Chronobiology

Living with the inner clock

A new medical understanding
of the right moment

Chronobiology

Living with the inner clock

A new medical understanding
of the right moment

Chronobiology

Living with the inner clock

A new medical understanding
of the right moment
Table of contents
There is a time for everything. Also for disease
and healing.....................................................................6
Light and darkness control our organs......................... 10
The intelligence of our inner clock................................ 12
Chronopharmacology:
the right formulation at the right time.......................... 14
Chronobiology of vitamins: which of them are
effective in the morning, which in the evening? .......... 16
Chronobiological practice: Let the new medical
understanding guide your day ..................................... 21
Nutrition ..................................................................... 21
Mobility........................................................................ 22
Heart health................................................................. 23
Metabolism................................................................... 24

Intestinal flora ............................................................. 25

Mood............................................................................ 26
Sleep............................................................................ 28
Eyes............................................................................. 29
Concentration............................................................... 30
Bone health.................................................................. 30
Womens health............................................................ 34
Pregnancy and breastfeeding........................................ 35
Mens health................................................................. 36
Fertility (men) ............................................................. 39
Skin............................................................................. 40
Hair & nails.................................................................. 42
Cellulite........................................................................ 44
Prevention of uncontrolled cell growth ........................ 46
The ultimate anti-aging preparation All good things
ready to hand: fighting the three major threats............. 47
Tips for the user: Additional information on
advanced chronobiological preparations ...................... 50
Summary ..................................................................... 60

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Published by Anti Aging News Inc.
Copyright 2010, Anti Aging News Inc.

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There is a time for everything.

Also for disease and healing.
External and internal time regulators control our physical, mental and emotional functions without the need for
us to interfere. The more intelligently we attune our life
to these rhythms, the greater the benefit we are able to
draw from them.
Whether it is the oral mucosa or the liver, each physiological system has its own biological rhythm. This
knowledge is of particular importance for disease
and healing. Every ailmentsuch as asthma, arthritis,
hypertension, depression, heart attacks, stomach ulcers,
sleeping problems, cerebral metabolic disturbances and
others has its own phases. And this has important
implications: the chronobiological factor of the active
ingredients that are used in disease prevention or treatment is of crucial importance.

6 am:

To date, we may only divine a small fraction of the

secrets underlying these substances. But a number of
important substances is already available as a chronobiologically meaningful formula, scientifically tested and
proven.
Initially, chronobiologists were being laughed at. Today,
their science is an acknowledged branch of research
which investigates the interconnections of body, mind
and time. You may be in for quite a surprise!

The organism
starts up

79 am:

Hormones at
their peak

Our body temperature decreases when we sleep

and our blood pressure rises as we wake up.
The most important conclusion drawn from a chronobiological viewpoint is that we possess a whole control package of genetically determined internal time regulators.
Most importantly, our body follows an internal 24-hour
cycle. Hormonal release fatefully depends on the
impulsesof our inner clocks.

89 AM:

Low
pain level

10 am12 noon:

Under the control of our brain, 150 messenger substances circulating in the blood inform our organs about
the current situation and prescribe specific consequences.
These hormones have a boosting as well as a curbing
effect. Our body temperature decreases during sleep, our
blood pressure rises as we wake up and so forth.
These rhythms repeat every 24 hours, day after day,
night after night. Scientists therefore speak of a circadian rhythm. This term comes from the Latin circa,
meaning around, and dies, meaning day. The
shortest up-and-down cycle is measured in the brain
waves: fractions of milliseconds. The longest daily
rhythms such as hunger or need for sleep extend
over many hours.
In every single moment, chronobiology transforms the
actions inside our organs into a unique and distinctive
spectacle. An hour later, nothing remains as it was an
hour ago.

It seems that with age, some of our inner clocks are

ticking more slowly while others are ticking faster. They
tend to go out of tune, and some of them stop ticking
altogether over the years. Organs begin to develop their
own rhythm and disturbances occur. If they remain
untreated, diseases may develop. Science distinguishes
around 80 illnesses which are all deemed sleep-related.

These rhythms repeat every 24 hours,

day after day, night after night.
This is exactly the goal which chronopharmacology
pursues: the right formulation at the right time. The current objective is to identify a circadian component in an
increasing number of diseases or physical dysfunctions.
This results in surprising options of treatment to the
point, more effective and with fewer side effects. Chronobiological medicines or food supplements recalibrate
our inner time regulators.

Fully fit and

wide awake,
brain functions
most efficiently

12 noon:

Time to eat,
digestion in
top gear

12 Pm:

Noon low,
time for a nap

34 Pm:

Light and darkness

control our organs
The light-darkness factor continuously adjusts our
everyday functions to a 24-hour rhythm. Inside our
body, its information is converted into a signaling hormone called melatonin. The latter completes a multitude
of tasks, already by daylight. Around 11pm, there is
usually a sudden surge in melatonin levels to between
eight and ten times the normal value. This is a signal for
many organs to slow down their activity and regenerate
themselves. Many elderly people, however, have largely
lost this nocturnal melatonin surge. Many rhythms
including sleep, blood pressure, body temperature
and hormones remain uncontrolled. A smart form of
chronobiological support is needed.
Exciting recent studies have come to valuable conclusions. Researchers are beginning to understand at what

10

hour tumor cells tend to divide. They are controlled by

time regulators that differ from those of healthy cells. It
is therefore of vital importance that therapeutic cyto
toxins be introduced into the target organ at a time when
their impact on tumor growth is higher, and when their
effect is less detrimental to the remaining cells.

Around 11pm there is usually a sudden

surge in melatonin levels to between
eight and ten times the normal value.

New upswing,
phase of learning,
long-term
memory

56 Pm:

Second high,
manual work

Chronopharmacology, the search for therapeutic measures which are in harmony with our inner clocks, is currently the most fascinating area of medical research.
We are gradually beginning to understand more and
more diseases as rhythm disorders. This is the first step
to take account of the principles of chronobiology in
healing.

11

69 Pm:

Regeneration
and relaxation,
good sense of
smell and taste

9 Pm:

The intelligence of our

inner clock
Each cell produces highly specific substances, such as the
building blocks of amino acids. Once the desirable concentration is reached, production stops. Enzymes decompose
the substances within hours. A new cycle begins.
Certain genes, which are also referred to as clock
genes, act as on/off switches for these processes. They
can be found in nearly any type of human tissue and
their impacts are incredibly multifaceted, sophisticated
and smart. All parts of the human body have receptors
that take up the information of messenger substances
and neuronal stimuli. Their sensitivity is controlled by
the clock genes, or one could simply say switched on
and off. This also applies to the effect of vitamins, trace
elements and other biologically effective substances,
including medicines.

12

The main switch is located in the so-called diencephalon,

a central part of the brain composed of two structures.
The diencephalon receives messages from special photo
cells located in the retina. These sensors, which have
been decoded only recently, do not recognize objects or
colors, but the times of the day, the ambient atmosphere
and the seasons. They are the starting point of a mechanism of action which in its entirety may be described as
a control room where all inner clocks are set. This control
room transfers the change between daytime and nighttime from the world outside to innumerable rhythms in
our body and attunes them to and among each other.
Light is a powerful pulse generator. Whether a person
survives a heart attack may depend on the suns rays
that shine through the window of the intensive care unit.
Beds in the northern wing of a hospital are mysteriously
associated with a higher mortality rate.

13

Stomach rests
stop eating

11 Pm:

Time for bed,

BUT:

11 PM1 AM:

Creativity at its
absolute peak

Chronopharmacology: the right

formulation at the right time
How quickly or effectively a biological substance is
absorbed and produces an effect after being taken
largely depends on the activity of the digestive tract. If
a substance is to produce an effect in a target organ at a
certain time, it needs to reach the liver on time. Yet this
passage through the digestive tract does not always take
place at the same rate. For instances, the blood supply
to the stomach and intestines is rich in the morning but
relatively low around lunchtime. This aspect is taken into
consideration in chronobiological formulations which are
given in the morning, at bedtime, or are provided with a
kind of time lock.

1 am:

best absorbed at bedtime? Which substances are compatible with each other? Which of them must be taken toge
ther to be at all effective? Which biological substances
may block the effect of others? Chronotherapy supports
the body exactly at a time when a maximum effect can
be achieved. This is how we increase efficacy. This is
how we reduce undesirable side effects.

Dream time

For many substances chronobiology already knows the

most effective time point. There is a number of modern
formulations which are truly smart. They contain specific
micro-biosubstances for the whole day and are perhaps
taken only once daily. A time lock or the different rates
of action of the individual substances assure that the
relevant effects are triggered one by one, according to a
circadian rhythm, and last well into the night.

All systems stop

except liver and
skin

14

2 am:

15

3 am:

Intensive
sleep phase

This new medical understanding may help to avoid doing

the right thing at the wrong time. Which substance has
its maximum effect in the morning? Which substance is

4 am:

Chronobiology of vitamins:
which of them are
effective in the morning,
which in the evening?

Taking a multi-component formulation in a chrono

biological form is simply essential and choosing a
different regime for men and women is even better.

Critical for
lung patients

Excessive intake of vitamins and mineral salts

without a clear concept bears its risks:
1. Intake is disturbed. A vitamin or mineral salt gets
blocked by another organic substance.

Most people regard vitamins as the givers of good health

and swallow them at any time, thinking that they can
do no wrong. Far from it! The stringent rules of chrono
biology also apply when you seek to remedy vitamin or
mineral salt deficiencies. Vitamins? Look at the clock
first!

2. No synergy effect. Individual vitamins will not be

16

e ffective unless taken concurrently with other vitamins

or trace elements.

3. Each organ has its individual peak time during

the day.

The time point is crucial. Firstly, because the effect of

some vitamins in the morning simply differs from their
effect in the evening. Secondly, because their effect on
the metabolism may disturb the 24-hour rhythm of our
bodys organs.

5 am:

Kidney at
lowest point

4. The biological effect of vitamins and trace elements

shows major daily fluctuations and influences the bodys

shifts of activity.

17

6 am:

The organism
starts up

6 am:

Vitamins which are taken with food or in the form of

food supplements require fats or water to be transported to their target areas. Let us look at the fat-soluble
vitamins first: Once they have dissolved inside the fat
molecules, these vitamins first of all reach the lymphatic
vessels, the primary vascular system of tissue fluid. The
lymphatic vessels are directly linked to only few organs.
The relevant vitamins accumulate primarily in fatty tissue and in the liver. Once inside the body, they cannot
easily be eliminated. As the storage capacity of fat is
huge, such vitamins should only be taken with utmost
care. There are only four fat-soluble vitamins: A, D, E,
and K. They are best taken in the morning after a plentiful breakfast, and are less effective when taken later in
the day.
Water is distributed all over the body: inside the cells,
in the blood, and in the interstitial tissue. Vitamin
substances dissolved in water are therefore virtually
universally effective, but also much more volatile. They
are regularly eliminated in the urine. Consistent daily

18

dosage avoids vitamin deficiencies or metabolic disorders. There are seven water-soluble vitamins in the B
group: folic acid (B9), pantothenic acid (B5), thiamine
(B1), cyanocobalamin (B12), riboflavin (B2), niacin (B3)
and pyridoxine (B6). Other water-soluble vitamins are
vitamin C (ascorbic acid), biotin (vitamin H), choline and
myo-inositol.

Vitamins: Consistent daily dosage

avoids vitamin deficiencies or
metabolic disorders.
Most vitamins have no direct effect and play only a contributory role in certain functions. This is why they are
commonly classified as co-enzymes or co-factors. The
remaining tasks are taken care of by other substances
and this only works if these are simultaneously available
in their active form.

19

The organism
starts up

79 am:

Hormones at
their peak

89 am:

Low
pain level

The more researchers become involved in this issue,

the more criteria have to be fulfilled. The challenge is to
apply two strictly separate but equally intelligent multivitamin-mineral products: one in the morning, the other
at bedtime. (They are already available; read Tips for
the user on the pages 5058)

Chronobiological practice:
Let the new medical
understanding guide your day

VitaBasix, an international pioneer in implementing

the concepts of chronobiology at the highest level, has
succeeded in developing a range of products, such as
Vitachron, which take the perfect time point into consideration. The morning and evening capsules, containing
more than three dozens of vitamins and minerals, cater
to womens needs and, in a slightly modified formula,
also to mens needs.

Nutrition:

20

To perform its myriad of tasks, our body needs to take

in valuable substances at very specific different times
of the day. Even people with a healthy diet may experience nutritional deficiencies, especially so when they are
exposed to everyday stress, environmental toxins, or
metabolic disorders. Scientific research has provided us
with accurate information on which nutrients the body
needs and when and at what dosage they provide optimal support for food digestibility. While some nutrients
ideally have a mutually enhancing effect, others may
even hamper the desired effect. Chronobiological practice
improves the ability of our organs to take up vital biosubstances. The vitamins, mineral salts, trace elements

21

10 AM12 noon:

Fully fit and

wide awake,
brain functions
most efficiently

12 noon:

Time to eat,
digestion in
top gear

12 pm:

Noon low,
time for a nap

34 pm:

and phytopharmaceuticals provided are supplied in a

smart combination at the right time point. The morning
capsule, for instance, helps the body to keep its energy
balance. The evening capsules helps to burn fats during
the night and remove toxins from the body. Gender-specific formulas take account of the different metabolism of
the female and male organs.

Chronobiological practice improves

the ability of our organs to take up
vital biosubstances.
Mobility:

The weight-bearing joints of the knee and hip, but also

the shoulder and wrist joints, are mostly affected by the
fraying of cartilage. This happens when the organism is
not adequately supplied with glucosamine, chondroitin
and hyaluronic acid, essential constituents contributing
to the formation of cartilage tissue. The new generation
of preparations supplements these substances of targeted

22

cartilage formation with further anti-inflammatory and

pain-relieving vital substances 24 hours a day. Thanks
to their anti-oxidative effect, they protect these zones
from free radicals at daytime, and use enzymes to foster
the production of cartilage tissue and synovial fluid during the night.

Heart health:

Nearly one in three adults exposes his or her heart

and blood vessels to the burden of hypertension. Most
therapies are primarily aimed at reducing blood pressure. MegaGrape BP, a recently investigated substance
derived from certain grape kernels, is able to do just
that. Rich in polyphenols, it delivers more oxygen into
the blood and thereby reduces blood pressure. The risk
of hypertension is nearly always associated with the
circadian rhythm. Blood pressure surges in the morning,
but drops at night taking a remedy at bedtime would
therefore be too dangerous. For this and other reasons,
intelligent combinations of active substances for cardiovascular health always strictly comply with the principles

23

New upswing,
phase of learning,
long-term
memory

56 pm:

Second high,
manual work

69 pm:

Regeneration
and relaxation,
good sense of
smell and taste

9 pm:

of chronobiology. Modern preparations such as Cardio

chron utilize another much-longed-for effect: a special
enzyme with its 285 amino acid components is able to
dissolve or prevent blood clotting. This enzyme based
on soy proteins is called nattokinase and known as an
Asian remedy for reversing or preventing cardiovascular

disease. MegaGrape BP and nattokinase also make a

perfect match with the three key substances that fight
the toxic amino acid homocysteine: folic acid and the
vitamins B12 and B6.

of malnutrition, overweight, lack of exercise, or genetic

disposition, glucose metabolism is seriously imbalanced.
The human organism is no longer able to take up glucose from the blood in order to nourish its cells. Excess
glucose remains in the blood stream, resulting in a rise
in blood glucose levels over the long term. This will dramatically damage blood vessels and organs. Intelligent
chronobiological preparations support the metabolism
with two different daytime and nighttime formulas. They
curb glucose release from the intestines into the blood as
well as facilitate glucose transfer into the cells. This leads
to a decrease in blood glucose levels. Another disorder
that is frequently present is disturbed fat metabolism,
which is remedied by certain enzymes und extracts that
foster fat burning and digestion. It is also important to
combat free radicals, which in diabetes mellitus patients
tend to be quite aggressive.

Metabolism:

Intestinal flora:

The risk of hypertension is nearly always

associated with the circadian rhythm,
such as a blood pressure surge
in the morning.

The main task of insulin in the blood is to supply the

cells with glucose so they can produce energy. In case

The maintenance of a healthy bacterial flora in the

intestine and its restoration after infectious and

24

25

Stomach rests
stop eating

11 pm:

Time for bed,

BUT:

11 PM1 am:

Creativity at its
absolute peak

1 am:

inflammatory diseases or antibiotic therapy is one of

the specialty areas of chronobiology. This treatment is
preparatory as well as preservative. Prebiotic substances
derived from indigestible fibers provide the perfect breeding ground for beneficial probiotics. Modern preparations
which are delicately attuned to the circadian rhythm
place particular emphasis on a morning supply of welltried fructose saccharides, mineral salts, special plant
root substances and a carefully balanced mix of different lactic acid bacteria. This enhances the effectiveness
of microorganisms in the evening, when the nutrients
meanwhile used up are replenished by the next dose.

Mood:

From a clinical viewpoint, one out of eight adults

develops depression. But mood swings affect a lot more
people in our civilized countries. The flow of information
between nervous cells does not work as it should. Mood
disturbances express themselves in many ways such as
lack of interest, feeling of inner emptiness, eating disorders, or pain. This is often caused by neurotransmitter

26

deficiency. Neurotransmitters are messenger substances

which mediate signal transmission. Serotonin, which is
commonly known as the happiness hormone, plays a
key role. The human body itself produces this substance

From a clinical viewpoint, one out of

eight adults develops depression.
by a sophisticated interplay of amino acids and enzymes.
Unluckily its production is curbed by the impact of various types of medicines. Serotonin deficiency cannot simply be remedied by the direct intake of serotonin, which
is why its precursors are so important. A novel twophase preparation assures that the vital components are
administered in a chronobiologically optimized manner
with one single tablet: one vital ingredient has a rapid
effect, the other is released more slowly. When taken in
the morning, the patented formula assures a serotonin
profile which is attuned to the daily rhythm.

27

Dream time

2 am:

All systems stop

except liver and
skin

3 am:

Intensive
sleep phase

4 am:

Sleep:

Melatonin is produced in the brain and released into the

blood. This hormone synchronizes our inner main clock.
Melatonin production takes largely place at night. Young
people normally experience an eight to tenfold increase
in melatonin levels before midnight. Melatonin production decreases later in life, and nighttime values often
increase only shortly and only to the double of daytime
levels. As a result, the bodys organs no longer receive
correct information about the changes between daytime
and nighttime, and the inner clock goes out of tune.

Melatonin synchronizes our

inner main clock.
Conventional sleeping pills may additionally suppress
melatonin production. Sleep disturbances and various
diseases begin to occur. If we want to help our body in
coping with this situation, we need to absorb enough
melatonin when falling asleep (short term) and subse-

28

quently during the sleeping phase (six to eight hours).

A chronobiological preparation for this specific purpose
has recently been launched.

Critical for
lung patients

Eyes:

Retinal or macular degeneration is an age-related vision

disturbance. One out of five people in their eighties
fall victim to this disease. It leads to the loss of central
vision. Two pigments from the plant family of carotenoids have been long known to be essential in protecting the retina from damage and degeneration: lutein
and zeaxanthin. They scavenge the free radicals which
damage the cellular tissue and they also prevent damage caused by ultraviolet radiation. Modern two-phase
preparations assure the rapid as well as retarded release
of a therapeutically effective amount of lutein and zeaxanthin, thus offering long-term protection.

29

5 am:

Kidney at
lowest point

6 am:

The organism
starts up

6 am:

Concentration:

When we have reached what in our modern days is

midlife, also our neuronal brain structures need addi
tional high-quality food supplements to retain their
functional capacity. Certain vitamins and trace elements
as well as phospholipids, antioxidants and plant e xtracts
improve mental fitness, concentration, memory and
cognitive abilities. Some substances have a stimulating effect and it is recommended to take them in the
morning. Other nutrients such as those fostering
long-term memory have a soothing and calming effect
and are therefore recommended at bedtime. How is a
food supplement expected to affect our cognitive skills?
Most importantly it should stimulate blood circulation,
enhance anti-oxidative activity, improve oxygen supply,
foster the formation of messenger substances between
neuronal structures and boost our energy level.

Bone health:

Today, people no longer have the guarantee of healthy

bones once they reach their middle years. The natural

30

balance between bone tissue formation and resorption

is often disturbed, resulting in lower bone density and
increased brittleness. Osteoporosis, the thinning of bone
tissue, is a slowly progressing disease which can only
be effectively controlled with highly bioavailable mineral
salts and vitamins needed to keep our bones strong.
Calcium is familiar to all of us, but the bone nutrient hy-

Calcium is familiar to everyone,

but the bone nutrient hydroxyapatite
is still largely unknown.
droxyapatite is still largely unknown. Hydroxyapatite is
the chief structural component of hard tissue in all vertebrates, accounting for 95 percent of the dental enamel
and nearly 50 percent of bone tissue. This active ingredient contains the essential element calcium as well as a
wide range of other nutrients vital for the human loco
motor system: phosphates, magnesium, fluoride, zinc,
copper, manganese, and others. During daytime, we need

31

The organism
starts up

79 am:

Hormones at
their peak

89 am:

Low
pain level

Chronobiology

Rhythm of Life

12 noon
Time to eat,
digestion in top gear

6 am
The organism
starts up

12 Pm
Noon low,
time for a nap

79 am
Hormones at
their peak
89 am
Low
pain level

10 am12 noon
Fully fit and wide
awake, brain functions
most efficiently

9 Pm
Stomach rests
stop eating
11 Pm
Time for bed,
BUT:

34 Pm
New upswing, phase of
learning, long-term memory

11 Pm1 am
Creativity at its
absolute peak

56 Pm
Second high,
manual work
32

5 am
Kidney at
lowest point

1 am
Dream time

69 Pm
Regeneration and
relaxation,
good sense of
smell and taste

33

2 am
All systems stop
except liver and skin
3 am
Intensive
sleep phase
4 am
Critical for
lung patients

6 am
The organism
starts up

10 AM12 noon:

much more of it than at night; this is why the chronobiological concept of morning and evening capsules is
additionally beneficial. A particularly highly advanced
preparation moreover separates the forming substances
(C, D, B6 and K1 vitamins in the morning) from the antiinflammatory and pain-relieving vital constituents (isoflavones, sulfurous compounds at bedtime). This results
in high efficacy through optimum absorption.

Womens health:

For many of us it is hard to imagine that the information structures of plants are very similar to those of the
human organism. There are substances which provide
information about day and night, spring and autumn.
These substances are similar to our hormones and are
therefore called phytohormones. Phytoestrogens play a
predominant role as they are comparable to the sexual
hormones produced by the human organism. Such plant
messenger substances almost optimally compensate the
bodys own production decrease while curbing overproduction. One can say, this astounding process fine-tunes

34

the bodys own hormone production. Innovative preparations, which are based on the chronobiological concepts
underlying the female body, regulate the female metabolism; they control i.a. hot flushes and mood swings during the day and foster a healthy sleep at night.

Plant substances provide

information about day and night,
about spring and autumn.
Pregnancy and breastfeeding:

The supply of special proteins, carefully selected vitamins and compatible mineral salts exactly in tune with
the circadian rhythm is vitally important for a healthy
pregnancy and breastfeeding period. More than three
dozens of vital substances, including trace elements and
fatty acids, are essential for our organism. Examples
include folic acid to counteract spinal deformations, iron
for blood building, calcium for the bones, etc. Moreover,
only the fine-tuned interaction of a number of antioxi-

35

Fully fit and

wide awake,
brain functions
most efficiently

12 noon:

Time to eat,
digestion in
top gear

12 pm:

Noon low,
time for a nap

dants can defend rapidly growing cells against free radical attack during this special period. For the first time,
mothers to be can rely on a product of optimal bioavailability for themselves and their baby, which supplies the
body with sufficient vitamin C and E in the morning and
delivers most B-group vitamins in the evening, thereby
fostering rather than inhibiting the uptake of the other
substances.

Mens health:

The decline of sexual hormone production in menas

well as its effects spans a period of 15 years or more.
The decline of hormones leads to a change in fat meta
bolism, muscle mass formation, heart and kidney functions as well as inner drive and libido. To maintain the
energy balance of the male organism, modern medicine
resorts to carotenoids, oils, flavonoids, phytosterines and
other natural plant constituents. (also read: Womens
health). Some extracts have a particularly stimulating
effect on the pituitary gland and increase the level of
bioavailable testosterone in the blood, which is synony-

36

For the first time, mothers to be can rely on a product of

optimal
bioavailability for themselves and their baby.
37

34 pm:

mous to male performance. A chronobiological formula

provides these supplements just at a time when the
organisms circadian clock demands them (example:
tribulus terrestris, which is contained in the evening
capsule, prepares the ground for the natural testosterone
surge in the morning).
Saw palmetto as well as a dozen of other plant constituents (such as pumpkin seed extract and resveratrol) with
a strong anti-inflammatory and cell-protective potential
serve to protect the prostate gland and may be used as a
supplemental therapy in the treatment of prostate gland
enlargement (benign prostatic hypertrophy/BPH). They
are best taken separately and at the right time of day,
split into a morning and evening capsule.

Fertility (men):

Throughout history, substances for boosting sexual

performance and male libido were held in high esteem in
every folk medicine. Today, infertility is increasingly also
becoming a problem for men, being triggered by environmental impacts, stress, addictive behavior, or medical causes such as inflammatory diseases and hormonal

Today, infertility is increasingly also

becoming a problem for men.
imbalances. A chronobiological (morning capsules,
evening capsules) combination of well-proven secondary
plant constituents can improve sperm quality and restore
the desired vitality.

New upswing,
phase of learning,
long-term
memory
56 pm:

Second high,
manual work

39

69 pm:

Regeneration
and relaxation,
good sense of
smell and taste
38

Skin:

The full replacement of dying or dead cells with new

ones takes 27 days on average. An intense suntan also
lasts that long. The daily rhythm of our skin is even
more interesting. There is a lot the skin has to cope with
throughout the day. It is a vital organ that detoxifies and
purifies our body. Skin renewal begins around 6 pm.
Loose, tiny scales containing harmful substances which
the body eliminates are shed from the skin. As many
substances are best absorbed in the evening, a facial
mask is much more effective now than at other times
during the day. Unfortunately, this is also the case with
environmental toxins and potentially allergenic substances. Chronobiology knows the secret behind optimal
cosmetic results: Highly active food supplements are not
only applied externally, but are also swallowed and reach
the deeper layers of the skin from within, through the
blood. Vital substances undergo certain processes during
digestion. The time of day influences their effectiveness.
The active ingredients administered in the morning and
evening are intelligently attuned and complement each

40

Natural beauty develops from within, but we can

support
the body also from outside.
41

9 pm:

other. This mix combats wrinkles and sagging skin from within, tightens the tissue
and supports the skin in defending the
body against harmful environmental
impacts. The improvement of blood
circulation and the elimination of free
radicals are a top priority.

Hair & nails:

Hair density on the head ranges between

200 and 900 hairs per square centimeter.
Our hair grows one third of a millimeter
each day. Up to 90 percent of the head hair is
consistently in a phase of proliferation. Especially in men, its growth diminishes with age. Some
ten percent of the human hair consists of water. Its
dry matter is mostly made up of special proteins, the
so-called keratins. Healthy hair has a high content of
cysteine, a sulfurous amino acid which makes the hair
stronger and protects it from free radicals and their
destructive effect on cells. The hair also needs silicon.

42

A lack of these substances needs to be replenished

around the clock.

Finger nails grow four times quicker

than toe nails. They consist of 100 to 150
stacked layers of cells.
Finger nails grow four times quicker than toe nails.
They consist of 100 to 150 stacked layers of cells.
Not only the horn substance keratin but also MSM, a
derivative of sulfur, and biotin (vitamin H) are essential
for healthy nails. Chronobiological preparations guarantee an optimal supply to meet the changing needs
throughout the day.

Stomach rests
stop eating

11 pm:

Time for bed,

BUT:

11 pm1 am:

Creativity at its
absolute peak
43

1 am:

Cellulite:

Cellulite develops when fat cells swell to between

60 and 100 times their size. These disturbing
pockets of fat primarily occur in the subcutaneous skin of buttocks, hips, thighs and
occasionally also upper arms, knees and
belly. Fats stored inside the cells should be
transformed into energy as needed. There
is usually a healthy balance between fat
storage and fat burning, but fat metabolism is subject to fluctuations in glucose
and fatty acid levels. Disorders of fat
metabolism are remedied by a double
strategy comprising external and internal treatment. Activation of fat burning,
the most important step, is achieved
with the help of special phytosubstances. A particularly active mix in the form
of a cream is massaged directly into the
skin in the morning. This supports the

44

regeneration of connective tissue, leaving the skin smooth

and supple. A dehydrating effect is also desirable. The
draining of water accumulation in tissue accelerates fat
mass reduction. The reduced volume of fat tissue also creates a renewed sense of wellbeing.

Disorders of fat metabolism are remedied

by a double strategy comprising external
and internal treatment.
Certain amino acids with anti-glucose properties prevent
the renewed transformation of glucose into fat reserves.
They are particularly beneficial during daytime. Other
substances are more effective in the evening. Modern
preparations take all chronobiological preconditions into
consideration to obtain a smooth and supple skin.

45

Dream time

2 am:

All systems stop

except liver and
skin

3 am:

Intensive
sleep phase

Prevention of uncontrolled cell growth:

Nutrition and genetic disposition each account for about

30percent of the general risk of developing cancer. Epidemiological studies confirm that a large number of plant
constituents have protective properties, which can meanwhile be explained by the results of research undertaken
in molecular biology.
Uncontrolled cell growth implies changes in the transcription inside the cell nucleus or the translation inside
the cell. This is exactly where the molecules of curcumin,
capsaicin, lycopene, catechines, resveratrol, or the bee
antibiotic propolis intervene. Their aim is to inhibit protein synthesis outside normal cell regulation. The chance
of success is even greater if the principles of chrono
biology are taken into account as well.

The ultimate anti-aging

preparation All good things
ready to hand: fighting the
three major threats
Aging is meanwhile regarded as the most critical risk
factor for all ailings that will determine our fate in the 21st
century. Due to their life expectancy, millions of people are
facing one or more of the following major threats:

Critical for
lung patients

5 am:

Kidney at
lowest point

Cardiovascular diseases
Dementia
Uncontrolled cell growth
The combined effect of silent inflammation and oxidative
stress on our organs has the potential to take our breath
away: heart problems, atherosclerosis (also referred to as

46

4 am:

47

6 am:

The organism
starts up

6 am:

arterial sclerosis), stroke, Alzheimers disease, depression, cancer, fibromyalgia, osteoarthritis, diabetes, metabolic syndrome, erectile dysfunction, orgasmic dysfunction, formation of wrinkles and cellulite.
The first and foremost prerequisite of successful age
management is preventing or attenuating inflammatory
stress and fighting the so-called free radicals (aggressive
oxygen molecules).

ResverAge is the first chronobiological

broad-spectrum anti-aging preparation.
It combines the best know-how from four
millennia of anti-aging medicine in an
all-in-one product.
For the individual it is almost impossible to put together
a perfect mix of effective secondary plant constituents.
Dosage, mutual interaction of the relevant substances and

48

their individual efficacy peaks require scientifically proven

formulas. ResverAge is the first chronobiological broadspectrum anti-aging preparation. It combines the best
know-how from four millennia of anti-aging medicine in
an all-in-one product.
The objectives of ResverAge are generally based on
highly effective secondary plant substances with antiinflammatory and anti-oxidative properties. The predominant share of these substances are phytoalexines from
the immune systems of plants. Nearly all of them were
discovered and tried out by the different branches of folk
medicine throughout the past four millennia. The essential
vitamins and vital substances are moreover administered
at the right time of day, in tune with the principles of
chronobiology.
All good things ready to hand: preventing silent inflammation, fighting the destructive power of free oxygen radicals, and using stimulated calorie restriction to activate
long-life genes in the human organism.

49

The organism
starts up

79 am:

Hormones at
their peak

89 am:

Low
pain level

10 am12 noon:

Tips for the user:

Heart health

Additional information on advanced

chronobiological preparations

plant constituents to optimally promote cardiovascular

health.

Cardiochron Chronobiological combination of mainly

Metabolism
The pharmaceutical products developed by chronobiology
pioneer VitaBasix are available at pharmacies or can be
obtained from the company Pharmatrans.
Sales hotline: 00800-8010 8040 (toll free)
or 0031-43-7999 070

Nutrition

Vitachron Multi-vitamin preparation enriched with

Fully fit and

wide awake,
brain functions
most efficiently

Diabetichron Innovative food supplement to regulate

glucose metabolism for diabetics.

Intestinal flora

Florachron improves the intestinal flora through a

chronobiologically designed prebiotic (morning) and probiotic (evening) mix of bacteria with a synergistic effect.

12 noon:

Time to eat,
digestion in
top gear

Mood

minerals to support a health-conscious and chrono

biologically perfect diet.

Tryptochron Chronobiological formulation for maintaining the serotonin profile adjusted to the daily
rhythm.

Mobility

Arthrochron Chronobiologically active food supplement

for persons with joints exposed to strain.

50

51

12 pm:

Noon low,
time for a nap

Sleep

Womens health

ior of falling asleep and sleeping through the night.

on plant extracts with an effect similar to that of

estrogen for the natural treatment of the symptoms of menopause.

Melachron Chronobiologically oriented natural formulation for improving the behav-

Eyes

Visiochron Chronobiological formulation with lutein and zeaxanthine for protecting

the retina against harmful effects.

Menochron Innovative food supplement based

Pregnancy and breastfeeding

Pregnachron Innovative food supplement

Concentration

Neurochron Chronobiologically active food supple-

ment based on plant extracts, vitamins and minerals

for the maintenance of mental fitness and enhancement of concentration.

Bone health

Osteochron Highly active mineral and vitamin

complex promoting the physiological metabolism

of the skeletal system through chronobiologically
controlled release.

52

for pregnant and breast-feeding women,

supplying mother and child with all vital
vitamins, minerals and trace elements.

Supplies mother and child

with all vital vitamins,
minerals and trace elements.

53

Our range of
chronobiological products:
Androchron Arthrochron Cardiochron Celluchron
Cerachron Diabetichron Fertilichron Florachron
Juvichron Melachron Menochron Neurochron
Oncochron Osteochron Pregnachron Prostachron
ResverAge Tryptochron Visiochron Vitachron

54

55

The four elements

of chronobiology:
the optimal substance
the right quantity
the selected target organ
the most effective time point

34 pm:

Mens health

Fruchtbarkeit (Mann)

the beginning of testosterone deficiency.

plants for increasing the vitality and mobility of sperms

and the sperm count.

Androchron Chronobiological food supplement for men over 50 with weak drive and
Prostachron Mixture of well-proven medicinal plant extracts for optimum protection

against age-related prostate complaints as well as for alleviating nocturia, formulated

on the basis of the latest chronobiological principles.
Prostate gland
Urine tube
Testicles

Bladder Bladder
Ureter Bladder neck
Kidney

Normal
prostate gland
Seminal vesicle

Formation of
residual urine
Enlarged
prostate

Fertilichron Chronobiological mixture of medicinal

Skin

Juvichron Unique combination of active ingredients for

the skin to achieve optimal cosmetic results.

Narrowed urine tube

New upswing,
phase of learning,
long-term
memory

Hair & nails

Cerachron Chronobiological form of administration of

56 pm:

Second high,
manual work

highly effective substances for healthy hair and nails.

Promotes hair growth from within.

Cellulite

Celluchron Innovative combination of active substances

administered on the basis of chronobiological principles
to fight cellulite from the inside and outside.

56

57

69 pm:

Regeneration
and relaxation,
good sense of
smell and taste

Prevention of uncontrolled cell growth

All good things ready to hand: 4000 years

of anti-aging medicine from east to west

Oncochron Chronobiological preparation for the preven-

tion of uncontrolled cell growth in the organs.

All good things ready to hand: ResverAge

The first chronobiological broad-spectrum
anti-aging preparation

Superfruits

ResverAge Chronobiological preparation offering protec-

Green cellular protection

With the natural power of Acai berries, Goji berries,

mangosteen, noni, pomegranate and many other
fruit extracts.

tion against the three major threats emanating from the

risk factor age:

With catechins, the active ingredients of green tea,

L-glutathione and many other extracts from vegetables
such as broccoli, cabbage, spinach, carrot and tomato.

Cardiovascular diseases

Multivitamin AM

Dementia

The activating vitamin mixture for the day, consisting

of beta-carotene, vitamins B6, C, D, E and K, choline,
inositol, chromium, lycopene and Bioperine.

Uncontrolled cell growth

Well-balanced combination of the most effective and
best investigated anti-inflammatory and anti-oxidative
secondary plant constituents from four millennia of antiaging medicine.

58

Anti-Inflammation

The combination of active ingredients against silent

inflammation: MSM, enzyme complex, grape seed
extract, Coral Calcium and beta-1,3-glucan.

a.m.

Red wine complex

The full force of red wine responsible for the

French paradox: resveratrol, quercetin,
catechins and OPC.

Omega 3

Vital elements that the body cannot produce by itself:

Omega3 complex (Omega600 USP, with DHA, EPA,
D-Alpha-Tocopherol, etc.)

Multivitamin PM

The regenerating vitamin mixture for the night, consisting

of vitamins B1, B2, B12, niacinamide, pantothenic acid,
biotin, folic acid, magnesium, Royal Jelly and Bioperine.

Further information about ResverAge can be found

on the internet under www.resverage.com

p.m.

Summary
Chronobiology works effectively through the optimal
substance, the exactly needed dosage, a new under
standing of the complex relationships, and the
sparking time point. The most important criteria
determining the effect achieved by a perfectly timed
application are: What is most effective when taken in
the morning? What does the body need in the evening?
Which substances have a mutually potentiating effect?
Which substances curb or distort the desired effect?
Today we know that many of the most popular and
successful therapies can be even further optimized. Many
substances may not have reached the target organ at the
right time of day or in the best pharmaceutical form yet.

line with the concept of a perfect top-to-toe 24-hour

food supplement. The products are manufactured in
compliance with good manufacturing practice (GMP)
standards. Quality, pureness of raw materials and
concentration are reviewed by independent testing
laboratories in keeping with FDA guidelines (US Food
and Drug Administration).

If you have any questions, please call the manufacturer,

VitaBasix, at 00800-1570 1570 (toll-free) or
0031-43-7999 317 or visit the website

www.vitabasix.com.

You may also speak to your doctor.

Chronotherapeutic preparations take account of the

effect of therapeutic influences in accordance with the
inner clock. The products described above are fully in

60

61

Information hotline:
Tel.: 00800-1570 1570
(toll free)
or 0031-43-7999 317

or on the website:
www.vitabasix.com

The latest findings in chronobiological research

help us to do the right thing at the right time.
Each organ, each individual cell in our body follows its own specific rhythm.
It is therefore evident that the effect of food supplements and medicines also
varies throughout the day.

Vitamins and trace elements Check the hour first!

Plant constituents Know the perfect time of day!
Multi-component preparations Test your tolerance!
Synergy effects Deliver the suitable vital constituents to the target organs at
the right time!
This is how you strengthen your organism exactly at a time when even little
support has a huge effect. The efficacy of the formulation you take is increased.
Adverse effects are reduced.

Chronobiology hotline:
00800-1570 1570 (toll free) or 0031-43-7999 317
More information is available on the website www.vitabasix.com