0.5-1.5 mg/
Lidocaine has been used as a local anesthetic for over 50 years. It works by blocking sodium channels in neurons, inhibiting nerve impulses. Lidocaine is widely distributed after IV administ…